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1. 发明申请

WO2003007691A1 IMPROVEMENTS IN OR RELATING TO A CUTTING HEAD FOR A CUTTING- AND CLEARING TOOL 审中-公开
标题翻译：用于切割和清除工具的切割头的改进或相关
公开(公告)号：WO2003007691A1
公开(公告)日：2003-01-30
申请号：PCT/SE2002/001320
申请日：2002-07-03
申请人： CARLSSON, Fredrik , CARLSSON, Jörgen
发明人： CARLSSON, Fredrik , CARLSSON, Jörgen
IPC分类号： A01D34/86
CPC分类号： A01D34/863
摘要： The present invention refers to a cutting head (1) attached to a rack (7) located above and/or at the side of said cutting head (1) and comprising a rigid or flexible suspension device (2), which is attached to a tool and said cutting head (1) is intended to machine different types of ground surfaces preferably cutting and clearance of vegetation, the cutting head (1) having at least one opening (9) forming a gap (14), which can be straddled around an obstacle (17). Said cutting head (1) is turnable around at least one rotation point (15), so that the cutting head (1) can machine at least a part of the ground surface around the obstacle (17) and said head (1) comprises at least two arms (10), which together form the gap (14), each of said arms supports at least one machining tool.
摘要翻译：本发明涉及一种安装在位于所述切割头（1）的上方和/或侧面上的齿条（7）的切割头（1），并且包括刚性或柔性的悬挂装置（2）工具和所述切割头（1）旨在加工不同类型的地面，优选切割和间隙植被，所述切割头（1）具有形成间隙（14）的至少一个开口（9），所述间隙可以跨越障碍（17）。所述切割头（1）围绕至少一个旋转点（15）可旋转，使得所述切割头（1）可以围绕所述障碍物（17）加工所述地面的至少一部分，并且所述头部（1）包括在至少两个臂（10）一起形成间隙（14），每个所述臂支撑至少一个加工工具。

2. 发明申请

WO2005103065A1 ANTHRACYCLINE DERIVATIVES 审中-公开
标题翻译：蒽醌衍生物
公开(公告)号：WO2005103065A1
公开(公告)日：2005-11-03
申请号：PCT/SE2005/000596
申请日：2005-04-22
申请人： EDWARDS, Katarina , SJÖBERG, Stefan , CARLSSON, Jörgen , GEDDA, Lars
发明人： EDWARDS, Katarina , SJÖBERG, Stefan , CARLSSON, Jörgen , GEDDA, Lars
IPC分类号： C07H15/24
CPC分类号： C07H15/24 , A61K9/1271 , A61K9/1278 , A61K31/70 , A61K31/704 , A61K51/0491
摘要： The present invention relates to new anthracycline derivatives and their use in cancer therapy and diagnosis. These anthracycline derivatives can be radiolabelled and used as an imaging agent in cancer diagnosis. The radiolabelled anthracycline derivatives can also be used together with a drug delivery system, in particular including a two-step targeting strategy, for treating solid and disseminated tumours. These drug delivery system can advantageously be used for treatment and diagnosis of breast cancer.
摘要翻译：本发明涉及新的蒽环类衍生物及其在癌症治疗和诊断中的应用。这些蒽环类衍生物可以放射性标记，并用作癌症诊断中的显像剂。放射性标记的蒽环类衍生物也可以与药物递送系统一起使用，特别是包括用于治疗固体和弥散性肿瘤的两步靶向策略。这些药物递送系统可以有利地用于乳腺癌的治疗和诊断。

3. 发明申请

WO2005003156A1 POLYPEPTIDES HAVING BINDING AFFINITY FOR HER2 审中-公开
标题翻译：对于HER2具有结合亲和力的多肽
公开(公告)号：WO2005003156A1
公开(公告)日：2005-01-13
申请号：PCT/SE2004/001049
申请日：2004-06-30
申请人： AFFIBODY AB , CARLSSON, Jörgen , STÅHL, Stefan , ERIKSSON, Tove , GUNNERIUSSON, Elin , NILSSON, Fredrik
发明人： CARLSSON, Jörgen , STÅHL, Stefan , ERIKSSON, Tove , GUNNERIUSSON, Elin , NILSSON, Fredrik
IPC分类号： C07K14/31
CPC分类号： C07K14/31 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.
摘要翻译：提供了多肽，其具有对HER2的结合亲和力，并且其与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。还提供了编码多肽的核酸，以及用于表达核酸的表达载体和宿主细胞。还提供了作为药物的这种多肽的用途，以及用于将与其缀合的物质引导至过表达HER2的细胞的靶向剂。还提供了用于进行方法的方法和试剂盒，哪些方法和试剂盒依赖于多肽与HER2的结合。

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