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1. 发明申请

WO2010074746A1 METHODS OF USE FOR OPSIN BINDING LIGANDS 审中-公开
标题翻译：用于OPSIN绑定配偶的方法
公开(公告)号：WO2010074746A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/006668
申请日：2009-12-22
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy Robert , WATTS, Karl, Shawn , FRYE, Leah, Lynn , FARID, Ramy, Samir
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy Robert , WATTS, Karl, Shawn , FRYE, Leah, Lynn , FARID, Ramy, Samir
IPC分类号： A01N57/00 , A61K31/675
CPC分类号： A61K31/675
摘要： Methods of use of compounds of the Formula I1 II, III, IV and/or V are disclosed for treating ophthalmic conditions related to the production of toxic visual cycle products that accumulate in the eye, and are associated with reactions of the visual cycle during medical procedures that expose the eye to light, most commonly the various forms of ophthalmic surgery and stabilize the proper folding of mutant opsins. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said treatments.
摘要翻译：公开了使用式IIII，III，IV和/或V化合物的方法用于治疗与积累在眼睛中的毒性视觉循环产物的生产有关的眼科疾病，并且与医学期间的视觉循环的反应相关使眼睛光亮的程序，最常见的是各种形式的眼科手术，并稳定突变蛋白的正确折叠。还描述了用于这些方法的化合物和组合物，单独或与其它治疗剂组合，以及筛选可用于所述治疗的新试剂的方法。

2. 发明申请

WO2013082000A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2013082000A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066598
申请日：2012-11-27
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , GREENWOOD, Jeremy, R. , FRYE, Leah, L.
发明人： GARVEY, David, S. , GREENWOOD, Jeremy, R. , FRYE, Leah, L.
IPC分类号： A61K31/472
CPC分类号： A61K31/472 , C07D217/06 , C07D217/26
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译：公开的化合物可用于治疗由眼睛中累积的毒性视觉循环产物引起或与其相关的眼部疾病，例如干性成人黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症，以及 /或视蛋白蛋白质的错位。还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。还公开了合成这些试剂的方法。

3. 发明申请

WO2012134971A2 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2012134971A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/030229
申请日：2012-03-23
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L.
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L.
IPC分类号： A61K31/407
CPC分类号： C07D209/86 , C07C35/38 , C07C35/52 , C07C43/23 , C07C49/675 , C07C49/697 , C07C49/747 , C07C49/755 , C07C251/36 , C07C251/38 , C07C2603/18 , C07D213/30 , C07D307/46 , C07D307/93 , C07D333/16 , C07D333/22 , C07D333/74 , C07D333/78
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of use.
摘要翻译：公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠和积聚在眼睛中的毒性视觉循环产物的产生。还描述了可以单独或与其它治疗剂组合的用于这些方法的化合物和组合物，以及使用方法。

4. 发明申请

WO2010147653A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2010147653A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/001739
申请日：2010-06-16
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N35/00 , A61K31/11
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
摘要翻译：公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠以及积聚在眼睛中的毒性视觉循环产物的产生。还描述了可用于这些方法中的单独或与其它治疗剂组合的化合物和组合物。

5. 发明申请

WO2013081642A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2013081642A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/000564
申请日：2012-11-29
申请人： BIKAM PHARMACEUTICALS, INC. , QUACH, Tan , BERMAN, Judd , GARVEY, David, S.
发明人： QUACH, Tan , BERMAN, Judd , GARVEY, David, S.
IPC分类号： A01N35/00
CPC分类号： C07C211/52 , C07C33/50 , C07C43/215 , C07C43/225 , C07C49/237 , C07C49/813 , C07C211/45 , C07C211/46 , C07C217/84 , C07C237/30 , C07C255/54 , C07C255/58 , C07C255/59 , C07C323/09 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D317/46 , C07D317/64 , C07D317/66
摘要： Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译：公开的化合物和组合物可用于治疗由于积累在眼睛中的毒性视觉循环产物的产生引起或与之相关的眼部疾病，例如干性成人黄斑变性，以及由突变视蛋白错误折叠引起或与之相关的病症蛋白质和/或视蛋白蛋白质的错误定位。还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。还公开了合成这些试剂的方法。

6. 发明申请

WO2013058809A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN结合配体，组合物和使用方法
公开(公告)号：WO2013058809A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/000522
申请日：2012-10-19
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N43/38
CPC分类号： C07D307/83 , C07C35/32 , C07C49/443 , C07C49/553 , C07C69/75 , C07C233/58 , C07C251/44 , C07C2102/24 , C07D209/34 , C07D209/46
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译：公开了用于治疗由眼部积聚的有毒视觉循环产物引起的或与眼部产生有关的眼科疾病的化合物，例如干性成人黄斑变性，以及由或由其引起的疾病涉及突变视蛋白的错误折叠和/或视蛋白蛋白的错误定位。还描述了单独或与其他治疗剂组合的这些化合物的组合物以及使用这些化合物和/或组合物的治疗方法。还公开了合成这些试剂的方法。

7. 发明申请

WO2011155983A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2011155983A1
公开(公告)日：2011-12-15
申请号：PCT/US2011/001028
申请日：2011-06-07
申请人： BIKAM PHARMACEUTICALS INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L.
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L.
IPC分类号： A61K31/015 , A01N43/38
CPC分类号： C07D333/78 , C07B2200/05 , C07C13/28 , C07C13/567 , C07C25/22 , C07C35/52 , C07C43/168 , C07C43/176 , C07C49/697 , C07C49/798 , C07C49/813 , C07C251/48 , C07C255/53 , C07C255/56 , C07C309/65 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/18 , C07D209/88
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compositions of these compounds, either alone or in combination with other therapeutic agents, are also disclosed, along with thereapeutic methods of using such compositions. Methods of synthesizing such compounds are also described.
摘要翻译：公开了可用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白错误折叠以及积聚在眼睛中的毒性视觉循环产物的产生的化合物。单独或与其它治疗剂组合的这些化合物的组合物，以及使用这些组合物的治疗方法也被公开。还描述了合成这些化合物的方法。

8. 发明申请

WO2012174064A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2012174064A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042178
申请日：2012-06-13
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S.
发明人： GARVEY, David, S.
IPC分类号： A01N35/00
CPC分类号： C07D333/22 , A61K31/045 , A61K31/12 , A61K31/277 , C07C25/06 , C07C25/13 , C07C25/18 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C49/792 , C07C49/813 , C07C49/84 , C07C255/53 , C07C255/56 , C07C259/18 , C07C2601/14 , C07C2601/16 , C07D307/42 , C07D307/46 , C07D333/16
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译：公开的化合物可用于治疗由眼睛中累积的毒性视觉循环产物引起或与其相关的眼部疾病，例如干性成人黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症，以及 /或视蛋白蛋白质的错位。还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。还公开了合成这些试剂的方法。

9. 发明申请

WO2007123818A2 ORGANIC NITRIC OXIDE ENHANCING SALTS OF PROSTAGLANDINS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：有机氮氧化物增强前列腺素，组合物和使用方法
公开(公告)号：WO2007123818A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/008427
申请日：2007-04-04
申请人： NITROMED, INC. , GARVEY, David, S.
发明人： GARVEY, David, S.
IPC分类号： A61K31/4245
CPC分类号： C07C405/00 , C07C2601/08 , C07C2601/10 , C07D207/40 , C07D211/28 , C07D211/54 , C07D211/94 , C07D213/82 , C07D413/04 , C07D413/12 , C07D453/02
摘要： The invention provides compositions and kits comprising at least one organic nitric oxide enhancing salt of a prostaglandin, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods, for'(a) treating ophthalmic disorders; (b) treating cerebrovascular disorders; (c) treating cardiovascular disorders; (d) treating benign prostatic hyperplasia (BPH); (e) treating peptic ulcers; (e) treating sexual dysfunctions and (f) inducing abortions. The organic nitric oxide enhancing compounds that form salts with the prostaglandins are organic nitrates, organic nitrites, nitrosothiols, thionitrites, thionitrates, NONOates, heterocyclic nitric oxide donors and/or nitroxides. The heterocyclic nitric oxide donors are furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.
摘要翻译：本发明提供了包含前列腺素的至少一种有机一氧化氮增强盐和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的组合物和试剂盒。本发明还提供了（a）治疗眼科疾病的方法，（b）治疗脑血管障碍; （c）治疗心血管疾病; （d）治疗良性前列腺增生（BPH）; （e）治疗消化性溃疡; （e）治疗性功能障碍和（f）诱导堕胎。与前列腺素形成盐的有机一氧化氮增强化合物是有机硝酸盐，有机亚硝酸盐，亚硝基硫醇，硫堇啶，硫堇酸盐，非硝酸盐，杂环一氧化氮供体和/或氮氧化物。杂环一氧化氮供体是呋喃糖，苏氨酸，恶三唑-5-酮和/或氧杂三唑-5-亚胺。

10. 发明申请

WO2007086884A3 ORGANIC NITRIC OXIDE DONOR SALTS OF ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2007086884A3
公开(公告)日：2007-08-02
申请号：PCT/US2006/005416
申请日：2006-02-16
申请人： NITROMED, INC. , ELLIS, James, L. , GARVEY, David, S. , LIN, Chia-En
发明人： ELLIS, James, L. , GARVEY, David, S. , LIN, Chia-En
IPC分类号： A01N43/04 , C07D277/00 , A61K31/44 , A61K31/70 , C07H15/00 , C07H17/00 , C07H5/04 , C07H5/06
摘要： The invention describes novel organic nitric oxide donor salts of a antimicrobial . compounds, and novel compositions and kits comprising at least one organic nitric oxide donor salt of an antimicrobial compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating bacterial infections; (b) treating viral infections; (c) treating fungal infections; and (d) treating lesions. In one embodiment the antimicrobial compounds of the invention are aztreonam, ciprofloxacin, doripenam, duramycin and tobramycin. The organic nitric oxide donors that form salts are preferably organic nitrates, organic nitrites, nitrosothiols, thionitrites and heterocyclic nitric oxide donors. The heterocyclic nitric oxide donors are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines. The methods of the invention are preferably for the treatment of bacterial infections associated with pulmonary diseases such as cystic fibrosis and for treating Bacillus anthracis infections.

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