专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1998009987A1 LACTAM INHIBITORS OF THROMBIN 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：WO1998009987A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015312
申请日：1997-09-05
申请人： BIOCHEM PHARMA, INC. , ST-DENIS, Yves , SIDDIQUI, M., Arshad , CODY, Wayne, Livingston , EDMUNDS, Jeremy, John , PLUMMER, Janet, Samartino
发明人： BIOCHEM PHARMA, INC.
IPC分类号： C07K05/078
CPC分类号： C07K5/0821 , C07K5/0202 , C07K5/06139
摘要： This invention relates to heterocyclic inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof having general formula (I), wherein W, X, Y R1 to R3 are as defined herein. Also, the invention relates to the use of such compounds and compositions as anticoagulants and as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction.
摘要翻译：本发明涉及酶凝血酶的杂环抑制剂及其制备方法及其具有通式（I）的药物组合物，其中W，X，Y R1至R3如本文所定义。此外，本发明涉及这样的化合物和组合物作为抗凝剂和作为药剂的用途，用于治疗和预防血栓形成疾病如静脉血栓形成，肺栓塞和动脉血栓形成，导致急性缺血事件如心肌梗塞或脑梗死。

2. 发明申请

WO1996019494A1 PEPTIDES HAVING IMMUNOMODULATORY ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的肽
公开(公告)号：WO1996019494A1
公开(公告)日：1996-06-27
申请号：PCT/CA1995000703
申请日：1995-12-15
申请人： BIOCHEM PHARMA INC. , PENNEY, Christopher, L.
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07K05/11
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , C07K14/66
摘要： The present invention relates to peptides having an immunomodulatory activity. The present invention is concerned with the tetrapeptide H-Lys-Asn-Pro-Tyr-OH (SEQ.ID NO:1) and analogues thereof as immunomodulators. The present invention also includes the use of such peptides as vaccine adjuvant.
摘要翻译：本发明涉及具有免疫调节活性的肽。本发明涉及四肽H-Lys-Asn-Pro-Tyr-OH（SEQ ID NO：1）及其类似物作为免疫调节剂。本发明还包括使用这样的肽作为疫苗佐剂。

3. 发明申请

WO1995029176A1 SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES 审中-公开
标题翻译：取代的具有抗病性的1,3-氧化物
公开(公告)号：WO1995029176A1
公开(公告)日：1995-11-02
申请号：PCT/CA1995000212
申请日：1995-04-19
申请人： BIOCHEM PHARMA INC. , MANSOUR, Tarek, S. , JIN, Haolun
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D411/04
CPC分类号： C07H21/00 , A61K31/505 , A61K31/506 , A61K45/06 , C07D409/04 , C07D411/04 , C07D473/00 , C07F7/1804 , A61K2300/00
摘要： This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of formula (I) wherein R1 is hydrogen, and R2 is cytosine or 5-fluorocytosine, and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.
摘要翻译：本发明涉及式（I）的新的顺式取代的1,3-氧硫杂环戊烷的单一对映异构体，其中R 1是氢，R 2是胞嘧啶或5-氟胞嘧啶，及其药学上可接受的盐和酯。本发明还涉及含有它们的药物组合物以及这些化合物作为抗病毒剂的用途，特别是在联合治疗中。

4. 发明申请

WO1993020100A1 NOVEL LIPOPHILIC OLIGOPEPTIDES WITH IMMUNOMODULATING ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的新型LIPOPHILIC OLIGEPEPTIDS
公开(公告)号：WO1993020100A1
公开(公告)日：1993-10-14
申请号：PCT/CA1993000144
申请日：1993-04-02
申请人： BIOCHEM PHARMA INC. , PENNEY, Christopher , ZACHARIE, Boulos
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07K05/06
CPC分类号： C07K5/0812 , A61K38/00 , C07C327/42 , C07K5/0215 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06104
摘要： New, small and structurally simple immunomodulating oligopeptides are disclosed. The oligopeptides of this invention possess a long, lipophilic alkyl chain. These immunododulating oligopeptides can be used in conjunction with anti-viral or anti-cancer agents in the treatment of human and animal diseases. Processes for the syntheses of immunomodulating chemicals are also disclosed.
摘要翻译：公开了新的，小的和结构简单的免疫调节寡肽。本发明的寡肽具有长的亲脂性烷基链。这些免疫调节寡肽可以与抗病毒剂或抗癌剂联合用于治疗人和动物疾病。还公开了免疫调节化学品的合成方法。

5. 发明申请

WO1993003027A1 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES 审中-公开
标题翻译： 1,3-氧化亚烷基核苷类似物
公开(公告)号：WO1993003027A1
公开(公告)日：1993-02-18
申请号：PCT/CA1992000321
申请日：1992-07-24
申请人： BIOCHEM PHARMA INC. , DIONNE, Gervais
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D411/04
CPC分类号： C07D411/04 , A61K31/506 , C12P17/167 , C12P19/40 , C12P41/001 , C12P41/006
摘要： The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to (-)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one and pharmaceutically acceptable derivatives and pharmaceutical formulations thereof.

6. 发明申请

WO1998028326A1 BICYCLIC THROMBIN INHIBITORS 审中-公开
标题翻译：双抗凝血酶抑制剂
公开(公告)号：WO1998028326A1
公开(公告)日：1998-07-02
申请号：PCT/US1997022985
申请日：1997-12-22
申请人： BIOCHEM PHARMA INC. , BACHAND, Benoit , DOHERTY, Annette, Marian , SIDDIQUI, M., Arshad , EDMUNDS, Jeremy, John
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07K05/02
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/1024
摘要： This invention relates to heterocyclic inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof having general formula (I): wherein A, B, C, D, E, X, Y, Z, R1, R2, R3 and R4, are as defined herein. Also, the invention relates to the use of such compounds and compositions as anticoagulants and as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction.
摘要翻译：本发明涉及酶凝血酶的杂环抑制剂及其制备方法及其具有通式（I）的药物组合物：其中A，B，C，D，E，X，Y，Z，R 1，R 2，R 3和R 4，如本文所定义。此外，本发明涉及这样的化合物和组合物作为抗凝剂和作为药剂的用途，用于治疗和预防血栓形成疾病如静脉血栓形成，肺栓塞和动脉血栓形成，导致急性缺血事件如心肌梗塞或脑梗死。

7. 发明申请

WO1997021706A1 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH 'beta'-CONFIGURATION 审中-公开
标题翻译：用β-配体合成二氧杂环己烷核苷的方法和组合物
公开(公告)号：WO1997021706A1
公开(公告)日：1997-06-19
申请号：PCT/CA1996000845
申请日：1996-12-13
申请人： BIOCHEM PHARMA INC. , MANSOUR, Tarek , CIMPOIA, Alex , BEDNARSKI, Krzystof
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D411/04
CPC分类号： C07D405/04 , Y02P20/55
摘要： The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 DEG C, wherein R1 and L are as defined herein.
摘要翻译：本发明涉及用于制备含有1,3-二氧戊环糖环的生物重要核苷类似物的方法和组合物。特别地，本发明涉及通过在约-10℃的温度下将式（II）的中间体将碱进行糖基化，其中R 1和L如本文所定义的，将β-（顺式）异构体的立体选择性合成。

8. 发明申请

WO1997007129A1 SOLUTION SYNTHESIS OF PERIPHERAL ACTING ANALGESIC OPIOID TETRAPEPTIDES 审中-公开
标题翻译：外周血白细胞介素四聚体的合成
公开(公告)号：WO1997007129A1
公开(公告)日：1997-02-27
申请号：PCT/CA1996000552
申请日：1996-08-15
申请人： BIOCHEM PHARMA INC. , RINALDI, Nicholas
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07K05/107
CPC分类号： C07K5/1016 , A61K38/00
摘要： This invention provides a bulk scale process for the solution synthesis of enantiomerically pure peripherally acting analgesic opioid tetrapeptides corresponding to formula (I): Tyr-(D)R1-R2-R3-NH2, where R1 is Ala or Arg; R2 is Phe or Phe(p-F); and R3 is Phe or Phe(p-F). A new and unique multi-step process is disclosed comprising the joining of two dipeptides using standard solution phase synthesis techniques, but adjusting the individual factors (e.g., solvents, activating agents, neutralizing agents etc.), to minimize racemization of the second amino acid. Tremendous cost efficiencies are achieved due to elimination of traditional sequential blocking-deblocking cycles and multiple chromatographic purification steps, which also enables these simple kilogram quantity methods to be scaled up to commercial production.
摘要翻译：本发明提供了用于溶液合成对应于式（I）的对映异构体纯的外用作用的镇痛阿片样四肽的大规模方法：Tyr-（D）R1-R2-R3-NH2，其中R1是Ala或Arg; R2是Phe或Phe（p-F）; 且R3为Phe或Phe（p-F）。公开了一种新的独特的多步骤方法，其包括使用标准溶液相合成技术连接两种二肽，但是调节各个因素（例如溶剂，活化剂，中和剂等），以使第二氨基酸的外消旋化最小化。由于消除了传统的顺序阻断 - 去封闭循环和多个色谱纯化步骤，从而实现了巨大的成本效率，这也使得这些简单的千克数量方法可以扩大到商业生产。

9. 发明申请

WO1995012588A1 ANTINEOPLASTIC HETERONAPHTHOQUINONES 审中-公开
标题翻译： ANTINEOPLOSTIC HETERONAPHTHOQUINONES
公开(公告)号：WO1995012588A1
公开(公告)日：1995-05-11
申请号：PCT/CA1994000210
申请日：1994-05-06
申请人： BIOCHEM PHARMA INC. , ATTARDO, Giorgio , WANG, Wuyi , BREINING, Tibor , LI, TieChao , ST.-DENIS, Yves , KRAUS, Jean-Louis
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07D311/76
CPC分类号： C07D493/04 , C07D311/76 , C07D311/92 , C07D335/08 , C07H17/00 , C07H17/04 , C07H17/08
摘要： Tricyclic heteronaphthoquinone derivatives, that have antineoplastic activity, are disclosed, together with processes for their synthesis. Some of these antineoplastic compounds have a saccharide moiety. Some members of this structurally distinct group exhibit activity against multiple drug resistant cancer cells.
摘要翻译：公开了具有抗肿瘤活性的三环杂萘醌衍生物及其合成方法。这些抗肿瘤化合物中的一些具有糖部分。该结构不同组的一些成员表现出抗多种耐药性癌细胞的活性。

10. 发明申请

WO1992020696A1 PROCESSES FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES 审中-公开
标题翻译：核苷酸二酯选择性合成方法
公开(公告)号：WO1992020696A1
公开(公告)日：1992-11-26
申请号：PCT/CA1992000209
申请日：1992-05-20
申请人： BIOCHEM PHARMA INC. , MANSOUR, Tarek , TSE, Allan, H., L.
发明人： BIOCHEM PHARMA INC.
IPC分类号： C07H19/04
CPC分类号： C07D405/04 , C07D307/24 , C07D317/32 , C07D317/34 , C07D327/04 , C07D339/06 , C07D409/04 , C07D411/04 , C07H19/04 , C07H19/06 , C07H19/16
摘要： The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式