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1. 发明申请

WO2016209749A1 SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS 审中-公开
标题翻译：作为PDE2抑制剂的取代的吡唑并咪唑类双环化合物
公开(公告)号：WO2016209749A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038292
申请日：2016-06-20
申请人： MERCK SHARP & DOHME CORP. , MORRIELLO, Gregori J. , CHANG, Lehua , FORSTER, Ashley , CHEN, Yili , DWYER, Michael, P. , BERGER, Richard , WANG, Ming , NANDA, Kausik K. , BUNDA, Jaime L. , SHIPE, William D.
发明人： MORRIELLO, Gregori J. , CHANG, Lehua , FORSTER, Ashley , CHEN, Yili , DWYER, Michael, P. , BERGER, Richard , WANG, Ming , NANDA, Kausik K. , BUNDA, Jaime L. , SHIPE, William D.
IPC分类号： C07D498/04 , C07D491/04 , C07D495/04
CPC分类号： C07D498/04 , A61P25/16 , A61P25/18 , A61P25/28 , C07D473/34 , C07D487/04
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译：本发明涉及可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病的治疗剂的式I的嘧啶甲酰胺化合物。本发明还涉及这些化合物用于治疗精神分裂症，精神病，帕金森病，帕金森病痴呆（PDD）或亨廷顿舞蹈症等神经和精神疾病以及与纹状体功能不全或基底神经节功能障碍相关的疾病的用途。

2. 发明申请

WO2012162241A3 REAL-TIME WIRELESS DYNAMIC TIRE PRESSURE SENSOR AND ENERGY HARVESTING SYSTEM 审中-公开
标题翻译：实时无线动态轮胎压力传感器和能量采集系统
公开(公告)号：WO2012162241A3
公开(公告)日：2013-03-21
申请号：PCT/US2012038842
申请日：2012-05-21
申请人： UNIV NORTHEASTERN , WANG MING L , WANG QI , MCDANIEL J GREGORY , SUN NIAN X
发明人： WANG MING L , WANG QI , MCDANIEL J GREGORY , SUN NIAN X
IPC分类号： B60C23/02
CPC分类号： B60C23/0474 , B60C23/041 , B60C23/0469 , B60C23/0486 , B60C23/0494 , B60R2021/01304 , B60R2021/01306 , B60R2021/01308 , B60W40/06 , G01D5/12 , G01N29/041
摘要： An instantaneous/real-time wireless dynamic tire pressure sensor (DTPS) for characterizing pavement qualities and for detecting surface and subsurface pavement defects under normal driving conditions. Signal processing provides quantitative assessment of surface conditions. DTPS includes a vehicle tire valve stem-mounted pressure sensor and wheel hub-mounted signal conditioning, amplification, and transmitting circuitry. A signal processing computer within the vehicle is wirelessly coupled to the hub-mounted circuitry. Tire pressure changes caused by ground vibration excitation from the interaction between the tire and pavement at normal driving speeds are detected. When acoustic radiation from a surface wave is significantly stronger than acoustic noise, subsurface information can be extracted. An energy harvester based on strong magnetostatic coupling between a high permeability core solenoid, fixed proximate a vehicle wheel, and a bias magnet array, fixedly mounted in conjunction with a dust shield, can provide power the DTPS.
摘要翻译：一种瞬时/实时无线动态轮胎压力传感器（DTPS），用于表征路面质量，并在正常驾驶条件下检测表面和地下路面缺陷。信号处理提供了表面条件的定量评估。 DTPS包括车辆轮胎气门杆安装压力传感器和轮毂安装的信号调理，放大和发射电路。车辆内的信号处理计算机无线地耦合到轮毂安装的电路。检测由正常行驶速度下的轮胎与路面之间的相互作用引起的地面振动引起的轮胎压力变化。当来自表面波的声辐射明显强于声学噪声时，可以提取地下信息。基于固定在车辆车轮附近的高磁导率磁芯螺线管和固定地与防尘罩一起安装的偏置磁体阵列之间的强静磁耦合的能量收集器可以为DTPS提供电力。

3. 发明申请

WO2007084926A3 COMPOSITIONS AND METHODS FOR HUMANIZATION AND OPTIMIZATION OF N-GLYCANS IN PLANTS 审中-公开
标题翻译：植物中N-糖苷的人工化和优化的组合物和方法
公开(公告)号：WO2007084926A3
公开(公告)日：2008-04-24
申请号：PCT/US2007060646
申请日：2007-01-17
申请人： BIOLEX THERAPEUTICS INC , COMMW SCIENT IND RES ORG , DICKEY LYNN F , COX KEVIN M , PEELE CHARLES G , WANG MING-BO
发明人： DICKEY LYNN F , COX KEVIN M , PEELE CHARLES G , WANG MING-BO
IPC分类号： C07K14/47 , A01H5/00 , C07K16/00 , C07K16/28 , C07K16/32 , C12N15/82 , C12P21/00
CPC分类号： C07K14/47 , C07K16/00 , C07K2317/13 , C07K2317/41 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C12N15/8257 , C12N15/8258
摘要： Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition of expression of al,3-fucosyltransferase (FucT) and ß 1 ,2-xylosyltransferase (XyIT) in a plant. Use of these constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a "humanized" N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the GO glycoform, are also provided.
摘要翻译：提供了改变高等植物中蛋白N-糖基化模式的方法。所述方法包括向植物中导入提供抑制植物中α1,3-岩藻糖基转移酶（FucT）和β1,2-木糖基转移酶（XylT）表达的重组构建体。使用这些构建体来抑制或抑制这些酶及其同种型的表达，有利地提供了具有“人源化”N-糖基化模式的内源和异源蛋白质的生产，而不影响植物生长和发育。提供了具有该蛋白N-糖基化模式的稳定转化的高等植物。还提供了糖蛋白组合物，包括单克隆抗体组合物，其具有基本上均匀的糖基化分布，并且其对于GO糖型基本上是均质的。

4. 发明申请

WO2007084926A2 COMPOSITIONS AND METHODS FOR HUMANIZATION AND OPTIMIZATION OF N-GLYCANS IN PLANTS 审中-公开
标题翻译：植物中N-糖苷的人工化和优化的组合物和方法
公开(公告)号：WO2007084926A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060646
申请日：2007-01-17
申请人： BIOLEX, INC. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , DICKEY, Lynn, F. , COX, Kevin, M. , PEELE, Charles, G. , WANG, Ming-bo
发明人： DICKEY, Lynn, F. , COX, Kevin, M. , PEELE, Charles, G. , WANG, Ming-bo
CPC分类号： C07K14/47 , C07K16/00 , C07K2317/13 , C07K2317/41 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C12N15/8257 , C12N15/8258
摘要： Methods for altering the N -glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition of expression of αl,3-fucosyltransferase (FucT) and β 1 ,2-xylosyltransferase (XyIT) in a plant. Use of these constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a "humanized" N -glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N -glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the GO glycoform, are also provided.
摘要翻译：提供了改变高等植物中蛋白质N-糖基化模式的方法。所述方法包括向植物中引入重组构建体，所述重组构建体在植物中抑制α1,3-岩藻糖基转移酶（FucT）和β1,2-木糖基转移酶（XylT）的表达。使用这些构建体来抑制或抑制这些酶及其同种型的表达，有利地提供了产生具有“人源化”的内源和异源蛋白质的内源和异源蛋白质。不影响植物生长和发育的N-糖基化模式。提供了具有这种蛋白质N-糖基化模式的稳定转化的高等植物。还提供了糖蛋白组合物，包括单克隆抗体组合物，其具有基本上均匀的糖基化特征并且对于GO糖型基本上是同质的。

5. 发明申请

WO2003011842A1 INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION 审中-公开
标题翻译：吲哚乙酸衍生物及其作为药物代谢物，中间体和制备方法的用途
公开(公告)号：WO2003011842A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/023614
申请日：2002-07-25
申请人： BAYER CORPORATION , LOWE, Derek, B. , WICKENS, Philip, L. , MA, Xin , ZHANG, Mingbao , BULLOCK, William, H. , COISH, Philip, D.G. , MUGGE, Ingo, A. , STOLLE, Andreas , WANG, Ming , WANG, Yamin , ZHANG, Chengzhi , ZHANG, Hai-Jun , ZHU, Lei , TSUTSUMI, Manami , LIVINGSTON, James, N.
发明人： LOWE, Derek, B. , WICKENS, Philip, L. , MA, Xin , ZHANG, Mingbao , BULLOCK, William, H. , COISH, Philip, D.G. , MUGGE, Ingo, A. , STOLLE, Andreas , WANG, Ming , WANG, Yamin , ZHANG, Chengzhi , ZHANG, Hai-Jun , ZHU, Lei , TSUTSUMI, Manami , LIVINGSTON, James, N.
IPC分类号： C07D263/32
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives of formula (I) which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates of formula (II) and (III) of indane acetic derivatives and to methods of preparation.
摘要翻译：本发明涉及式（I）的新型茚满乙酸衍生物，其可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病。本发明还涉及二氢化茚衍生物的式（II）和（III）的中间体和制备方法。

6. 发明申请

WO2022048951A1 COPOLYMER DERIVED FROM SUBSTITUTED BENZOPINACOL AND USE OF THE SAME AS POLYMERIZATION INITIATOR 审中-公开
公开(公告)号：WO2022048951A1
公开(公告)日：2022-03-10
申请号：PCT/EP2021/073385
申请日：2021-08-24
申请人： BASF COATINGS GMBH , WANG, Ming
发明人： SUI, Ling Yu , LIU, Na , HINDALEKAR, Shrirang , PATEL, Mushtaq , MULAY, Rahul , CHEN, Qin Yuan , YANG, Yang
IPC分类号： C08F265/06 , C09D151/00 , C08F220/18 , C08F218/16 , C07C33/38
摘要： The present invention relates to a copolymer comprising, (A) allyloxycarboxyl substituted benzopinacol monomer of formula (I) and (B) at least one ethylenically unsaturated monomer, in copolymerized from, and use of the copolymer as a radical polymerization initiator. The present invention also relates to the allyloxycarboxyl substituted benzopinacol monomer of formula (I).

7. 发明申请

WO2020096916A2 INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION 审中-公开
公开(公告)号：WO2020096916A2
公开(公告)日：2020-05-14
申请号：PCT/US2019/059582
申请日：2019-11-04
申请人： MERCK SHARP & DOHME CORP. , YU, Wensheng , KOZLOWSKI, Joseph, A. , CLAUSEN, Dane James , LIU, Jian , YU, Younong , WANG, Ming , LI, Bing
发明人： YU, Wensheng , KOZLOWSKI, Joseph, A. , CLAUSEN, Dane James , LIU, Jian , YU, Younong , WANG, Ming , LI, Bing
IPC分类号： A61K31/47
摘要： The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.

8. 发明申请

WO2017000277A1 SUBSTITUTED TRIAZOLO BICYCLICCOMPOUNDS AS PDE2 INHIBITORS 审中-公开
标题翻译：作为PDE2抑制剂的替代三唑基双酚化合物
公开(公告)号：WO2017000277A1
公开(公告)日：2017-01-05
申请号：PCT/CN2015/083060
申请日：2015-07-01
申请人： MERCK SHARP & DOHME CORP. , MORRIELLO, Gregori J. , CHANG, Lehua , FOSTER, Ashley , CHEN, Yili , DWYER, Michael , GUO, Zack Zhiqiang , WANG, Ming , XU, Shimin , BO, Yingjian , FU, Jianmin
发明人： MORRIELLO, Gregori J. , CHANG, Lehua , FOSTER, Ashley , CHEN, Yili , DWYER, Michael , GUO, Zack Zhiqiang , WANG, Ming , XU, Shimin , BO, Yingjian , FU, Jianmin
IPC分类号： C07D471/04 , A61K31/4353 , A61K31/519 , A61P25/14
CPC分类号： A61K31/4196 , A61K31/52 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , C07D471/04 , C07D487/04
摘要： The present invention is directed to substituted triazolo bicycliccompounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译：本发明涉及式（I）的取代三唑并二环化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病的治疗剂。本发明还涉及这些化合物用于治疗精神分裂症，精神病，帕金森病，帕金森病痴呆（PDD）或亨廷顿舞蹈症等神经和精神疾病以及与纹状体功能不全或基底神经节功能障碍相关的疾病的用途。

9. 发明申请

WO2016054804A1 SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE 审中-公开
标题翻译：作为HIF PROLYL羟基酶抑制剂的替代吡咯烷
公开(公告)号：WO2016054804A1
公开(公告)日：2016-04-14
申请号：PCT/CN2014/088318
申请日：2014-10-10
申请人： MERCK SHARP & DOHME CORP. , UJJAINWALLA, Fez , TAN, John Qiang , DANG, Qun , SINZ, Christopher J. , CRESPO, Alejandro , WANG, Ming , CHEN, Yili , CAI, Jiaqiang , WU, Fan , DU, Xiaoxing
发明人： UJJAINWALLA, Fez , TAN, John Qiang , DANG, Qun , SINZ, Christopher J. , CRESPO, Alejandro , WANG, Ming , CHEN, Yili , CAI, Jiaqiang , WU, Fan , DU, Xiaoxing
IPC分类号： C07D239/36 , C07D401/04 , C07D403/04 , C07D417/04 , A61K31/505 , A61K31/506 , A61K31/66 , A61P7/00
CPC分类号： C07D239/36 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译：本发明涉及抑制HIF脯氨酰羟化酶的式I化合物，其用于促进促红细胞生成素的内源性产生的用途，以及用于治疗与减少红细胞生成素的内源产生如贫血和类似病症相关的病症，以及包含这种化合物和药用载体。

10. 发明申请

WO2015112465A1 ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS 审中-公开
标题翻译：异喹啉衍生物作为MGAT2抑制剂
公开(公告)号：WO2015112465A1
公开(公告)日：2015-07-30
申请号：PCT/US2015/011939
申请日：2015-01-20
申请人： MERCK SHARP & DOHME CORP. , BERGER, Richard , BLIZZARD, Timothy, A. , CAMPBELL, Brian, T. , CHEN, Helen, Y. , DEBENHAM, John, S. , DEWNANI, Sunita, V. , DUBOIS, Byron , GUDE, Candido , GUO, Zhiqiang , HARPER, Bart , HU, Zhiyong , LIN, Songnian , LIU, Ping , WANG, Ming , UJJAINWALLA, Feroze , XU, Jiayi , XU, Libo , ZHANG, Rui
发明人： BERGER, Richard , BLIZZARD, Timothy, A. , CAMPBELL, Brian, T. , CHEN, Helen, Y. , DEBENHAM, John, S. , DEWNANI, Sunita, V. , DUBOIS, Byron , GUDE, Candido , GUO, Zhiqiang , HARPER, Bart , HU, Zhiyong , LIN, Songnian , LIU, Ping , WANG, Ming , UJJAINWALLA, Feroze , XU, Jiayi , XU, Libo , ZHANG, Rui
IPC分类号： C07D471/04
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/14 , C07D471/04
摘要： The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译：式I化合物作为MGAT2抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。

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