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1. 发明申请

WO2014176448A3 THERMODILUTION CATHETER SYSTEMS AND METHODS FOR DETERMINING BLOOD FLOW RATES 审中-公开
标题翻译：热血导管系统和测定血流速率的方法
公开(公告)号：WO2014176448A3
公开(公告)日：2014-12-24
申请号：PCT/US2014035339
申请日：2014-04-24
申请人： BOSTON SCIENT SCIMED INC
发明人： ANDERSON JAMES M , WEBER JAN , KOCH STEVEN J , GIRTON TIMOTHY S , DE BRUYNE BERNARD , PIJLS HJ NICO
IPC分类号： A61B5/028 , A61M25/00
CPC分类号： A61B5/026 , A61B5/028
摘要： Catheter systems and methods for determining blood flow rates based on temperature measurements by thermodilution. The catheter may include a fluid lumen defined between inner and outer tubular members for delivering an indicator fluid, and a guidewire lumen defined by the inner tubular member. The catheter may include fluid infusion openings at the distal end region of the outer tubular member configured to permit the indicator fluid to exit the catheter from the fluid lumen, and a fluid hole located at the distal end region of the inner tubular member configured to permit the indicator fluid to pass from the fluid lumen into the guidewire lumen. A temperature sensor positioned on a guidewire may be positioned within the guidewire lumen to measure the temperature of the indicator fluid entering the guidewire lumen through the fluid hole. A blood flow rate may be calculated based on the measured temperature.
摘要翻译：基于热稀释温度测量确定血流速度的导管系统和方法。导管可以包括限定在用于输送指示剂流体的内部和外部管状构件之间的流体内腔以及由内部管状构件限定的导丝内腔。导管可以包括在外管状部件的远端区域处的流体注入开口，该流体注入开口被配置成允许指示剂流体从流体管腔离开导管，位于内管状部件的远端区域处的流体孔被配置成允许指示剂流体从流体腔流入导丝腔。定位在导丝上的温度传感器可定位在导丝内腔内以测量通过流体孔进入导丝内腔的指示剂流体的温度。基于测量的温度可以计算血液流量。

2. 发明申请

WO2009088969A3 DETACHMENT MECHANISMS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：可移植设备的分离机制
公开(公告)号：WO2009088969A3
公开(公告)日：2010-01-21
申请号：PCT/US2009000017
申请日：2009-01-05
申请人： BOSTON SCIENT SCIMED INC , TEOH CLIFFORD , WILLIAMS MICHAEL , MIRIGIAN GREGORY E , CARROLL KIRSTEN , ANDERSON JAMES M , RASSAT JAY , ARCAND BENJAMIN , SUTERMEISTER DEREK
发明人： TEOH CLIFFORD , WILLIAMS MICHAEL , MIRIGIAN GREGORY E , CARROLL KIRSTEN , ANDERSON JAMES M , RASSAT JAY , ARCAND BENJAMIN , SUTERMEISTER DEREK
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209
摘要： Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies.
摘要翻译：本文公开了一种用于血管闭塞装置的分离机构，其允许快速操作者控制将血管闭塞装置释放到选定部位。还公开了包括这些分离机构的血管闭塞组件和使用这些分离机构和血管闭塞组件的方法。

3. 发明申请

WO2015161181A9 DEVICES AND METHODS FOR THERAPEUTIC HEAT TREATMENT 审中-公开
标题翻译：用于治疗热处理的装置和方法
公开(公告)号：WO2015161181A9
公开(公告)日：2015-11-19
申请号：PCT/US2015026344
申请日：2015-04-17
申请人： BOSTON SCIENT SCIMED INC
发明人： SUTERMEISTER DEREK C , HAVERKOST PATRICK A , OSTROOT TIMOTHY A , HANSON CASS ALEXANDER , LINDQUIST JEFFREY S , KRONSTEDT JOSEPH ALAN , WEBER JAN , ANDERSON JAMES M , WILLARD MARTIN R
IPC分类号： A61B18/08 , A61B17/00 , A61B18/00 , A61B18/14
CPC分类号： A61B18/082 , A61B17/320725 , A61B18/04 , A61B18/14 , A61B18/1492 , A61B2017/00088 , A61B2017/22061 , A61B2018/00011 , A61B2018/00125 , A61B2018/00136 , A61B2018/00148 , A61B2018/00154 , A61B2018/0016 , A61B2018/00178 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00595 , A61B2018/00601 , A61B2018/00642 , A61B2018/00714 , A61B2018/00815 , A61B2018/087 , A61B2018/1465 , A61K41/0052 , A61K47/6957 , A61M25/0043 , A61M2025/0042 , A61N1/406
摘要： Methods and devices (e.g., for nerve modulation) may include at least one thermistor and a balloon having a balloon wall. In one or more embodiments, the medical device is configured and arranged to transfer heat to the medical device surroundings. In one or more embodiments, the at least one thermistor is a portion of a thermistor array disposed on the balloon wall, the thermistor array including a plurality of thermistors and operatively engaged with a source of electric current. In one or more embodiments, the device includes at least one flexible circuit mounted on the outer surface of the expandable balloon, the at least one flexible circuit including at least one temperature-sensing device that includes at least one thermistor, wherein at least a portion of a conductive layer is electronically coupled to the thermistor, with the proviso that no electrode is associated with the conductive layer.
摘要翻译：方法和装置（例如，用于神经调制）可以包括至少一个热敏电阻和具有球囊壁的球囊。在一个或多个实施例中，医疗装置被配置和布置成将热量传递到医疗装置周围环境。在一个或多个实施例中，所述至少一个热敏电阻是设置在气球壁上的热敏电阻阵列的一部分，热敏电阻阵列包括多个热敏电阻并且与电流源可操作地接合。在一个或多个实施例中，该装置包括安装在可膨胀气囊的外表面上的至少一个柔性电路，所述至少一个柔性电路包括至少一个包括至少一个热敏电阻的温度感测装置，其中至少一部分导电层的电极电耦合到热敏电阻，条件是没有电极与导电层相关联。

4. 发明申请

WO2014059165A2 RENAL NERVE MODULATION DEVICES AND METHODS 审中-公开
标题翻译：肾神经调节装置和方法
公开(公告)号：WO2014059165A2
公开(公告)日：2014-04-17
申请号：PCT/US2013064370
申请日：2013-10-10
申请人： BOSTON SCIENT SCIMED INC
发明人： SUTERMEISTER DEREK C , MUNSINGER JOEL R , OSTROOT TIMOTHY A , ANDERSON JAMES M
IPC分类号： A61B18/12 , A61B18/14 , A61B18/16 , A61N1/02 , A61N1/14
CPC分类号： A61B18/1206 , A61B17/22004 , A61B18/1233 , A61B18/1492 , A61B18/16 , A61B18/1815 , A61B2018/0022 , A61B2018/00285 , A61B2018/00404 , A61B2018/00434 , A61B2018/00577 , A61B2018/00654 , A61B2018/00755 , A61B2018/00875 , A61B2018/1467 , A61B2018/165
摘要： Systems for nerve and tissue modulation are disclosed. An example system may include an intravascular nerve modulation system including an elongated shaft having a proximal end region and a distal end region. The system may further include one or more ablation electrodes affixed to the distal end region of the elongated shaft. One or more ground pad electrodes may be provided and connected to a processor configured to modulate the impedance of each circuit completed between the ablation electrodes and the ground pads.
摘要翻译：公开了用于神经和组织调制的系统。示例系统可以包括血管内神经调节系统，该血管内神经调节系统包括具有近端区域和远端区域的细长轴。该系统可以进一步包括固定到细长轴的远端区域的一个或多个消融电极。一个或多个接地焊盘电极可以被提供并连接到处理器，该处理器被配置为调制在消融电极和接地焊盘之间完成的每个电路的阻抗。

5. 发明申请

WO2013158676A3 RENAL NERVE MODULATION CATHETER DESIGN 审中-公开
标题翻译：肾脏神经调节导管设计
公开(公告)号：WO2013158676A3
公开(公告)日：2014-03-27
申请号：PCT/US2013036831
申请日：2013-04-16
申请人： BOSTON SCIENT SCIMED INC
发明人： WANG HUISUN , SUTERMEISTER DEREK C , ANDERSON JAMES M
IPC分类号： A61B18/14 , A61M25/01
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/1472
摘要： System for nerve modulation and method for making and using the same are disclosed. An example system may include an elongate shaft having a proximal end region, a deflectable distal end region and a lumen extending to the deflectable distal end region. The deflectable distal end region may include an electrode surrounded by a permeable membrane. The permeable membrane may be fluidly connected to the lumen.
摘要翻译：公开了用于神经调制的系统及其制造和使用方法。示例性系统可以包括具有近端区域，可偏转远端区域和延伸到可偏转远端区域的内腔的细长轴。可偏转的远端区域可以包括被可渗透膜包围的电极。渗透膜可以流体连接到内腔。

6. 发明申请

WO2013116521A3 GUIDE EXTENSION CATHETER 审中-公开
标题翻译：指导延伸导管
公开(公告)号：WO2013116521A3
公开(公告)日：2014-03-20
申请号：PCT/US2013024148
申请日：2013-01-31
申请人： BOSTON SCIENT SCIMED INC
发明人： ANDERSON JAMES M , WANG HUISUN , SUTERMEISTER DEREK C , KOCH STEVEN J , GUNDALE BENJAMIN P , MILLER PAUL J
IPC分类号： A61M25/01 , A61B17/12 , A61F2/95
CPC分类号： A61M25/0662 , A61B17/1204 , A61B17/12136 , A61B2017/00526 , A61M25/0009 , A61M25/0052 , A61M25/0069 , A61M25/01 , A61M25/0105 , A61M25/04 , A61M2025/0681 , F04C2270/0421
摘要： Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a push member having a proximal portion with a proximal stiffness, a distal portion with a distal stiffness different from the proximal stiffness, and a transition portion disposed between the proximal portion and the distal portion. The transition portion may provide a smooth transition between the proximal stiffness and the distal stiffness. The push member may have a first outer diameter. A distal tubular member may be attached to the push member. The distal tubular member may have a second outer diameter larger than the first outer diameter.
摘要翻译：公开了用于制造和使用医疗装置的医疗装置和方法。示例性医疗装置可以包括引导延伸导管。引导延伸导管可以包括具有近端刚度的近端部分的推动构件，具有不同于近侧刚度的远侧刚度的远端部分和设置在近端部分和远端部分之间的过渡部分。过渡部分可以在近端刚度和远侧刚度之间提供平滑的过渡。推动构件可以具有第一外径。远侧管状构件可以附接到推动构件。远侧管状构件可具有大于第一外径的第二外径。

7. 发明申请

WO2013028993A3 DEVICE AND METHODS FOR NERVE MODULATION 审中-公开
标题翻译：用于神经调节的装置和方法
公开(公告)号：WO2013028993A3
公开(公告)日：2013-04-18
申请号：PCT/US2012052313
申请日：2012-08-24
申请人： BOSTON SCIENT SCIMED INC , SUTERMEISTER DEREK , OSTROOT TIM A , ANDERSON JAMES M
发明人： SUTERMEISTER DEREK , OSTROOT TIM A , ANDERSON JAMES M
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435
摘要： The disclosure pertains to an intravascular system for nerve modulation through a wall of a blood vessel and methods of use therefor, wherein the system is capable of nerve modulation by one or more ablations of a blood vessel adjacent to the nerve to be modulated. The intravascular system is suited for modulation of renal nerves.
摘要翻译：本公开涉及一种用于通过血管壁进行神经调节的血管内系统及其使用方法，其中该系统能够通过与待调节的神经相邻的血管的一次或多次消融来进行神经调节。血管内系统适用于调节肾神经。

8. 发明申请

WO2010011470A2 CATHETER HAVING ELECTRICALLY CONDUCTIVE PATHWAYS 审中-公开
标题翻译：具有电导通道的导管
公开(公告)号：WO2010011470A2
公开(公告)日：2010-01-28
申请号：PCT/US2009049031
申请日：2009-06-29
申请人： BOSTON SCIENT SCIMED INC , ANDERSON JAMES M , JAGGER KARL A , DELANDER ALLEN , MILLER RICHARD R
发明人： ANDERSON JAMES M , JAGGER KARL A , DELANDER ALLEN , MILLER RICHARD R
IPC分类号： A61F2/958 , A61M25/06 , A61N1/05
CPC分类号： A61B5/05 , A61B1/00114 , A61B5/0215 , A61B5/036 , A61B17/2202 , A61B18/1492 , A61B2017/22001 , A61B2090/064 , A61B2562/222 , A61M25/0012 , A61M25/005 , A61M2025/105 , A61M2025/1086 , A61N1/05
摘要： Medical devices having electrically conductive pathways are disclosed. More particularly, the disclosure is directed to catheter shafts including an electrically conductive wire embedded in a polymeric tube. The disclosure is also directed to catheter shafts including an electrically conductive media coextruded in a polymeric tube. The disclosure is also directed to catheter shafts including electrically conductive pathways formed with electrically conductive ink, paste, adhesive and/or epoxy.
摘要翻译：公开了具有导电通路的医疗装置。更具体地，本公开涉及包括嵌入聚合物管中的导电线的导管轴。本公开还涉及导管轴，包括共挤出在聚合物管中的导电介质。本公开还涉及导电轴，包括由导电油墨，糊剂，粘合剂和/或环氧树脂形成的导电通路。

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