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1. 发明申请

WO2013019733A3 METHODS, COMPOSITIONS AND KITS FOR THERAPEUTIC TREATMENT WITH WET SPUN MICROSTRUCTURES 审中-公开
公开(公告)号：WO2013019733A3
公开(公告)日：2013-06-06
申请号：PCT/US2012048860
申请日：2012-07-30
申请人： UNIV BROWN , MATHIOWITZ EDITH , LAVIN FORMERLY DECOTEAU DANYA , HOPKINS RICHARD
发明人： MATHIOWITZ EDITH , LAVIN FORMERLY DECOTEAU DANYA , HOPKINS RICHARD
IPC分类号： A61K47/48 , A61K9/14 , A61K9/16 , A61K31/573 , A61K47/30
CPC分类号： A61K31/573 , A61K9/0092 , A61K45/06 , A61L15/24 , A61L15/26 , A61L15/44 , A61L17/005 , A61L17/10 , A61L17/12 , A61L27/16 , A61L27/18 , A61L27/56 , A61L27/58 , A61L2300/43 , A61L2300/45 , A61L2300/61 , A61L2300/622 , C08L67/04 , C08L39/06
摘要： Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold.

2. 发明申请

WO2010101962A1 TISSUE ENGINEERED HUMAN PULMONARY VALVES WITH CYCLIC PRESSURE BIOREACTOR ACCELERATED SEEDING STRATEGIES AND METHODS FOR ASSESSING INFLAMMATORY POTENTIAL OF PUTATIVE SCAFFOLDS FOR TISSUE ENGINEERED HEART VALVES 审中-公开
标题翻译：组织工程人员脉动阀与循环压力生物反应器加速种子策略和方法评估用于组织工程心脏瓣膜的潜在危险因素的潜在危险
公开(公告)号：WO2010101962A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/025980
申请日：2010-03-02
申请人： THE CHILDREN'S MERCY HOSPITAL , HOPKINS, Richard, A.
发明人： HOPKINS, Richard, A.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/2472 , A61L27/3625 , A61L27/3641 , A61L27/3687 , A61L27/38 , A61L27/3839 , A61L2430/40
摘要： The invention provides for bio-engineered or tissue engineered heart valves that are more efficiently recellularized and/or have a decreased inflammatory potential. The heart valves are generally decellularized and then recellularized using autologous cells wherein the valves are subjected to pulsatile motion during the recellularization process. Tissue engineered heart valves subjected to the pulsatile motion are characterized by having at least 20% of the cells that remain on or in said previously decellularized tissue two weeks after the recellularization process are located below or interior to the basement membrane of said tissue. A method of making bio- engineered tissues having these characteristic is also disclosed. Further provided is a bio-assay and related method for determining the inflammatory potential of a tissue.
摘要翻译：本发明提供了更有效地接收和/或具有降低的炎症潜能的生物工程化或组织工程化的心脏瓣膜。心脏瓣膜通常脱细胞化，然后使用自体细胞进行细胞增殖，其中在受体细胞化过程中阀受到脉动运动。经受脉动运动的组织工程心脏瓣膜的特征在于，在接收细胞化过程位于所述组织的基底膜的下面或内部时，至少20％的细胞保留在或之前的所述先前脱细胞组织中。还公开了具有这些特征的制备生物工程组织的方法。进一步提供了用于确定组织的炎症电位的生物测定和相关方法。

3. 发明申请

WO2009152384A1 SOLUTIONS FOR TISSUE ENGINEERING AND METHODS OF USE 审中-公开
标题翻译：用于组织工程的解决方案和使用方法
公开(公告)号：WO2009152384A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/047115
申请日：2009-06-11
申请人： THE CHILDREN'S MERCY HOSPITAL , HOPKINS, Richard
发明人： HOPKINS, Richard
IPC分类号： C07K14/495 , A61K38/00
CPC分类号： A61L27/3695 , A61L27/3604 , A61L2430/40 , C12N5/0068 , C12N2521/00 , C12N2533/90
摘要： The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided.
摘要翻译：本发明提供了制备用于细胞增殖的脱细胞组织的溶液和方法。该解决方案提供胶原调理以恢复胶原三螺旋结构，增强组织的胶原结构，以及通过将其置于促进再结晶的环境中生物制备脱细胞组织。还提供了根据本发明的用于细胞外组织再细胞化的方法和解决方案。

4. 发明申请

WO2005119244A9 PEPTIDE MODULATORS OF CELLULAR PHENOTYPE AND BI-NUCLEIC ACID FRAGMENT LIBRARY 审中-公开
标题翻译：细胞膜和二核酸片段图谱的肽调节剂
公开(公告)号：WO2005119244A9
公开(公告)日：2007-03-01
申请号：PCT/AU2005000801
申请日：2005-06-03
申请人： PHYLOGICA LTD , WATT PAUL MICHAEL , HOPKINS RICHARD , FEAR MARK , MILECH NADIA MARIAN DOROTHY
发明人： WATT PAUL MICHAEL , HOPKINS RICHARD , FEAR MARK , MILECH NADIA MARIAN DOROTHY
IPC分类号： G01N30/00 , C07H21/04 , C12N15/10 , G01N33/50
CPC分类号： G01N33/5008 , C12N15/1079
摘要： The present invention provides a non-hybrid screening method for the identification and/or isolation of a peptide that is capable of modulating a phenotype in a cell, tissue or organism. For example, the non-hybrid screening method identifies a peptide that is derived from an organism that is unrelated to the cell, tissue or organism. Alternatively, or in addition, the non-hybrid screening method identifies a peptide thaty is capable of rescuing the cell, tissue or organism from cell death or inducing a cell, tissue or organism to grow. The present invention also provides a non-hybrid screening method for identifying a peptide that is useful for treating a disease and/or disorder.
摘要翻译：本发明提供了用于鉴定和/或分离能够调节细胞，组织或生物体中的表型的肽的非混合筛选方法。例如，非混合筛选方法鉴定了衍生自与细胞，组织或生物体无关的生物体的肽。或者或另外，非混合筛选方法鉴定能够从细胞死亡或诱导细胞，组织或生物生长的细胞，组织或生物体拯救的肽。本发明还提供了用于鉴定可用于治疗疾病和/或病症的肽的非杂交筛选方法。

5. 发明申请

WO2004106543A1 AN IMPROVED GENETIC SCREEN FOR INTERACTION INTERFACE MAPPING 审中-公开
标题翻译：用于交互界面映射的改进的遗传屏幕
公开(公告)号：WO2004106543A1
公开(公告)日：2004-12-09
申请号：PCT/AU2004/000723
申请日：2004-05-31
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard , BOGOYEVITCH, Marie
发明人： WATT, Paul Michael , HOPKINS, Richard , BOGOYEVITCH, Marie
IPC分类号： C12Q1/68
CPC分类号： C12N15/1055 , C12Q1/6897 , C12Q2565/201
摘要： The present invention provides improved reverse hybrid assay methods for identifying amino acid residues within a protein that are required for its interaction or physical association with another protein, wherein disruption of an interaction between a protein of interest and its binding partner protein is assayed for a library of mutations of said protein of interest, and maintenance of an interaction between the protein of interest and another binding partner is assayed simultaneously in a single step, thereby reducing the incidence of uninformative mutations in the protein of interest that are detected.
摘要翻译：本发明提供了改进的用于鉴定蛋白质内与氨基酸残基相互作用或与另一种蛋白质相互作用所必需的氨基酸残基的改进的反向杂交测定方法，其中测定目标蛋白质与其结合配偶体蛋白质之间的相互作用的破坏为文库的所述目的蛋白质的突变，以及在一个步骤中同时测定目的蛋白质和另一个结合配偶体之间的相互作用的维持，从而降低检测到的感兴趣的蛋白质中的不知情突变的发生率。

6. 发明申请

WO2013152036A1 DISPOSABLE SINGLE USE SELF-CONTAINED CYCLIC PRESSURE AND FLOW BIOREACTOR SYSTEM 审中-公开
标题翻译：可单独使用自包含循环压力和流量生物反应器系统
公开(公告)号：WO2013152036A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/035018
申请日：2013-04-02
申请人： THE CHILDREN'S MERCY HOSPITAL , HOPKINS, Richard , CONVERSE, Gabriel , BUSE, Eric
发明人： HOPKINS, Richard , CONVERSE, Gabriel , BUSE, Eric
IPC分类号： A01N1/02
CPC分类号： C12N5/069 , A61F2/2472 , C12M21/08 , C12M23/38 , C12M29/10
摘要： The present invention provides for a bioreactor system (3, 4) that is suited for one time use. The bioreactor system (3, 4) comprises a first bioreactor vessel (1), a second bioreactor vessel (20), a tissue retainer (35), and a cap (40). Advantageously, the bioreactor system (3, 4) of the present invention provides a sterile environment that is maintained over the course of cell seeding applications.
摘要翻译：本发明提供适合于一次使用的生物反应器系统（3,4）。生物反应器系统（3,4）包括第一生物反应器容器（1），第二生物反应器容器（20），组织保持器（35）和帽（40）。有利地，本发明的生物反应器系统（3,4）提供在细胞播种应用过程中保持的无菌环境。

7. 发明申请

WO2012034188A1 PEPTIDE INHIBITORS OF CD40L SIGNALING AND USES THEREFOR 审中-公开
标题翻译： CD40L信号肽肽抑制剂及其用途
公开(公告)号：WO2012034188A1
公开(公告)日：2012-03-22
申请号：PCT/AU2011/001198
申请日：2011-09-16
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard , HOFFMANN, Katrin
发明人： WATT, Paul Michael , HOPKINS, Richard , HOFFMANN, Katrin
IPC分类号： C07K14/195 , C07K7/08 , C07K14/235 , A61K38/10 , C07K14/205 , C07K14/245 , A61K38/16 , C07K14/21 , C07K14/255 , A61P7/04 , C07K14/215 , C07K14/32 , A61P37/00 , C07K14/22
CPC分类号： C07K14/195 , A61K38/00 , C07K14/21 , C07K14/235 , C07K14/255 , C07K14/36 , C12N9/0071 , C12N9/1007 , C12N9/1205 , C12N9/22 , C12N9/2417 , C12N9/2451 , C12N9/80 , C12N9/88 , C12N9/90 , C12N9/93 , C12Y402/01059 , C12Y601/01014 , C12Y603/05002 , Y02A50/481
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L- dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-Cd40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译：本发明提供了包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基肽抑制剂的组合物。更具体地，本发明的肽基抑制剂衍生自不表达CD40-Cd40L共刺激途径的天然来源。本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

8. 发明申请

WO2010003193A1 PEPTIDE INHIBITORS OF CD40L SIGNALING AND USES THEREFOR 审中-公开
标题翻译： CD40L信号肽肽抑制剂及其用途
公开(公告)号：WO2010003193A1
公开(公告)日：2010-01-14
申请号：PCT/AU2009/000896
申请日：2009-07-13
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard
发明人： WATT, Paul Michael , HOPKINS, Richard
IPC分类号： C07K14/195 , A61K38/10 , A61P7/04 , A61P31/12 , A61P35/00 , A61P37/00 , C07K7/08 , C07K14/205 , C07K14/21 , C07K14/215 , C07K14/22 , C07K14/235 , C07K14/245 , C07K14/255 , C07K14/32 , A61K38/16
CPC分类号： C07K14/195 , A61K38/00 , C07K7/08
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译：本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导蛋白抑制剂。更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

9. 发明申请

WO2008109223A3 UNIVERSAL INTERFACE FOR MEDICAL IMAGING RECEPTORS 审中-公开
标题翻译：医学成像受体的通用界面
公开(公告)号：WO2008109223A3
公开(公告)日：2008-12-11
申请号：PCT/US2008053174
申请日：2008-02-06
申请人： INFIMED INC , HOPKINS RICHARD , KHUTORYANSKY OSCAR
发明人： HOPKINS RICHARD , KHUTORYANSKY OSCAR
IPC分类号： G06F3/048
CPC分类号： H04N5/23203 , H04N1/00347 , H04N5/23222 , H04N5/23225 , H04N2005/2255 , H04N2201/0051
摘要： The present invention provides a plurality of interchangeable modules each of which is adapted to interface with at least one image receptor having predetermined physical interface parameters, including means for receiving image data from the at least one image receptor, processing means for converting the received image data into a converted, common format, and bus means for adapting to and communicating with a mother board. The interchangeable modules can be embodied in a plurality of daughter boards that are adapted for electrical connection to a mother board. Each daughter board can include the physical interface corresponding with the image receptor for which it has been programmed to receive data, with the physical interface being adapted for extending outwardly from a cabinet enclosing the daughter board and mother board.
摘要翻译：本发明提供了多个可互换模块，每个可互换模块适于与具有预定物理接口参数的至少一个图像接收器接口，包括用于从至少一个图像接收器接收图像数据的装置，用于将接收到的图像数据转换为通用格式，以及用于适应母板通信的总线方式。可互换模块可以体现在适于与主板电连接的多个子板中。每个子板可以包括对应于其已被编程为接收数据的图像接收器的物理接口，物理接口适于从包围子板和母板的机柜向外延伸。

10. 发明申请

WO2008034162A1 COMPOSITIONS AND USES THEREOF IN THE TREATMENT OF WOUNDS 审中-公开
标题翻译：组合物及其在治疗伤口中的应用
公开(公告)号：WO2008034162A1
公开(公告)日：2008-03-27
申请号：PCT/AU2007/000121
申请日：2007-02-06
申请人： PHYLOGICA LIMITED , THE MCCOMB FOUNDATION, INC. , FEAR, Mark , WATT, Paul , HOPKINS, Richard , MILECH, Nadia
发明人： FEAR, Mark , WATT, Paul , HOPKINS, Richard , MILECH, Nadia
IPC分类号： A61P17/02 , A61K38/10 , A61K38/08 , A61K38/17
CPC分类号： C07K14/4703 , A61K38/00 , C07K2319/00
摘要： The present invention provides a topical composition comprising (i) an amount of an AP-1 signaling inhibitor sufficient to reduce, delay or prevent apoptosis and/or necrosis induced by dermal wounding and/or to induce and/or enhance proliferation of a cell; and (ii) a suitable carrier or excipient e.g., a topical carrier or excipient or other carrier or excipient for dermal application. For example, the AP-1 signaling inhibitor is a peptide analog comprising the sequence set forth in SEQ ID NO: 104. The present invention also provides a method of treating a dermal wound comprising topically administering said topical composition to a subject suffering from a dermal wound.
摘要翻译：本发明提供一种局部组合物，其包含（i）足以减少，延迟或预防由皮肤伤口诱导的凋亡和/或坏死和/或诱导和/或增强细胞增殖的量的AP-1信号传导抑制剂; 和（ii）合适的载体或赋形剂，例如用于皮肤施用的局部载体或赋形剂或其它载体或赋形剂。例如，AP-1信号传导抑制剂是包含SEQ ID NO：104所示序列的肽类似物。本发明还提供了一种治疗皮肤伤口的方法，包括将局部组合物局部施用于患有真皮的受试者伤口。

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