专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008034161A1 NEUROPROTECTIVE PEPTIDE INHIBITORS OF AP-1 SIGNALING AND USES THEREFOR 审中-公开
标题翻译： AP-1信号的神经保护肽抑制剂及其用途
公开(公告)号：WO2008034161A1
公开(公告)日：2008-03-27
申请号：PCT/AU2007/000092
申请日：2007-01-31
申请人： PHYLOGICA LIMITED , WATT, Paul , MILECH, Nadia , FEAR, Mark
发明人： WATT, Paul , MILECH, Nadia , FEAR, Mark
IPC分类号： C07K14/195 , A61P25/16 , C07K19/00 , A61K38/10 , A61P25/28 , C12N15/18 , A61K38/16 , C07K7/08 , C12N15/31 , A61P25/06 , C07K14/16 , C12N15/49 , A61P25/08 , C07K14/50
CPC分类号： C07K14/4703 , A61K38/00 , C07K2319/00
摘要： The present invention provides AP-1 signaling inhibitory peptides comprising the amino acid sequences of SEQ ID NOS: 28-31, 36-39, 45-48, 54-57 and 62-65, compositions comprising one or a plurality of said peptides, and methods of treatment of neurological disorders comprising the administration of the peptide(s) or compositions.
摘要翻译：本发明提供包含SEQ ID NO：28-31,36-39,45-48,54-57和62-65的氨基酸序列的AP-1信号传导抑制肽，包含一个或多个所述肽的组合物，以及治疗神经障碍的方法，包括施用肽或组合物。

2. 发明申请

WO2007097923A2 METHOD OF CONSTRUCTING AND SCREENING LIBRARIES OF PEPTIDE STRUCTURES 审中-公开
标题翻译：构建和筛选肽结构的方法
公开(公告)号：WO2007097923A2
公开(公告)日：2007-08-30
申请号：PCT/US2007003393
申请日：2007-02-07
申请人： PHYLOGICA LTD , WATT PAUL MICHAEL , DUNBRACK ROLAND
发明人： WATT PAUL MICHAEL , DUNBRACK ROLAND
IPC分类号： C40B40/10
CPC分类号： C07K1/047 , C07K1/00 , C07K7/08 , C07K14/001 , C12N15/1037 , C12N15/1072 , C12N15/1089 , C12Q1/18 , C40B30/02 , C40B40/10 , G01N33/6824 , G01N33/6845 , G01N2500/10 , G06F19/18 , G06F19/22
摘要： The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer -readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
摘要翻译：本发明提供用于生产用于药物筛选应用的肽结构库的方法，其能够独立于衍生自其的蛋白质中的人造支架或侧翼序列折叠或假定其天然构象。图书馆可以是高度多样化的，因为它们代表了自然界中存在的蛋白质结构的所有组成部分。这些库也可以是非冗余的或归一化的，使得存在于源数据集中和/或本质上的特定结构的偏移被删除。在特别优选的实施方案中，本发明提供了通过该方法制备的30,000个独立折叠结构。本发明还提供了包括与肽库相关的结构数据的计算机可读介质和系统，以及用于显示和筛选文库的方法。

3. 发明申请

WO2005123170A1 WOUND DRESSINGS FOR VACUUM THERAPY 审中-公开
标题翻译：创新疗法用于真菌治疗
公开(公告)号：WO2005123170A1
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002423
申请日：2005-06-20
申请人： ETHICON, INC. , WATT, Paul, William , GREGORY, Sara, Jayne , TROTTER, Patrick, John , SILCOCK, Derek, Walter , MARSDEN, Donald, Christopher
发明人： WATT, Paul, William , GREGORY, Sara, Jayne , TROTTER, Patrick, John , SILCOCK, Derek, Walter , MARSDEN, Donald, Christopher
IPC分类号： A61M27/00
CPC分类号： A61M27/00 , A61F13/0206 , A61F13/0213 , A61F13/0216 , A61F13/0226 , A61F2013/00165 , A61F2013/0017 , A61F2013/00536 , A61F2013/0091 , A61M1/0088 , A61M1/0092
摘要： A wound dressing for vacuum therapy comprising: a cover configured for placement over the wound to maintain a reduced pressure over the wound and adapted for communication with a source of vacuum, and a screen structure for placement between the cover and the wound, wherein the screen structure is adapted to remove or inactivate undesirable components from the wound environment and/or to concentrate desirable components present; in the wound environment. Also provided are kits for the assembly of such wound dressings, and systems comprising the wound dressings in combination with a source of vacuum.
摘要翻译： 1.一种用于真空治疗的伤口敷料，包括：盖，其构造成用于放置在伤口上以保持在伤口上的减压并适于与真空源连通，以及用于放置在盖和伤口之间的屏幕结构，其中屏幕结构适于从伤口环境中去除或灭活不需要的组分和/或浓缩存在的所需组分; 在伤口环境中。还提供了用于组装这种伤口敷料的套件，以及包括与真空源组合的伤口敷料的系统。

4. 发明申请

WO2005121803A1 MEASUREMENT OF CYTOSKELETAL PROTEINS AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND THERAPY 审中-公开
标题翻译：细胞因子蛋白质的测定及其在诊断，预防和治疗中的应用
公开(公告)号：WO2005121803A1
公开(公告)日：2005-12-22
申请号：PCT/GB2005/002256
申请日：2005-06-09
申请人： ETHICON, INC. , SHAH, Faraia , CLARK, Rachael , TROTTER, Patrick, John , WATT, Paul, William , CULLEN, Breda, Mary
发明人： SHAH, Faraia , CLARK, Rachael , TROTTER, Patrick, John , WATT, Paul, William , CULLEN, Breda, Mary
IPC分类号： G01N33/68
CPC分类号： G01N33/6893
摘要： The present invention relates to monitoring patients for an inflammatory condition or infection (preferably wound infection) by testing an extracellular fluid such as a wound fluid for an elevated level of: (i) vimentin; (ii) a vimentin breakdown product; or (iii) a marker indicative of the presence of vimentin. The present invention provides methods of diagnosis and prognosis, wound dressings, devices (e.g. biosensors) and kits for use in such methods.
摘要翻译：本发明涉及通过测试诸如伤口液的细胞外液体升高的水平来监测患者的炎症状况或感染（优选伤口感染）：（i）波形蛋白; （ii）波形蛋白分解产物; 或（iii）指示波形蛋白存在的标志物。本发明提供诊断和预后的方法，伤口敷料，用于这些方法的装置（例如生物传感器）和试剂盒。

5. 发明申请

WO2005016972A1 ANTIMICROBIAL POLYMERS 审中-公开
标题翻译：抗微生物聚合物
公开(公告)号：WO2005016972A1
公开(公告)日：2005-02-24
申请号：PCT/GB2004/003465
申请日：2004-08-12
申请人： ETHICON, INC. , ENGEL, Robert , COHEN, JaimeLee, Iolani , MELKONIAN, Karin , WATT, Paul
发明人： ENGEL, Robert , COHEN, JaimeLee, Iolani , MELKONIAN, Karin , WATT, Paul
IPC分类号： C08B37/00
CPC分类号： A01N43/90 , A01N43/32 , A01N57/36 , A61L15/28 , A61L15/46 , A61L2300/208 , A61L2300/216 , A61L2300/404 , C08B37/0084 , C08F8/44
摘要： The present invention is concerned with providing antimicrobial compounds and processes for the production thereof More particularly, the present invention provides antimicrobial polymeric materials comprising a polymer linked to a positively charged moiety via a carboxyl group. The present invention also provides processes for the production of such antimicrobial compounds and uses therefor.
摘要翻译：本发明涉及提供抗微生物化合物及其制备方法。更具体地说，本发明提供包含通过羧基与带正电荷部分连接的聚合物的抗微生物聚合材料。本发明还提供了生产这种抗微生物化合物的方法及其用途。

6. 发明申请

WO2004074472A1 MODULATING SCREENING THRESHOLDS FOR N-HYBRID SCREENING 审中-公开
标题翻译：调制N混合筛选筛选机
公开(公告)号：WO2004074472A1
公开(公告)日：2004-09-02
申请号：PCT/AU2004/000216
申请日：2004-02-20
申请人： PHYLOGICA LIMITED , WATT, Paul , HOPKINS, Richard , CULL, Vanessa , FEAR, Mark , MILECH, Nadia
发明人： WATT, Paul , HOPKINS, Richard , CULL, Vanessa , FEAR, Mark , MILECH, Nadia
IPC分类号： C12N15/09
CPC分类号： C12Q1/6811 , G01N2510/00
摘要： The present invention provides improved N-hybrid assays. In particular, the present invention provides an improved reverse N-hybrid assays comprising modulating the amount of a substrate of a reporter gene and/or the amount of a reporter gene thereby enhancing cell death in the absence of a peptide inhibitor of a DNA- protein or protein- protein interaction and/or enhancing cell survival in the presence of a peptide inhibitor of a DNA-protein or protein interaction. Furthermore, the present invention provides an improved forward N-hybrid assay comprising modulating the amount of a reporter gene thereby enhancing cell death in the absence of a heterologous peptide or protein capable of binding to the DNA or protein in a cell and enhancing cell survival in the presence of a heterologous peptide or protein capable of binding to the DNA or protein in a cell.
摘要翻译：本发明提供了改进的N-杂交试验。特别地，本发明提供了改进的逆N杂交测定法，其包括调节报告基因的底物量和/或报道基因的量，从而在不存在DNA-蛋白质的肽抑制剂的情况下增强细胞死亡或蛋白质 - 蛋白质相互作用和/或在DNA-蛋白质或蛋白质相互作用的肽抑制剂存在下增强细胞存活。此外，本发明提供改进的正向N-杂交测定法，其包括调节报道基因的量，从而在不存在能够结合细胞中的DNA或蛋白质的异源肽或蛋白质的情况下增强细胞死亡，并增强细胞存活能够结合细胞中的DNA或蛋白质的异源肽或蛋白质的存在。

7. 发明申请

WO1998000446A1 OXIDIZED OLIGOSACCHARIDES 审中-公开
标题翻译：氧化低聚物
公开(公告)号：WO1998000446A1
公开(公告)日：1998-01-08
申请号：PCT/GB1997001726
申请日：1997-06-27
申请人： JOHNSON & JOHNSON MEDICAL, INC. , DOYLE, Peter, John , SAFERSTEIN, Lowell , LORIMER, Elaine , WATT, Paul, William
发明人： JOHNSON & JOHNSON MEDICAL, INC.
IPC分类号： C08B37/00
CPC分类号： C08B15/04 , A61L15/28 , A61L15/44 , A61L15/46 , C07G3/00 , C08B11/20 , C08B15/00 , C08L1/04
摘要： The invention provides oligosaccharides having molecular weights in the range 1000 to 50,000 and obtained by partial hydrolysis of oxidized polysaccharides such as oxidized regenerated cellulose (ORC). The oligosaccharides are useful as or in wound dressings, and for binding peptides or proteins.
摘要翻译：本发明提供分子量在1000〜50,000之间的寡糖，并通过部分水解氧化多糖如氧化再生纤维素（ORC）而获得。寡糖可用作或在伤口敷料中，以及用于结合肽或蛋白质。

8. 发明申请

WO2005119244A9 PEPTIDE MODULATORS OF CELLULAR PHENOTYPE AND BI-NUCLEIC ACID FRAGMENT LIBRARY 审中-公开
标题翻译：细胞膜和二核酸片段图谱的肽调节剂
公开(公告)号：WO2005119244A9
公开(公告)日：2007-03-01
申请号：PCT/AU2005000801
申请日：2005-06-03
申请人： PHYLOGICA LTD , WATT PAUL MICHAEL , HOPKINS RICHARD , FEAR MARK , MILECH NADIA MARIAN DOROTHY
发明人： WATT PAUL MICHAEL , HOPKINS RICHARD , FEAR MARK , MILECH NADIA MARIAN DOROTHY
IPC分类号： G01N30/00 , C07H21/04 , C12N15/10 , G01N33/50
CPC分类号： G01N33/5008 , C12N15/1079
摘要： The present invention provides a non-hybrid screening method for the identification and/or isolation of a peptide that is capable of modulating a phenotype in a cell, tissue or organism. For example, the non-hybrid screening method identifies a peptide that is derived from an organism that is unrelated to the cell, tissue or organism. Alternatively, or in addition, the non-hybrid screening method identifies a peptide thaty is capable of rescuing the cell, tissue or organism from cell death or inducing a cell, tissue or organism to grow. The present invention also provides a non-hybrid screening method for identifying a peptide that is useful for treating a disease and/or disorder.
摘要翻译：本发明提供了用于鉴定和/或分离能够调节细胞，组织或生物体中的表型的肽的非混合筛选方法。例如，非混合筛选方法鉴定了衍生自与细胞，组织或生物体无关的生物体的肽。或者或另外，非混合筛选方法鉴定能够从细胞死亡或诱导细胞，组织或生物生长的细胞，组织或生物体拯救的肽。本发明还提供了用于鉴定可用于治疗疾病和/或病症的肽的非杂交筛选方法。

9. 发明申请

WO2005056066A3 PH DEPENDENT MEDICINAL COMPOSITIONS 审中-公开
标题翻译： PH依赖性药物组合物
公开(公告)号：WO2005056066A3
公开(公告)日：2005-09-15
申请号：PCT/GB2004005204
申请日：2004-12-08
申请人： ETHICON INC , TROTTER PATRICK , WATT PAUL , ENGEL ROBERT , MELKONIAN KARIN J , COHEN JAIMELEE IOLANI
发明人： TROTTER PATRICK , WATT PAUL , ENGEL ROBERT , MELKONIAN KARIN J , COHEN JAIMELEE IOLANI
IPC分类号： A61L15/20 , A61L26/00 , C07D487/08
CPC分类号： A61L15/20 , A61L26/008 , C07D487/08
摘要： The present invention provides a medicinal composition comprising water and a Ph-dependent gelling or thickening agent, whereby at 30 °C and pH about 11 the composition is substantially liquid, and at 30 °C and pH about 7 the composition is semi-solid. The invention further provides a thickening or gelling compound for use in a gelling composition as described herein.
摘要翻译：本发明提供了一种包含水和Ph-依赖性胶凝剂或增稠剂的医药组合物，其中在30℃和pH约11下该组合物基本上是液体，并且在30℃和pH约7下该组合物是半固体。本发明进一步提供用于本文所述的胶凝组合物中的增稠或胶凝化合物。

10. 发明申请

WO2005075015A1 TREATMENT DEVICE FOR WOUND THERAPY 审中-公开
标题翻译：治疗治疗设备
公开(公告)号：WO2005075015A1
公开(公告)日：2005-08-18
申请号：PCT/GB2005/000079
申请日：2005-01-12
申请人： ETHICON, INC. , GUNNIGLE, Stephen, Michael , GREGORY, Sarah-Jayne , NISBET, Lorraine , WATT, Paul, William
发明人： GUNNIGLE, Stephen, Michael , GREGORY, Sarah-Jayne , NISBET, Lorraine , WATT, Paul, William
IPC分类号： A61M35/00
CPC分类号： B65D83/30 , A61M35/003 , B05B1/28
摘要： A wound treatment device (1, 10) comprising a housing (2, 11) having a first opening and a second opening (6, 13), wherein the device further comprises an adhesive-coated flange (3, 12) around the first opening for attachment of the device around a wound to be treated, and wherein the second opening (6, 13) is adapted for attachment to an aerosol container (7).
摘要翻译：一种伤口治疗装置（1,10），包括具有第一开口和第二开口（6,13）的壳体（2,11），其中所述装置还包括围绕所述第一开口的粘合剂涂覆的凸缘（3,12）用于将装置附接在待处理的伤口周围，并且其中第二开口（6,13）适于附接到气溶胶容器（7）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式