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1. 发明申请

WO2005000883A1 POLYPEPTIDES HAVING BINDING AFFINITY FOR INSULIN 审中-公开
标题翻译： STAPHYLOCOCCAL蛋白A（SPA）变体及其方法
公开(公告)号：WO2005000883A1
公开(公告)日：2005-01-06
申请号：PCT/SE2004/001050
申请日：2004-06-30
申请人： AFFIBODY AB , GUNNERIUSSON, Elin , FELDWISCH, Joachim , NYGREN, Per-Åke
发明人： GUNNERIUSSON, Elin , FELDWISCH, Joachim , NYGREN, Per-Åke
IPC分类号： C07K14/31
CPC分类号： C07K16/26 , C07K14/31 , C07K2318/20 , C07K2319/00
摘要： A polypeptide, which has a binding affinity for insulin such that the K D value of the interaction is at most 1 x 10 -6 M is provided. The polypeptide is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are additionally provided. Also provided is a method of separation of insulin present in a sample from other constituents in the sample, which method comprises a step of affinity separation, in which step a polypeptide according to the invention is used. Also provided is a method of detection of insulin in a sample, in which method a polypeptide according to the invention is used.
摘要翻译：提供对胰岛素具有结合亲和力的多肽，使得相互作用的KD值至多为1×10 -6 M。该多肽与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。另外提供了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。还提供了将样品中存在的胰岛素与样品中其他组分分离的方法，该方法包括亲和力分离步骤，其中使用根据本发明的多肽。还提供了在样品中检测胰岛素的方法，其中使用根据本发明的多肽。

2. 发明申请

WO2012096760A1 RADIOLABLED HER2 BINDING PEPTIDES 审中-公开
公开(公告)号：WO2012096760A1
公开(公告)日：2012-07-19
申请号：PCT/US2011/065777
申请日：2011-12-19
申请人： GENERAL ELECTRIC COMPANY , AFFIBODY AB , SYUD, Faisal , LEE, Brian Duh-Lan , ZHANG, Rong , IVESON, Peter , SCHAFFER, Paul , ERIKSSON, Tove , GUNNERIUSSON, Elin , FREJD, Fredrik , ABRAHMSEN, Lars , FELDWISCH, Joachim , HERNE, Nina , LENDEL, Christofer
发明人： SYUD, Faisal , LEE, Brian Duh-Lan , ZHANG, Rong , IVESON, Peter , SCHAFFER, Paul , ERIKSSON, Tove , GUNNERIUSSON, Elin , FREJD, Fredrik , ABRAHMSEN, Lars , FELDWISCH, Joachim , HERNE, Nina , LENDEL, Christofer
IPC分类号： A61K51/08 , A61K101/02 , C07K14/31
CPC分类号： A61K51/088 , C07B59/008 , C07K14/31 , C07K14/71 , C07K16/32
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译：包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

3. 发明申请

WO2005003156A1 POLYPEPTIDES HAVING BINDING AFFINITY FOR HER2 审中-公开
标题翻译：对于HER2具有结合亲和力的多肽
公开(公告)号：WO2005003156A1
公开(公告)日：2005-01-13
申请号：PCT/SE2004/001049
申请日：2004-06-30
申请人： AFFIBODY AB , CARLSSON, Jörgen , STÅHL, Stefan , ERIKSSON, Tove , GUNNERIUSSON, Elin , NILSSON, Fredrik
发明人： CARLSSON, Jörgen , STÅHL, Stefan , ERIKSSON, Tove , GUNNERIUSSON, Elin , NILSSON, Fredrik
IPC分类号： C07K14/31
CPC分类号： C07K14/31 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.
摘要翻译：提供了多肽，其具有对HER2的结合亲和力，并且其与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。还提供了编码多肽的核酸，以及用于表达核酸的表达载体和宿主细胞。还提供了作为药物的这种多肽的用途，以及用于将与其缀合的物质引导至过表达HER2的细胞的靶向剂。还提供了用于进行方法的方法和试剂盒，哪些方法和试剂盒依赖于多肽与HER2的结合。

4. 发明申请

WO2011056124A1 HER3 BINDING POLYPEPTIDES 审中-公开
标题翻译： HER3结合多糖
公开(公告)号：WO2011056124A1
公开(公告)日：2011-05-12
申请号：PCT/SE2010/051164
申请日：2010-10-27
申请人： AFFIBODY AB , FREJD, Fredrik , GUNNERIUSSON, Elin , KRONQVIST, Nina , LÖFBLOM, John , STÅHL, Stefan
发明人： FREJD, Fredrik , GUNNERIUSSON, Elin , KRONQVIST, Nina , LÖFBLOM, John , STÅHL, Stefan
IPC分类号： C07K14/31 , C07K14/705
CPC分类号： C07K16/32 , C07K14/31 , C07K14/705 , C07K16/2863 , C07K2318/20 , C07K2319/21 , C07K2319/31
摘要： Thedisclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EX 2 X 3 X 4 A X 6 X 7 EIW X 11 LPNL X 16 X 17 X 18 QX 20 X 21 AFIX 25 X 26 LX 28 D, and ii) an amino acid sequence which has at least 90 % identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.
摘要翻译：该披露提供了包含HER3结合基序BM的HER3结合多肽，其基序由选自i）EX2X3X4A X6X7EIW X11LPNL X16X17X18QX20 X21AFIX25 X26LX28D的氨基酸序列组成，以及ii）与SEQ ID NO：1的氨基酸序列具有至少90％同一性的氨基酸序列 i）中定义的序列，其中所述多肽结合HER3的细胞外结构域。还提供了对HER3和HER2或HER3和EGFR具有结合亲和力并包含HER3的双特异性配体。和HER2结合多肽或EGFR结合多肽。

5. 发明申请

WO2009077175A1 POLYPEPTIDE DERIVED FROM PROTEIN A AND ABLE TO BIND PDGF 审中-公开
标题翻译：从蛋白A衍生的多肽可以结合到PDGF
公开(公告)号：WO2009077175A1
公开(公告)日：2009-06-25
申请号：PCT/EP2008/010776
申请日：2008-12-17
申请人： AFFIBODY AB , LINDBORG, Malin , GUNNERIUSSON, Elin , LENDEL, Christofer
发明人： LINDBORG, Malin , GUNNERIUSSON, Elin , LENDEL, Christofer
IPC分类号： C12N15/10 , C07K1/04 , G01N33/68 , C07K14/31 , C07K14/49
CPC分类号： C07K1/047 , C07K14/31 , C07K14/49
摘要： The invention provides a platelet derived growth factor receptor beta (PDGF- Rβ) binding polypeptide, comprising a platelet derived growth factor receptor beta binding motif, PBM , which motif consists of an amino acid sequence as defined herein, wherein the PDGF-Rβ-binding polypeptide binds to PDGF-Rβ such that the K D value of the interaction is at most 1 x 10 -6 M. Also provided are methods and uses of said polypeptide in treatment and diagnosis of PDGF-Rβ-related conditions.
摘要翻译：本发明提供了一种血小板衍生生长因子受体β（PDGF-Rβ）结合多肽，其包含血小板衍生生长因子受体β结合基序，PBM，其基序由本文定义的氨基酸序列组成，其中PDGF-Rβ结合多肽与PDGF-Rβ结合，使得相互作用的KD值至多为1×10 -6 M。还提供了所述多肽在治疗和诊断PDGF-Rβ相关病症中的方法和用途。

6. 发明申请

WO2010079079A2 PDGF-Rβ BINDERS 审中-公开
标题翻译： PDGF-RβBINDERS
公开(公告)号：WO2010079079A2
公开(公告)日：2010-07-15
申请号：PCT/EP2009/067447
申请日：2009-12-17
申请人： GENERAL ELECTRIC COMPANY , MARINO, Michael Ernest , SYUD, Faisal Ahmed , SCHAFFER, Paul , LEE, Brian Duh-Lan , ZHANG, Rong , LINDBORG, Malin , GUNNERIUSSON, Elin , LENDEL, Christofer
发明人： MARINO, Michael Ernest , SYUD, Faisal Ahmed , SCHAFFER, Paul , LEE, Brian Duh-Lan , ZHANG, Rong , LINDBORG, Malin , GUNNERIUSSON, Elin , LENDEL, Christofer
IPC分类号： A61K49/14 , A61K51/08
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14 , A61K51/08 , A61K51/1027 , C07K2319/00
摘要： Provided herein are PDGF-Rβ imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-β. Also provided are in vivo imaging methods using the imaging agents.
摘要翻译：本文提供了PDGF-Rβ显像剂，其是用信号发生器（例如顺磁性标记，放射性核素或荧光团）标记的多肽，其中成像剂特异性结合PDGFR-β。还提供了使用成像剂的体内成像方法。

7. 发明申请

WO2009077569A1 BIOKINETICS OF FAST-CLEARING POLYPEPTIDES 审中-公开
标题翻译：快速清除多糖的生物活性
公开(公告)号：WO2009077569A1
公开(公告)日：2009-06-25
申请号：PCT/EP2008/067774
申请日：2008-12-17
申请人： GENERAL ELECTRIC COMPANY , LENDEL, Christofer , GUNNERIUSSON, Elin , LINDBORG, Malin , LEE, Brian Duh-Lan , CASTLE, Jason William , SYUD, Faisal Ahmed , MARINO, Michael Ernest
发明人： LENDEL, Christofer , GUNNERIUSSON, Elin , LINDBORG, Malin , LEE, Brian Duh-Lan , CASTLE, Jason William , SYUD, Faisal Ahmed , MARINO, Michael Ernest
IPC分类号： C07K16/24 , C07K16/00 , C07K16/28 , C07K16/32 , C07K19/00 , G01N33/00
CPC分类号： C07K16/2863 , A61K51/1084 , A61K51/109 , C07K16/00 , C07K16/241 , C07K16/32 , C07K2318/20 , C07K2319/00
摘要： Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.
摘要翻译：本文提供了减少特异性结合靶标的多肽体内肝脏摄取的方法，包括：（a）提供特异性结合靶标的多肽; 和（b）用酸性氨基酸残基取代来自步骤（a）的天然多肽的至少一个碱性或至少一个中性氨基酸残基以产生修饰的多肽，其中所述修饰的多肽表现出至少0.05- 0.1个pH值小于天然多肽的等电点。还提供了使用本发明方法制备的多肽以及采用该方法和试剂的成像技术。

8. 发明申请

WO2017072280A1 NEW POLYPEPTIDE HAVING AFFINITY TO PD-L1 审中-公开
标题翻译：新的多肽对PD-L1具有亲和力
公开(公告)号：WO2017072280A1
公开(公告)日：2017-05-04
申请号：PCT/EP2016/076040
申请日：2016-10-28
申请人： AFFIBODY AB
发明人： WAHLBERG, Elisabet , GUNNERIUSSON, Elin
IPC分类号： C07K14/00 , A61K38/16 , C07K14/435
CPC分类号： C07K14/70532 , A61K38/00
摘要： The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1 binding polypeptide comprising the sequence ERNX 4 AAX 7 EIL X 11 LPNLX 16 X 17 X 18 QX 20 WAFIWX 26 LX 28 D. The present disclosure also relates to the use of such a PD-L1 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
摘要翻译：本公开内容涉及一类对程序性死亡配体1（PD-L1）具有结合亲和力的工程化多肽，并提供包含序列ERNX4的PD-L1结合多肽 AAX 7 EIL X 11 LPNLX 16 X 17下一级18 18下一级分类： QX <20> WAFIWX 26 。本公开还涉及这种PD-L1结合多肽作为治疗剂，预后剂和/或诊断剂的用途。

9. 发明申请

WO2016042083A1 NEW POLYPEPTIDES 审中-公开
标题翻译：新的多糖
公开(公告)号：WO2016042083A1
公开(公告)日：2016-03-24
申请号：PCT/EP2015/071339
申请日：2015-09-17
申请人： AFFIBODY AB
发明人： ABRAHMSÉN, Lars , EKBLAD, Caroline , GUNNERIUSSON, Elin , GRÄSLUND, Torbjörn , SEIJSING, Johan , LÖFBLOM, John , LINDBORG, Malin , FREJD, Fredrik , GUDMUNDSDOTTER, Lindvi
IPC分类号： A61K39/395 , C07K14/735 , C07K14/74 , C07K14/31 , A61K39/00
CPC分类号： C07K14/00 , A61K38/00 , C07K14/31 , C07K14/70535 , C07K14/70539 , C07K2319/00 , C07K2319/30 , C07K2319/74
摘要： The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein said first and second monomer unitseach comprisesan FcRn binding motif. Said FcRn binding dimerbinds FcRn with higher capacity compared to said first monomer unitor second monomer unit alone.The present disclosure also relates to the use of said FcRn binding dimeras an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
摘要翻译：本公开涉及具有对新生儿Fc受体FcRn的结合亲和力的工程化多肽的二聚体，并提供包含第一单体单元，第二单体单元和氨基酸接头的FcRn结合二聚体，其中所述第一和第二单体单元包括FcRn结合基序。所述FcRn结合二聚体与单独的所述第一单体单体或第二单体单元相比，具有更高容量的FcRn。本公开还涉及所述FcRn结合二聚体用于改变药代动力学和药效学性质以及作为治疗剂的用途。

10. 发明申请

WO2014096163A1 NEW POLYPEPTIDES 审中-公开
标题翻译：新的多糖
公开(公告)号：WO2014096163A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/077334
申请日：2013-12-19
申请人： AFFIBODY AB
发明人： ABRAHMSÉN, Lars , HÖIDÉN-GUTHENBERG, Ingmarie , GUNNERIUSSON, Elin
IPC分类号： C07K16/32 , C07K14/435
CPC分类号： C07K16/40 , C07K14/435 , C07K14/47 , C07K16/30 , C07K2317/92 , C07K2318/20
摘要： The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX(CAIX), and provides a CAIX binding polypeptide comprising the sequence EX 2 X 3 X 4 AX 6 X 7 EIX 10 X 11 LPN LX 16 X 17 X 18 QX 20 X 21 AFIX 25 X 26 LWD. The present disclosure also relates to the use of such a CAIX binding polypeptide as a diagnostic, prognostic agent and/or therapeutic agent.
摘要翻译：本公开涉及对碳酸酐酶IX（CAIX）具有结合亲和力的一类工程化多肽，并提供包含序列EX2X3X4AX6X7EIX10X11LPN LX16X17X18QX20 X21AFIX25X26LWD的CAIX结合多肽。本公开还涉及这种CAIX结合多肽作为诊断，预后剂和/或治疗剂的用途。

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