专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996031539A1 ANTIBODIES AND THEIR USE IN CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译：抗体及其在癌症治疗和诊断中的应用
公开(公告)号：WO1996031539A1
公开(公告)日：1996-10-10
申请号：PCT/GB1996000783
申请日：1996-04-01
申请人： BIOINVENT INTERNATIONAL AB , KIDDLE, Simon, John , CARLSSON, Roland , JANSSON, Bo
发明人： BIOINVENT INTERNATIONAL AB , KIDDLE, Simon, John
IPC分类号： C07K16/30
CPC分类号： C07K16/3069 , A61K38/00 , A61K47/6869
摘要： The present invention relates to antibodies, particularly to antibodies for use in cancer therapy and diagnosis, the antibodies having substantially the same binding specificity as EXT1-7C12 monoclonal antibody. This antibody is obtainable from a hybridoma cell line deposited at BCCM under reference LMBP1360CB. The antibody is shown to bind to a variety of carcinomas with a high intensity and degree of selectivity as demonstrated by immunohistochemistry analysis and cell binding assays. Compared to a panel of other monoclonal antibodies, the EXT1-7C12 antibody demonstrates a greater selectivity in binding to tumour cells, binding especially well to tumours of the ovary. The invention also includes antibodies having substantially the same binding specificity as monoclonal antibody EXT1-7C12, and mutants, derivatives, functional equivalents or fragments of the antibody. Applications of the antibodies include the therapy or diagnosis of cancer, e.g. in targeting cytotoxic compounds to cancer.
摘要翻译：本发明涉及抗体，特别是用于癌症治疗和诊断的抗体，所述抗体具有与EXT1-7C12单克隆抗体基本上相同的结合特异性。该抗体可从参考LMBP1360CB在BCCM保藏的杂交瘤细胞系获得。通过免疫组织化学分析和细胞结合测定证明抗体显示结合多种癌症具有高强度和高度的选择性。与一组其他单克隆抗体相比，EXT1-7C12抗体在结合肿瘤细胞方面表现出更大的选择性，特别是与卵巢肿瘤结合。本发明还包括具有与单克隆抗体EXT1-7C12基本上相同的结合特异性的抗体，以及抗体的突变体，衍生物，功能等同物或片段。抗体的应用包括癌症的治疗或诊断，例如。将细胞毒性化合物靶向癌症。

2. 发明申请

WO1997010330A1 COMBINED LIGAND AND RECEPTOR DISPLAY 审中-公开
标题翻译：组合配对和受体显示
公开(公告)号：WO1997010330A1
公开(公告)日：1997-03-20
申请号：PCT/GB1996002271
申请日：1996-09-13
申请人： BIOINVENT INTERNATIONAL AB , KIDDLE, Simon, John , BORREBAECK, Carl , MALMBORG, Anki , SÖDERLIND, Eskil
发明人： BIOINVENT INTERNATIONAL AB , KIDDLE, Simon, John
IPC分类号： C12N15/10
CPC分类号： C40B40/02 , C07K14/005 , C07K14/245 , C07K2319/00 , C12N15/1037 , C12N15/1055 , C12N15/70 , C12N2710/16122 , C12N2740/16222
摘要： A method for selecting nucleic acid sequences encoding ligand and receptor molecules capable of specific binding to each other is disclosed in which nucleic acid encoding ligand or receptor molecules is expressed in a host microorganism in combination with a surface molecule, such as E. coli pili, so that the ligand or receptor are displayed on the surface of the host microorganism. A replicable genetic unit, such as a filamentous bacteriophage, is used to display candidate binding partners to the ligand or receptor, with the binding of the ligand or receptor to the candidate binding partner mediating the transfer of nucleic acid from the replicable genetic unit to the microorganism. The method can be highly selective as the host microorganism is modified so that it does not display the surface molecule other than as a fusion with the ligand or receptor molecule. The method is rapid and simple and opens up new applications based on the detection of ligand and receptors where both are unknown.
摘要翻译：公开了选择能够相互特异性结合的配体和受体分子的核酸序列的方法，其中编码配体或受体分子的核酸在宿主微生物中与表面分子如大肠杆菌大肠杆菌，使得配体或受体显示在宿主微生物的表面上。可复制的遗传单位，例如丝状噬菌体，用于向配体或受体显示候选结合配偶体，其中配体或受体与候选结合配偶体结合，该候选结合配偶体介导核酸从可复制遗传单位转移至微生物。该方法可以是高度选择性的，因为宿主微生物被修饰，使得它不显示表面分子而不是与配体或受体分子的融合。该方法快速简单，并且基于配体和受体的检测开启了新的应用，其中两者都是未知的。

3. 发明申请

WO2002083937A3 METHODS USING O6-ALKYLGUANINE-DNA ALKYLTRANSFERASES 审中-公开
公开(公告)号：WO2002083937A3
公开(公告)日：2002-10-24
申请号：PCT/GB2002/001636
申请日：2002-04-05
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , KIDDLE, Simon, John , JOHNSSON, Kai , GENDREIZIG, Susanne , KEPPLER, Antje
发明人： KIDDLE, Simon, John , JOHNSSON, Kai , GENDREIZIG, Susanne , KEPPLER, Antje
IPC分类号： G01N33/532
摘要： A method using O 6 -alkylguanine-DNA alkyltransferases (AGT) is disclosed for transferring a label from a substrate to a fusion protein comprising the AGT. This allows the detection and/or manipulating of the fusion protein, both in vitro and in vivo , by attaching molecules to the fusion proteins that introduce a new physical or chemical property to the fusion protein. Examples of such molecules are, among others, spectroscopic probes or reporter molecules, affinity tags, molecules generating reactive radicals, cross-linkers, ligands mediating protein-protein interactions or molecules suitable for the immobilisation of the fusion protein.

4. 发明申请

WO1996031199A1 PHARMACEUTICAL MICROENCAPSULATION 审中-公开
标题翻译：药物微生物学
公开(公告)号：WO1996031199A1
公开(公告)日：1996-10-10
申请号：PCT/GB1996000809
申请日：1996-04-03
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John , JORDAN, Olivier , RANIERI, John , AEBISCHER, Patrick , CLEMENCE, Jean-François
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John
IPC分类号： A61K09/50
CPC分类号： A61L27/3804 , A61K9/5026 , A61K9/5089 , A61K2035/128 , C12N5/0677 , C12N11/04
摘要： A method of producing a microencapsulated pharmaceutical formulation is disclosed comprising causing a dye to be attached to the surface of pharmaceutical particles or particle clusters and applying a source of radiant energy to the dye in the presence of a liquid polymeric or polymerisable material so as to cause the material to cross-link, producing a conformal layer of cross-linked polymer on the particulate surfaces. Preferably, the polymer provides an immuno-protective layer around the particles, while allowing therapeutic components to exit the microcapsules. Microencapsulated pharmaceutical formulations and their medical use are also disclosed, especially for the treatment of diabetes by encapsulating insulin secreting cells.
摘要翻译：公开了一种生产微胶囊化药物制剂的方法，其包括使染料附着在药物颗粒或颗粒簇的表面上，并在液体聚合或可聚合材料的存在下将辐射能源施加到染料上，从而引起交联的材料，在颗粒表面上产生交联聚合物的共形层。优选地，聚合物在颗粒周围提供免疫保护层，同时允许治疗成分离开微胶囊。还公开了微囊化药物制剂及其医疗用途，特别是用于通过包封胰岛素分泌细胞治疗糖尿病。

5. 发明申请

WO2002083937A2 METHODS USING O6-ALKYLGUANINE-DNA ALKYLTRANSFERASES 审中-公开
标题翻译：使用O 6 - 甘氨酸 - DNA烷基转移酶的方法
公开(公告)号：WO2002083937A2
公开(公告)日：2002-10-24
申请号：PCT/GB2002/001636
申请日：2002-04-05
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , KIDDLE, Simon, John , JOHNSSON, Kai , GENDREIZIG, Susanne , KEPPLER, Antje
发明人： KIDDLE, Simon, John , JOHNSSON, Kai , GENDREIZIG, Susanne , KEPPLER, Antje
IPC分类号： C12Q1/48
CPC分类号： G01N33/531 , C07K2319/20 , C07K2319/60
摘要： A method using O 6 -alkylguanine-DNA alkyltransferases (AGT) is disclosed for transferring a label from a substrate to a fusion protein comprising the AGT. This allows the detection and/or manipulating of the fusion protein, both in vitro and in vivo , by attaching molecules to the fusion proteins that introduce a new physical or chemical property to the fusion protein. Examples of such molecules are, among others, spectroscopic probes or reporter molecules, affinity tags, molecules generating reactive radicals, cross-linkers, ligands mediating protein-protein interactions or molecules suitable for the immobilisation of the fusion protein.
摘要翻译：公开了使用O 6 - 烷基鸟嘌呤-DNA烷基转移酶（AGT）的方法将标记从底物转移到包含AGT的融合蛋白。这允许在体外和体内通过将融合蛋白连接到融合蛋白上来检测和/或操纵融合蛋白，所述融合蛋白向融合蛋白引入新的物理或化学性质。这样的分子的实例是光谱探针或报告分子，亲和标签，产生反应性基团的分子，交联剂，介导蛋白质 - 蛋白质相互作用的配体或适合固定融合蛋白的分子。

6. 发明申请

WO1996025487A1 MATERIALS AND METHODS RELATING TO THE REGULATION OF POLYPEPTIDE PRODUCTION IN CELLS 审中-公开
标题翻译：关于细胞中多肽生产调节的材料和方法
公开(公告)号：WO1996025487A1
公开(公告)日：1996-08-22
申请号：PCT/GB1996000256
申请日：1996-02-07
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John , THORENS, Bernard
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John
IPC分类号： C12N05/10
CPC分类号： C12N15/67 , C07K14/4705 , C07K14/575 , C07K14/62 , C07K14/72
摘要： This application relates to cell lines transfected with (a) nucleic acid encoding one or more hormone receptors, the receptors being capable of transmitting a signal, and (b) nucleic acid encoding a desired polypeptide, the nucleic acid encoding the polypeptide being under the control of a promoter containing regulatory elements responsive to the signal transmitted by the receptor(s) so that transcription of the nucleic acid encoding the desired polypeptide is modulated by the level of the hormone(s) in the patient. Preferably, the receptors are the GIP or GLP-1 receptors controlling the production of insulin in the cells in response to changes in the metabolic status of a patient. The application also relates to compositions comprising these cells and their use in methods of medical treatment.
摘要翻译：本申请涉及用（a）编码一种或多种激素受体的核酸转染的细胞系，该受体能够传递信号，和（b）编码所需多肽的核酸，编码该多肽处于控制之下的核酸的启动子，其含有响应于由受体传递的信号的调节元件，使得编码所需多肽的核酸的转录受到患者体内激素水平的调节。优选地，受体是响应于患者的代谢状态的变化而控制细胞中胰岛素产生的GIP或GLP-1受体。本申请还涉及包含这些细胞的组合物及其在医学治疗方法中的用途。

7. 发明申请

WO1998034628A1 COMPOSITION FOR THE TREATMENT OF HAEMORRHOIDS AND OTHER ANORECTAL INFLAMMATIONS 审中-公开
标题翻译：用于治疗肝炎和其他异常炎症的组合物
公开(公告)号：WO1998034628A1
公开(公告)日：1998-08-13
申请号：PCT/GB1997000338
申请日：1997-02-05
申请人： AU PHARMACEUTICALS, INC. , KIDDLE, Simon, John , IVY, Jeffery, Wade , PAYNE, Curtis, Emery , BURDA, Christopher, Dominic
发明人： AU PHARMACEUTICALS, INC. , KIDDLE, Simon, John
IPC分类号： A61K35/78
CPC分类号： A61K36/53 , A61K31/135 , A61K36/16 , A61K36/185 , A61K36/232 , A61K36/258 , A61K36/532 , A61K36/886 , A61K36/898 , A61K31/045 , A61K2300/00
摘要： This invention relates to an externally applied lotion that causes irritation or mild inflammation of the skin or mucous membranes for the purpose of relieving pain in haemorrhoids and the method of making such lotion. The formulation of the present invention contains ingredients to perform the five functions of vasoconstrictor, astringent, analgesic, antipruritic, and anesthetic. An alternate embodiment of the invention provides a formulation of the invention having a suitable viscosity to enable the lotion to be applied by a spray applicator directly to the site of application.
摘要翻译：本发明涉及引起皮肤或粘膜的刺激或轻度炎症以减轻痔疮疼痛的外用洗剂和制备这种洗剂的方法。本发明的制剂含有进行血管收缩剂，收敛剂，止痛剂，止痒剂和麻醉剂五种功能的成分。本发明的替代实施方案提供了本发明的制剂，其具有适合的粘度，以使洗剂能够通过喷雾器直接施加到施用部位。

8. 发明申请

WO1998015631A1 ATTENUATED MICROORGANISM STRAINS EXPRESSING HPV PROTEINS 审中-公开
标题翻译：表达HPV蛋白的衰老微生物菌株
公开(公告)号：WO1998015631A1
公开(公告)日：1998-04-16
申请号：PCT/GB1997002740
申请日：1997-10-07
申请人： FONDATION POUR LE PERFECTIONNEMENT ET LA RECHERCHE EN GYNECOLOGIE-OBSTETRIQUE , KIDDLE, Simon, John , HAEFLIGER, Denise, Nardelli , KRAEHENBUHL, Jean-Pierre
发明人： FONDATION POUR LE PERFECTIONNEMENT ET LA RECHERCHE EN GYNECOLOGIE-OBSTETRIQUE , KIDDLE, Simon, John
IPC分类号： C12N15/37
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N15/74 , C12N2710/20022 , C12N2710/20023 , Y02A50/476 , Y02A50/484 , Y10S977/804 , Y10S977/904 , Y10S977/917
摘要： This application relates to the use of attenuated prokaryotic microorganism strains (such as Salmonella) expressing nucleic acid encoding HPV proteins as vaccines against HPV infection and the associated increased risk of cancer. In particular, the work shows that it is possible to assemble VLPs in a prokaryotic organism and that nasal immunization of mice with the strains HPV-specific conformationally dependent and neutralizing antibodies in serum and genital secretions. The experiments described herein show that it is also possible to assemble chimeric VLPs of an HPV including a fusion partner and that tumor protection can be induced.
摘要翻译：本申请涉及使用表达编码HPV蛋白的核酸的减毒原核生物微生物菌株（如沙门氏菌）作为HPV感染疫苗和相关的增加的癌症风险。特别是，这项工作表明，有可能在原核生物体中组装VLP，并且可以在血清和生殖道分泌物中对具有HPV特异性构象依赖性和中和抗体的菌株进行鼻腔免疫。本文所述的实验表明，还可以组装包含融合配偶体的HPV的嵌合VLP并且可以诱导肿瘤保护。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式