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1. 发明申请

WO2009064746A3 MULTI-PATH, MULTI-MAGNIFICATION, NON-CONFOCAL FLUORESCENCE EMISSION ENDOSCOPY APPARATUS AND METHODS 审中-公开
标题翻译：多路径，多倍放大，非共焦荧光发射内窥镜装置和方法
公开(公告)号：WO2009064746A3
公开(公告)日：2009-07-16
申请号：PCT/US2008083164
申请日：2008-11-12
申请人： UNIV CORNELL , WEBB WATT W , XU CHRIS
发明人： WEBB WATT W , XU CHRIS
IPC分类号： A61B1/00 , A61B1/07
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00165 , A61B1/00172 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0062 , A61B5/0086 , G02B13/146 , G02B21/04 , G02B23/243 , G02B26/103
摘要： Embodiments of the invention include an optical system and an optical system module, coupled to a distal end of a fluorescence emission endoscope apparatus, an optical waveguide-based fluorescence emission endoscopy system, and a method for remotely- controlled, multi -magnification imaging of a target or fluorescence emission collection from a target with a fluorescence emission endoscope apparatus. An exemplary system includes an objective lens disposed in a distal end of an endoscope apparatus. The lens is adapted to transmit both a visible target illumination and a fluorescence-emission-inducing target illumination as well as fluorescence-emission and visible light from the target. Thee system can thus simultaneously provide low magnification, large field of view imaging and high magnification, high-resolution multiphoton imaging with a single lens system.
摘要翻译：本发明的实施例包括耦合到荧光发射内窥镜设备的远端的光学系统和光学系统模块，基于光波导的荧光发射内窥镜系统以及用于远程控制的多图像缩放成像的方法用荧光发射内窥镜装置从目标收集目标或荧光发射。示例性系统包括设置在内窥镜设备的远端中的物镜。该透镜适于传输可见目标照明和荧光发射诱导目标照明以及来自目标的荧光发射和可见光。因此，您的系统可以同时提供低倍率，大视场成像和高倍率，高分辨率的多光子成像与单镜头系统。

2. 发明申请

WO2012134427A3 FLUORESCENCE IMAGING APPARATUS AND METHOD 审中-公开
标题翻译：荧光成像装置及方法
公开(公告)号：WO2012134427A3
公开(公告)日：2012-12-27
申请号：PCT/US2011022193
申请日：2011-01-24
申请人： UNIV CORNELL , XU CHRIS , HOWARD SCOTT , STRAUB ADAM , ZHU GUANGHAO
发明人： XU CHRIS , HOWARD SCOTT , STRAUB ADAM , ZHU GUANGHAO
IPC分类号： G01N21/64 , G01B9/04
CPC分类号： G01N21/64 , G01N21/6408 , G01N21/6456 , G02F1/01
摘要： A fluorescence emission imaging method and apparatus allows for high frame rate imaging in scattering medium as well as for fluorescence, phosphorescence, or luminescence lifetime imaging, time-resolved fluorescence, phosphorescence, or luminescence lifetime spectroscopy and imaging. A method involves providing an illumination beam, propagating the illumination beam to a light modulator array, modulating the illumination beam so as to generate an array of point sources, wherein each of the point sources is modulated at a frequency, imaging the modulated illumination beam on the object, and detecting a fluorescent, phosphorescent, or luminescent emission from the object. An optical imaging component in the form of a modulation mask has multiple bands. Each band has alternating transmissive and/or reflective and/or absorptive regions that are patterned such that light scanned over a band will be modulated at a band-related frequency.
摘要翻译：荧光发射成像方法和装置允许散射介质中的高帧率成像以及荧光，磷光或发光寿命成像，时间分辨荧光，磷光或发光寿命光谱和成像。一种方法包括提供照明光束，将照明光束传播到光调制器阵列，调制照明光束以产生点光源阵列，其中每个点光源以一个频率被调制，对被调制的照明光束进行成像并且检测来自物体的荧光，磷光或发光发射。调制掩模形式的光学成像部件具有多个带。每个带具有交替的透射和/或反射和/或吸收区域，其被图案化，使得在频带上扫描的光将以带相关频率被调制。

3. 发明申请

WO2008052153A3 PRODUCTION OF OPTICAL PULSES AT A DESIRED WAVELENGTH USING SOLITON SELF-FREQUENCY SHIFT 审中-公开
标题翻译：使用SOLITON自拍移位在所需波长下生产光学脉冲
公开(公告)号：WO2008052153A3
公开(公告)日：2008-06-26
申请号：PCT/US2007082623
申请日：2007-10-26
申请人： CORNELL RES FOUNDATION INC , XU CHRIS , VAN HOWE JAMES
发明人： XU CHRIS , VAN HOWE JAMES
IPC分类号： G02F1/035
CPC分类号： G02F1/3513 , G01N21/6408 , G01N21/6458 , G01N2021/653 , G01N2201/0696 , G02B6/02009 , G02B6/02214 , G02B6/03644 , G02B21/06 , G02B21/16 , G02F2203/17 , G02F2203/26 , G02F2203/54
摘要： An apparatus for producing optical pulses of a desired wavelength includes an optical pulse source operable to generate input optical pulses at a first wavelength, and a higher order mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by soliton self-frequency shift (SSFS). The present invention also relates to a method of producing optical pulses having a desired wavelength. This method includes generating input optical pulses using an optical pulse source, where the input optical pulses have a fist wavelength and a first spatial mode. The input optical pulses are delivered into an HOM fiber module to alter the wavelength of the input optical pulses from the first wavelength to a desired wavelength by soliton serf-frequency shift (SSFS) within the HOM fiber module, thereby producing output optical pulses having the desired wavelength.
摘要翻译：用于产生所需波长的光脉冲的装置包括可用于产生第一波长的输入光脉冲的光脉冲源和可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，此后通过孤子自频移（SSFS）产生所需波长的输出光脉冲。本发明还涉及一种产生具有所需波长的光脉冲的方法。该方法包括使用光脉冲源产生输入光脉冲，其中输入光脉冲具有第一波长和第一空间模式。输入光脉冲被输送到HOM光纤模块中，以通过HOM光纤模块内的孤子serf-frequency shift（SSFS）将输入光脉冲的波长从第一波长改变到期望的波长，从而产生具有所需波长。

4. 发明申请

WO2006093962A3 SIMULTANEOUS SPATIAL AND TEMPORAL FOCUSING OF FEMTOSECOND PULSES 审中-公开
标题翻译：同时空间和时间聚焦的FEMTOSECOND脉冲
公开(公告)号：WO2006093962A3
公开(公告)日：2008-05-15
申请号：PCT/US2006007088
申请日：2006-03-01
申请人： CORNELL RES FOUNDATION INC , ZHU GUANGHAO , XU CHRIS
发明人： ZHU GUANGHAO , XU CHRIS
IPC分类号： G02B27/10 , G01B11/24 , G01J3/30 , G02B1/10 , G02B5/28 , G02B27/44 , G02B27/46 , H04J14/02
CPC分类号： G02B21/06 , G02B21/16
摘要： A technique for simultaneous spatial and temporal focusing of femtosecond pulses improves the signal-to-background ratio (SBR) in multiphoton imaging. This is achieved by spatially separating spectral components of pulses into a "rainbow beam" and recombining these components at the spatial focus of an imaging system (100). The temporal pulse width becomes a function of distance, with the shortest pulse width confined to the spatial focus. The technique can significantly improve the axial confinement and reduce the background excitation in multiphoton microscopy, and thereby increase the imaging depth in highly scattering biological specimens.
摘要翻译：飞秒脉冲同时空间和时间聚焦的技术提高了多光子成像中的信号背景比（SBR）。这通过将脉冲的频谱分量空间分离成“彩虹波束”并在成像系统（100）的空间焦点处重组这些分量来实现。时间脉冲宽度成为距离的函数，其中最短的脉冲宽度限于空间焦点。该技术可以显着改善轴向限制，并减少多光子显微镜中的背景激发，从而增加高散射生物样本中的成像深度。

5. 发明申请

WO2006102074A2 ALL-OPTICAL, CONTINUOUSLY TUNABLE, PULSE DELAY GENERATOR USING WAVELENGTH CONVERSION AND DISPERSION 审中-公开
标题翻译：全光，连续可调，使用波长转换和分散的脉冲延迟发生器
公开(公告)号：WO2006102074A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009703
申请日：2006-03-17
申请人： CORNELL RES FOUNDATION INC , GAETA ALEXANDER , SHARPING JAY E , XU CHRIS
发明人： GAETA ALEXANDER , SHARPING JAY E , XU CHRIS
IPC分类号： G02B1/10
CPC分类号： G02F1/39 , G02F2201/20
摘要： A technique for generating variable pulse delays uses one or more nonlinear-optical processes such as cross-phase modulation, cross-gain modulation, self-phase modulation, four-wave mixing or parametric mixing, combined with group-velocity dispersion. The delay is controllable by changing the wavelength and/or power of a control laser. The delay is generated by introducing a controllable wavelength shift to a pulse of light, propagating the pulse through a material or an optical component that generates a wavelength dependent time delay, and wavelength shifting again to return the pulse to its original wavelength.
摘要翻译：用于产生可变脉冲延迟的技术使用一个或多个非线性光学过程，例如跨相位调制，交叉增益调制，自相位调制，四波混频或参数混合，与组速度色散组合。通过改变控制激光器的波长和/或功率可以控制延迟。通过将可控波长移位引入到光脉冲中，将脉冲传播通过产生波长相关时间延迟的材料或光学部件，再次进行波长偏移以将脉冲返回到其原始波长来产生延迟。

6. 发明申请

WO2008052155A3 SYSTEM FOR PRODUCING OPTICAL PULSES OF A DESIRED WAVELENGTH USING CHERENKOV RADIATION 审中-公开
标题翻译：使用CHERENKOV辐射产生所需波长的光学脉冲的系统
公开(公告)号：WO2008052155A3
公开(公告)日：2008-08-07
申请号：PCT/US2007082625
申请日：2007-10-26
申请人： CORNELL RES FOUNDATION INC , XU CHRIS , VAN HOWE JAMES , LEE JENNIFER
发明人： XU CHRIS , VAN HOWE JAMES , LEE JENNIFER
IPC分类号： H01S3/30
CPC分类号： G02F1/3513 , G01N21/6408 , G01N21/6458 , G01N2021/653 , G01N2201/0696 , G02B6/02009 , G02B6/02214 , G02B6/03644 , G02B21/06 , G02B21/16 , G02F2203/17 , G02F2203/26 , G02F2203/54
摘要： The present invention includes an apparatus and method for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher-order-mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by exciting Cherenkov radiation using the input optical pulses. The present invention also relates to a method of producing optical pulses having a desired wavelength, where the input optical pulses have a first wavelength and a first spatial mode and the output optical pulses have a second wavelength and a second spatial mode, which may be converted to another spatial mode.
摘要翻译：本发明包括用于产生所需波长的光脉冲的装置和方法。该装置包括可用于产生第一波长的输入光脉冲的光脉冲源。该装置还包括可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，此后通过使用输入光脉冲激发切伦科夫辐射来产生所需波长的输出光脉冲。本发明还涉及一种产生具有期望波长的光脉冲的方法，其中输入光脉冲具有第一波长和第一空间模式，并且输出光脉冲具有第二波长和第二空间模式，其可被转换到另一个空间模式。

7. 发明申请

WO2011163353A3 ON-DEMAND DUAL FREQUENCY LASER SOURCES FOR NON-LINEAR OPTICAL MICROSCOPY AND MICRO-SPECTROSCOPY IMAGING SYSTEMS 审中-公开
标题翻译：用于非线性光学显微镜和微光谱成像系统的双频激光源
公开(公告)号：WO2011163353A3
公开(公告)日：2012-02-23
申请号：PCT/US2011041441
申请日：2011-06-22
申请人： HARVARD COLLEGE , CORNELL RES FOUNDATION INC , XU CHRIS , XIE XIAOLIANG SUNNEY , FREUDIGER CHRISTIAN W , WANG KE , SAAR BRIAN G , LEE JENNIFER H
发明人： XU CHRIS , XIE XIAOLIANG SUNNEY , FREUDIGER CHRISTIAN W , WANG KE , SAAR BRIAN G , LEE JENNIFER H
IPC分类号： G01J3/10 , G01N21/01
CPC分类号： G01N21/65 , G01J3/10 , G01N2021/655
摘要： An illumination system is disclosed for use in non-linear modulation transfer microscopy and micro-spectroscopy. The illumination system includes a laser system for providing a first train of pulses at a center optical frequency ?1, and an optical assembly for collinearly combining a first train of pulses with a second train of pulses having a center optical frequency of ?2 as synchronized excitation fields for non¬ linear modulation transfer microscopy and micro-spectroscopy. The laser system includes a continuous wave laser for providing a first continuous wave field, a first chirp modulator system comprising a means to receive the first continuous wave field, a means to receive a trigger signal, a first phase modulator and a first electro-optic modulator; and a first pulse compression unit.
摘要翻译：公开了用于非线性调制转移显微镜和微光谱的照明系统。照明系统包括用于提供中心光频率λ1的第一脉冲序列的激光系统，以及用于将第一脉冲串与第二脉冲序列共线组合的光学组件，所述第二脉冲序列具有同步的中心光频率ω2 用于非线性调制转移显微镜和微光谱的激发场。激光系统包括用于提供第一连续波场的连续波激光器，包括接收第一连续波场的装置的第一线性调频系统，接收触发信号的装置，第一相位调制器和第一电光调制器; 和第一脉冲压缩单元。

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