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1. 发明申请

WO2011126946A1 VASO-OCCLUSIVE DEVICES 审中-公开
标题翻译： VASO-OCCLUSIVE设备
公开(公告)号：WO2011126946A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/030972
申请日：2011-04-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , MURPHY, Richard
发明人： CHEN, Hancun , MURPHY, Richard
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B2017/00831 , A61B2017/12054 , A61B2017/12063 , A61B2090/3966
摘要： Vaso-occlusive device includes a coil having a proximal and a distal end; the coil comprises a helically wounded elongated member having a core and an outer layer, the outer layer made from a metal or alloy that has a different stiffness than a core's stiffness. Vaso-occlusive device includes a first coil and a second coil coupled to each other such that at least one loop from the first coil is between two adjacent loops from the second coil; the first coil is made from a first material, and the second coil is made from a second material stiffer than the first material. Vaso-occlusive device includes an outer coil having a plurality of loops that define a lumen therethrough, and an inner coil located within the lumen of the outer coil; each of the outer and the inner coils is made from a metal or an alloy.
摘要翻译：血管闭塞装置包括具有近端和远端的线圈; 线圈包括具有芯和外层的螺旋形受伤的细长构件，外层由具有与芯刚度不同的刚度的金属或合金制成。血管闭塞装置包括彼此联接的第一线圈和第二线圈，使得来自第一线圈的至少一个回路位于来自第二线圈的两个相邻的回路之间; 第一线圈由第一材料制成，并且第二线圈由比第一材料更硬的第二材料制成。血管闭塞装置包括具有限定通过其中的腔的多个环的外部线圈和位于外部线圈的内腔内的内部线圈; 外线圈和内线圈均由金属或合金制成。

2. 发明申请

WO2011062844A1 DELIVERY WIRE ASSEMBLY FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：交付设备传送系统的交付线组件
公开(公告)号：WO2011062844A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/056483
申请日：2010-11-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , MURPHY, Richard , CASTELLI, Shana
发明人： CHEN, Hancun , MURPHY, Richard , CASTELLI, Shana
IPC分类号： A61B17/12 , A61B17/00 , A61F2/82
CPC分类号： A61B17/12022 , A61B17/12031 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B2017/00292 , A61B2017/00734 , A61B2017/12063
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature, the assembly having a distal end portion comprising a proximal rigid segment, a distal rigid segment, and a flexible segment disposed between the proximal and distal rigid segments. The assembly also has a delivery wire conduit having a proximal tubular portion coupled to a distal coil portion, the respective tubular and coil portions defining a conduit lumen. A plug is seated in the conduit lumen and secured to an interior surface of the delivery wire conduit. A core wire is disposed in the conduit lumen and having a distal end extending through the plug, so that the plug secures the core wire to the delivery wire conduit. The plug may form a substantially fluid tight seal of the conduit lumen.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件，所述组件具有包括近端刚性段，远侧刚性段和设置在近端和远端刚性段之间的柔性段的远端部分。组件还具有输送线导管，其具有联接到远端线圈部分的近端管状部分，相应的管状部分和线圈部分限定导管腔。塞子位于导管管腔中并固定到输送线管道的内表面。芯线设置在导管管腔中并且具有延伸穿过插塞的远端，使得插头将芯线固定到输送线导管。塞子可以形成导管管腔的基本上流体密封的密封。

3. 发明申请

WO2010120653A1 DELIVERY WIRE FOR OCCLUSIVE DEVICE DELIVERY SYSTEM AND METHOD OF MANUFACTURE 审中-公开
标题翻译：用于交付设备传送系统的交付线及其制造方法
公开(公告)号：WO2010120653A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030620
申请日：2010-04-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
发明人： CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B2017/12063 , Y10T29/49826
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature includes a delivery wire conduit having a proximal tubular portion coupled to a distal coil portion, the respective tubular and coil portions defining a conduit lumen, a plug at least partially seated in the conduit lumen and coupled to an interior surface of the coil portion so as to form a substantially fluid tight seal of the conduit lumen, and a core wire disposed in the conduit lumen, the core wire having a distal end extending through the plug and coupled to an occlusive device.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括输送线导管，其具有联接到远端线圈部分的近端管状部分，相应的管状部分和线圈部分限定导管管腔，塞子至少部分地位于导管管腔中并联接到线圈部分的内表面，以便形成导管管腔的基本上流体密封的密封，以及设置在导管管腔中的芯线，芯线具有延伸穿过插塞的远端并耦合到闭塞装置。

4. 发明申请

WO2010117883A1 DELIVERY WIRE FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：用于交付设备传送系统的交付线
公开(公告)号：WO2010117883A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/029700
申请日：2010-04-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
发明人： CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B90/39 , A61B2017/12063 , A61B2017/12068 , A61M2025/09133 , A61M2025/0915
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature includes a delivery wire conduit having a proximal tubular portion connected to a distal coil portion, and a conduit lumen extending through the proximal tubular portion and the distal coil portion. The delivery wire assembly also includes a core wire disposed in the conduit lumen and having a distal end coupled to an occlusive device. The distal coil portion of the delivery wire assembly includes a plurality of zones and the plurality of zones decrease in stiffness distally along the length of the distal coil portion of the delivery wire assembly.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括输送线导管，其具有连接到远侧线圈部分的近端管状部分和延伸穿过近端管状部分和远端线圈部分的管腔。输送线组件还包括设置在导管管腔中并且具有联接到闭塞装置的远端的芯线。输送线组件的远端线圈部分包括多个区域，并且多个区域沿着输送线组件的远端线圈部分的长度向远侧减小。

5. 发明申请

WO2011060128A2 DELIVERY WIRE ASSEMBLY FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：交付设备传送系统的交付线组件
公开(公告)号：WO2011060128A2
公开(公告)日：2011-05-19
申请号：PCT/US2010/056330
申请日：2010-11-11
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , MURPHY, Richard , DAO, Jimmy
发明人： CHEN, Hancun , MURPHY, Richard , DAO, Jimmy
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/0088 , A61B2017/12063 , A61B2018/00083
摘要： A core wire of a delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature, includes a wire having a polyimide coating, with a polymer jacket disposed around the polyimide coating, and a hypotube disposed around the polymer jacket. The delivery wire assembly further comprises a delivery wire conduit including a coil disposed around the wire, wherein a proximal end of the coil is connected to a distal end of the hypotube. The polyimide coating may be enhanced with a nano-particle or micro-fiber ceramic, such as yttria-stabilized zirconia.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件的芯线包括具有聚酰亚胺涂层的线，聚酰亚胺涂层周围设置聚合物护套，以及设置在聚合物护套周围的海波管。输送线组件还包括输送线导管，其包括设置在线周围的线圈，其中线圈的近端连接到海波管的远端。聚酰亚胺涂层可以用纳米颗粒或微纤维陶瓷如氧化钇稳定的氧化锆来增强。

6. 发明申请

WO2010120694A1 ELECTRICAL CONTACT FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：电气设备输送系统的电气接触
公开(公告)号：WO2010120694A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030753
申请日：2010-04-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , GUO, Lantao , DAO, Jimmy , VO, Justin , WILLIAMS, Michael , MURPHY, Richard
发明人： CHEN, Hancun , GUO, Lantao , DAO, Jimmy , VO, Justin , WILLIAMS, Michael , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B2017/12063
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature includes a delivery wire conduit having a proximal tubular portion coupled to a distal coil portion, the respective tubular and coil portions defining a conduit lumen. A core wire is disposed in the conduit lumen and having a distal end coupled to an occlusive device, wherein an elongate electrical contact body at least partially seated in the conduit lumen and coupled to a proximal end of the core wire, the electrical contact body and the proximal tubular portion forming a junction. A coil collar is disposed around the electrical contact body near the junction.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括输送线导管，其具有联接到远端线圈部分的近端管状部分，相应的管状部分和线圈部分限定导管腔。芯线布置在导管管腔中并且具有联接到闭塞装置的远端，其中细长电接触体至少部分地位于导管管腔中并且联接到芯线的近端，电接触体和近端管状部分形成结。在接头附近的电接触体周围设置线圈套圈。

7. 发明申请

WO2006076476A2 VASO-OCCLUSIVE DEVICES WITH ATTACHED POLYMER STRUCTURES 审中-公开
标题翻译：具有连接聚合物结构的VASO-OCCLUSIVE设备
公开(公告)号：WO2006076476A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001055
申请日：2006-01-11
申请人： BOSTON SCIENTIFIC SCIMED, INC. , PORTER, Stephen, Christopher , QUE, Like , DAO, Jimmy, D. , CASTELLI, Shana, B. , MURPHY, Richard , AGANON, Nestor , CAMINS, Lilibeth, S.
发明人： PORTER, Stephen, Christopher , QUE, Like , DAO, Jimmy, D. , CASTELLI, Shana, B. , MURPHY, Richard , AGANON, Nestor , CAMINS, Lilibeth, S.
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B2017/00004 , A61B2017/12054 , A61B2017/12063 , D03D13/004
摘要： Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices comprising at least one polymer structure and methods of making and using these devices.
摘要翻译：本文公开了用于形成阻塞患者脉管系统的血管闭塞装置。更具体地，本文公开了包含至少一种聚合物结构的血管闭塞装置以及制造和使用这些装置的方法。

8. 发明申请

WO2006138536A1 VASO-OCCLUSIVE DELIVERY DEVICE WITH KINK RESISTANT, FLEXIBLE DISTAL END 审中-公开
标题翻译： VASO-OCCLUSIVE传送装置，具有抗振动，灵活的远端
公开(公告)号：WO2006138536A1
公开(公告)日：2006-12-28
申请号：PCT/US2006/023443
申请日：2006-06-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HENRY, Bill , DALY, Charles , FORD, Russell , WILLIAMS, Michael , DUONG, Hanh , RAMZIPOOR, Kamal , TEOH, Clifford , MURPHY, Richard , HUFFMASTER, Andrew , MCGILL, Scott , DEVANEY, Hughie
发明人： HENRY, Bill , DALY, Charles , FORD, Russell , WILLIAMS, Michael , DUONG, Hanh , RAMZIPOOR, Kamal , TEOH, Clifford , MURPHY, Richard , HUFFMASTER, Andrew , MCGILL, Scott , DEVANEY, Hughie
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12154 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61M25/09 , A61M2025/09133
摘要： A device (60) for delivering an occlusive element (62) includes an elongate sheath (64) having a lumen (66) therein. An elongate core member (68) is disposed within the lumen (66) and is formed from a proximal portion (68a) and distal portion (68b) connected via a joint (70). The distal portion (68b) of the elongate core member includes a severable junction (90) secured to the occlusive element ((62). A marker coil (78) is coaxially arranged around the distal portion of the elongate core member (68) and is partially disposed inside the sheath lumen (66). A coil member (80) is coaxially arranged around the distal portion (68b) of the elongate core member and coaxially arranged around at least a portion of the marker coil (78) extending outside the lumen (66) of the sheath (64). The coil member (80) is secured at a distal end thereof to the distal portion of the elongate core member (68b). The device (60) resists axial compression while allowing for radial bending.
摘要翻译：用于输送闭塞元件（62）的装置（60）包括其中具有内腔（66）的细长护套（64）。细长芯部件（68）设置在内腔（66）内，并由经由接头（70）连接的近端部分（68a）和远端部分（68b）形成。细长芯部件的远端部分（68b）包括固定到闭塞元件（62）上的可分开的接头（90），标记线圈（78）围绕细长芯部件（68）的远端部分同轴设置，线圈构件（80）围绕所述细长芯构件的远端部分（68b）同轴地布置，并且围绕所述标记线圈（78）的至少一部分同轴地布置，所述标记线圈护套（64）的内腔（66），线圈构件（80）的远端固定在细长芯构件（68b）的远端部分上，装置（60）抵抗轴向压缩同时允许径向弯曲。

9. 发明申请

WO2012109367A1 VASO-OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译： VASO-OCCLUSIVE设备交付系统
公开(公告)号：WO2012109367A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024349
申请日：2012-02-08
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED , CHEN, Hancun , MURPHY, Richard
发明人： CHEN, Hancun , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/12063
摘要： A vaso-occlusive device delivery system includes a delivery wire assembly having a core wire disposed in a delivery wire lumen, and a vaso-occlusive device having a tapered proximal end and defining a vaso-occlusive device lumen, wherein a tether is disposed in the lumen and secured to the core wire. A link may be attached to each of the core wire, the proximal end of the vaso-occlusive device, and the tether. Alternatively, the system may include a transition member attached to the vaso-occlusive device and secured to the core wire.
摘要翻译：血管闭塞装置递送系统包括具有布置在输送丝腔内的芯线的输送线组件和具有锥形近端并限定血管闭塞装置内腔的血管闭塞装置，其中系绳设置在内腔并固定在芯线上。连接件可以连接到芯线，血管闭塞装置的近端和系绳中的每一个。或者，系统可以包括附接到血管闭塞装置并固定到芯线的过渡构件。

10. 发明申请

WO2013039829A1 VASO-OCCLUSIVE DEVICE 审中-公开
标题翻译： VASO-OCCLUSIVE设备
公开(公告)号：WO2013039829A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054428
申请日：2012-09-10
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED , MURPHY, Richard , CHEN, Hancun
发明人： MURPHY, Richard , CHEN, Hancun
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12145 , A61B17/1215
摘要： A vaso-occlusive device includes a coil made from coil wire, wherein the coil wire includes a core containing a core material having a first electrical potential covered by a coating containing a coating material having a second electrical potential, wherein the second electrical potential is less than the first electrical potential. A method of manufacturing a vaso-occlusive device includes cladding a core with a magnesium containing coating to form a wire, wrapping the wire around a mandrel to form a coil, and heat-setting the coiled wire. A method of occluding a body cavity with a vaso-occlusive device includes delivering the vaso-occlusive device to a body cavity and inducing a reduction reaction in the body cavity and adjacent the vaso-occlusive device, wherein the reduction reaction reduces infections and promotes cell proliferation in the body cavity.
摘要翻译：一种血管闭塞装置包括由线圈线制成的线圈，其中所述线圈线包括芯，所述芯包含具有由包含具有第二电位的涂层材料的涂层覆盖的第一电位的芯材料，其中所述第二电势较小比第一个电位。制造血管闭塞装置的方法包括用含镁涂层包覆芯以形成线，将线围绕心轴缠绕以形成线圈，并对线圈进行热定型。用血管闭塞装置闭塞体腔的方法包括将血管闭塞装置输送到体腔并在体腔内和邻近血管闭塞装置处引起还原反应，其中还原反应减少感染并促进细胞体腔增生。

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