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1. 发明申请

WO2006034512A3 PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES 审中-公开
标题翻译：苯基取代的喹啉和喹唑啉类化合物治疗糖尿病
公开(公告)号：WO2006034512A3
公开(公告)日：2006-06-08
申请号：PCT/US2005034867
申请日：2005-09-23
申请人： BAYER PHARMACEUTICALS CORP , CANTIN DAVID , MAGNUSON STEVEN , GUNN DAVID , BULLOCK WILLIAM , BURKE JENNIFER , FU WENLANG , KUMARASINGHE ELLALAHEWAGE SATH , LIANG SIDNEY X , NEWCOM JASON , OGUTU HERBERT , OLAGUE ALAN , WANG MING , WICKENS PHILIP , ZHANG ZHONGHUA , BIERER DONALD
发明人： CANTIN DAVID , MAGNUSON STEVEN , GUNN DAVID , BULLOCK WILLIAM , BURKE JENNIFER , FU WENLANG , KUMARASINGHE ELLALAHEWAGE SATH , LIANG SIDNEY X , NEWCOM JASON , OGUTU HERBERT , OLAGUE ALAN , WANG MING , WICKENS PHILIP , ZHANG ZHONGHUA , BIERER DONALD
IPC分类号： A61K31/47 , A61K31/519 , C07D215/04 , C07D215/12 , C07D239/72
CPC分类号： C07D239/95 , C07D215/14 , C07D215/18 , C07D215/42 , C07D215/48 , C07D215/54 , C07D215/56 , C07D239/86 , C07D239/91 , C07D239/94 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/10 , C07D409/10
摘要： The invention relates to 2-phenyl-substituted quinoline and quinazoline compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译：本发明涉及2-苯基取代的喹啉和喹唑啉化合物，药物组合物和用于治疗糖尿病和相关病症的方法。

2. 发明申请

WO2006110763A9 PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：吡嗪衍生物及其用于治疗癌症的用途
公开(公告)号：WO2006110763A9
公开(公告)日：2007-12-06
申请号：PCT/US2006013505
申请日：2006-04-07
申请人： BAYER PHARMACEUTICALS CORP , NAGARATHNAM DHANAPALAN , CHEN YUANWEI , FU WENLANG , WANG MING , BIERER DONALD , BRANDS MICHAEL , WANG YAMIN , BEAR BRIAN R , MILLER DAVID , SCHMITT AARON , MULL ERIC , ZHAO JIN
发明人： NAGARATHNAM DHANAPALAN , CHEN YUANWEI , FU WENLANG , WANG MING , BIERER DONALD , BRANDS MICHAEL , WANG YAMIN , BEAR BRIAN R , MILLER DAVID , SCHMITT AARON , MULL ERIC , ZHAO JIN
IPC分类号： C07D401/12 , A61K31/506
CPC分类号： C07D401/12
摘要： This invention relates to novel compounds (I) and processes for their preparation, methods of tr
摘要翻译：本发明涉及新化合物（Ⅰ）及其制备方法，

3. 发明申请

WO2006110447A3 PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：吡嗪衍生物及其在治疗癌症中的应用
公开(公告)号：WO2006110447A3
公开(公告)日：2007-01-18
申请号：PCT/US2006012828
申请日：2006-04-07
申请人： BAYER PHARMACEUTICALS CORP , NAGARATHNAM DHANAPALAN , CHEN YUANWEI , FU WENLANG , WANG MING , BIERER DONALD , BRANDS MICHAEL , WANG YAMIN , BEAR BRIAN R
发明人： NAGARATHNAM DHANAPALAN , CHEN YUANWEI , FU WENLANG , WANG MING , BIERER DONALD , BRANDS MICHAEL , WANG YAMIN , BEAR BRIAN R
IPC分类号： C07D401/12 , A61K31/506 , C07D401/14 , C07D405/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14
摘要： This invention relates to novel compounds (I) and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译：本发明涉及新化合物（I）及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

4. 发明申请

WO2005035507A3 4-AMINOPYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗高反应性疾病的4-氨基吡啶衍生物
公开(公告)号：WO2005035507A3
公开(公告)日：2006-08-31
申请号：PCT/US2004033430
申请日：2004-10-08
申请人： BAYER PHARMACEUTICALS CORP , DIXON JULIE A , NAGARATHNAM DHANAPALAN , ZHANG LEI , WANG CHUNGUANG , YI LIN , CHEN YUANWEI , CHEN JIANQING , BEAR BRIAN , BRANDS MICHAEL , HILLISCH ALEXANDER , BIERER DONALD , WANG MING , FU WENLANG , HENTEMANN MARTIN F , BULLION ANN-MARIE
发明人： DIXON JULIE A , NAGARATHNAM DHANAPALAN , ZHANG LEI , WANG CHUNGUANG , YI LIN , CHEN YUANWEI , CHEN JIANQING , BEAR BRIAN , BRANDS MICHAEL , HILLISCH ALEXANDER , BIERER DONALD , WANG MING , FU WENLANG , HENTEMANN MARTIN F , BULLION ANN-MARIE
IPC分类号： C07D401/12 , A61K31/506 , A61K31/5377 , A61P35/00 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R 2 , G, G', and G" represent substituent groups and R 2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; M表示CH或N.药物含有这些化合物的组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法也被公开并要求保护。

5. 发明申请

WO2006044762A3 TETRAHYDRO-5H-PYRIMIDO[4,5-D]AZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR 审中-公开
标题翻译：可用于治疗与5-HT2C受体相关的疾病的四氢-5H-嘧啶并[4,5-D]氮杂嘌呤衍生物
公开(公告)号：WO2006044762A3
公开(公告)日：2006-08-03
申请号：PCT/US2005037193
申请日：2005-10-14
申请人： BAYER PHARMACEUTICALS CORP , CAMPBELL ANN-MARIE , COISH PHILIP , O'CONNOR STEPHEN , SIBLEY EVELYN , WRIGHT HAROLD , WANG MING , BIERER DONALD
发明人： CAMPBELL ANN-MARIE , COISH PHILIP , O'CONNOR STEPHEN , SIBLEY EVELYN , WRIGHT HAROLD , WANG MING , BIERER DONALD
IPC分类号： A61K31/55
CPC分类号： C07D487/04
摘要： The invention relates to tetrahydro-5H-pyrimido[4,5-d]azepine compounds of Formula (I) that are useful in the treatment or prevention of diseases and/or behaviors that involve the 5-HT 2C receptor. The compounds of the present invention may also be used for the treatment or prevention of diseases and/or disorders including obesity, obesity-related disorders such as diabetes, feeding behavior disorders, eating disorders such as bulimia and anorexia nervosa, and premenstrual tension.
摘要翻译：本发明涉及可用于治疗或预防涉及5-HT 2C 的疾病和/或行为的式（I）的四氢-5H-嘧啶并[4,5-d] >受体。本发明化合物还可用于治疗或预防包括肥胖症，肥胖症相关病症如糖尿病，摄食行为障碍，进食障碍如贪食症和神经性厌食症以及经前紧张的疾病和/或病症。

6. 发明申请

WO0220526A3 CYCLIC AND ACYCLIC AMIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR USE AS PROGESTERONE RECEPTOR BINDING AGENTS 审中-公开
标题翻译：包含它们作为孕激素受体结合剂的循环和ACYCLIC和药物组合物
公开(公告)号：WO0220526A3
公开(公告)日：2002-05-30
申请号：PCT/US0127007
申请日：2001-08-30
申请人： BAYER AG , BULLOCK WILLIAM H , KLUENDER HAROLD C E , COLLIBEE WILLIAM L , DALLY ROBERT , RODRIGUEZ MARTHA E , WANG MING
发明人： BULLOCK WILLIAM H , KLUENDER HAROLD C E , COLLIBEE WILLIAM L , DALLY ROBERT , RODRIGUEZ MARTHA E , WANG MING
IPC分类号： C07D295/12 , A61K31/136 , A61K31/155 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/426 , A61K31/438 , A61K31/439 , A61K31/445 , A61K31/47 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P5/24 , A61P5/42 , A61P15/00 , A61P15/02 , A61P15/04 , A61P15/06 , A61P15/08 , A61P15/12 , A61P19/08 , A61P19/10 , A61P35/00 , A61P43/00 , C07C257/14 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/14 , C07D211/72 , C07D215/38 , C07D221/20 , C07D221/22 , C07D223/12 , C07D223/14 , C07D223/32 , C07D225/02 , C07D235/26 , C07D265/30 , C07D277/04 , C07D295/125 , C07D453/06 , C07D487/08 , A61K31/435 , C07D295/13
CPC分类号： C07D295/125 , A61K31/136 , A61K31/395 , A61K31/40 , A61K31/438 , A61K31/445 , A61K31/47 , A61K31/5375 , A61K31/55 , C07C257/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/22 , C07D211/72 , C07D221/22 , C07D223/32 , C07D487/08
摘要： Disclosed are cyclic and acyclic amidines, pharmaceutical compositions containing such amidines, and their use in treating or preventing progesterone receptor mediated diseases or conditions, such as osteopenia and osteoporosis.
摘要翻译：公开了环状和非环状脒基，含有这种脒的药物组合物及其在治疗或预防孕酮受体介导的疾病或病症如骨质减少和骨质疏松症中的用途。

7. 发明申请

WO0212854A3 SYSTEMS AND METHODS FOR PROVIDING INFORMATION CONCERNING CHROMOPHORES IN PHYSIOLOGICAL MEDIA 审中-公开
标题翻译：提供生理介质中色素信息的系统和方法
公开(公告)号：WO0212854A3
公开(公告)日：2002-12-19
申请号：PCT/US0124301
申请日：2001-08-03
申请人： PHOTONIFY TECHNOLOGIES INC , CHENG XUEFENG , XU XIAORONG , ZHOU SHUOMING , WANG LAI , WANG MING , LI FENG , HU GUOBAO
发明人： CHENG XUEFENG , XU XIAORONG , ZHOU SHUOMING , WANG LAI , WANG MING , LI FENG , HU GUOBAO
IPC分类号： G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1455 , C12Q1/04 , G01N21/27 , G01N21/31 , G01N21/33 , G01N21/35 , G01N21/49 , G01N33/483 , G01N33/72 , G06F17/10
CPC分类号： A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/413 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , A61B2562/046 , G01N21/359 , G01N21/49 , G01N2021/3144
摘要： The present invention generally relates to systems and methods for providing information about chromophores in physiological media. More particularly, the invention relates to non-invasive systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The system generally includes a portable probe having a source module (122) for irradiating into the medium electromagnetic radiation, a detector module (124) detecting radiation from a target area in the medium, and a processing module (140) determining the absolute values of the chromophore concentrations and the ratios thereof based on input and output parameters of the source and detector modules. In one aspect, the invention provides a solution for unknown parameters of the chromophores in a medium using a novel processing algorithm. In another aspect, the invention concerns a portable unit for performing the requisite measurements, which unit includes a movable member having one or more radiation sources and one or more radiation detectors, and an actuator designed to cause the member to move along predetermined curvilinear paths. Properties of the chromophores are measured for individual voxels defined along each motion path, and/or cross-voxels defined at the intersection of voxels along different motion paths. These measured values are then used in a preferred embodiment to generate two- or three-dimensional images of the distribution of chromophores or their properties. In other aspects, the invention includes various patterns for the optimal distribution of sources and detectors for the optical probe, and self-calibrating operation of the probe substantially in real-time.
摘要翻译：本发明一般涉及在生理介质中提供关于发色团的信息的系统和方法。更具体地，本发明涉及用于确定氧合和/或脱氧血红蛋白的绝对值及其在生理介质中的比例的非侵入性系统和方法。该系统通常包括便携式探头，其具有用于照射介质电磁辐射的源模块（122），检测器模块（124），用于检测来自介质中的目标区域的辐射;以及处理模块（140），其确定绝对值基于源和检测器模块的输入和输出参数的发色团浓度及其比例。一方面，本发明使用新颖的处理算法提供了介质中发色团的未知参数的解决方案。在另一方面，本发明涉及用于执行必要的测量的便携式单元，该单元包括具有一个或多个辐射源和一个或多个辐射检测器的可动构件以及被设计成使构件沿着预定的曲线路径移动的致动器。对沿着每个运动路径定义的个体体素测量发色团的性质，和/或在沿不同运动路径的体素交点处定义的交叉体素。然后将这些测量值用于优选实施方案中以产生发色团分布或其性质的二维或三维图像。在其他方面，本发明包括用于光学探针的源和检测器的最佳分布的各种图案，以及基本上实时地自动校准探针的操作。

8. 发明申请

WO2011082210A2 METHOD AND SYSTEM FOR INCREASING HYDROGEN YIELD/PRODUCTION IN A REFINERY 审中-公开
标题翻译：增加炼油厂氢气产量/生产的方法和系统
公开(公告)号：WO2011082210A2
公开(公告)日：2011-07-07
申请号：PCT/US2010062315
申请日：2010-12-29
申请人： CHEVRON USA INC , GORSKI ALAN , OKEOWO OLUWASIJIBOMI , WANG MING
发明人： GORSKI ALAN , OKEOWO OLUWASIJIBOMI , WANG MING
IPC分类号： C01B3/56 , B01D71/02 , C01B3/34
CPC分类号： C01B3/501 , B01D71/021 , C01B3/26 , C01B3/38 , C01B2203/0233 , C01B2203/0405 , C01B2203/048 , C01B2203/063 , C01B2203/142 , Y02P20/52
摘要： A method and system for capturing hydrogen gas in a refinery is disclosed. The system comprises a first membrane and pre-reformer. The membrane is suitable for separating a refinery fuel gas feed, which includes hydrogen gas and hydrocarbon gases, into a hydrogen gas depleted retentate stream and a hydrogen gas enriched permeate stream. The pre-reformer receives the retentate stream from the first membrane and catalytically converts the retentate stream into an outlet stream of hydrogen and methane gases. The system may further include a reformer which receives at least a portion of the outlet stream and catalytically converts the methane gas into hydrogen and carbon oxides. A second membrane may be used for separating the outlet stream into a second hydrogen depleted retentate stream and second hydrogen enriched permeate stream. The reformer, in this case, receives the second hydrogen depleted retentate stream to provide methane for steam reforming. Because hydrogen is removed from the original refinery fuel gas feed fed to the pre-reformer and/or the outlet stream fed to the reformer, additional hydrocarbons can be fed to the pre-reformer and/or reformer, in place of the removed hydrogen gas, to increase the overall hydrogen gas production from the system.
摘要翻译：公开了一种用于捕获炼油厂中的氢气的方法和系统。该系统包括第一膜和预重整器。该膜适用于将包括氢气和碳氢化合物气体的炼油厂燃料气进料分离成氢气贫化渗余物流和富氢气渗透物流。预重整器接收来自第一膜的滞留物流并将滞留物流催化转化成氢和甲烷气体的出口物流。该系统还可以包括接收至少一部分出口物流并将甲烷气体催化转化成氢和碳氧化物的重整器。第二膜可用于将出口物流分离成第二贫氢渗余物物流和第二富氢渗透物物流。在这种情况下，重整器接收第二贫氢截留物流以提供用于蒸汽重整的甲烷。因为从输送到预重整器的原始炼油厂燃气供给和/或供给到重整器的出口物流中除去氢，可以将另外的烃供给到预重整器和/或重整器，代替除去的氢气，以增加系统的总体氢气产量。

9. 发明申请

WO2008100610A2 WATER PURIFICATION 审中-公开
标题翻译：净水
公开(公告)号：WO2008100610A2
公开(公告)日：2008-08-21
申请号：PCT/US2008002092
申请日：2008-02-14
申请人： BATTELLE MEMORIAL INSTITUTE , MONZYK BRUCE F , VON FAHNESTOCK FRANK M , ROSE JAMES K , CONKLE HAROLD N , WANG MING , CHAUHAN SATYA P , BRUCE RUEY K , HIGHSMITH TENISHA
发明人： MONZYK BRUCE F , VON FAHNESTOCK FRANK M , ROSE JAMES K , CONKLE HAROLD N , WANG MING , CHAUHAN SATYA P , BRUCE RUEY K , HIGHSMITH TENISHA
IPC分类号： C02F1/52 , B01D11/04 , B01D17/02 , B01D21/24 , C02F1/26 , C02F103/10
CPC分类号： C02F1/26 , C02F1/5236 , C02F1/5245 , C02F1/542 , C02F1/66 , C02F2101/101 , C02F2101/103 , C02F2101/105 , C02F2101/106 , C02F2101/12 , C02F2101/163 , C02F2101/166 , C02F2101/203 , C02F2101/206 , C02F2101/22 , C02F2101/30 , C02F2103/10
摘要： The invention provides an efficient method to purify an aqueous solution, typically mine drainage water, especially of anions and cations present in the aqueous solution as dissolved solids, the anions and cations are removed by treatment with a positively charged extractant having at least eight carbon atoms, whereby an unstable emulsion is formed; the unstable emulsion is allowed to break into an extract phase loaded with the anions and cations, and a water phase depleted in anions and cations; a floe inherently forms in the loaded extractant phase and then the loaded extractant phase and floe are separated from the purified water and treated to remove the anions and cations as concentrated useful products; the treated aqueous phase now reduced in anion and/or cation content is also separated from the emulsion as a purified aqueous solution. The extractant phase is preferably recycled. A continuous water purification process is provided.
摘要翻译：本发明提供了一种净化水溶液的有效方法，通常将溶解固体中的水溶液中特别是阴离子和阳离子的排泄水，特别是阴离子和阳离子矿化，通过用具有至少8个碳原子的带正电的萃取剂处理除去阴离子和阳离子由此形成不稳定的乳液; 允许不稳定的乳液分解成负载阴离子和阳离子的萃取相，以及阴离子和阳离子中耗尽的水相; 在负载的萃取相中固有地形成絮凝物，然后将负载的萃取相和絮凝物与纯化水分离并处理以除去作为浓缩有用产物的阴离子和阳离子; 现在将阴离子和/或阳离子含量还原的处理过的水相也作为纯化水溶液与乳液分离。萃取相优选是循环的。提供连续的水净化过程。

10. 发明申请

WO0212854A9 SYSTEMS AND METHODS FOR PROVIDING INFORMATION CONCERNING CHROMOPHORES IN PHYSIOLOGICAL MEDIA 审中-公开
标题翻译：用于提供关于生理介质中的生色团的信息的系统和方法
公开(公告)号：WO0212854A9
公开(公告)日：2002-10-17
申请号：PCT/US0124301
申请日：2001-08-03
申请人： PHOTONIFY TECHNOLOGIES INC , CHENG XUEFENG , XU XIAORONG , ZHOU SHUOMING , WANG LAI , WANG MING , LI FENG , HU GUOBAO
发明人： CHENG XUEFENG , XU XIAORONG , ZHOU SHUOMING , WANG LAI , WANG MING , LI FENG , HU GUOBAO
IPC分类号： G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1455 , C12Q1/04 , G01N21/27 , G01N21/31 , G01N21/33 , G01N21/35 , G01N21/49 , G01N33/483 , G01N33/72 , G06F17/10 , G01N
CPC分类号： A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/413 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , A61B2562/046 , G01N21/359 , G01N21/49 , G01N2021/3144
摘要： The present invention generally relates to systems and methods for providing information about chromophores in physiological media. More particularly, the invention relates to non-invasive systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The system in a preferred embodiment generally includes a portable probe having a source module for irradiating into the medium electromagnetic radiation, a detector module detecting radiation from a target area in the medium, and a processing module determining the absolute values of the chromophore concentrations and their ratios thereof based on input and output parameters of the source and detector modules. In one aspect, the invention provides a solution for the unknown paramters of the chromophores in a medium using a novel processing algorithm. In another aspect, the invention concerns a portable unit for performing the requisite measurements, which unit includes a movable member having one or more radiation sources and one or more radiation detectors, and an actuator designed to cause the member to move along predetermined curvilinear paths. Properties of the chromophores are measured for individual voxels defined along each motion path, and/or cross-voxels defined at the intersection of voxels along different motion paths. These measured values are then used in a preferred embodiment to generate two- or three-dimensional images of the distribution of chromophores or their properties. In other aspects, the invention includes various patterns for the optimal distribution of sources and detectors for the optical probe, and self-calibrating operation of the probe substantially in real-time.
摘要翻译：本发明总体上涉及用于提供关于生理介质中的发色团的信息的系统和方法。更具体地说，本发明涉及用于确定生理介质中含氧和/或脱氧血红蛋白及其比例的绝对值的非侵入式系统和方法。优选实施例中的系统通常包括便携式探头，该便携式探头具有用于照射介质中的电磁辐射的源模块，检测来自介质中的目标区域的辐射的检测器模块和处理模块，该处理模块确定发色团浓度及其浓度其比例基于源和检测器模块的输入和输出参数。一方面，本发明使用新颖的处理算法为介质中未知的发色团参数提供解决方案。另一方面，本发明涉及一种用于执行必要测量的便携式单元，该单元包括具有一个或多个辐射源和一个或多个辐射探测器的可动构件以及设计成使构件沿预定曲线路径移动的致动器。对于沿着每个运动路径定义的单个体素和/或沿着不同运动路径的体素交叉处定义的交叉体素，测量发色团的性质。然后在优选实施例中使用这些测量值来生成发色团分布或其性质的二维或三维图像。在其他方面，本发明包括用于光学探针的源和检测器的最佳分布的各种模式，以及基本上实时地对探针进行自校准操作。

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