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1. 发明申请

WO2008106121A2 MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON STYRENE-ISOBUTYLENE COPOLYMERS 审中-公开
标题翻译：基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗器械
公开(公告)号：WO2008106121A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/002504
申请日：2008-02-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , LINDQUIST, Jeffrey, S. , STRICKLER, Frederick, H. , BODEN, Mark , SEPPALA, Jan , MILLER, Paul, J.
发明人： LINDQUIST, Jeffrey, S. , STRICKLER, Frederick, H. , BODEN, Mark , SEPPALA, Jan , MILLER, Paul, J.
IPC分类号： A61L31/04 , A61L29/04 , A61L27/16 , A61L27/34 , A61L31/10 , A61L29/08
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。

2. 发明申请

WO2009039429A2 THERAPEUTIC AGENT-ELUTING MEDICAL DEVICES HAVING TEXTURED POLYMERIC SURFACES 审中-公开
标题翻译：具有纹理聚合物表面的治疗剂治疗医疗器械
公开(公告)号：WO2009039429A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/077101
申请日：2008-09-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Alden , BODEN, Mark , STRICKLER, Frederick, H. , TENNEY, Barron, W.
发明人： FLANAGAN, Alden , BODEN, Mark , STRICKLER, Frederick, H. , TENNEY, Barron, W.
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/414 , A61L2300/416 , C08L71/02
摘要： A medical device comprising: (a) a substrate having first and second surfaces, (b) a therapeutic-agent-eluting polymeric layer disposed over the first substrate surface and (c) a textured polymeric layer that is textured to promote cell attachment, cell growth, or both, disposed over the second surface.
摘要翻译：一种医疗装置，包括：（a）具有第一和第二表面的基底，（b）设置在所述第一基底表面上的治疗剂洗脱聚合物层，和（c）织构化的纹理聚合物层，以促进细胞附着，细胞生长或两者，设置在第二表面上。

3. 发明申请

WO2009076582A2 MELT PROCESSED MATERIALS FOR MEDICAL ARTICLES 审中-公开
标题翻译：用于医疗文章的金属加工材料
公开(公告)号：WO2009076582A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/086530
申请日：2008-12-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STRICKLER, Frederick, H. , TENNEY, Barron , BODEN, Mark
发明人： STRICKLER, Frederick, H. , TENNEY, Barron , BODEN, Mark
IPC分类号： C08J9/12
CPC分类号： C08F6/005 , A61L27/34 , A61L29/085 , A61L31/10 , C08F20/10 , C08J9/122 , C08J2201/03 , C08J2353/02 , C08J2367/02 , Y02P20/544 , C08L53/02
摘要： In accordance with an aspect of the invention, methods of forming medical articles are provided, which comprise (a) preparing a melt phase that comprises a molten polymer and a supercritical fluid, (b) forming a polymeric region from the melt phase, and (c) cooling the polymeric region. In certain embodiments, the supercritical fluid is formed from chemical species (e.g., CO 2 , propane, etc.) that are gases at room temperature (25°C) and atmospheric pressure (1 atm). According to another aspect of the present invention, medical articles are provided which comprise melt-processed polymeric materials. The polymeric materials have a composition that cannot be melt processed without the use of melt-viscosity reducing additives due to thermal degradation, and yet the polymeric material does not contain such additives.
摘要翻译：根据本发明的一个方面，提供了形成医疗制品的方法，其包括（a）制备包含熔融聚合物和超临界流体的熔融相，（b）从熔融相形成聚合物区域，和 c）冷却聚合物区域。在某些实施方案中，超临界流体由在室温（25℃）和大气压（1atm）下为气体的化学物质（例如，CO 2，丙烷等）形成。根据本发明的另一方面，提供了包含熔融加工的聚合材料的医疗制品。聚合物材料具有不会由于热降解而不使用熔融粘度降低添加剂而不能熔融加工的组合物，而聚合物材料不含这些添加剂。

4. 发明申请

WO2008106176A1 MEDICAL ARTICLES FOR LONG TERM IMPLANTATION 审中-公开
标题翻译：长期植入医疗文章
公开(公告)号：WO2008106176A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002604
申请日：2008-02-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HELMUS, Michael, N. , TENNEY, Barron , XU, Yixin , ALVES, Kevin, M. , STRICKLER, Frederick, H. , MILLER, Kathleen, M. , BODEN, Mark
发明人： HELMUS, Michael, N. , TENNEY, Barron , XU, Yixin , ALVES, Kevin, M. , STRICKLER, Frederick, H. , MILLER, Kathleen, M. , BODEN, Mark
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： A61F2/07 , A61F2/06 , A61F2/915 , A61F2002/009 , A61F2002/072 , A61F2002/075 , A61F2250/0024 , A61L27/427 , A61L27/56 , A61L31/128 , A61L31/146
摘要： According to an aspect of the present invention, long term medical articles are provided which include the following: first and second body contacting ( e.g. , tissue and/or body-fluid contacting) porous polymeric layers (120, 130); a polymeric barrier layer (120) disposed between the first and second porous polymer layers; and a reinforcement element (150). According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: a reinforcement element; a blood contacting porous polymeric layer having a surface energy ranging between 0,2 and 0,3mN/cm (20 and 30 dynes/cm) disposed over an inner surface of the reinforcement element; and an additional porous polymeric layer formed over an outer surface of the reinforcement element.
摘要翻译：根据本发明的一个方面，提供了长期医疗制品，其包括以下：第一和第二体接触（例如，组织和/或体液接触）多孔聚合物层（120,130）; 设置在第一和第二多孔聚合物层之间的聚合物阻挡层（120）和加强件（150）。根据本发明的另一方面，提供了用于长期植入的管状医疗制品，其包括：加强元件; 设置在增强元件的内表面上的表面能范围在0.2和0.3mN / cm（20和30达因/厘米）之间的血液接触多孔聚合物层; 以及形成在增强元件的外表面上的另外的多孔聚合物层。

5. 发明申请

WO2008024510A2 MEDICAL DEVICES HAVING IMPROVED MECHANICAL PERFORMANCE 审中-公开
标题翻译：具有改进的机械性能的医疗装置
公开(公告)号：WO2008024510A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018840
申请日：2007-08-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STRICKLER, Frederick, H. , BODEN, Mark
发明人： STRICKLER, Frederick, H. , BODEN, Mark
IPC分类号： A61L27/26 , A61F2/00
CPC分类号： A61L27/16 , A61L29/041 , A61L31/048 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。

6. 发明申请

WO2007075244A1 MEDICAL DEVICES HAVING POLYMERIC REGIONS THAT CONTAIN FLUOROCARBON-CONTAINING BLOCK COPOLYMERS 审中-公开
标题翻译：具有含有含氟嵌段共聚物的聚合物区域的医疗器械
公开(公告)号：WO2007075244A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/045259
申请日：2006-11-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STRICKLER, Frederick, H. , SAHATJIAN, Ronald, A.
发明人： STRICKLER, Frederick, H. , SAHATJIAN, Ronald, A.
IPC分类号： C08F293/00 , A61L27/34 , A61L27/00 , A61L29/00 , C09D153/00
CPC分类号： C08L53/00 , C08F293/00 , C08F293/005 , C09D153/00
摘要： In one aspect, the present invention provides implantable or insertable medical devices, which contain at least one polymeric region. The polymeric region contains at least one fluorocarbon-containing block copolymer, which, in turn, contains (a) at least one fluorocarbon-containing, low glass transition temperature (low Tg) copolymer chain and (b) at least one glass transition temperature (high Tg) polymer chain.
摘要翻译：在一个方面，本发明提供了包含至少一个聚合物区域的可植入或可插入的医疗装置。聚合物区域含有至少一种含碳氟化合物的嵌段共聚物，其又包含（a）至少一种含碳氟化合物，低玻璃化转变温度（低Tg）共聚物链和（b）至少一个玻璃化转变温度高Tg）聚合物链。

7. 发明申请

WO2008027107A2 MEDICAL DEVICES HAVING POLYMERIC REGIONS WITH IMPROVED ADHESION 审中-公开
标题翻译：具有改善粘合性的聚合物区域的医疗装置
公开(公告)号：WO2008027107A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/014892
申请日：2007-06-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STRICKLER, Frederick, H.
发明人： STRICKLER, Frederick, H.
IPC分类号： A61L31/04
CPC分类号： A61L31/041 , A61L31/14 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insert able medical devices are provided, which contain at least one polymeric region in contact with a metallic region. The polymeric region contains at least one block copolymer that contains at least one low Tg block and at least one high Tg block. The polymeric region contains at least one polymer that contains at least one adhesion promoting group selected from one or more of halo-silane, alkoxy-silane, epoxy, anhydride, phenoxy, hydroxyl, amino, sulfonate and carboxyl groups, which at least one polymer may correspond to the block copolymer, a supplemental polymer, or both.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含与金属区域接触的至少一个聚合物区域。聚合物区域含有至少一种包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。聚合物区域含有至少一种含有至少一种选自卤代硅烷，烷氧基 - 硅烷，环氧，酸酐，苯氧基，羟基，氨基，磺酸酯和羧基中的一种或多种粘附促进基团的聚合物，该至少一种聚合物可以对应于嵌段共聚物，补充聚合物，或两者。

8. 发明申请

WO2006083904A2 MEDICAL DEVICES HAVING POROUS POLYMERIC REGIONS FOR CONTROLLED DRUG DELIVERY AND REGULATED BIOCOMPATIBILITY 审中-公开
标题翻译：具有多个聚合物区域用于控制药物递送和调节生物活性的医疗装置
公开(公告)号：WO2006083904A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/003455
申请日：2006-02-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RICHARD, Robert, E. , STRICKLER, Frederick, H. , SCHWARZ, Marlene, C. , FAUST, Rodolf , SHRIRANG, Ranade, V. , HELMUS, Michael, N.
发明人： RICHARD, Robert, E. , STRICKLER, Frederick, H. , SCHWARZ, Marlene, C. , FAUST, Rodolf , SHRIRANG, Ranade, V. , HELMUS, Michael, N.
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrate polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸且可进行生物分解的聚合物的生物分解聚合物相，区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米级尺寸的崩解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

9. 发明申请

WO2006014606A2 MEDICAL DEVICES CONTAINING COPOLYMERS WITH GRAFT COPOLYMER ENDBLOCKS FOR DRUG DELIVERY 审中-公开
标题翻译：含有用于药物递送的共聚酯封端剂的共聚物的医疗装置
公开(公告)号：WO2006014606A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/025518
申请日：2005-07-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STRICKLER, Frederick, H. , RICHARD, Robert, E.
发明人： STRICKLER, Frederick, H. , RICHARD, Robert, E.
IPC分类号： A61L27/00
CPC分类号： A61L31/16 , A61L29/041 , A61L29/16 , A61L31/048 , A61L2300/602
摘要： The present invention provides a medical device comprising a release region and a therapeutic agent disposed within over beneath the release region, and the release region includes a copolymer comprising a low T g block and at least one graft copolymer endblock having a main chain and a plurality of side chains.
摘要翻译：本发明提供了一种医疗装置，其包括设置在释放区域下方的释放区域和治疗剂，并且释放区域包括包含低T嵌段和至少一个接枝共聚物末端嵌段的共聚物具有主链和多个侧链。

10. 发明申请

WO2008109098A3 MEDICAL DEVICES HAVING IMPROVED PERFORMANCE 审中-公开
公开(公告)号：WO2008109098A3
公开(公告)日：2008-09-12
申请号：PCT/US2008/002906
申请日：2008-03-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BRITO, Shaina , STRICKLER, Frederick, H.
发明人： BRITO, Shaina , STRICKLER, Frederick, H.
IPC分类号： A61L27/16 , A61L29/04 , A61L31/04
摘要： In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block

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