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1. 发明申请

WO2012078843A3 MULTI-PATH, MULTI-MAGNIFICATION, NON-CONFOCAL FLUORESCENCE EMISSION ENDOSCOPY APPARATUS AND METHODS 审中-公开
公开(公告)号：WO2012078843A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/063909
申请日：2011-12-08
申请人： CORNELL UNIVERSITY , XU, Chunhui (Chris) , WEBB, Watt W. , SCHERR, Douglas S. , OUZOUNOV, Dimitre Gueorguiev , RIVERA, David R. , BROWN, Christopher M. , KOBAT, Demirhan , HULAND, David , HOWARD, Scott S.
发明人： XU, Chunhui (Chris) , WEBB, Watt W. , SCHERR, Douglas S. , OUZOUNOV, Dimitre Gueorguiev , RIVERA, David R. , BROWN, Christopher M. , KOBAT, Demirhan , HULAND, David , HOWARD, Scott S.
IPC分类号： A61B1/273 , A61B1/07 , A61B1/012
摘要： An optical scanner, scanner apparatus, or scanner assembly,which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.

2. 发明申请

WO2011091340A1 MULTI-FOCAL OPTICAL COMPONENT, OPTICAL SYSTEM, AND IMAGING METHOD 审中-公开
标题翻译：多功能光学元件，光学系统和成像方法
公开(公告)号：WO2011091340A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/022186
申请日：2011-01-24
申请人： CORNELL UNIVERSITY , WEBB, Watt W. , XU, Chris , CHEN, Minghan
发明人： WEBB, Watt W. , XU, Chris , CHEN, Minghan
IPC分类号： G02B3/00 , A61B1/005 , A61B1/002 , G02B21/00 , G01J1/58 , G01N21/64
CPC分类号： A61B1/00188 , A61B1/00172 , A61B1/043 , A61B5/0068 , A61B5/0084 , G02B3/10 , G02B21/0028 , G02B23/2423
摘要： An optical lens comprising a lens body that transmits light in an optical path there through, wherein the lens body consists of an anterior surface, a posterior surface, and a medium there between, further wherein one of the anterior surface and the posterior surface has a single curvature and the other of the anterior surface and the posterior surface has at least two optical zones each having a different curvature. An optical system, comprising a multi-photon endoscope having a distal end, and the optical lens disposed in the distal end. A method for obtaining an image of an object comprising providing the multi-photon endoscope, propagating light from the endoscope scanner one optical zone of the lens to focus the light at a focus location, and propagating light from the scanner through a different optical zones of the lens to focus the light at a different focus location.
摘要翻译：一种光学透镜，包括透光体，所述透镜体通过其中的光路传播光，其中所述透镜体由前表面，后表面和其间的介质组成，其中所述前表面和所述后表面之一具有单曲率和前表面和后表面中的另一个具有至少两个具有不同曲率的光学区域。一种光学系统，包括具有远端的多光子内窥镜和设置在远端的光学透镜。一种用于获得对象的图像的方法，包括提供多光子内窥镜，将来自内窥镜扫描仪的光传播到透镜的一个光学区域，以将光聚焦在聚焦位置，并且将来自扫描仪的光传播通过不同的光学区域镜头将光线聚焦在不同的焦点位置。

3. 发明申请

WO2009064746A3 MULTI-PATH, MULTI-MAGNIFICATION, NON-CONFOCAL FLUORESCENCE EMISSION ENDOSCOPY APPARATUS AND METHODS 审中-公开
标题翻译：多路径，多倍放大，非共焦荧光发射内窥镜装置和方法
公开(公告)号：WO2009064746A3
公开(公告)日：2009-07-16
申请号：PCT/US2008083164
申请日：2008-11-12
申请人： UNIV CORNELL , WEBB WATT W , XU CHRIS
发明人： WEBB WATT W , XU CHRIS
IPC分类号： A61B1/00 , A61B1/07
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00165 , A61B1/00172 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0062 , A61B5/0086 , G02B13/146 , G02B21/04 , G02B23/243 , G02B26/103
摘要： Embodiments of the invention include an optical system and an optical system module, coupled to a distal end of a fluorescence emission endoscope apparatus, an optical waveguide-based fluorescence emission endoscopy system, and a method for remotely- controlled, multi -magnification imaging of a target or fluorescence emission collection from a target with a fluorescence emission endoscope apparatus. An exemplary system includes an objective lens disposed in a distal end of an endoscope apparatus. The lens is adapted to transmit both a visible target illumination and a fluorescence-emission-inducing target illumination as well as fluorescence-emission and visible light from the target. Thee system can thus simultaneously provide low magnification, large field of view imaging and high magnification, high-resolution multiphoton imaging with a single lens system.
摘要翻译：本发明的实施例包括耦合到荧光发射内窥镜设备的远端的光学系统和光学系统模块，基于光波导的荧光发射内窥镜系统以及用于远程控制的多图像缩放成像的方法用荧光发射内窥镜装置从目标收集目标或荧光发射。示例性系统包括设置在内窥镜设备的远端中的物镜。该透镜适于传输可见目标照明和荧光发射诱导目标照明以及来自目标的荧光发射和可见光。因此，您的系统可以同时提供低倍率，大视场成像和高倍率，高分辨率的多光子成像与单镜头系统。

4. 发明申请

WO2012078843A2 MULTI-PATH, MULTI-MAGNIFICATION, NON-CONFOCAL FLUORESCENCE EMISSION ENDOSCOPY APPARATUS AND METHODS 审中-公开
标题翻译：多途径，多重放大，非共焦荧光发射内窥镜装置及方法
公开(公告)号：WO2012078843A2
公开(公告)日：2012-06-14
申请号：PCT/US2011063909
申请日：2011-12-08
申请人： UNIV CORNELL , XU CHUNHUI CHRIS , WEBB WATT W , SCHERR DOUGLAS S , OUZOUNOV DIMITRE GUEORGUIEV , RIVERA DAVID R , BROWN CHRISTOPHER M , KOBAT DEMIRHAN , HULAND DAVID , HOWARD SCOTT S
发明人： XU CHUNHUI CHRIS , WEBB WATT W , SCHERR DOUGLAS S , OUZOUNOV DIMITRE GUEORGUIEV , RIVERA DAVID R , BROWN CHRISTOPHER M , KOBAT DEMIRHAN , HULAND DAVID , HOWARD SCOTT S
CPC分类号： A61B5/0071 , A61B1/005 , A61B1/313 , A61B5/0062 , A61B5/0068 , A61B5/0084 , A61B90/20 , G01N21/645 , G01N2021/6484
摘要： An optical scanner, scanner apparatus, or scanner assembly,which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.
摘要翻译：可能特别有利于在多光子显微镜中使用的光学扫描器，扫描器装置或扫描器组件包括第一可驱动弯曲部件，垂直于第一部件安装的第二可驱动弯曲部件，以及至少一个光波导件或所述第一和第二弯曲部件两者，其中所述至少一个光波导提供用于在光源和靶之间的多光子激发辐射传递的传播路径和在所述目标和检测器之间的多光子诱发的发射辐射传递。 GRIN继电器镜头。包含扫描仪和GRIN中继透镜的多光子显微镜。

5. 发明申请

WO2004074504A3 FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开
公开(公告)号：WO2004074504A3
公开(公告)日：2004-09-02
申请号：PCT/US2003/037963
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , WIESNER, Ulrich , OW, Hooisweng , LARSON, Daniel, E. , WEBB, Watt, W.
发明人： WIESNER, Ulrich , OW, Hooisweng , LARSON, Daniel, E. , WEBB, Watt, W.
IPC分类号： B32B5/16
摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.

6. 发明申请

WO2009064753A1 NON-IMAGING, WEAKLY FOCUSED FLUORESCENCE EMISSION APPARATUS AND METHODS 审中-公开
标题翻译：非成像，弱荧光荧光发射装置和方法
公开(公告)号：WO2009064753A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083174
申请日：2008-11-12
申请人： CORNELL UNIVERSITY , WEBB, Watt W. , XU, Chris
发明人： WEBB, Watt W. , XU, Chris
IPC分类号： A61B5/00 , A61B5/048 , A61B5/05
CPC分类号： A61B5/0059 , A61B5/4088 , G01N21/6428
摘要： Apparatus and methods relating to non-imaging, multiphoton fluorescence and optical second harmonic generation (SHG) (and higher harmonic generation) emission and detection. A weakly focused excitation beam is used to generate fluorescence emission in a volume of between about 0.1 cm 3 to one cubic centimeter (1 cm 3 ), which is significantly larger than the conventional MPM focal volume. A method for shaping and/or controlling (confining) the focal volume of a non-imaging, fluorescence emission excitation field in a target medium involves decoupling the axial dimension dependence of the focal volume from the lateral spot size of the excitation field. The method involves the step of spatially separating at least some of the spectral components of a short duration, multichromatic excitation field outside of the focal volume and spatially recombining the spectral components in a short duration, high intensity, weakly focused field incident on the target medium. The apparatus and methods described herein are particularly suitable for, but not limited to, non-invasive, in-vivo biological assay and disease state indication in target tissue and, more particularly, to potential early detection of Alzheimer's and other diseases.
摘要翻译：与非成像，多光子荧光和光二次谐波产生（SHG）（和高次谐波产生）发射和检测相关的装置和方法。使用弱聚焦的激发光束产生体积在约0.1cm 3至1立方厘米（1cm 3）之间的荧光发射，其明显大于常规MPM焦点体积。用于成形和/或控制（限制）目标介质中的非成像荧光发射激发场的焦点体积的方法包括将焦点体积的轴向尺寸依赖性与激励场的横向光点尺寸相分离。该方法包括将聚焦体外外的短持续时间多色激发场中的至少一些光谱分量空间分离的步骤，并且在入射到目标介质上的短持续时间，高强度，弱聚焦场中空间重组光谱分量。本文描述的装置和方法特别适用于但不限于靶组织中的非侵入性，体内生物测定和疾病状态指示，更具体地说，涉及阿尔茨海默病和其他疾病的潜在早期检测。

7. 发明申请

WO2009064746A2 MULTI-PATH, MULTI-MAGNIFICATION, NON-CONFOCAL FLUORESCENCE EMISSION ENDOSCOPY APPARATUS AND METHODS 审中-公开
标题翻译：多途径，多重放大，非共焦荧光发射内窥镜装置及方法
公开(公告)号：WO2009064746A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083164
申请日：2008-11-12
申请人： CORNELL UNIVERSITY , WEBB, Watt, W. , XU, Chris
发明人： WEBB, Watt, W. , XU, Chris
IPC分类号： A61B1/00 , A61B1/07
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00165 , A61B1/00172 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0062 , A61B5/0086 , G02B13/146 , G02B21/04 , G02B23/243 , G02B26/103
摘要： Embodiments of the invention include an optical system and an optical system module, coupled to a distal end of a fluorescence emission endoscope apparatus, an optical waveguide-based fluorescence emission endoscopy system, and a method for remotely- controlled, multi -magnification imaging of a target or fluorescence emission collection from a target with a fluorescence emission endoscope apparatus. An exemplary system includes an objective lens disposed in a distal end of an endoscope apparatus. The lens is adapted to transmit both a visible target illumination and a fluorescence-emission-inducing target illumination as well as fluorescence-emission and visible light from the target. Thee system can thus simultaneously provide low magnification, large field of view imaging and high magnification, high-resolution multiphoton imaging with a single lens system.
摘要翻译：本发明的实施例包括耦合到荧光发射内窥镜装置的远端的光学系统和光学系统模块，基于光波导的荧光发射内窥镜检查系统，以及用于远程控制的多放大成像用荧光发射内窥镜装置从靶标靶或荧光发射采集。示例性系统包括设置在内窥镜装置的远端中的物镜。透镜适于透射可见目标照明和荧光发射诱导目标照明以及来自靶的荧光发射和可见光。因此，您可以通过单个透镜系统同时提供低倍率，大视野成像和高倍率，高分辨率多光子成像。

8. 发明申请

WO2004074504A2 FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开
标题翻译：荧光硅基纳米粒子
公开(公告)号：WO2004074504A2
公开(公告)日：2004-09-02
申请号：PCT/US0337963
申请日：2003-11-26
申请人： CORNELL RES FOUNDATION INC , WIESNER ULRICH , OW HOOISWENG , LARSON DANIEL E , WEBB WATT W
发明人： WIESNER ULRICH , OW HOOISWENG , LARSON DANIEL E , WEBB WATT W
IPC分类号： G01N33/50 , G01N33/58 , C12Q
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.
摘要翻译：本发明总体上涉及荧光纳米颗粒，更具体地涉及具有共价连接的有机染料的小于30nm的基于二氧化硅的荧光纳米颗粒。本发明提供包含荧光团中心核和二氧化硅壳的荧光单分散二氧化硅纳米粒子，其中纳米粒子的辐射特性取决于核的化学（组成）和二氧化硅壳的存在。在本发明的一个方面中，核 - 壳结构提供荧光量子效率的增强。本发明通常提供对包封在二氧化硅颗粒内的染料分子的光物理性质的控制，其尺寸低至30nm及以下。这种控制是通过改变二氧化硅化学和纳米尺寸的粒子结构来实现的，并且与游离染料相比导致明显的亮度增强。

9. 发明申请

WO1997011355A1 MULTI-PHOTON LASER MICROSCOPY 审中-公开
标题翻译：多光子激光显微镜
公开(公告)号：WO1997011355A1
公开(公告)日：1997-03-27
申请号：PCT/US1996014519
申请日：1996-09-18
申请人： CORNELL RESEARCH FOUNDATION, INC. , WEBB, Watt, W. , XU, Chris
发明人： CORNELL RESEARCH FOUNDATION, INC.
IPC分类号： G01N21/64
CPC分类号： G02B21/002 , G01N21/6458 , G02B21/0076 , G02B21/0084
摘要： A laser scanning micrsocope (10) produces molecular excitation in a target material (14) by simultaneous absorption of three or more photons to thereby provide intrinsic three-dimensional resolution. Fluorophores having single photon absorption in the short (ultraviolet or visible) wavelength range are excited by a beam (16) of strongly focused subpicosecond pulses of laser light of relatively long (red or infrared) wavelength range. The fluorophores absorb at about one third, one fourth or even smaller fraction of the laser wavelength to produce fluoroscent images of living cells and other microscopic objects. The fluoroscent emission from the fluorophores increases cubicly, quarticly or even higher power law with the excitation intensity so that by focusing the laser light, fluorescence as well as photobleaching are confined to the vicinity of the focal plane. This feature provides depth of field resolution comparable to that produced by confocal laser scanning microscopes, and in addition reduces photobleaching and phototoxicity.
摘要翻译：激光扫描微透镜（10）通过同时吸收三个或更多个光子在目标材料（14）中产生分子激发，从而提供固有的三维分辨率。在短（紫外或可见）波长范围内具有单光子吸收的荧光团由具有相对较长（红色或红外）波长范围的激光的强烈聚焦的亚秒脉冲的光束（16）激发。荧光团吸收激光波长的约三分之一，四分之一甚至更小的部分，以产生活细胞和其他微观物体的荧光图像。来自荧光团的荧光发射随着激发强度增加立方，四方或甚至更高的幂定律，使得通过聚焦激光，荧光和光漂白被限制在焦平面附近。该特征提供了与共焦激光扫描显微镜产生的景深相当的景深分辨率，并且还减少了光漂白和光毒性。

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