专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009100057A1 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY 审中-公开
标题翻译：具有PROSTAGLANDIN活性的取代环孢菌素
公开(公告)号：WO2009100057A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/032943
申请日：2009-02-03
申请人： ALLERGAN, INC. , BURK, Robert, M.
发明人： BURK, Robert, M.
IPC分类号： C07C405/00 , A61K31/192 , A61K31/047 , A61P27/06 , A61P27/02
CPC分类号： C07C405/00 , C07C405/0008
摘要： 11,15, 19-trihydroxy-9-halo-prostaglandin analogues and its use as ocular hypotensive agents. Ocular hypotensive agents are useful in the treatment of a number of various ocular hypertensive conditions, such as post-surgical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts.
摘要翻译： 11,15,19-三羟基-9-卤代 - 前列腺素类似物及其用作眼压降血压药。眼部降血压药物可用于治疗许多各种眼部高血压病症，如手术后和激光后小梁切除术眼高压发作，青光眼，以及作为手术前辅助治疗。

2. 发明申请

WO2009091764A3 BETA-LACTAMS FOR THE TREATMENT OF GLAUCOMA, OCULAR HYPERTENSION, BALDNESS AND HAIR LOSS 审中-公开
公开(公告)号：WO2009091764A3
公开(公告)日：2009-07-23
申请号：PCT/US2009/030894
申请日：2009-01-14
申请人： ALLERGAN, INC. , DINH, Danny, T. , OLD, David, W. , BURK, Robert, M.
发明人： DINH, Danny, T. , OLD, David, W. , BURK, Robert, M.
IPC分类号： C07D409/06 , C07D205/08 , A61K31/397 , A61P27/06 , A61P27/02 , A61P17/14
摘要： Compounds comprising Formula (I) or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, R, D, and n are as described. Disclosed herein are compounds useful in treating glaucoma, inflammatory bowel disease, the stimulation of hair growth, and the stimulation of the conversation of vellus hair to terminal hair.

3. 发明申请

WO2009061811A8 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDING ACTIVITY 审中-公开
公开(公告)号：WO2009061811A8
公开(公告)日：2009-05-14
申请号：PCT/US2008/082469
申请日：2008-11-05
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
IPC分类号： C07D263/34 , C07D333/40 , A61K31/381 , A61P27/06
摘要： Disclosed herein are compounds having a formula: (I) Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

4. 发明申请

WO2007001671A1 USE OF 3- OR 7-THIA- OR 3 , 7-DITΗIAPR0STEN0IC ACID DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：用于治疗炎症性皮肤病的3-或7-三唑或3,7-二硫代吗啉酸衍生物的用途
公开(公告)号：WO2007001671A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/019137
申请日：2006-05-17
申请人： ALLERGAN, INC. , BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F. , KEDZIE, Karen, M. , GIL, Daniel, W.
发明人： BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F. , KEDZIE, Karen, M. , GIL, Daniel, W.
IPC分类号： A61K31/5575 , A61K31/559 , A61P1/04 , A61P1/06
CPC分类号： A61K31/557 , A61K31/5575 , A61K31/559 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： Disclosed herein is the use of a compound represented by the general formula (I) for the treatment of a mammal suffering from an inflammatory bowel disease; wherein A, B, D, X, Y, Z, R 1 , R 3 , and R 4 are as defined in the specification.
摘要翻译：本文公开了由通式（I）表示的化合物用于治疗患有炎症性肠病的哺乳动物的用途; 其中A，B，D，X，Y，Z，R 1，R 3和R 4如说明书中所定义。

5. 发明申请

WO2006121822A1 USE OF β-LACTAMS FOR THE TREATMENTOF IBD AND GLAUCOMA 审中-公开
标题翻译：用于治疗IBD和GLAUCOMA的β-LACTAMS的使用
公开(公告)号：WO2006121822A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/017336
申请日：2006-05-02
申请人： ALLERGAN, INC. , OLD, David, W. , DINH, Danny, T. , BURK, Robert, M.
发明人： OLD, David, W. , DINH, Danny, T. , BURK, Robert, M.
IPC分类号： A61K31/397 , C07D205/08 , A61P27/08 , A61P1/00
CPC分类号： C07D205/08 , A61K31/397
摘要： The use of compounds of the general formula (I) or a pharmaceutically acceptable salt or a prodrug thereof for the treatment of IBD and glaucoma is disclosed, wherein Y, A, R, D, and n are as described. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：公开了将通式（I）的化合物或其药学上可接受的盐或前体药物用于治疗IBD和青光眼，其中Y，A，R，D和n如上所述。还公开了与之相关的方法，组合物和药物。

6. 发明申请

WO2006058063A1 2,3,4-SUBSTITUTED-CYCLOPENTANONES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗药物的2,3,4-取代的环戊二烯
公开(公告)号：WO2006058063A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/042428
申请日：2005-11-21
申请人： ALLERGAN, INC. , DONDE, Yariv , HOLOBISKI, Mark , POSNER, Mari, F. , BURK, Robert, M. , GARST, Michael, E.
发明人： DONDE, Yariv , HOLOBISKI, Mark , POSNER, Mari, F. , BURK, Robert, M. , GARST, Michael, E.
IPC分类号： C07C405/00 , C07D333/16 , C07D333/62 , A61K31/5575 , A61P27/06
CPC分类号： C07D333/62 , C07C323/52 , C07C405/0033 , C07C2601/08 , C07D333/56
摘要： Disclosed herein are compounds comprising Formula (I), or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, B, J, and E are further described. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：本文公开了包含式（I）的化合物或其药学上可接受的盐或前药; 其中进一步描述Y，A，B，J和E。还公开了与之相关的方法，组合物和药物。

7. 发明申请

WO2006014206A1 PROSTAGLANDIN ANALOGS 审中-公开
标题翻译： PROSTAGLANDIN模拟
公开(公告)号：WO2006014206A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/019408
申请日：2005-05-31
申请人： ALLERGAN, INC. , OLD, David, W. , DINH, Danny, T. , BURK, Robert, M.
发明人： OLD, David, W. , DINH, Danny, T. , BURK, Robert, M.
IPC分类号： C07D223/10
CPC分类号： C07D401/06 , C07D223/10
摘要： Compounds comprising formula (I) or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, and E are as described herein. These compounds are useful for treating diseases.
摘要翻译：包含式（I）化合物或其药学上可接受的盐或前药的化合物在本文中公开。 A，X，J和E如本文所述。这些化合物可用于治疗疾病。

8. 发明申请

WO2003037433A1 CO-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2 ANALOGS AS EP2-RECEPTOR AGONISTS 审中-公开
标题翻译： CO-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2模拟物作为EP2受体激动剂
公开(公告)号：WO2003037433A1
公开(公告)日：2003-05-08
申请号：PCT/US2001/028609
申请日：2001-10-26
申请人： ALLERGAN, INC.
发明人： BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F.
IPC分类号： A61P27/06
CPC分类号： C07D333/24 , A61K31/559
摘要： The invention relates to the use of derivatives of E-type prostaglandins as EP 2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: wherein the hatched segment represents an α bonds, the solid triangle represents a β bond, the wavy segments represent a α or β bond, dashed lines represent a double bond or a single bond, R 3 is heteroaryl or a substituted heteroaryl radical, R 1 and R 2 are independently selected from the group consisting of hydrogen or a lower alkyl radical having up to six carbon atoms, or a lower acyl radical having up to six carbon atoms, R is selected from the group consisting of CO 2 R 4 , CONR 4 2?, CH 2 OR 4 , CONR 4 SO 2 R 4 , P(O)(OR 4 ) and wherein R 4 is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is O or an integer of from 1 to 4.
摘要翻译：本发明涉及E型前列腺素衍生物作为EP2激动剂的用途，一般而言，特别是作为眼睛低血压剂。根据本发明使用的PGE衍生物由下式I表示：其中阴影线段表示α键，实心三角形表示β键，波浪段表示α或β键，虚线表示双键或单键，R 3是杂芳基或取代的杂芳基，R 1和R 2独立地选自氢或具有至多6个碳原子的低级烷基或低级具有至多6个碳原子的酰基，R选自CO 2 R 4，CONR 4，CH 2，或OR 4，CONR 4 SO 2 R 4，P（O ）（OR 4），并且其中R 4选自H，苯基和具有1至6个碳原子且n为0或1至4的整数的低级烷基。

9. 发明申请

WO1996036599A1 CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLAKENYL DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF OCULAR HYPERTENSION 审中-公开
标题翻译：环丙沙星（ENE）OIC酸，作为用于治疗OCAL高血压的治疗药物的2-异噻唑烷基衍生物
公开(公告)号：WO1996036599A1
公开(公告)日：1996-11-21
申请号：PCT/US1996006849
申请日：1996-05-14
申请人： ALLERGAN
发明人： ALLERGAN , BURK, Robert, M.
IPC分类号： C07C405/00
CPC分类号： C07D307/79 , A61K31/557 , A61K31/559 , C07D277/30 , C07D307/54 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/60
摘要： The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by formula (I), wherein wavy line attachments indicate either the alpha alpha or beta beta configuration; hatched segments indicate alpha configuration; solid triangles are used to indicate beta configuration, dashed bonds represent a double bond, or a single bond, R is a substituted heteroaryl radical, R is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of -OR and -N(R )2, Y is = O or represents 2 hydrogen radicals. Certain of the compounds represented by formula (I) comprise another aspect of the present invention.
摘要翻译：本发明涉及使用F型前列腺素衍生物作为眼部低血压。根据本发明使用的PGF衍生物由式（I）表示，其中波浪线附着物指示αα或ββ构型; 阴影线段表示alpha配置; 固体三角形用于表示β构型，虚线键表示双键或单键，R是取代的杂芳基，R 1是氢或具有至多6个碳原子的低级烷基，X选自由-OR 1和-N（R 1）2组成的组，Y为= O或表示2个氢原子。某些由式（I）表示的化合物包括本发明的另一方面。

10. 发明申请

WO2011071620A1 STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF 审中-公开
标题翻译： PROSTGLANDIN AGONIST PRODRUGS的稳定的水性组合物及其使用方法
公开(公告)号：WO2011071620A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/055590
申请日：2010-11-05
申请人： ALLERGAN, INC. , BURK, Robert, M. , IM, Wha Bin
发明人： BURK, Robert, M. , IM, Wha Bin
IPC分类号： A61K9/08 , A61K31/4025 , A61K31/4436 , A61K47/12 , A61P27/06
CPC分类号： A61K47/12 , A61K9/0048 , A61K31/4025 , A61K31/4436 , A61K31/559 , A61K47/02 , A61K47/10 , A61K47/26
摘要： The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders.
摘要翻译：本发明基于以下发现：前列腺素类激动剂前药组合物的水稳定性（因此保质期）显着增加通过将组合物掺入某些明确定义的羧酸中，然后将组合物的pH从约 4.0至约8.0。因此，本发明的组合物和方法提供了市售的局部药物治疗各种眼部疾病所需的水稳定性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式