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1. 发明申请

WO2007106402A3 METHODS AND APPARATUS FOR NEAR FIELD IRRADIATION 审中-公开
标题翻译：近场辐射的方法和装置
公开(公告)号：WO2007106402A3
公开(公告)日：2008-02-21
申请号：PCT/US2007006103
申请日：2007-03-09
申请人： HARVARD COLLEGE , ISSADORE DAVID , HUNT THOMAS , ADAMSON KRISTI , WESTERVELT ROBERT , ROGERS RICK
发明人： ISSADORE DAVID , HUNT THOMAS , ADAMSON KRISTI , WESTERVELT ROBERT , ROGERS RICK
IPC分类号： B01J19/12 , G01N33/53 , H05B6/72 , H05B6/80
CPC分类号： H05B6/72 , B01L3/5027 , B01L7/52 , B01L2300/0822 , B01L2300/1866 , G01N1/44
摘要： Irradiation methods and apparatus configured to deliver power, via electromagnetic fields at a variety of frequencies and power levels, in a localized fashion to a target area. In one example, an electromagnetic field generator is disposed on a substrate and configured to deliver power via electromagnetic energy to a thin region proximate to (above) a surface of the substrate, wherein electromagnetic field intensity decreases significantly beyond the thin region. Such methods and apparatus are particularly useful in a wide variety of processes involving chemical and/or physical interactions in connection with a sample of interest located in the thin region. In different aspects, irradiator apparatus may be configured as disposable devices, and/or used in combination with one or more microfluidic or sensing components, for a variety of medical / laboratory / diagnostic methods and instrumentation implementations.
摘要翻译：该照射方法和装置被配置为以局部方式通过各种频率和功率水平的电磁场向目标区域传递电力。在一个示例中，电磁场发生器设置在基板上并且被配置为经由电磁能传递电力到靠近（高于）基板表面的薄区域，其中电磁场强度显着地减小到薄区域之外。这种方法和装置在涉及与位于薄区域中的感兴趣样品相关的化学和/或物理相互作用的各种各样的方法中特别有用。在不同方面，辐射器装置可被配置为一次性装置，和/或与一个或多个微流体或感测部件组合使用，用于各种医疗/实验室/诊断方法和仪器实施。

2. 发明申请

WO2005099419A9 METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操纵和/或检测生物样本和其他对象的方法和装置
公开(公告)号：WO2005099419A9
公开(公告)日：2005-12-01
申请号：PCT/US2005012719
申请日：2005-04-13
申请人： HARVARD COLLEGE , HAM DONHEE , WESTERVELT ROBERT , HUNT THOMAS , LIU YONG , LEE HAKHO
发明人： HAM DONHEE , WESTERVELT ROBERT , HUNT THOMAS , LIU YONG , LEE HAKHO
IPC分类号： G01R33/30 , G01R33/465 , G01R33/56
CPC分类号： G01R33/302 , B01L3/502761 , B01L2200/0668 , B01L2200/147 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N15/1031 , G01N24/08 , G01N24/10 , G01R33/307 , G01R33/34092 , G01R33/3415 , G01R33/465 , G01R33/4808 , G01R33/5604
摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.
摘要翻译：用于操作，检测，成像，表征，分选和/或组装生物或其他材料的方法和装置，涉及CMOS或其他基于半导体的技术和微流体的集成。在一个实现中，与使用标准协议制造的IC芯片上实现与电场和/或磁场的产生相关的各种组件。产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便促进在生物相容性环境中引入和去除细胞，或其它悬浮的粒子/物体在流体中。由IC芯片产生的图案化电场和/或磁场可以捕获并移动微流体系统内的生物细胞或其它物体。可以使用各种频率的信号来控制电场和/或磁场产生组件，以便通过测量与相互作用相关联的共振特性来检测一个或多个感兴趣的细胞，颗粒或感兴趣的物体，甚至是感兴趣的粒子或物体的类型样本和一个或多个场产生装置之间。这样的系统可以用于各种生物和医学相关应用，包括细胞分选和组织组装。

3. 发明申请

WO2005099419A3 MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES OR OTHER OBJECTS 审中-公开
标题翻译：操纵和/或检测生物样本或其他物体
公开(公告)号：WO2005099419A3
公开(公告)日：2007-11-22
申请号：PCT/US2005012719
申请日：2005-04-13
申请人： HARVARD COLLEGE , HAM DONHEE , WESTERVELT ROBERT , HUNT THOMAS , LIU YONG , LEE HAKHO
发明人： HAM DONHEE , WESTERVELT ROBERT , HUNT THOMAS , LIU YONG , LEE HAKHO
IPC分类号： G01N27/00 , G01N33/53 , G01R33/30 , G01R33/465 , G01R33/56
CPC分类号： G01R33/302 , B01L3/502761 , B01L2200/0668 , B01L2200/147 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N15/1031 , G01N24/08 , G01N24/10 , G01R33/307 , G01R33/34092 , G01R33/3415 , G01R33/465 , G01R33/4808 , G01R33/5604
摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting or assembly of biological or other matenals, involving an integration of CMOS or other semiconductor-based technology and microfluidics are disclosed In one implementation, vapous components relating to the generation of electric or magnetic fields, implemented on an IC chip, are used to manipulate or detect one or more dielectpc or magnetic particles and to distinguish different types of particles A microfluidic system integrated with the IC chip facilitates the introduction and removal of cells or other particles of interest suspended in a fluid Patterned electpc or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system Field generating components may also be applied to generate signals of vapous frequencies to measure resonance charactepstics of objects of interest
摘要翻译：公开了涉及CMOS或其他基于半导体的技术和微流体的集成的生物或其它成像的操作，检测，成像，表征，分选或装配的方法和装置。在一个实施方案中，涉及电或磁在IC芯片上实现的场用于操纵或检测一个或多个介质或磁性颗粒并区分不同类型的颗粒与IC芯片集成的微流体系统有助于引入和去除悬浮在由IC芯片产生的流体图案化的电场或磁场可以捕获并移动微流体系统内的生物细胞或其他物体。场产生组件也可以应用于产生不同频率的信号以测量感兴趣对象的共振特征

4. 发明申请

WO2006076380A3 MEDIA STORAGE ORGANIZER AND METHOD FOR USING SAME 审中-公开
标题翻译：媒体存储组织及其使用方法
公开(公告)号：WO2006076380A3
公开(公告)日：2009-04-16
申请号：PCT/US2006000858
申请日：2006-01-10
申请人： SPECTRUM CONCEPTS INC , HUNT THOMAS
发明人： HUNT THOMAS
IPC分类号： A47G29/00
CPC分类号： G11B33/0461
摘要： A media storage organizer and method as disclosed relate to a storage device for attachment to a support structure to hold a collection of media objects in a side-by-side generally upright manner. At least one organizer mount secures a media object support transversely to the support structure and helps the support to move along a path of travel generally parallel to the plane of the media objects. A stop limits the forward movement of the support to a display position. In one embodiment, at lease one retainer may be disposed above the media object support and spaced from an end thereof for engaging a media object to help limit the number of media objects positioned on the media object support. The retainer enables the media object to lean at an angle over the retainer against the support structure while engaging the retainer, thereby providing a gap between two portions of the collection of media objects to facilitate viewing of the faces of a media object at the gap and to facilitate flipping of the media objects about their bottom edges for media object selection purposes.
摘要翻译：所公开的介质存储组织器和方法涉及一种用于附接到支撑结构以将大致直立方式并排的介质物体的集合保持的存储装置。至少一个组织器支架横向于支撑结构固定介质对象支撑，并帮助支撑件沿着大致平行于介质物体的平面的行进路径移动。停止将支撑件向前移动限制到显示位置。在一个实施例中，至少一个保持器可以设置在介质对象支撑件上方并与其端部间隔开以接合介质对象以帮助限制定位在介质对象支撑件上的介质对象的数量。保持器使得媒体对象能够在与保持器接合的同时以一定角度倾斜在支撑结构上，从而在媒体对象集合的两个部分之间提供间隙，以便于在间隙处观看媒体对象的面部，并且以便于介质物体围绕其底部边缘的翻转，用于媒体对象选择目的。

5. 发明申请

WO2004104298A3 SINGLE PLY TISSUE PRODUCTS SURFACE TREATED WITH A SOFTENING AGENT 审中-公开
标题翻译：单面组织产品表面处理与软化剂
公开(公告)号：WO2004104298A3
公开(公告)日：2005-09-09
申请号：PCT/US2004006913
申请日：2004-03-04
申请人： KIMBERLY CLARK CO , LIU KOU-CHANG , SHANNON TOM G , ALLEN PETER J , CARLOW GEOF , GOULET MIKE , BURDEN PAUL , AYKENS GREG , CAPIZZI JOE , HUNT THOMAS , LINSKENS DIANE , WENDLER ROGER , WNEK JOHN
发明人： LIU KOU-CHANG , SHANNON TOM G , ALLEN PETER J , CARLOW GEOF , GOULET MIKE , BURDEN PAUL , AYKENS GREG , CAPIZZI JOE , HUNT THOMAS , LINSKENS DIANE , WENDLER ROGER , WNEK JOHN
IPC分类号： B05B7/08 , B05B15/02 , B05C5/02 , B32B29/00 , D21H17/59 , D21H21/22 , D21H21/24 , D21H23/50 , D21H27/00 , D21H27/30
CPC分类号： D21H21/24 , B05B7/0807 , B05B15/0208 , B05B15/0258 , B05C5/027 , D21H17/59 , D21H23/50 , D21H27/008 , Y10T428/24463 , Y10T428/31971 , Y10T428/31975 , Y10T428/31978 , Y10T428/31986 , Y10T428/31993
摘要： Tissue products are described that have been topically treated with a chemical additive, such as a softener. The softener may be, for instance, a polysiloxane. The polysiloxane is topically applied to a tissue sheet, such as a single ply sheet, so as to form a Z-directional gradient in the sheet. Particular, most of the polysiloxane remains on the surface of the tissue product as opposed to migrating to the center of the sheet. In this manner, tissue sheets are formed with improved softness at lower levels of polysiloxane and without the need for applying any surfactants to the sheet. A system for applying chemical additives to tissue sheets is also described. The system includes a chemical additive applicator, such as a meltblown die that emits the chemical additive through a plurality of orifices. In one embodiment, the system includes a device for periodically cleaning the orifices during application of the chemical additive. The cleaning device may be, for instance, a brush that traverses across the die head when desired.
摘要翻译：已经描述了已经用诸如软化剂的化学添加剂局部处理的组织产品。软化剂可以是例如聚硅氧烷。将聚硅氧烷局部施加到诸如单层片材的薄页纸上，以在片材中形成Z方向的梯度。特别地，大多数聚硅氧烷保留在组织产品的表面上，而不是迁移到片材的中心。以这种方式，在较低水平的聚硅氧烷下形成具有改善的柔软度的薄页纸，并且不需要对片材施加任何表面活性剂。还描述了一种将化学添加剂施加到薄页纸上的系统。该系统包括化学添加剂施加器，例如通过多个孔排放化学添加剂的熔喷模头。在一个实施例中，系统包括用于在施加化学添加剂期间周期性地清洁孔的装置。清洁装置可以是例如当期望穿过模头时的刷子。

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