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1. 发明申请

WO2011141928A1 PROCESS FOR THE PREPARATION OF HIGHLY PURE BEXAROTENE 审中-公开
标题翻译：制备高纯双酚A的方法
公开(公告)号：WO2011141928A1
公开(公告)日：2011-11-17
申请号：PCT/IN2011/000322
申请日：2011-05-09
申请人： IND-SWIFT LABORATORIES LIMITED , BHIRUD, Shekhar, Bhaskar , SARIN, Gurdeep, Singh , SHARMA, Bimal, Kumar , GERA, Pardeep
发明人： BHIRUD, Shekhar, Bhaskar , SARIN, Gurdeep, Singh , SHARMA, Bimal, Kumar , GERA, Pardeep
IPC分类号： C07C63/44 , C07C49/788 , C07C69/76 , C07C13/38
CPC分类号： C07C49/792 , C07C49/798 , C07C51/09 , C07C51/48 , C07C67/30 , C07C67/343 , C07C2602/10 , C07C63/66 , C07C69/82 , C07C69/76
摘要： The present invention provides an improved process for the preparation of highly pure bexarotene of formula (I). The present invention also provides impurities of bexarotene, method of isolation and identification of these impurities, and use of these impurities as reference marker as well as reference standard.
摘要翻译：本发明提供了制备式（I）的高纯度贝沙罗汀的改进方法。本发明还提供了贝沙罗林的杂质，这些杂质的分离和鉴定方法，以及这些杂质作为参考标记物的用途以及参考标准。

2. 发明申请

WO2010065446A2 PERFUME SYSTEMS 审中-公开
标题翻译： PERFUME系统
公开(公告)号：WO2010065446A2
公开(公告)日：2010-06-10
申请号：PCT/US2009/066082
申请日：2009-11-30
申请人： THE PROCTER & GAMBLE COMPANY , SMETS, Johan , DENUTTE, Hugo, Robert Germain , PINTENS, An , STANTON, David, Thomas , VAN AKEN, Koen , LAUREYN, Inge, Helena Hubert , DENOLF, Bram , VRIELYNCK, Freek, Annie Camiel
发明人： SMETS, Johan , DENUTTE, Hugo, Robert Germain , PINTENS, An , STANTON, David, Thomas , VAN AKEN, Koen , LAUREYN, Inge, Helena Hubert , DENOLF, Bram , VRIELYNCK, Freek, Annie Camiel
IPC分类号： A61K8/11 , C07C49/00 , C07C49/20 , C07C49/213
CPC分类号： C11D3/50 , A61K8/732 , A61K8/84 , A61Q5/02 , A61Q13/00 , C07C33/05 , C07C33/14 , C07C49/203 , C07C49/213 , C07C49/217 , C07C49/225 , C07C49/255 , C07C49/293 , C07C49/557 , C07C49/792 , C07C49/794 , C07C57/03 , C07C69/007 , C07C255/07 , C07C255/33 , C07C2601/04 , C07C2601/16 , C11B9/003 , C11B9/0034 , C11B9/0061 , C11B9/0065
摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
摘要翻译：本申请涉及香水原料，香水递送系统和包含这种香料原料和/或这种香料递送系统的消费品，以及制造和使用这种香料原料，香水递送系统和消费品的方法。这样的香料原料和组合物，包括本文公开的递送系统扩展了香水社区的选择，因为这样的香料原料可以提供特性变化，并且这样的组合物可以提供所需的气味分布。

3. 发明申请

WO2008011964A1 NEUE MATERIALIEN FÜR ORGANISCHE ELEKTROLUMINESZENZVORRICHTUNGEN 审中-公开
标题翻译：用于有机电致发光新材料
公开(公告)号：WO2008011964A1
公开(公告)日：2008-01-31
申请号：PCT/EP2007/005848
申请日：2007-07-02
申请人： MERCK PATENT GMBH , STOESSEL, Philipp , BUESING, Arne , HEIL, Holger
发明人： STOESSEL, Philipp , BUESING, Arne , HEIL, Holger
IPC分类号： C09K11/06 , H05B33/14 , C07C15/38 , C07D311/82
CPC分类号： C09K11/06 , C07C13/62 , C07C43/275 , C07C49/792 , C07C211/61 , C07C2603/24 , C07C2603/54 , C07C2603/94 , C07D311/82 , C07D493/06 , C09K2211/1011 , C09K2211/1088 , H01L51/006 , H01L51/0061 , H01L51/0073 , H05B33/14 , Y10S428/917
摘要： Die vorliegende Erfindung betrifft die Verbindungen gemäß Formel (1) bis (8) und deren Verwendung in organischen Elektrolumineszenz- vorrichtungen, insbesondere in blau emittierenden Vorrichtungen. Die Verbindungen gemäß Formel (1) bis (8) werden als Hostmaterial oder Dotand in der emittierenden Schicht oder auch in einer Loch- oder Elektronentransportschicht verwendet.
摘要翻译：本发明涉及式（1）〜（8）的化合物和器件，以它们的有机电致发光用途，特别是在发蓝色光的器件。根据式（1）〜（8）被用作主体材料或掺杂剂在发光层中或在空穴或电子输送层的化合物。

4. 发明申请

WO1997020877A2 POLY(9,9'-SPIRO-BISFLUORENES), THE PRODUCTION AND USE OF SAME 审中-公开
标题翻译：聚（9,9'- SPIROBISFLUORENE），生产及其用途
公开(公告)号：WO1997020877A2
公开(公告)日：1997-06-12
申请号：PCT/EP1996005091
申请日：1996-11-19
申请人： JAPAT LTD. , CIBA-GEIGY JAPAN LIMITED , RIETZ, Ralf-Roman , WERNET, Wolfgang
发明人： JAPAT LTD. , CIBA-GEIGY JAPAN LIMITED
IPC分类号： C08G61/00
CPC分类号： C09K11/06 , C07C17/12 , C07C25/22 , C07C49/792 , C07C49/813 , C07C63/49 , C08G61/00 , Y10S428/917
摘要： Poly(bis-9,9'-fluorenes) are disclosed with identical or different recurring structural elements of formula (I), in which the two R1 groups independently of one another stand for H, C1-C18-alkyl, C6-C14-aryl, C7-C15-aralkyl, C1-C18-alkoxy, R2-(O-CnH2n)m-O-, C1-C18 alkylthio, C1-C18-dialkylamino, -C(O)OH, -C(O)O-C1-C18-alkyl, -C(O)-N(C1-C18-alkyl)2, SO3H, -SO3-C1-C18-alkyl, -SO2-N(C1-C18-alkyl)2, C1-C17-alkyl-C(O)-O- or C1-C17-alkyl-C(O)-, R2 stands for H or C1-C12-alkyl, n is a number between 2 and 6 and m is a number between 1 and 12. The polymers can be used on their own or mixed with at least one additional fluorophore whose absorption band overlaps with the emission band (fluorescence emission) of the polymer of formula (I), as an active radiating layer for light-emitting diodes, screens and display elements.
摘要翻译：聚（双 - 9,9'fluorene），其具有相同或不同的重复结构式（I）的元件，其中两个R 1独立地为H，C1-C18烷基，C6-C14芳基，C7-C15芳烷基，C1-C18 烷氧基，R 2 - （O-为CnH2n）米O-，C1-C18烷硫基，C1-C18二烷基氨基，-C（O）OH，-C（O）O-C1-C18烷基，-C（O） -N（C1-C18烷基）2，-SO 3 H，-SO 3-C1-C18烷基，-SO2-N（C1-C18烷基）2，C1-C17烷基-C（O）-O-或 C1-C17烷基-C（O） - ，R2是H或C1-C12烷基，n是一个数为2至6，并且m为1至12个可以重叠的聚合物中，作为活性放射线层为发光二极管，显示和显示元件单独地或与至少一种另外的荧光团，其发射带（Fluoreszensemmission）式（I）的聚合物的吸收谱带的混合物。

5. 发明申请

WO1996022957A1 PROCESS FOR THE PRODUCTION OF 2-(SUBSTITUTED BENZOYL)-1,3 CYCLOHEXANEDIONES 审中-公开
标题翻译： 2-（取代苯甲酰基）-1,3环己酮的制备方法
公开(公告)号：WO1996022957A1
公开(公告)日：1996-08-01
申请号：PCT/GB1996000081
申请日：1996-01-16
申请人： ZENECA LIMITED , BROWN, Stephen, Martin , RAWLINSON, Howard , WIFFEN, Jonathan, William
发明人： ZENECA LIMITED
IPC分类号： C07C45/54
CPC分类号： C07C315/04 , C07C45/54 , C07C317/24 , C07C49/792
摘要： A process for preparing a compound of formula (I), where R , R , R , R , R and R are independently hydrogen or C1-6 alkyl; R is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R , R and R independently are hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NO2, phenoxy or substituted phenoxy; RbS(O)n Om in which m is 0 or 1, n is 0, 1 or 2 and Rb is C1-4 alkyl, C1-4 haloalkyl, phenyl or benzyl, NHCORc in which Rc is C1-4 alkyl, NRdRe in which Rd and Re independently are hydrogen or C1-4 alkyl; RfC(O)- in which Rf is hydrogen, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy; SO2NRgRh in which Rg and Rh independently are hydrogen or C1-4 alkyl; or any two of R , R and R together with the carbon atoms to which they are attached form a 5 or 6 membered heterocyclic ring containing up to three heteroatoms selected from O, N or S and which may be optionally substituted by C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, =NOC1-4 alkyl, or halogen; which process comprises the rearrangement of a compound of formula (II), where R , R , R , R , R , R , R , R , R and R are as defined in relation to formula (I), in the presence of a base and a polar aprotic solvent characterised in that the process is carried out in a reaction medium substantially free of hydrogen cyanide or cyanide anion.
摘要翻译：制备式（I）化合物的方法，其中R 1，R 2，R 3，R 4，R 5和R 6独立地是氢或C 1-6烷基 ; R 7是卤素，氰基，NO 2，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基或R a，其中R a是C 1-4烷基; R 8，R 9和R 10独立地是氢，卤素，C 1-4烷基，C 1-4烷氧基，C 1-4卤代烷基，C 1-4卤代烷氧基，CN，NO 2，苯氧基或取代的苯氧基; RbS（O）n Om，其中m为0或1，n为0,1或2，Rb为C1-4烷基，C1-4卤代烷基，苯基或苄基，NHCORc，其中Rc为C1-4烷基，NRdRe为哪个Rd和Re独立地是氢或C 1-4烷基; RfC（O） - ，其中R f为氢，C 1-4烷基，C 1-4卤代烷基或C 1-4烷氧基; 其中Rg和Rh独立地为氢或C1-4烷基的SO2NRgRh; 或R 8，R 9和R 10中的任何两个与它们所连接的碳原子一起形成含有至多三个选自O，N或S的杂原子的5或6元杂环，并且其中可以任选地被C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，= NOC 1-4烷基或卤素取代; 该方法包括式（II）化合物的重排，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，在碱和极性非质子溶剂的存在下，R 8，R 9和R 10如关于式（I）所定义，其特征在于该方法在基本上无反应的反应介质中进行的氰化氢或氰化物阴离子。

6. 发明申请

WO1996015100A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
标题翻译：杂环化合物，其制备和使用
公开(公告)号：WO1996015100A1
公开(公告)日：1996-05-23
申请号：PCT/DK1995000444
申请日：1995-11-08
申请人： NOVO NORDISK A/S , PELLICCIARI, Roberto , LUNEIA, Roberto , LOMBARDI, Grazia , MORONI, Flavio
发明人： NOVO NORDISK A/S
IPC分类号： C07C229/46
CPC分类号： C07D257/04 , C07C17/2637 , C07C45/30 , C07C45/46 , C07C61/39 , C07C63/49 , C07C229/50 , C07C2602/08 , C07C2602/10 , C07D209/42 , C07D307/84 , C07D333/68 , C07C22/04 , C07C47/546 , C07C49/84 , C07C49/792
摘要： The present invention relates to therapeutically active heterocyclic compounds of formula (I), wherein n is 0, 1 or 2; and X is -O-, -S, -N(R )- or -CH2-; and R is H, NH2, NHR or OH; and R and R independently are H, COOH; COOR , CONH2, CONHR , CON(R )2, CONHSO2R or tetrazole; and R is H, OH, NH2, NHR ; CF3, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, C3-6-cycloalkyl, phenyl or C1-4-alkoxy; and R is H, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, phenyl or C3-6-cycloalkyl; and ring A can be partly or completely saturated or aromatic, or a salt thereof with a pharmaceutically acceptable acid or base, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to the metabotropic glutamate receptor system.
摘要翻译：本发明涉及式（I）的治疗活性杂环化合物，其中n为0,1或2; 并且X是-O - ， - S，-N（R 5） - 或-CH 2 - ; 并且R 1是H，NH 2，NHR 5或OH; R 2和R 3独立地为H，COOH; COOR 5，CONH 2，CONHR 5，CON（R 5）2，CONHSO 2 R 5或四唑; 且R 4为H，OH，NH 2，NHR 5; CF 3，C 1-8烷基，C 2-8 - 烯基，C 2-8 - 炔基，C 3-6 - 环烷基，苯基或C 1-4 - 烷氧基; R 5为H，C 1-8 - 烷基，C 2-8 - 烯基，C 2-8 - 炔基，苯基或C 3-6 - 环烷基; 并且环A可以是部分或完全饱和的或芳族的，或其与药学上可接受的酸或碱的盐，其制备方法和包含该化合物的药物组合物。该新化合物可用于治疗与代谢型谷氨酸受体系统相关的中枢神经系统疾病。

7. 发明申请

WO1990003979A2 ANTI-ANDROGEN COMPOUNDS 审中-公开
标题翻译：抗雄虫化合物
公开(公告)号：WO1990003979A2
公开(公告)日：1990-04-19
申请号：PCT/US1989004312
申请日：1989-10-02
申请人： ARCH DEVELOPMENT CORPORATION
发明人： ARCH DEVELOPMENT CORPORATION , LIAO, Shutsung , PATAKI, John , HARVEY, Ronald, G.
IPC分类号： C07J01/100
CPC分类号： C07J63/008 , A61K31/045 , A61K31/05 , A61K31/12 , A61K31/22 , C07C39/17 , C07C45/513 , C07C45/516 , C07C49/657 , C07C49/665 , C07C49/747 , C07C49/753 , C07C49/792 , C07C2603/26 , C07J1/0055 , C07J1/0059 , C07J1/007 , C07J1/0088
摘要： Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
摘要翻译：公开了新型抗雄激素，包括二氢菲衍生物，其合成方法及其在治疗与过度雄激素活性相关的疾病中的用途。

8. 发明申请

WO1988002357A2 PROCESS FOR THE PRODUCTION OF ALKYLENE OR CYCLICALLY LINKED COMPOUNDS 审中-公开
标题翻译：生产链烷基金环链化合物的方法
公开(公告)号：WO1988002357A2
公开(公告)日：1988-04-07
申请号：PCT/EP1987000527
申请日：1987-09-16
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , POETSCH, Eike , REIFFENRATH, Volker
IPC分类号： C07B41/00
CPC分类号： C07C255/00 , C07C13/28 , C07C15/54 , C07C25/18 , C07C43/21 , C07C49/792 , C07C49/813 , C07D239/26 , C09K19/3001
摘要： Compounds having formula (I): R1-(Ao)k-(Z1-A1)m-Zo-(E)n-(Q)o-(Z2-A2)p-R2, can be easily produced in high yields from organic zinc compounds having formula (II): R1-(Ao)k-(Z1-A1)m-Zo-ZnY and compounds having formula (III): X-(E)n-(Q)o-(Z2-A2)p-R2, in which Ao, A1, A2, E, R1, R2, Zo, Z1, Z2, Q, k, m, n, o and p have the given meaning.
摘要翻译：这是很容易大量具有式（I）R 1 - （AO）化合物K-（Z1-A1）M-ZO-（E）N（Q）邻 - （Z2-A2）p-R2的产生（II）R 1 - （A 0）k - （Z 1 -Al）m -Zo-ZnY的有机锌化合物和具有式（III）X-（E）n-（Q）o - （Z2-A2）p-R2，其中A0，A1，A2，E，R1，R2，Z0，Z1，Z2，Q，k，m，n，o和p具有给定的含义。

9. 发明申请

WO1986005486A1 CYCLOHEXANE DERIVATIVES 审中-公开
标题翻译：环己酮衍生物
公开(公告)号：WO1986005486A1
公开(公告)日：1986-09-25
申请号：PCT/EP1986000164
申请日：1986-03-21
申请人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... , POHL, Ludwig , SCHEUBLE, Bernhard , HITTICH, Reinhard , EIDENSCHINK, Rudolf , KURMEIER, Hans-Adolf , WÄCHTLER, Andreas
发明人： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...
IPC分类号： C07C121/60
CPC分类号： C07C255/00 , C07C13/28 , C07C25/18 , C07C43/184 , C07C43/188 , C07C43/21 , C07C43/225 , C07C45/004 , C07C45/46 , C07C49/313 , C07C49/792 , C09K19/3003 , C09K19/3068
摘要： Cyclohexane derivatives of formula R -A -Z -A -R in which R and R are in each case an alkyl group with 1-10 C atoms, in which also one or two non neighboring CH2 groups can be replaced by O atoms and/or -CO- groups and/or -CO-O- groups and/or -CH=CH- groups, one of the remainder R and R , also H, F, Cl, Br, CN or R -A -Z -, A is -A-, A -A- or -A-A -, A is a substituted trans-1,4-cyclohexyl group substituted in 2 , 3 , 5 and/or 6 position, substituted once or substituted several times by F and/or Cl and/or Br and/or CN and/or an alkyl group or a fluoridated alkyl group, each with 1-10 atoms, in which also one or two not neighboring CH2 groups can be replaced by O atoms and/or -CO- groups and/or -CO-O- groups; which also, as the case may be, can be substituted in 1 and/or 4 position, A , A and A are in each case an unsubstituted 1,4-phenylene, or a 1,4-phenyl substituted by one or two F and/or Cl atoms and/or CH3 groups and/or CN groups, in which also one or two CH groups can be replaced by N atoms and/or NO, 1,4-cyclohexylene, in which one or two not neighboring CH2 groups may be substituted by O atoms, 1,3-dithiane-2,5-diyl, piperidine-1,4-diyl, 1,4-bicyclo(2,2,2)-octylene-, decahydronaphthalene-2,6-diyl-, or 1,2,3,4-tetrahydronaphthalene-2,6-diyl groups, Z and Z are either -CO-O-, -O-CO-, -CH2CH2-, OCH2-, -CH2O or a single link, and R is H, an alkyl group with 1-10, in which also one or two not-neighboring CH2 groups can be replaced by O atoms and/or -CO- groups and/or -CO-O- groups and/or -CH=CH- groups; F, Cl,Br or CN, it being understood that if Z = -CO-O- A in beta -position, to the -CO-O- bridge it carries no equatorial substitutes, are suitable as components for liquid crystal phases.
摘要翻译：式R 1 -A 1 -Z 1 -A 2 -R 2的环己烷衍生物，其中R 1和R 2各自为具有1-10个 C原子，其中一个或两个不相邻的CH 2基团可以被O原子和/或-CO-基团和/或-CO-O-基团和/或-CH = CH-基团取代，其余的R 1和R 2，还有H，F，Cl，Br，CN或R 3 -A 3 - 2，A 1是-A-，A 4 - A-或-AA 4 - ，A是在2，3，5和/或6位上取代的取代的反式-1,4-环己基，取代一次或被F和/或Cl和/或Br和/或CN和/或烷基或氟化烷基取代几次，每个具有1-10个原子，其中一个或两个不相邻的CH 2基团可以被 O原子和/或-CO-基团和/或-CO-O-基团; 根据情况也可以在1位和/或4位取代，A 2，A 3和A 4在每种情况下都是未取代的1,4- 亚苯基或被一个或两个F和/或Cl原子和/或CH 3基团和/或CN基团取代的1,4-苯基，其中一个或两个CH基团可以被N原子和/或NO，其中一个或两个不相邻的CH2基团可以被O原子取代的1,4-亚环己基，1,3-二噻烷-2,5-二基，哌啶-1,4-二基，1,4-双环（2， 2,2,2-辛基 - 十氢萘-2,6-二基或1,2,3,4-四氢化萘-2,6-二基，Z 1和Z 2均为-CO-O - ， - O - CO - ， - CH 2 CH 2 - ，OCH 2 - ， - CH 2 O或单环，并且R 3是H，具有1-10的烷基，其中还有一个或两个不相邻的CH 2基团被O原子和/或-CO-基团和/或-CO-O-基团和/或-CH = CH-基团取代; F，Cl，Br或CN，可以理解，如果β-β中的Z 1 = -CO-O- A 1，则对于-CO-O-桥，其不携带赤道替代物，适合作为组分用于液晶相。

10. 发明申请

WO1983003247A1 FRIEDEL CRAFT REACTIONS 审中-公开
标题翻译： FRIEDEL CRAFT反应
公开(公告)号：WO1983003247A1
公开(公告)日：1983-09-29
申请号：PCT/GB1983000074
申请日：1983-03-11
申请人： BUSH BOAKE ALLEN LIMITED , FERBER, Gerald, John , GODDARD, Peter, Jonathan , HOLDEN, Robert, Stanley
发明人： BUSH BOAKE ALLEN LIMITED
IPC分类号： C07B27/00
CPC分类号： C07C49/792 , B01J19/002 , C07C2/861 , C07C29/36 , C07C29/44 , C07C45/46 , C07C2527/126 , C07C2602/08 , C07C2602/10 , C07C13/465 , C07C13/48 , C07C33/34 , C07C33/22 , C07C33/483 , C07C29/40
摘要： An indane, tetralin or phenyl alcohol is made by a heterogeneous, fast, exothermic Friedel Craft reaction and the reaction mixture is cooled to a temperature at which substantial by-product formation is avoided by continuously utilising the heat of reaction to boil solvent from the reaction mixture. The reaction mixture is generally maintained below atmospheric pressure, typically 20 to 100 mm Hg. The process is of particular value for the production of aryl alcohols by reacting an indane or tetralin with ethylene oxide or propylene oxide.
摘要翻译：茚满，四氢化萘或苯醇通过异相，快速，放热的Friedel Craft反应制备，反应混合物冷却至避免大量副产物形成的温度，连续利用反应热从反应中溶解溶剂混合物。反应混合物通常保持低于大气压，通常为20至100mm Hg。该方法对于通过使茚满或四氢化萘与环氧乙烷或环氧丙烷反应来制备芳基醇是特别有价值的。

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