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1. 发明申请

WO0233057A2 CYTOCHROME P450 MONOOXYGENASES CONSISTING OF THERMOPHILIC BACTERIA 审中-公开
标题翻译： CYTOCHROM P450 MONOXYGENASES来自嗜热细菌
公开(公告)号：WO0233057A2
公开(公告)日：2002-04-25
申请号：PCT/EP0111958
申请日：2001-10-16
申请人： BASF AG , HAUER BERNHARD , SCHMID ROLF , MERKL RAINER , BLASCO FRANCESCA
发明人： HAUER BERNHARD , SCHMID ROLF , MERKL RAINER , BLASCO FRANCESCA
IPC分类号： C12N15/09 , C12M1/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/53 , C12P1/04 , C12P7/00 , C12R1/01 , C12N9/00
CPC分类号： C12N9/0077 , C12P1/04
摘要： The invention relates to novel cytochrome P450 monooxygenases consisting of thermophilic bacteria, especially the species Thermus sp., nucleotide sequences coding for the same, the recombinant production of said monooxygenases and the use thereof for the microbiological oxidation of organic compounds.
摘要翻译：本发明涉及来自嗜热菌的新的细胞色素P450单加氧酶，尤其是杆菌属栖热菌种，核苷酸序列编码为此，重组生产这些单加氧酶的和它们用于有机化合物的微生物氧化的用途。

2. 发明申请

WO0107574A2 MODIFIED CYTOCHROME P450 MONOOXYGENASES 审中-公开
标题翻译：修饰的CYTOCHROM P450 MONOOXYGENASES
公开(公告)号：WO0107574A2
公开(公告)日：2001-02-01
申请号：PCT/EP0007252
申请日：2000-07-27
申请人： BASF AG , HAUER BERNHARD , PLEISS JUERGEN , SCHWANEBERG ULRICH , SCHMITT JUTTA , FISCHER MARKUS , SCHMID ROLF , LI QING SHAN
发明人： HAUER BERNHARD , PLEISS JUERGEN , SCHWANEBERG ULRICH , SCHMITT JUTTA , FISCHER MARKUS , SCHMID ROLF , LI QING-SHAN
IPC分类号： C12M1/40 , C12N1/21 , C12N9/02 , C12N15/09 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/42 , C12P7/64 , C12P17/10 , C12P17/16 , C12Q1/26 , C12R1/11 , C12R1/19 , C12N9/00
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0077 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/42 , C12P17/10 , C12P17/165 , C12Q1/26 , G01N2333/90245
摘要： The invention relates to modified cytochrome P450 monooxygenases comprising a modified substrate profile, to nucleic acid sequences that code therefor, to expression constructs and vectors, and to recombinant microorganisms which contain these vectors. The invention also relates to methods for microbiologically producing terminally or subterminally hydroxylated aliphatic carboxylic acids.
摘要翻译：本发明涉及具有改变的底物轮廓，编码核酸序列，表达构建体和载体，含有用于微生物生产终端或近hydroylierter脂族羧酸，这些载体和方法重组微生物修饰细胞色素P450单加氧酶。

3. 发明申请

WO03027669A2 METHOD FOR PRODUCING A NORMALIZED GENE LIBRARY FROM NUCLEIC ACID EXTRACTS OF SOIL SAMPLES AND THE USE THEREOF 审中-公开
标题翻译：用于从地下样品的核酸分泌物产生归一化基因库的方法及其用途
公开(公告)号：WO03027669A2
公开(公告)日：2003-04-03
申请号：PCT/EP0210510
申请日：2002-09-19
申请人： BASF AG , HAUER BERNHARD , MATUSCHEK MARKUS , SCHMID ROLF , BUTA CHRISTIANE , KAUFFMANN ISABELLE , LAEMMLE KATRIN , ZIPPER HUBERT
发明人： HAUER BERNHARD , MATUSCHEK MARKUS , SCHMID ROLF , BUTA CHRISTIANE , KAUFFMANN ISABELLE , LAEMMLE KATRIN , ZIPPER HUBERT
IPC分类号： G01N33/50 , B01J20/281 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N30/26 , G01N30/88 , G01N33/24
CPC分类号： G01N33/24
摘要： The invention relates to a method for producing a normalized gene library from nucleic acid extracts of soil samples and to the genetic structures and vectors used therein. The invention further relates to the use of the normalized gene library for screening genes that encode novel biocatalysts from soil samples.
摘要翻译：本发明涉及从土壤样品的核酸提取物生产标准化基因文库的方法，以及其中使用的基因结构和载体。此外，还包括使用标准化基因库筛选编码来自Bodenprogen的新生物催化剂的基因。

4. 发明申请

WO2007113336A3 FUNCTIONAL EXPRESSION OF TRIACYLGLYCEROL LIPASES 审中-公开
标题翻译：三酰甘油脂肪酶功能表达
公开(公告)号：WO2007113336A3
公开(公告)日：2008-05-02
申请号：PCT/EP2007053416
申请日：2007-04-05
申请人： BASF SE , HAUER BERNHARD , HAERING DIETMAR , BRANNEBY CECILIA , RUSNAK MONIKA , LIU DANNI , SCHMID ROLF
发明人： HAUER BERNHARD , HAERING DIETMAR , BRANNEBY CECILIA , RUSNAK MONIKA , LIU DANNI , SCHMID ROLF
IPC分类号： C12N9/20 , C12N5/10 , C12Q1/44 , C12Q1/61
CPC分类号： C12N9/20 , C12Q1/44 , C12Q1/61 , G01N2333/918
摘要： The present invention relates to nucleic acids encoding triacylglycerol lipases, to vectors comprising such nucleic acids, to host cells comprising such nucleic acids or vectors, to methods of expressing triacylglycerol lipases in prokaryotes, to methods of detecting and producing triacylglycerol lipases, to triacylglycerol lipases which can be obtained in this manner, and to the use of triacylglycerol lipase-encoding nucleic acids, vectors and recombinant host cells for the abovementioned methods.
摘要翻译：本发明涉及的核酸编码的三酰基甘油脂肪酶，例如核酸，其包含载体，宿主细胞包含此类核酸或载体，方法为在原核生物中的三酰基甘油脂肪酶，用于检测方法的表达和生产的三酰基甘油脂肪酶的可获得从而甘油三酯脂肪酶，以及使用的编码脂酶的三酰甘油，核酸，载体和重组宿主细胞对于所提到的方法。

5. 发明申请

WO2011123961A8 STIRLING MACHINE 审中-公开
标题翻译：搅拌机
公开(公告)号：WO2011123961A8
公开(公告)日：2012-11-15
申请号：PCT/CH2011000065
申请日：2011-03-29
申请人： BUDLIGER JEAN-PIERRE , SCHMID ROLF
发明人： BUDLIGER JEAN-PIERRE , SCHMID ROLF
IPC分类号： F02G1/043
CPC分类号： F02G1/0435 , F02G1/043 , F02G1/047 , F02G1/0535 , F02G2243/202 , F02G2244/52 , F02G2253/02 , F02G2253/04 , F02G2270/30 , F02G2270/40 , F02G2270/80 , F02G2280/10 , F02G2280/20
摘要： This Stirling machine comprises a transfer piston (6, 6a) and a moving part (14) of a generator or of an electric motor, the transfer piston (6, 6a) periodically displacing a working gas between an expansion chamber (VE) and a compression chamber (Vc) which chambers are respectively associated with two working faces of the transfer piston (6, 6a) of which the cross-sectional area ratio ac/aE is > 0.35 so that its displacement along an axis X oriented towards the expansion volume (VE) generates an in-phase working gas pressure component Px that opposes the displacement of the piston (6, 6a), so that all of the mechanical energy produced is transmitted to the moving part (14). This machine comprises a resonant second piston (10) coupled to the transfer piston (6, 6a) by a quantity of energy that is proportional to the pressure component Px.
摘要翻译：该斯特林机器包括发电机或电动机的转移活塞（6,6a）和运动部分（14），转移活塞（6,6a）周期性地使工作气体在膨胀室（VE）和压缩室（Vc），其分别与传送活塞（6,6a）的两个工作面相关联，其横截面积比ac / aE大于0.35，使得其沿着朝向膨胀体积的轴线X的位移（VE）产生与活塞（6,6a）的位移相对的同相工作气体压力分量Px，使得产生的所有机械能传递到运动部件（14）。该机器包括通过与压力分量Px成比例的一定量的能量耦合到传送活塞（6,6a）的共振第二活塞（10）。

6. 发明申请

WO2009118176A8 NOVEL 12 ALPHA-HYDROXYSTEROID DEHYDROGENASES, PRODUCTION AND USE THEREOF 审中-公开
标题翻译：新的12α-羟基类固醇氢化物，它们的制备和使用
公开(公告)号：WO2009118176A8
公开(公告)日：2010-10-28
申请号：PCT/EP2009002190
申请日：2009-03-25
申请人： PHARMAZELL GMBH , AIGNER ARNO , GROSS RALF , SCHMID ROLF , BRAUN MICHAEL , MAUER STEFFEN
发明人： AIGNER ARNO , GROSS RALF , SCHMID ROLF , BRAUN MICHAEL , MAUER STEFFEN
IPC分类号： C12N9/04
CPC分类号： C12P33/02 , C12N9/0006 , C12Y101/01176
摘要： The invention relates to 12 a-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 a-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 a-hydroxysteroids using said enzyme, a method for enzymatic reduction of 12-ketosteroids using said enzyme, a method for qualitative or quantitative determination of 12-ketosteroids and/or12a-hydroxysteroids using said 12a-hydroxysteroid dehydrogenases and a method for production of ursodesoxycholic acid, comprising the enzyme-catalysed cholic acid oxidation using said 12 a-hydroxysteroid dehydrogenases.
摘要翻译：本发明涉及新颖的12a-羟基类固醇脱氢酶，核酸序列，表达盒和编码它的载体; 含有相应编码核酸序列的重组微生物; 制备这种12a-羟基类固醇脱氢酶的方法; 使用这些酶对12a-羟基类固醇进行酶促氧化的方法，使用这些酶对12-酮类固醇进行酶促还原的方法; 使用根据本发明的12a-羟基类固醇脱氢酶定性或定量测定12-酮类固醇或12a-羟基类固醇的方法; 以及使用本发明的12a-羟基类固醇脱氢酶生成包含酶催化的胆酸氧化的熊去氧胆酸的方法。

7. 发明申请

WO0151457A3 METHOD FOR PRODUCING ARYL-IMINOMETHYL-CARBAMIC ACID ESTERS 审中-公开
标题翻译：用于生产芳基 - 亚氨基甲基氨基
公开(公告)号：WO0151457A3
公开(公告)日：2002-01-17
申请号：PCT/EP0100262
申请日：2001-01-11
申请人： BOEHRINGER INGELHEIM PHARMA , BRANDENBURG JOERG , SOYKA RAINER , SCHMID ROLF , ANDERSKEWITZ RALF , BAUER ROLF , HAMM RAINER , KROEBER JUTTA
发明人： BRANDENBURG JOERG , SOYKA RAINER , SCHMID ROLF , ANDERSKEWITZ RALF , BAUER ROLF , HAMM RAINER , KROEBER JUTTA
IPC分类号： C07C269/00 , C07C271/00 , C07C271/20 , C07C271/64 , C07C255/54 , C07C271/12
CPC分类号： C07C271/00 , C07C269/00 , C07C271/20 , C07C271/64
摘要： The invention relates to a method for producing compounds of formula (I) wherein the radicals R and R have the meanings given in the description and in the claims, which can be used on a large scale.
摘要翻译：本发明涉及用于式（I）的化合物的制备方法在工业上适用的方法，其中的基团R <1>和R <2>可以具有在说明书和权利要求中所提及的含义。

8. 发明申请

WO2011157512A2 POWER SUPPLY UNIT FOR SIGNAL LUMINAIRES 审中-公开
标题翻译：电源用于信号灯泡
公开(公告)号：WO2011157512A2
公开(公告)日：2011-12-22
申请号：PCT/EP2011058312
申请日：2011-05-21
申请人： SIEMENS SCHWEIZ AG , SCHMID ROLF , DIETHELM BERNHARD
发明人： SCHMID ROLF , DIETHELM BERNHARD
IPC分类号： H02J9/06 , B61L29/24 , H05B33/08
CPC分类号： H02J9/06 , B61L5/1881 , B61L2207/02 , H02J9/065 , H05B33/0815 , Y02B20/346 , Y02B20/347
摘要： For signal luminaires (LED1, LEDn), which indicate the term STOP or DANGER upon activation, a circuit comprising a first operating case feed unit (20) and a second auxiliary source (24) is proposed for the purpose of reliable power supply. In this case, the second auxiliary source (24) is inductively (T1) coupled to the signal luminaire electric circuit (27); while the signal luminaires (LED1, LEDn) are capacitively coupled to ground (groundaux). The use of switches during operation in the fall-back level is obviated in this way.
摘要翻译：对于信号灯（LED1，LEDN）指示字STOP或危险当被激活时，向电源固定到具有第一操作情况下食品单元（20）和第二辅助源（24）的电路，提出了第二辅助源（24）是电感性的（T1）耦合到所述信号灯电路（27）; 而信号灯（LED1，LEDN）电容性地耦合到的质量（Groundaux）耦合。通过这种方式，在回退操作使用交换机消除。

9. 发明申请

WO2007090844A8 TRIHYDROCHLORIDE FORMS OF A DIHYDROPTERIDINONE DERIVATIVE AND PROCESSES FOR PREPARATION 审中-公开
标题翻译：二氢蝶啶酮衍生物的三氢氯酸盐形式和制备方法
公开(公告)号：WO2007090844A8
公开(公告)日：2007-10-11
申请号：PCT/EP2007051139
申请日：2007-02-07
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , GRAUERT MATTHIAS , LINZ GUENTER , SCHMID ROLF , SIEGER PETER
发明人： GRAUERT MATTHIAS , LINZ GUENTER , SCHMID ROLF , SIEGER PETER
IPC分类号： C07D475/00 , A61K31/19
CPC分类号： C07D475/00
摘要： The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1- piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6- oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
摘要翻译：本发明涉及二氢奎尼酸衍生物的特定盐，即化合物N- [反式-4- [4-（环丙基甲基）-1-哌嗪基]环己基] -4 - [[（7R）-7 - 乙基-5,6,7,8-四氢-5-甲基-8-（1-甲基乙基）-6-氧代-2-蝶啶基]氨基] -3-甲氧基 - 苯甲酰胺，以其结晶形式与水的水合物，其制造方法，以及其在药物组合物中的用途。

10. 发明申请

WO2006018222A8 HYDRATES AND POLYMORPHS OF 4-[[(7R)-8-CYCLOPENTYL-7-ETHYL-5,6,7,8-TETRAHYDRO-5-METHYL-4-6-OXO-2-PIPERIDINYL]AMINO]-3-METHOXY-N-(1-METHYL-4-PIPERIDINYL) BENZAMIDE, METHODS FOR THE PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS 审中-公开
标题翻译：水合物和4的多晶型物 - [[（7R）-8-环戊基-7-乙基-5,6,7,8-四氢-5-甲基4-6-氧代-2-哌啶基]氨基] -3-甲氧基 -N-（1-甲基-4-哌啶基） - 苯甲酰胺，其制备方法及其作为药物的用途
公开(公告)号：WO2006018222A8
公开(公告)日：2006-06-15
申请号：PCT/EP2005008736
申请日：2005-08-11
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , LINZ GUENTER , SIEGER PETER , KRAEMER GERD F , RALL WERNER , HERTER ROLF , HOFFMANN MATTHIAS , SCHMID ROLF
发明人： LINZ GUENTER , SIEGER PETER , KRAEMER GERD F , RALL WERNER , HERTER ROLF , HOFFMANN MATTHIAS , SCHMID ROLF
IPC分类号： C07D475/00 , A61K31/519 , A61P35/00 , C07D211/58
CPC分类号： C07D211/58 , C07D475/00
摘要： The invention relates to novel hydrates and novel polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl) benzamide, methods for the production thereof, and the use thereof as medicaments.
摘要翻译：本发明涉及新的水合物和新的多晶型4 - [[（7R）-8-环戊基-7-乙基-5,6,7,8-四氢-5-甲基-6-氧代-2-蝶啶基]氨基] 3-甲氧基-N-（1-甲基-4-哌啶基）苯甲酰胺，它们的制备方法和它们作为药物的用途。

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