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1. 发明申请

WO1993003027A1 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES 审中-公开
标题翻译： 1,3-氧化亚烷基核苷类似物
公开(公告)号：WO1993003027A1
公开(公告)日：1993-02-18
申请号：PCT/CA1992000321
申请日：1992-07-24
申请人： BIOCHEM PHARMA INC. , DIONNE, Gervais
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D411/04
CPC分类号： C07D411/04 , A61K31/506 , C12P17/167 , C12P19/40 , C12P41/001 , C12P41/006
摘要： The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to (-)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one and pharmaceutically acceptable derivatives and pharmaceutical formulations thereof.

2. 发明申请

WO1996019494A1 PEPTIDES HAVING IMMUNOMODULATORY ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的肽
公开(公告)号：WO1996019494A1
公开(公告)日：1996-06-27
申请号：PCT/CA1995000703
申请日：1995-12-15
申请人： BIOCHEM PHARMA INC. , PENNEY, Christopher, L.
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07K05/11
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , C07K14/66
摘要： The present invention relates to peptides having an immunomodulatory activity. The present invention is concerned with the tetrapeptide H-Lys-Asn-Pro-Tyr-OH (SEQ.ID NO:1) and analogues thereof as immunomodulators. The present invention also includes the use of such peptides as vaccine adjuvant.
摘要翻译：本发明涉及具有免疫调节活性的肽。本发明涉及四肽H-Lys-Asn-Pro-Tyr-OH（SEQ ID NO：1）及其类似物作为免疫调节剂。本发明还包括使用这样的肽作为疫苗佐剂。

3. 发明申请

WO1995029176A1 SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES 审中-公开
标题翻译：取代的具有抗病性的1,3-氧化物
公开(公告)号：WO1995029176A1
公开(公告)日：1995-11-02
申请号：PCT/CA1995000212
申请日：1995-04-19
申请人： BIOCHEM PHARMA INC. , MANSOUR, Tarek, S. , JIN, Haolun
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D411/04
CPC分类号： C07H21/00 , A61K31/505 , A61K31/506 , A61K45/06 , C07D409/04 , C07D411/04 , C07D473/00 , C07F7/1804 , A61K2300/00
摘要： This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of formula (I) wherein R1 is hydrogen, and R2 is cytosine or 5-fluorocytosine, and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.
摘要翻译：本发明涉及式（I）的新的顺式取代的1,3-氧硫杂环戊烷的单一对映异构体，其中R 1是氢，R 2是胞嘧啶或5-氟胞嘧啶，及其药学上可接受的盐和酯。本发明还涉及含有它们的药物组合物以及这些化合物作为抗病毒剂的用途，特别是在联合治疗中。

4. 发明申请

WO1993020100A1 NOVEL LIPOPHILIC OLIGOPEPTIDES WITH IMMUNOMODULATING ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的新型LIPOPHILIC OLIGEPEPTIDS
公开(公告)号：WO1993020100A1
公开(公告)日：1993-10-14
申请号：PCT/CA1993000144
申请日：1993-04-02
申请人： BIOCHEM PHARMA INC. , PENNEY, Christopher , ZACHARIE, Boulos
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07K05/06
CPC分类号： C07K5/0812 , A61K38/00 , C07C327/42 , C07K5/0215 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06104
摘要： New, small and structurally simple immunomodulating oligopeptides are disclosed. The oligopeptides of this invention possess a long, lipophilic alkyl chain. These immunododulating oligopeptides can be used in conjunction with anti-viral or anti-cancer agents in the treatment of human and animal diseases. Processes for the syntheses of immunomodulating chemicals are also disclosed.
摘要翻译：公开了新的，小的和结构简单的免疫调节寡肽。本发明的寡肽具有长的亲脂性烷基链。这些免疫调节寡肽可以与抗病毒剂或抗癌剂联合用于治疗人和动物疾病。还公开了免疫调节化学品的合成方法。

5. 发明申请

WO1997016183A1 THIAMORPHINANS WITH NEUROPROTECTIVE ACTIVITY 审中-公开
标题翻译：具有神经保护活性的噻吗啉酮
公开(公告)号：WO1997016183A1
公开(公告)日：1997-05-09
申请号：PCT/CA1996000728
申请日：1996-10-30
申请人： BIOCHEM PHARMA INC. , LEMAIRE, Simon
发明人： BIOCHEM PHARMA INC.
IPC分类号： A61K31/38
CPC分类号： C07D335/04 , A61K31/38 , A61K31/382
摘要： The present invention relates to morphinan derivatives that are neuroprotective against excitatory amino acid (EAA) cytotoxicity. In particular, morphinan derivatives of the invention act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor and are useful as protective agents against peripheral and central nervous system NMDA-receptor mediated toxicity and convulsions.
摘要翻译：本发明涉及对兴奋性氨基酸（EAA）细胞毒性具有神经保护作用的吗啡喃衍生物。特别地，本发明的吗啡喃衍生物作为离子型NMDA（N-甲基 - （D） - 天冬氨酸）受体的拮抗剂起作用，可用作抗周围和中枢神经系统NMDA-受体介导的毒性和抽搐的保护剂。

6. 发明申请

WO1997003979A1 POLYCYCLIC ALCALOID-DERIVATIVES AS NMDA-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为NMDA受体拮抗剂的多环类衍生物衍生物
公开(公告)号：WO1997003979A1
公开(公告)日：1997-02-06
申请号：PCT/CA1996000468
申请日：1996-07-12
申请人： BIOCHEM PHARMA INC. , DIMAIO, John , DIXIT, Dilip, M.
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D337/16
CPC分类号： C07C215/44 , C07D225/08 , C07D313/20 , C07D337/16
摘要： Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 abd R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. That act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor.
摘要翻译：式（I）的多环生物碱，其中R 1为H，C 1-6烷基或任选被极性基团取代的C 6-12芳基; R2 abd R3独立地为H，OH，C1-6烷基，-C（NH）-NH2，带正电荷的基团或任选被NH 2，OH，C 1-6烷基或卤素取代的C 7-13芳烷基; 或R 2和R 3一起形成任选地加入杂原子的5至6元环; R4是H，C1-6烷基，OR6，SR6或N（R6）2，其中每个R6独立地是H，C1-3烷基; X是O，S，SO，SO 2，N-R 5或C（R 5）2，其中每个R 5独立地是H，C 1-6烷基或任选被一个或多个杂原子中断的C 7-13芳烷基; n为0〜2的整数; m是0至3的整数; 条件是当X是CH 2时，R 1不是CH 3，R 2和R 3不都是H，R 4不是OH，m不是3且n不是0。作为离子型NMDA（N-甲基 - （D）天冬氨酸）受体。

7. 发明申请

WO1995035297A1 NOVEL SUBSTITUTED PURINYL DERIVATIVES WITH IMMUNOMODULATING ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的新型取代的嘌呤衍生物
公开(公告)号：WO1995035297A1
公开(公告)日：1995-12-28
申请号：PCT/CA1995000356
申请日：1995-06-21
申请人： BIOCHEM PHARMA INC. , PENNEY, Christopher , ZACHARIE, Boulos , GAGNON, Lyne , ATTARDO, Giorgio , CONNOLLY, Timothy , ST-DENIS, Yves , KADHIM, Salam , ELY, Guy
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D473/00
CPC分类号： A61K31/7052 , A61K31/52 , A61K38/00 , C07D473/00 , C07D473/34 , C07K5/0808 , A61K31/505 , A61K31/675 , A61K31/513 , A61K2300/00
摘要： The present invention covers substituted purinyl compounds. In particular, the present invention concerns 6-substituted purinyl alkoxycarbonyl amino acids, more particularly arginine derivatives. The present invention further includes substituted purinyl compounds which stimulate the immune system and thereby help protect the body against pathogens and cancer.
摘要翻译：本发明涉及取代的嘌呤基化合物。特别地，本发明涉及6-取代的嘌呤基烷氧基羰基氨基酸，更特别是精氨酸衍生物。本发明还包括刺激免疫系统并由此有助于保护身体免受病原体和癌症的取代的嘌呤基化合物。

8. 发明申请

WO1993003376A1 IMMUNOASSAY FOR THE SIMULTANEOUS DETECTION OF HIV-1, HIV-2, HTLV-I AND HTLV-II ANTIBODIES 审中-公开
标题翻译：免疫检测HIV-1，HIV-2，HTLV-1和HTLV-II抗体的同时检测
公开(公告)号：WO1993003376A1
公开(公告)日：1993-02-18
申请号：PCT/CA1992000322
申请日：1992-07-24
申请人： BIOCHEM PHARMA INC.
发明人： BIOCHEM PHARMA INC. , LACROIX, Martial , DWYER, Robert, J. , ZREIN, Maan
IPC分类号： G01N33/569
CPC分类号： C07K14/005 , C12N2740/14022 , C12N2740/16022 , G01N33/56988
摘要： This invention relates to immunoassay kits which can be used to simultaneously detect antibodies in a biological specimen to the following viruses: HIV-1, HIV-2, HTLV-I and HTLV-II. This invention also relates to the process of making and using these immunoassay kits.
摘要翻译：本发明涉及免疫测定试剂盒，其可用于同时检测以下病毒的生物样本中的抗体：HIV-1，HIV-2，HTLV-1和HTLV-II。本发明还涉及制备和使用这些免疫测定试剂盒的方法。

9. 发明申请

WO1997034894A1 NAPHTHYRIDINE DERIVATIVES AND THEIR ANALOGUES INHIBITING CYTOMEGALOVIRUS 审中-公开
标题翻译：萘啶衍生物及其抑制细胞因子的模拟物
公开(公告)号：WO1997034894A1
公开(公告)日：1997-09-25
申请号：PCT/CA1997000182
申请日：1997-03-14
申请人： BIOCHEM PHARMA INC. , JIN, Haolun , CHAN, Laval, Chun-Kong , WANG, Wei , STEFANAC, Tomislav , MANSOUR, Tarek, S. , NGUYEN-BA, Paul , LAVALLEE, Jean-François , FALARDEAU, Guy
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D471/06
CPC分类号： C07D471/04 , C07D215/48
摘要： The present invention relates to heterocyclic compounds, more particularly naphthyridine compounds having antiviral activity. In particular, compounds of formula (I) wherein B, W, X, Y, R1, R2, R3, R4, and n are as defined herein, are useful in the therapy and prophylaxis of cytomegalovirus (CMV) infection in mammals.
摘要翻译：本发明涉及具有抗病毒活性的杂环化合物，更特别是萘啶化合物。特别地，其中B，W，X，Y，R 1，R 2，R 3，R 4和n如本文所定义的式（I）化合物可用于治疗和预防哺乳动物中的巨细胞病毒（CMV）感染。

10. 发明申请

WO1997003978A1 NOVEL HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN AND USE THEREOF 审中-公开
标题翻译：用于治疗疼痛和用途的新型杂环化合物
公开(公告)号：WO1997003978A1
公开(公告)日：1997-02-06
申请号：PCT/CA1996000467
申请日：1996-07-12
申请人： BIOCHEM PHARMA INC. , DIMAIO, John
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D337/16
CPC分类号： C07C215/44 , C07D225/08 , C07D313/20 , C07D337/16
摘要： Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl, or halogen; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. For the treatment of pain and pharmaceutically acceptable compositions comprising those compounds. The compounds of this invention act as agonists at the opiate receptor.
摘要翻译：式（I）的多环生物碱，其中R 1为H，C 1-6烷基或任选被极性基团取代的C 6-12芳基; R2和R3独立地是H，OH，C1-6烷基，-C（NH）-NH2，带正电荷的基团或任选被NH 2，OH，C 1-6烷基或卤素取代的C 7-13芳烷基; 或R 2和R 3一起形成任选地加入杂原子的5至6元环; R4是H，C1-6烷基，OR6，SR6或N（R6）2，其中每个R6独立地是H，C1-3烷基或卤素; X是O，S，SO，SO 2，N-R 5或C（R 5）2，其中每个R 5独立地是H，C 1-6烷基或任选被一个或多个杂原子中断的C 7-13芳烷基; n为0〜2的整数; m是0至3的整数; 条件是当X是CH 2时，R 1不是CH 3，R 2和R 3不同时为H，R 4不为OH，m不为3且n不为0.对于用于治疗包含那些化合物的疼痛和药学上可接受的组合物。本发明化合物作为鸦片剂受体的激动剂。

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