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1. 发明申请

WO2010019782A3 METHODS, SYSTEMS, AND PRODUCTS FOR CONDUCTING DROPLET OPERATIONS 审中-公开
标题翻译：用于传导滴落操作的方法，系统和产品
公开(公告)号：WO2010019782A3
公开(公告)日：2010-05-14
申请号：PCT/US2009053725
申请日：2009-08-13
申请人： STURMER RYAN A , SMITH GREGORY F , FOGLEMAN MICHAEL , BRAFFORD KEITH R , RONGALI SAI RAM , ADVANCED LIQUID LOGIC INC
发明人： STURMER RYAN A , SMITH GREGORY F , FOGLEMAN MICHAEL , BRAFFORD KEITH R , RONGALI SAI RAM
IPC分类号： B01J19/08 , G06F9/455 , G06F19/00
CPC分类号： G06F19/00 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , F04B17/00 , F04B19/006 , F04B49/065
摘要： The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided.
摘要翻译：本发明提供了修改的液滴致动器系统，软件和软件执行的用于液滴致动器操作和液滴致动器系统的方法，其被配置和编程为执行这样的软件。本发明的软件组件的一个方面是用于微流体系统的每个硬件组件的接口描述文件，该文件允许改变硬件组件，而无需修改用于执行液滴操作协议的程序。本发明的软件组件的另一个方面是建立微滴执行器配置的电极 - 电极关系和其他方面，其可以在编程微滴操作方案时使用。本发明的软件组件的另一个方面是预定义的电极元件的物理设计库，其可以在构建电极布局时被液滴致动器设计者使用。本发明的软件组件的另一方面是包含液滴致动器的物理和电气描述的液滴致动器描述文件。本发明的软件组件的另一方面是用于确定液滴致动器中的液滴操作路线的路由器组件。本发明的软件组件的另一个方面是使用三态矢量来在液滴致动器中编程序列。还提供了其他方面。

2. 发明申请

WO2012037308A3 DROPLET ACTUATOR SYSTEMS, DEVICES AND METHODS 审中-公开
标题翻译： DROPLET执行机构系统，设备和方法
公开(公告)号：WO2012037308A3
公开(公告)日：2012-06-28
申请号：PCT/US2011051691
申请日：2011-09-15
申请人： ADVANCED LIQUID LOGIC INC , FOGLEMAN MICHAEL , STURMER RYAN A , SMITH GREGORY F
发明人： FOGLEMAN MICHAEL , STURMER RYAN A , SMITH GREGORY F
IPC分类号： B01J19/00 , C12Q1/68 , G01N27/26 , G01N27/447
CPC分类号： B81B7/02 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2400/0424 , B01L2400/0427 , C12Q1/6825 , G01F22/00 , G01N35/10 , C12Q2527/107 , C12Q2563/159 , C12Q2565/629
摘要： The present invention is directed to droplet actuator systems, devices, and methods. In one embodiment, a microfluidic article of manufacture is provided. The microfluidic article of manufacture includes a first substrate; a second substrate separated from the first substrate to form a droplet operations gap; gap height setting spacers associated with the first and/or second substrate or situated between the first and second substrates; a spring forcing the second substrate against the gap height setting spacers, thereby establishing a substantially uniform gap height between the first and second substrates; and electrodes associated with the first and/or second substrate and configured to conduct droplet operations in the droplet operations gap.
摘要翻译：本发明涉及液滴致动器系统，装置和方法。在一个实施例中，提供微流体制造品。微流体制品包括第一基底; 从所述第一基板分离以形成液滴操作间隙的第二基板; 与第一和/或第二基底相关联或位于第一和第二基底之间的间隙高度设定间隔物; 弹簧迫使第二基板抵靠间隙高度设定间隔件，从而在第一和第二基板之间建立基本均匀的间隙高度; 以及与第一和/或第二基板相关联并且被配置为在液滴操作间隙中进行液滴操作的电极。

3. 发明申请

WO2011002957A3 DROPLET ACTUATOR DEVICES AND METHODS 审中-公开
标题翻译：液滴驱动器装置和方法
公开(公告)号：WO2011002957A3
公开(公告)日：2011-08-04
申请号：PCT/US2010040705
申请日：2010-07-01
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
发明人： POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
IPC分类号： B41J2/06 , B41J2/175 , B41J29/38
CPC分类号： B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
摘要： The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
摘要翻译：本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。在一个实施例中，本发明提供了促进三维液滴操作的液滴致动器。在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。在另一个实施例中，本发明提供了一种用于组装液滴致动器的磁性夹具。在另一个实施例中，本发明提供了与微流体系统结合使用的简单，低成本的电源。在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。在又一个实施例中，本发明提供了使用等离子体处理工艺制造以提高衬底表面能量的液滴致动器装置。

4. 发明申请

WO2008051310A3 DROPLET MANIPULATION SYSTEMS 审中-公开
标题翻译： DROPLET操作系统
公开(公告)号：WO2008051310A3
公开(公告)日：2009-04-16
申请号：PCT/US2007011298
申请日：2007-05-09
申请人： ADVANCED LIQUID LOGIC INC , UNIV DUKE , PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
发明人： PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
IPC分类号： B01D57/00
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L7/54 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2200/16 , B01L2300/027 , B01L2300/0819 , B01L2300/089 , B01L2300/1827 , B01L2400/0421 , B01L2400/0427 , B01L2400/0448 , G01N33/49 , G01N2035/1034
摘要： The present invention relates to systems and methods for controlling droplet movements on a droplet microactuator and a droplet microactuator device, system and method for processing and/or analyzing samples. According to one aspect, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another aspect, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a means for coupling the cartridge to the analyzer unit which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit.
摘要翻译：本发明涉及用于控制液滴微致动器上的液滴运动的系统和方法以及液滴微致动器装置，用于处理和/或分析样品的系统和方法。根据一个方面，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中系统被编程和配置为允许用户实现通过与用户界面交互来进行液滴操作。根据另一方面，提供一种样品分析器，其包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及用于将盒耦合到分析器单元的装置，其将电子和/或光学对准在分析器单元上从带有电子或光学接收装置的墨盒输出。

5. 发明申请

WO2011106314A3 METHOD OF MAKING NUCLEIC ACID LIBRARIES 审中-公开
标题翻译：制备核酸图谱的方法
公开(公告)号：WO2011106314A3
公开(公告)日：2012-02-23
申请号：PCT/US2011025711
申请日：2011-02-22
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , ECKHARDT ALLEN E , SUDARSAN ARJUN , SRINIVASAN VIJAY , ROUSE JEREMY , YI UICHONG , TROTTA NICHOLAS , DHOPESHWARKAR RAHUL , THWAR PRASANNA , SMITH GREGORY F , NORTON SCOTT , LINNARTZ PETER
发明人： POLLACK MICHAEL G , ECKHARDT ALLEN E , SUDARSAN ARJUN , SRINIVASAN VIJAY , ROUSE JEREMY , YI UICHONG , TROTTA NICHOLAS , DHOPESHWARKAR RAHUL , THWAR PRASANNA , SMITH GREGORY F , NORTON SCOTT , LINNARTZ PETER
IPC分类号： C12N15/10 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B50/08
CPC分类号： C12N15/1075 , B01J19/0046 , C12N15/1006 , C40B40/08 , C40B50/06
摘要： A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.
摘要翻译：制备与油接触的液滴核酸文库的方法，包括：（a）在油中的液滴中的平端核酸片段以产生平端核酸片段; （b）使油中的液滴中的平端核酸片段磷酸化以产生磷酸化的核酸片段; 将A尾连接到油中的液滴中的磷酸化核酸片段以产生A尾核酸片段; 和（d）将核酸衔接子偶联到油中的液滴中的A尾核酸片段，以产生包含衔接子连接的核酸片段的核酸文库。

6. 发明申请

WO2007079208A3 FILLER TUBE ASSEMBLY 审中-公开
标题翻译：填充管组件
公开(公告)号：WO2007079208A3
公开(公告)日：2007-12-27
申请号：PCT/US2006049538
申请日：2006-12-28
申请人： SMITH GREGORY F , SMITH DAVID G
发明人： SMITH GREGORY F , SMITH DAVID G
IPC分类号： B65B31/00
CPC分类号： B63B25/082
摘要： A filler tube assembly is used with a fuel pump nozzle having a pressure sensing port.The filler tube assembly includes a receiver having an inner wall defining an aperture, which receives the pump nozzle. The inner wall defines an orifice and a seal is coupled to the inner wall about the orifice for defining a chamber between the inner wall, the seal, and the fuel pump nozzle when the fuel pump nozzle is disposed in the aperture. A vacuum tube has a coupled end in fluid communication with the orifice and an open end in fluid communication with the fuel tank. The receiver defines a rim for seating the fuel pump nozzle in the aperture to align the pressure sensing port with the orifice. When fuel covers the open end of the vacuum tube, a pressure change is transmitted through the filler tube assembly to the pressure sensing port.
摘要翻译：加油管组件与具有压力感测端口的燃料泵喷嘴一起使用。加油管组件包括接收器，该接收器具有限定孔的内壁，该内壁容纳泵喷嘴。内壁限定孔口，并且密封件围绕孔口联接到内壁，用于在燃料泵喷嘴设置在孔中时在内壁，密封件和燃料泵喷嘴之间形成腔室。真空管具有与孔口流体连通的联接端和与燃料箱流体连通的开口端。接收器限定用于将燃料泵喷嘴放置在孔中的边缘，以使压力感测端口与孔口对准。当燃料覆盖真空管的开口端时，压力变化通过加注管组件传递到压力感测端口。

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