专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009061811A8 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDING ACTIVITY 审中-公开
公开(公告)号：WO2009061811A8
公开(公告)日：2009-05-14
申请号：PCT/US2008/082469
申请日：2008-11-05
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
IPC分类号： C07D263/34 , C07D333/40 , A61K31/381 , A61P27/06
摘要： Disclosed herein are compounds having a formula: (I) Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

2. 发明申请

WO2007115020A3 THERAPEUTIC PROSTAGLANDIN COMPOUNDS FOR THE TREATMENT OF GLAUCOMA 审中-公开
公开(公告)号：WO2007115020A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/065010
申请日：2007-03-27
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H. , HOLOBOSKI, Mark , POSNER, Mari, F. , BURK, Robert, M.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H. , HOLOBOSKI, Mark , POSNER, Mari, F. , BURK, Robert, M.
IPC分类号： C07C59/56 , C07C59/86 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/40 , A61K31/5575 , A61P27/06
摘要： Compounds having a structure are disclosed herein (Formula I). Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.

3. 发明申请

WO2006055481A1 2,3,4-SUBSTITUTED CYCLOPENTANONES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗药物的2,3,4-替代环孢素
公开(公告)号：WO2006055481A1
公开(公告)日：2006-05-26
申请号：PCT/US2005/041171
申请日：2005-11-14
申请人： ALLERGAN , INC. , DONDE, Yariv , BURK, Robert, M. , GARST, Michael, E. , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , BURK, Robert, M. , GARST, Michael, E. , NGUYEN, Jeremiah, H.
IPC分类号： C07C405/00 , C07D333/60 , C07D333/62 , A61P27/06 , A61K31/5575
CPC分类号： C07D333/62 , C07C405/0025 , C07D333/56
摘要： Disclosed herein are compounds comprising Formula (I) or a pharmaceutically acceptable salt or a prodrug thereof, wherein a dashed line represents the presence or absence of a bond; Y is a carboxylic acid, sulfonic acid, or phosphonic acid functional group; or an amide or ester thereof comprising from 0 to 12 carbon atoms; or Y is hydroxymethyl or an ether thereof comprising from 0 to 12 carbon atoms; or Y is a tetrazolyl functional group; A is -(CH 2 ) 6 -, cis -CH 2 -CH=CH-(CH 2 ) 3 -, or -CH2-C =- C-(CH 2 ) 3 - wherein 1 or 2 carbons may be substituted with S or O; B is hydrogen, C 1-6 hydrocarbyl, CN, CO2H , or -(CH 2 ) m X(CH 2 ) p H, wherein m is at least 1 and the sum of m and p is from 1 to 5; X is S or O; J is H, CH 3 , or CF 3 D is a covalent bond, CH 2 . O, or S; and E is an aromatic heterobicyclic ring system which may have substituents comprising up to 6 non-hydrogen atoms each. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：本文公开了包含式（I）或其药学上可接受的盐或其前药的化合物，其中虚线表示键的存在或不存在; Y是羧酸，磺酸或膦酸官能团; 或其包含0至12个碳原子的酰胺或酯; 或Y是含有0至12个碳原子的羟甲基或其醚; 或Y为四唑基官能团; A是 - （CH 2 CH 2）6 - ，顺式-CH 2 -CH = CH-（CH 2 CH 2））3 - 或-CH 2 -C = -C（CH 2）3 - ，其中1或2个碳可被S 或O; B是氢，C 1-6烃基，CN，CO 2 H，或 - （CH 2 CH 2）m X （CH 2）n H，其中m为至少1，m和p之和为1至5; X为S或O; J是H，CH 3，或CF 3 D是共价键，CH 2。 O或S; 并且E是芳族杂双环系统，其可以具有各自含有多达6个非氢原子的取代基。还公开了与其相关的方法，组合物和药物。

4. 发明申请

WO2004071428A3 10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE 审中-公开
公开(公告)号：WO2004071428A3
公开(公告)日：2004-08-26
申请号：PCT/US2004/003433
申请日：2004-02-06
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： A61K31/557
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I); wherein the dashed line indicates the presence or absence of a bond, the hatched wedge indicates the α (down) configuration, and the solid triangle indicates the β (up) configuration; B is a single, double, or triple covalent bond; n is 0-6; X is CH 2 , S or O; Y is any pharmaceutically acceptable salt of C0 2 H, or C0 2 R, CONR 2 , CONHCH 2 CH 2 0H, CON(CH 2 CH 2 OH) 2 ,CH 2 OR, P(O)(OR) 2 , CONRSO 2 R, SONR 2 , or formula (Ia) R is H, C 1-6 alkyl or C 2-6 alkenyl; R 2 and R 3 are C 1-6 linear alkyl which may be the same or different, and may be bonded to each other such that they form a ring incorporating the carbon to which they are commonly attached.

5. 发明申请

WO2007131012A1 12-ARYL OR HETEROARYL PROSTAGLANDIN ANALOGS 审中-公开
公开(公告)号：WO2007131012A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/067985
申请日：2007-05-02
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C59/90 , C07C59/56 , C07C59/54 , C07D333/40 , A61K31/5575 , A61K31/559 , A61P27/06
CPC分类号： C07C59/90 , C07C59/56 , C07C65/17 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D409/12 , C07D417/12
摘要： A compound having structure (I) is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.
摘要翻译：本文公开了具有结构（I）的化合物。还公开了与其有关的组合物，药物和治疗方法。

6. 发明申请

WO2007130902A2 THERAPEUTIC CYCLOPENTANE DERIVATIVES 审中-公开
标题翻译：治疗性环磷酰胺衍生物
公开(公告)号：WO2007130902A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/067762
申请日：2007-04-30
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C23/08 , C07C69/65 , A61K31/215
CPC分类号： C07C69/732 , C07B2200/07 , C07C57/54 , C07C57/62 , C07C57/68 , C07C59/56 , C07C59/72 , C07C65/19 , C07C65/26 , C07C205/56 , C07C255/57 , C07C309/10 , C07C309/42 , C07C323/17 , C07C323/52 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/08 , C07D277/24 , C07D277/56 , C07D307/68 , C07D333/16 , C07D333/38 , C07D333/40 , C07D335/06 , C07D405/10 , C07D409/10 , C07F9/3834 , C07F9/3882 , C07F9/65515
摘要： Described herein are compounds having Formula (I) and therapeutic methods, compositions, and medicaments, related thereto.
摘要翻译：本文描述了具有式（I）的化合物及其相关的治疗方法，组合物和药物。

7. 发明申请

WO2009137413A1 THERAPEUTIC CYCLOPENTANE DERIVATIVES 审中-公开
标题翻译：治疗性环孢素衍生物
公开(公告)号：WO2009137413A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/042725
申请日：2009-05-04
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C255/46 , C07C405/00 , C07D265/30 , A61P17/14 , A61P27/06 , A61K31/557
CPC分类号： C07C255/46 , C07C405/00 , C07C2601/08 , C07C2601/10 , C07D295/088
摘要： Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein B, Y, and A are as described in claims 1-10. Methods, compositions, and medicaments related thereto are also disclosed, for treating baldness, glaucoma or inflammatory bowel diseases.
摘要翻译：公开了包含式（I）的化合物或其药学上可接受的盐，其中B，Y和A如权利要求1-10所述。还公开了用于治疗秃发，青光眼或炎症性肠病的方法，组合物和与之相关的药物。

8. 发明申请

WO2007140136A2 THERAPEUTIC CYCLOPENTANE DERIVATIVES 审中-公开
标题翻译：治疗性环孢素衍生物
公开(公告)号：WO2007140136A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/069120
申请日：2007-05-17
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
CPC分类号： C07F9/3826
摘要： Disclosed herein is a compound having a structure [(I)] or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：本文公开了具有[（I）]结构或其药学上可接受的盐的化合物或其前药。还公开了与之相关的治疗方法，组合物和药物。

9. 发明申请

WO2007131012A9 12-ARYL OR HETEROARYL PROSTAGLANDIN ANALOGS 审中-公开
公开(公告)号：WO2007131012A9
公开(公告)日：2007-11-15
申请号：PCT/US2007/067985
申请日：2007-05-02
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C59/90 , C07C59/56 , C07C59/54 , C07D333/40 , A61K31/5575 , A61K31/559 , A61P27/06
摘要： A compound having structure (I) is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.

10. 发明申请

WO2009132085A1 SUBSTITUTED ARYLCYCLOPENTENES AS PROSTAGLANDIN EP2 AGONISTS 审中-公开
标题翻译：取代的ARYLCYCLOPENTENES作为PROSTAGLANDIN EP2激动剂
公开(公告)号：WO2009132085A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041385
申请日：2009-04-22
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07D333/38 , A61K31/381 , A61P27/06 , A61P17/14
CPC分类号： C07D333/38 , Y10S514/88
摘要： Compounds comprising formula (I) or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, and B are as described. Methods, compositions, and medicaments for the treatment of glaucoma, ocula hypertension and inflammatory bowel disease, and for the stimulation of hair growth are also disclosed.
摘要翻译：公开了包含式（I）化合物或其药学上可接受的盐或前体药物的化合物，其中Y，A和B如上所述。还公开了用于治疗青光眼，高眼压症和炎症性肠病以及用于刺激头发生长的方法，组合物和药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式