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1. 发明申请

WO2011091340A1 MULTI-FOCAL OPTICAL COMPONENT, OPTICAL SYSTEM, AND IMAGING METHOD 审中-公开
标题翻译：多功能光学元件，光学系统和成像方法
公开(公告)号：WO2011091340A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/022186
申请日：2011-01-24
申请人： CORNELL UNIVERSITY , WEBB, Watt W. , XU, Chris , CHEN, Minghan
发明人： WEBB, Watt W. , XU, Chris , CHEN, Minghan
IPC分类号： G02B3/00 , A61B1/005 , A61B1/002 , G02B21/00 , G01J1/58 , G01N21/64
CPC分类号： A61B1/00188 , A61B1/00172 , A61B1/043 , A61B5/0068 , A61B5/0084 , G02B3/10 , G02B21/0028 , G02B23/2423
摘要： An optical lens comprising a lens body that transmits light in an optical path there through, wherein the lens body consists of an anterior surface, a posterior surface, and a medium there between, further wherein one of the anterior surface and the posterior surface has a single curvature and the other of the anterior surface and the posterior surface has at least two optical zones each having a different curvature. An optical system, comprising a multi-photon endoscope having a distal end, and the optical lens disposed in the distal end. A method for obtaining an image of an object comprising providing the multi-photon endoscope, propagating light from the endoscope scanner one optical zone of the lens to focus the light at a focus location, and propagating light from the scanner through a different optical zones of the lens to focus the light at a different focus location.
摘要翻译：一种光学透镜，包括透光体，所述透镜体通过其中的光路传播光，其中所述透镜体由前表面，后表面和其间的介质组成，其中所述前表面和所述后表面之一具有单曲率和前表面和后表面中的另一个具有至少两个具有不同曲率的光学区域。一种光学系统，包括具有远端的多光子内窥镜和设置在远端的光学透镜。一种用于获得对象的图像的方法，包括提供多光子内窥镜，将来自内窥镜扫描仪的光传播到透镜的一个光学区域，以将光聚焦在聚焦位置，并且将来自扫描仪的光传播通过不同的光学区域镜头将光线聚焦在不同的焦点位置。

2. 发明申请

WO2009064753A1 NON-IMAGING, WEAKLY FOCUSED FLUORESCENCE EMISSION APPARATUS AND METHODS 审中-公开
标题翻译：非成像，弱荧光荧光发射装置和方法
公开(公告)号：WO2009064753A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083174
申请日：2008-11-12
申请人： CORNELL UNIVERSITY , WEBB, Watt W. , XU, Chris
发明人： WEBB, Watt W. , XU, Chris
IPC分类号： A61B5/00 , A61B5/048 , A61B5/05
CPC分类号： A61B5/0059 , A61B5/4088 , G01N21/6428
摘要： Apparatus and methods relating to non-imaging, multiphoton fluorescence and optical second harmonic generation (SHG) (and higher harmonic generation) emission and detection. A weakly focused excitation beam is used to generate fluorescence emission in a volume of between about 0.1 cm 3 to one cubic centimeter (1 cm 3 ), which is significantly larger than the conventional MPM focal volume. A method for shaping and/or controlling (confining) the focal volume of a non-imaging, fluorescence emission excitation field in a target medium involves decoupling the axial dimension dependence of the focal volume from the lateral spot size of the excitation field. The method involves the step of spatially separating at least some of the spectral components of a short duration, multichromatic excitation field outside of the focal volume and spatially recombining the spectral components in a short duration, high intensity, weakly focused field incident on the target medium. The apparatus and methods described herein are particularly suitable for, but not limited to, non-invasive, in-vivo biological assay and disease state indication in target tissue and, more particularly, to potential early detection of Alzheimer's and other diseases.
摘要翻译：与非成像，多光子荧光和光二次谐波产生（SHG）（和高次谐波产生）发射和检测相关的装置和方法。使用弱聚焦的激发光束产生体积在约0.1cm 3至1立方厘米（1cm 3）之间的荧光发射，其明显大于常规MPM焦点体积。用于成形和/或控制（限制）目标介质中的非成像荧光发射激发场的焦点体积的方法包括将焦点体积的轴向尺寸依赖性与激励场的横向光点尺寸相分离。该方法包括将聚焦体外外的短持续时间多色激发场中的至少一些光谱分量空间分离的步骤，并且在入射到目标介质上的短持续时间，高强度，弱聚焦场中空间重组光谱分量。本文描述的装置和方法特别适用于但不限于靶组织中的非侵入性，体内生物测定和疾病状态指示，更具体地说，涉及阿尔茨海默病和其他疾病的潜在早期检测。

3. 发明申请

WO2012078843A3 MULTI-PATH, MULTI-MAGNIFICATION, NON-CONFOCAL FLUORESCENCE EMISSION ENDOSCOPY APPARATUS AND METHODS 审中-公开
公开(公告)号：WO2012078843A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/063909
申请日：2011-12-08
申请人： CORNELL UNIVERSITY , XU, Chunhui (Chris) , WEBB, Watt W. , SCHERR, Douglas S. , OUZOUNOV, Dimitre Gueorguiev , RIVERA, David R. , BROWN, Christopher M. , KOBAT, Demirhan , HULAND, David , HOWARD, Scott S.
发明人： XU, Chunhui (Chris) , WEBB, Watt W. , SCHERR, Douglas S. , OUZOUNOV, Dimitre Gueorguiev , RIVERA, David R. , BROWN, Christopher M. , KOBAT, Demirhan , HULAND, David , HOWARD, Scott S.
IPC分类号： A61B1/273 , A61B1/07 , A61B1/012
摘要： An optical scanner, scanner apparatus, or scanner assembly,which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.

4. 发明申请

WO2013170145A1 DUAL MODE MICROENDOSCOPE APPARATUS, METHOD AND APPLICATIONS 审中-公开
标题翻译：双模微观设备，方法与应用
公开(公告)号：WO2013170145A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040547
申请日：2013-05-10
申请人： CORNELL UNIVERSITY
发明人： OUZOUNOV, Dimitre G. , XU, Chunhui (Chris) , WEBB, Watt W.
IPC分类号： A61B1/00 , A61B1/07
CPC分类号： G02B23/2438 , A61B1/00096 , A61B1/00188 , A61B1/043 , A61B1/0638 , G02B17/0896 , G02B21/06 , G02B21/16
摘要： A microendoscope, and a microendoscopy method related to the microendoscope, each include a tube housing, where an end of the tube housing is shaped and finished to facilitate collection of light emitted from a sample when examined using the microendoscope. In addition, a catadioptric lens assembly, an endomicroscope that includes the catadioptric lens assembly and a microendoscopy method for microscopic analysis that uses the endomicroscope are predicated upon a second element and a third element within the catadioptric lens assembly that each has a dichroic coating. The placement of the dichroic coating on the second element and the third element provides for different magnification factors as a function of illumination wavelength when using the microendoscopy method.
摘要翻译：微型内窥镜和与内窥镜相关的微内窥镜检查方法各自包括管壳体，其中管壳体的端部成形和完成，以便当使用微型内窥镜检查时便于收集从样品发射的光。此外，反射折射透镜组件，包括反射折射透镜组件的内窥镜组件和使用内窥镜的微观分析的微内镜检查方法基于反射折射透镜组件内的每个具有二向色性涂层的第二元件和第三元件。当使用微内镜检查方法时，二向色涂层在第二元件和第三元件上的放置提供作为照明波长的函数的不同放大系数。

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