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1. 发明申请

WO2009080811A1 POLYPEPTIDE LIBRARIES WITH A PREDETERMINED SCAFFOLD 审中-公开
标题翻译：具有预测SCAFFOLD的多肽图书馆
公开(公告)号：WO2009080811A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/068168
申请日：2008-12-22
申请人： AFFIBODY AB , ABRAHMSÉN, Lars , HERNE, Nina , LENDEL, Christofer , FELDWISCH, Joachim
发明人： ABRAHMSÉN, Lars , HERNE, Nina , LENDEL, Christofer , FELDWISCH, Joachim
IPC分类号： C07K1/04 , C12N15/10 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/31 , C07K1/047 , C12N15/1037 , C12N15/1041 , C12N15/1044 , C12N15/1075 , C40B40/10 , G01N33/6845 , G01N2333/31
摘要： Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q, wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling. Furthermore, methods for selecting a desired polypeptide having an affinity for a predetermined target from a population of polypeptides, isolation of a polynucleotide encoding a desired polypeptide having an affinity for a predetermined target, identifying a desired polypeptide having an affinity for a predetermined target, selecting and identifying a desired polypeptide having affinity for a predetermined target, and production of a desired polypeptide having an affinity for a predetermined target are disclosed.
摘要翻译：基于常见支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q，其中每个X分别对应于在群体中变化的氨基酸残基被披露。还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。此外，公开了这样的多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方法与编码该成员的多核苷酸物理或空间相关联。此外，从多肽群体中选择对预定靶标具有亲和性的期望多肽的方法，分离编码对预定靶标具有亲和性的期望多肽的多核苷酸，鉴定对预定靶标具有亲和性的期望多肽，选择并鉴定对预定靶标具有亲和力的所需多肽，以及对预定靶标具有亲和性的所需多肽的制备。

2. 发明申请

WO2005000883A1 POLYPEPTIDES HAVING BINDING AFFINITY FOR INSULIN 审中-公开
标题翻译： STAPHYLOCOCCAL蛋白A（SPA）变体及其方法
公开(公告)号：WO2005000883A1
公开(公告)日：2005-01-06
申请号：PCT/SE2004/001050
申请日：2004-06-30
申请人： AFFIBODY AB , GUNNERIUSSON, Elin , FELDWISCH, Joachim , NYGREN, Per-Åke
发明人： GUNNERIUSSON, Elin , FELDWISCH, Joachim , NYGREN, Per-Åke
IPC分类号： C07K14/31
CPC分类号： C07K16/26 , C07K14/31 , C07K2318/20 , C07K2319/00
摘要： A polypeptide, which has a binding affinity for insulin such that the K D value of the interaction is at most 1 x 10 -6 M is provided. The polypeptide is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are additionally provided. Also provided is a method of separation of insulin present in a sample from other constituents in the sample, which method comprises a step of affinity separation, in which step a polypeptide according to the invention is used. Also provided is a method of detection of insulin in a sample, in which method a polypeptide according to the invention is used.
摘要翻译：提供对胰岛素具有结合亲和力的多肽，使得相互作用的KD值至多为1×10 -6 M。该多肽与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。另外提供了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。还提供了将样品中存在的胰岛素与样品中其他组分分离的方法，该方法包括亲和力分离步骤，其中使用根据本发明的多肽。还提供了在样品中检测胰岛素的方法，其中使用根据本发明的多肽。

3. 发明申请

WO2012096760A1 RADIOLABLED HER2 BINDING PEPTIDES 审中-公开
公开(公告)号：WO2012096760A1
公开(公告)日：2012-07-19
申请号：PCT/US2011/065777
申请日：2011-12-19
申请人： GENERAL ELECTRIC COMPANY , AFFIBODY AB , SYUD, Faisal , LEE, Brian Duh-Lan , ZHANG, Rong , IVESON, Peter , SCHAFFER, Paul , ERIKSSON, Tove , GUNNERIUSSON, Elin , FREJD, Fredrik , ABRAHMSEN, Lars , FELDWISCH, Joachim , HERNE, Nina , LENDEL, Christofer
发明人： SYUD, Faisal , LEE, Brian Duh-Lan , ZHANG, Rong , IVESON, Peter , SCHAFFER, Paul , ERIKSSON, Tove , GUNNERIUSSON, Elin , FREJD, Fredrik , ABRAHMSEN, Lars , FELDWISCH, Joachim , HERNE, Nina , LENDEL, Christofer
IPC分类号： A61K51/08 , A61K101/02 , C07K14/31
CPC分类号： A61K51/088 , C07B59/008 , C07K14/31 , C07K14/71 , C07K16/32
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译：包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

4. 发明申请

WO2009080810A1 NEW POLYPEPTIDES HAVING AFFINITY FOR HER2 审中-公开
标题翻译：具有HER2感染力的新型多肽
公开(公告)号：WO2009080810A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/068167
申请日：2008-12-22
申请人： AFFIBODY AB , ABRAHMSÉN, Lars , HERNE, Nina , FELDWISCH, Joachim , LENDEL, Christofer , TOLMACHEV, Vladimir
发明人： ABRAHMSÉN, Lars , HERNE, Nina , FELDWISCH, Joachim , LENDEL, Christofer , TOLMACHEV, Vladimir
IPC分类号： C07K14/31 , C07K14/485 , A61K38/18 , A61K51/08 , A61P35/00 , G01N33/68
CPC分类号： A61K51/08 , A61K38/00 , A61K51/088 , C07K16/32
摘要： HER2 binding polypeptides comprising the amino acid sequence EX 1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX 2 E AKKLNDSQ wherein X 1 in position 2 is M, I or L, and X 2 in position 39 is S or C (SEQ ID NO:1 ) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.
摘要翻译： HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。此外，公开了包含螯合环境的这些肽。还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法公开了治疗这种癌症的方法。此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

5. 发明申请

WO2005000883A8 POLYPEPTIDES HAVING BINDING AFFINITY FOR INSULIN 审中-公开
标题翻译：具有胰岛素结合亲和力的多肽
公开(公告)号：WO2005000883A8
公开(公告)日：2005-03-03
申请号：PCT/SE2004001050
申请日：2004-06-30
申请人： AFFIBODY AB , GUNNERIUSSON ELIN , FELDWISCH JOACHIM , NYGREN PER-AAKE
发明人： GUNNERIUSSON ELIN , FELDWISCH JOACHIM , NYGREN PER-AAKE
IPC分类号： A61P5/50 , C07K14/31 , C07K16/26 , C07K1/22 , C07K16/00 , C12N9/16 , C12N15/10
CPC分类号： C07K16/26 , C07K14/31 , C07K2318/20 , C07K2319/00
摘要： A polypeptide, which has a binding affinity for insulin such that the KD value of the interaction is at most 1 x 10 M is provided. The polypeptide is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are additionally provided. Also provided is a method of separation of insulin present in a sample from other constituents in the sample, which method comprises a step of affinity separation, in which step a polypeptide according to the invention is used. Also provided is a method of detection of insulin in a sample, in which method a polypeptide according to the invention is used.
摘要翻译：提供对胰岛素具有结合亲和力的多肽，使得相互作用的KD值至多为1×10 -6 M。该多肽与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。另外提供了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。还提供了将样品中存在的胰岛素与样品中其他组分分离的方法，该方法包括亲和力分离步骤，其中使用根据本发明的多肽。还提供了在样品中检测胰岛素的方法，其中使用根据本发明的多肽。

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