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1. 发明申请

WO1998011012A2 CONTAINER CLOSURE FOR FLEXIBLE CONTAINERS 审中-公开
标题翻译：集装箱闭式容器
公开(公告)号：WO1998011012A2
公开(公告)日：1998-03-19
申请号：PCT/US1997016035
申请日：1997-09-10
申请人： ALLERGAN
发明人： ALLERGAN , DEMEL, Robert, J.
IPC分类号： B67B00/00
CPC分类号： B65D83/0055 , A61F9/0008 , A61J1/1406 , A61J1/1425 , A61J1/1475 , B65D41/185
摘要： Container closure apparatus including a rigid container having an open end with a top edge along a collapsible container disposed within the rigid container and having an open end. A cap means for covering the rigid and flexible container open ends and a plug seal providing a primary seal between the rigid container and the flexible container. The plug seal includes, in combination, a peripheral outwardly extending wall portion on the flexible container and a depending portion, extending from the cap means, for pressing the wall portion against an inside wall of the rigid container. A gasket seal provides a secondary seal between the rigid container and the flexible container. The gasket seal includes, in combination, a lip outwardly extending from the flexible container open end and a groove, disposed in the cap means, for pressing the lip against the rigid container top edge. The cap is secured to the rigid container in a position enabling the depending portion means to press the extending wall against the rigid container inside wall and enabling the groove means to press lip against the rigid container top edge.
摘要翻译：容器封闭装置包括刚性容器，该刚性容器具有敞开的端部，沿着可容纳容器的顶部边缘设置，所述容器设置在刚性容器内并具有开口端。用于覆盖刚性和柔性容器开口端的盖装置和在刚性容器和柔性容器之间提供初级密封的塞子密封件。塞子密封件组合地包括柔性容器上的外围向外延伸的壁部分和从盖装置延伸的悬垂部分，用于将壁部分压靠在刚性容器的内壁上。垫圈密封件在刚性容器和柔性容器之间提供二次密封。垫圈密封件组合地包括从柔性容器开口端向外延伸的唇缘和设置在盖装置中的用于将唇部压靠在刚性容器顶部边缘上的凹槽。盖子固定在刚性容器上，使得悬垂部分装置能够将延伸壁压靠在刚性容器内壁上，并且能够使凹槽装置将唇部压靠在刚性容器顶部边缘上。

2. 发明申请

WO1997048672A2 SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY 审中-公开
标题翻译：具有反义和/或反义拮抗剂类生物活性的取代的四氢萘甲酸和二氢萘酮衍生物
公开(公告)号：WO1997048672A2
公开(公告)日：1997-12-24
申请号：PCT/US1997010725
申请日：1997-06-19
申请人： ALLERGAN
发明人： ALLERGAN , VULIGONDA, Vidyasagar , TENG, Min , BEARD, Richard, L. , JOHNSON, Alan, T. , LIN, Yuan , CHANDRARATNA, Roshantha, A. , SONG, Tae, K. , WONG, Harold, N. , DUONG, Tien, T. , GILLETT, Samuel, J.
IPC分类号： C07C69/587
CPC分类号： C07C251/44 , C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
摘要： Compounds of formulas (1-6) where the symbols have the meaning described in the specification, have retinoid and/or retinoid antagonist-like biological acitivity.
摘要翻译：符号具有本说明书中描述的含义的式（1-6）化合物具有类视黄醇和/或维生素A拮抗剂样生物活性。

3. 发明申请

WO1997037666A1 USE OF PHOSPHINYLOXYALKYL AND PHOSPHONAMIDOALKYL DERIVATIVES OF CYCLOPENTANE(ENE) AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗剂的环戊烷（ENE）的磷酰氧基甲基和磷酰胺基衍生物的使用
公开(公告)号：WO1997037666A1
公开(公告)日：1997-10-16
申请号：PCT/US1997005738
申请日：1997-04-07
申请人： ALLERGAN
发明人： ALLERGAN , BURK, Robert, M.
IPC分类号： A61K31/66
CPC分类号： A61K31/662 , A61K31/664 , C07F9/4081 , C07F9/4473
摘要： The present invention relates to cyclopentane (or cyclopentene) heptanoic or cyclopentane (or cyclopentene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl, 1-esters, and derivatives thereof, useful as therapeutic agents. In particular, the therapeutic agents of this invention are useful as ocular hypotensives.
摘要翻译：本发明涉及可用作治疗剂的环戊烷（或环戊烯）庚酸或环戊烷（或环戊烯）庚烯酸，2-烃基氧膦基烷基或膦酰胺基烷基，1-酯及其衍生物。特别地，本发明的治疗剂可用作眼睛低血压剂。

4. 发明申请

WO1997031895A2 CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：环丙沙星（ENE）OIC酸，作为治疗剂的2-异亮氨酸衍生物
公开(公告)号：WO1997031895A2
公开(公告)日：1997-09-04
申请号：PCT/US1997002313
申请日：1997-02-20
申请人： ALLERGAN
发明人： ALLERGAN , BURK, Robert, M.
IPC分类号： C07C405/50
CPC分类号： A61K31/559 , A61K31/5585
摘要： The present invention provides to cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amino groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl derivatives. In particular, these derivatives are 7-[5-hydroxy-2-(heteroatom-substituted hydroxyhydrocarbyl)-3-hydroxycyclopentyl] heptanoic or heptenoic acids and amine, amide, ether, ester and alcohol derivatives of said acids wherein one or more of said hydroxy groups are replaced with an ether group. These compounds are potent ocular hypotensive and are particularly suited for the management of glaucoma. Moreover, the compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; with additional application in gastrointestinal disease, reproduction, fertility, incontinence, shock, inflammation, immune regulation, disorder of bone metabolism, renal dysfunction, cancer and other hypoproliferative diseases.
摘要翻译：本发明提供环戊烷庚酸，2位可以被羟基，烷氧基，氨基和氨基取代的杂芳基烷基或链烯基衍生物。 1-OH环戊烷庚酸，2个杂芳基烯基衍生物。特别地，这些衍生物是所述酸的7- [5-羟基-2-（杂原子取代的羟基烃基）-3-羟基环戊基]庚酸或庚烯酸和胺，酰胺，醚，酯和醇衍生物，其中一个或多个所述羟基被醚基取代。这些化合物是有效的眼低血压并且特别适用于治疗青光眼。此外，本发明的化合物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 在胃肠道疾病，繁殖，生育能力，失禁，休克，炎症，免疫调节，骨代谢紊乱，肾功能障碍，癌症和其他低增殖性疾病中具有额外应用。

5. 发明申请

WO1997005890A1 METHOD OF INCREASING TEAR PRODUCTION BY TOPICAL ADMINISTRATION OF MURAMYL PEPTIDE 审中-公开
标题翻译：通过局部施用木糖肽增加生产力的方法
公开(公告)号：WO1997005890A1
公开(公告)日：1997-02-20
申请号：PCT/US1996012928
申请日：1996-08-06
申请人： ALLERGAN , VOET, Martin, A.
发明人： ALLERGAN
IPC分类号： A61K38/14
CPC分类号： A61K38/14
摘要： The present invention provides a method of treating an aqueous-deficient dry eye state in a patient suffering therefrom, which method includes the step of administering a muramyl peptide, e.g. N-acetyl-D-glucosaminyl-( beta 1-4)-acetyl muramyl-L-alanyl-D-isoglutamine (GMDP).
摘要翻译：本发明提供了治疗患有其的患者的缺水型干眼症状的方法，该方法包括以下步骤：施用胞壁酰基肽，例如， N-乙酰基-D-葡糖胺基 - （β-1-4） - 乙酰基胞壁酰-L-丙氨酰-D-异谷氨酰胺（GMDP）。

6. 发明申请

WO1996035424A1 ARYL-IMIDAZOLINES AND ARYL-IMIDAZOLES USEFUL AS ALPHA-2 ADRENERGIC AGONISTS WITHOUT CARDIOVASCULAR SIDE EFFECTS 审中-公开
标题翻译： ARYL-IMIDAZOLINES和ARYL-IMIDAZOLES有用的ALPHA-2 ADRENERGIC AGONISTS无心脏副作用
公开(公告)号：WO1996035424A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006633
申请日：1996-05-09
申请人： ALLERGAN
发明人： ALLERGAN , MUNK, Stephen, A. , BURKE, James, A. , LAI, Ronald, K.
IPC分类号： A61K31/495
CPC分类号： A61K31/498 , A61K31/538
摘要： Methods are disclosed for treating a mammal with a condition that responds to alpha -2 agonist treatment without causing cardiovascular side effects using compounds of formula (II) wherein R1 is H, alkyl of 1 to 4 carbon atoms or a halogen atom, X is O or NH and A is H or an oxo group and wherein said compound does not cause a concomitant reduction in blood pressure of said mammal.
摘要翻译：公开了治疗哺乳动物的方法，所述哺乳动物具有响应α-2激动剂治疗而不引起心血管副作用的病症，其中R 1为H，1至4个碳原子的烷基或卤原子，X为O 或NH和A是H或氧代基，并且其中所述化合物不会引起所述哺乳动物血压的伴随降低。

7. 发明申请

WO1997045405A1 CYCLOPENTAN(EN)OIC ACID, 2-ALKENYL DERIVATIVES AS THERAPEUTIC AGENTS IN THE TREATMENT OF OCULAR HYPERTENSION 审中-公开
标题翻译： CYCLOPENTAN（EN）OIC ACID，2-烷基衍生物作为治疗药物治疗OCAL高血压
公开(公告)号：WO1997045405A1
公开(公告)日：1997-12-04
申请号：PCT/US1997008123
申请日：1997-05-14
申请人： ALLERGAN , GARST, Michael, E. , ROOF, Michael, B. , CHAN, Ming, F. , WOODWARD, David, F. , BURK, Robert, M. , GAC, Todd, S. , ANDREWS, Steven, W.
发明人： ALLERGAN
IPC分类号： C07C405/00
CPC分类号： A61K31/5575 , C07C405/00 , Y10S514/913
摘要： The invention relates to the use of omega chain modified prostaglandins as ocular hypotensive. The derivatives used in accordance with the invention are encompassed by structure formula (I): wherein the hatched segments represent alpha bonds; the wavy segments represent an alpha or beta bond; dashed lines represent a double bond or a single bond; X is selected from the group consisting of -OR and N(R2); Y is = O or represents 2 hydrogen radicals, provided that Y represents 2 hydrogen radicals when X is OH; R is hydrogen or a lower radical having up to six carbon atoms; R is = O or hydroxy; m is = 0, 2, 4 or 6, provided that m is not 4 when the wavy segment represents a beta bond; n is 0, 2, 4 or 6, x and y are 0 or 1, provided that x is 1 when y is 0 and y is 1 when x is 0; or 9, 11 and/or 15 ester derivatives of said compounds of formula (I), e.g. a C1 and C6 alkyl ester derivative; or a pharmaceutical acceptable salt thereof.
摘要翻译：本发明涉及使用ω-链修饰的前列腺素作为眼压降低。根据本发明使用的衍生物包括在结构式（I）中：其中阴影线段表示α键; 波浪段代表α或β键; 虚线表示双键或单键; X选自-OR和N（R2）; Y为= O或表示2个氢原子，条件是当X为OH时，Y表示2个氢原子; R是氢或具有至多6个碳原子的低级基团; R为= O或羟基; m = 0,2,4或6，条件是当波浪段代表β键时m不为4; n为0,2,4或6，x和y为0或1，条件是当y为0时x为1，x为0时x为1; 或所述式（I）化合物的9,11和/或15酯衍生物，例如。 C1和C6烷基酯衍生物; 或其药学上可接受的盐。

8. 发明申请

WO1997045078A1 ULTRASONIC HANDPIECE WITH MULTIPLE PIEZOELECTRIC ELEMENTS AND HEAT DISSIPATOR 审中-公开
标题翻译：具有多个压电元件和散热器的超声波
公开(公告)号：WO1997045078A1
公开(公告)日：1997-12-04
申请号：PCT/US1997008434
申请日：1997-05-14
申请人： ALLERGAN
发明人： ALLERGAN , MEHTA, Pravin, V. , BROMFIELD, George
IPC分类号： A61F09/007
CPC分类号： B06B1/0618 , A61B2018/00035 , A61F9/00745
摘要： Handpiece apparatus (10) is provided for disruption and removal of tissue, tumours, bone, cartilage, calculi or the like which includes an arrangement of piezoelectric crystals (28, 30, 32) and a heat sink (36) in order to control crystal temperature despite interruption of cooling irrigation flow through the handpiece.
摘要翻译：提供手机装置（10），用于破坏和去除组织，肿瘤，骨，软骨，结石等，其包括压电晶体（28,30,32）和散热器（36）的布置，以便控制晶体尽管中断冷却冲洗流经机头的温度。

9. 发明申请

WO1997029788A1 COMPOSITIONS AND METHODS FOR ENZYME DEACTIVATION 审中-公开
标题翻译：用于酶灭活的组合物和方法
公开(公告)号：WO1997029788A1
公开(公告)日：1997-08-21
申请号：PCT/US1997001533
申请日：1997-02-05
申请人： ALLERGAN
发明人： ALLERGAN , HUNT, Terrence, J.
IPC分类号： A61L02/18
CPC分类号： G02C13/008 , A61L12/126 , C11D3/0078 , C11D3/38663
摘要： Enzyme compositions and methods employing enzyme compositions are disclosed which are useful for cleaning contact lenses. In one embodiment, a composition in accordance with the present invention comprises an enzyme component effective when released in a liquid medium to remove debris from a contact lens located in the liquid medium; and an autolysing agent effective when released in the liquid medium to effect autolysis of the enzyme component located in the liquid medium. This composition is preferably structured so that the enzyme component is released in the liquid medium before the autolysing agent is so released. The period of time between the release of the enzyme component and the autolysing agent is sufficient to allow the enzyme component to effectively remove debris from a contact lens which is introduced into the liquid medium before or at the same time the enzyme component is released in the liquid medium.
摘要翻译：公开了使用酶组合物的酶组合物和方法，其可用于清洁隐形眼镜。在一个实施方案中，根据本发明的组合物包含在液体介质中释放时有效的酶组分，以从位于液体介质中的隐形眼镜去除碎屑; 以及在液体介质中释放时有效的自溶剂，以实现位于液体介质中的酶组分的自溶。该组合物优选构造成使得在自发溶剂如此释放之前酶组分在液体介质中释放。酶组分和自动溶解剂的释放之间的时间段足以使酶组分有效地从隐形眼镜去除碎屑，该隐形眼镜在酶成分释放之前或同时被释放到液体介质中液体介质。

10. 发明申请

WO1997026842A1 PRIMARY AND SUPPLEMENTAL INTRAOCULAR LENS SYSTEM 审中-公开
标题翻译：主要和补充性眼内镜系统
公开(公告)号：WO1997026842A1
公开(公告)日：1997-07-31
申请号：PCT/US1997000923
申请日：1997-01-22
申请人： ALLERGAN
发明人： ALLERGAN , PORTNEY, Valdemar
IPC分类号： A61F02/16
CPC分类号： A61F2/1648 , A61F2220/0025 , A61F2250/0036
摘要： Supplemental intraocular lenses may be attached to conventional primary intraocular lenses using annular wrap-around clamps or adhesive. New primary intraocular lens configurations have pockets for accommodating relatively small, supplemental intraocular lenses therein.
摘要翻译：补充的眼内透镜可以使用环形环绕夹具或粘合剂附接到常规的初级眼内透镜。新的初级眼内透镜结构具有用于在其中容纳相对较小的补充眼内透镜的口袋。

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