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1. 发明申请

WO2004074472A1 MODULATING SCREENING THRESHOLDS FOR N-HYBRID SCREENING 审中-公开
标题翻译：调制N混合筛选筛选机
公开(公告)号：WO2004074472A1
公开(公告)日：2004-09-02
申请号：PCT/AU2004/000216
申请日：2004-02-20
申请人： PHYLOGICA LIMITED , WATT, Paul , HOPKINS, Richard , CULL, Vanessa , FEAR, Mark , MILECH, Nadia
发明人： WATT, Paul , HOPKINS, Richard , CULL, Vanessa , FEAR, Mark , MILECH, Nadia
IPC分类号： C12N15/09
CPC分类号： C12Q1/6811 , G01N2510/00
摘要： The present invention provides improved N-hybrid assays. In particular, the present invention provides an improved reverse N-hybrid assays comprising modulating the amount of a substrate of a reporter gene and/or the amount of a reporter gene thereby enhancing cell death in the absence of a peptide inhibitor of a DNA- protein or protein- protein interaction and/or enhancing cell survival in the presence of a peptide inhibitor of a DNA-protein or protein interaction. Furthermore, the present invention provides an improved forward N-hybrid assay comprising modulating the amount of a reporter gene thereby enhancing cell death in the absence of a heterologous peptide or protein capable of binding to the DNA or protein in a cell and enhancing cell survival in the presence of a heterologous peptide or protein capable of binding to the DNA or protein in a cell.
摘要翻译：本发明提供了改进的N-杂交试验。特别地，本发明提供了改进的逆N杂交测定法，其包括调节报告基因的底物量和/或报道基因的量，从而在不存在DNA-蛋白质的肽抑制剂的情况下增强细胞死亡或蛋白质 - 蛋白质相互作用和/或在DNA-蛋白质或蛋白质相互作用的肽抑制剂存在下增强细胞存活。此外，本发明提供改进的正向N-杂交测定法，其包括调节报道基因的量，从而在不存在能够结合细胞中的DNA或蛋白质的异源肽或蛋白质的情况下增强细胞死亡，并增强细胞存活能够结合细胞中的DNA或蛋白质的异源肽或蛋白质的存在。

2. 发明申请

WO2008034162A1 COMPOSITIONS AND USES THEREOF IN THE TREATMENT OF WOUNDS 审中-公开
标题翻译：组合物及其在治疗伤口中的应用
公开(公告)号：WO2008034162A1
公开(公告)日：2008-03-27
申请号：PCT/AU2007/000121
申请日：2007-02-06
申请人： PHYLOGICA LIMITED , THE MCCOMB FOUNDATION, INC. , FEAR, Mark , WATT, Paul , HOPKINS, Richard , MILECH, Nadia
发明人： FEAR, Mark , WATT, Paul , HOPKINS, Richard , MILECH, Nadia
IPC分类号： A61P17/02 , A61K38/10 , A61K38/08 , A61K38/17
CPC分类号： C07K14/4703 , A61K38/00 , C07K2319/00
摘要： The present invention provides a topical composition comprising (i) an amount of an AP-1 signaling inhibitor sufficient to reduce, delay or prevent apoptosis and/or necrosis induced by dermal wounding and/or to induce and/or enhance proliferation of a cell; and (ii) a suitable carrier or excipient e.g., a topical carrier or excipient or other carrier or excipient for dermal application. For example, the AP-1 signaling inhibitor is a peptide analog comprising the sequence set forth in SEQ ID NO: 104. The present invention also provides a method of treating a dermal wound comprising topically administering said topical composition to a subject suffering from a dermal wound.
摘要翻译：本发明提供一种局部组合物，其包含（i）足以减少，延迟或预防由皮肤伤口诱导的凋亡和/或坏死和/或诱导和/或增强细胞增殖的量的AP-1信号传导抑制剂; 和（ii）合适的载体或赋形剂，例如用于皮肤施用的局部载体或赋形剂或其它载体或赋形剂。例如，AP-1信号传导抑制剂是包含SEQ ID NO：104所示序列的肽类似物。本发明还提供了一种治疗皮肤伤口的方法，包括将局部组合物局部施用于患有真皮的受试者伤口。

3. 发明申请

WO2005119244A1 MODULATORS OF BIOCHEMICAL CHARACTERISTICS 审中-公开
标题翻译：生物化学特性调节剂
公开(公告)号：WO2005119244A1
公开(公告)日：2005-12-15
申请号：PCT/AU2005/000801
申请日：2005-06-03
申请人： PHYLOGICA LIMITED , WATT, Paul, Michael , HOPKINS, Richard , FEAR, Mark , MILECH, Nadia, Marian, Dorothy
发明人： WATT, Paul, Michael , HOPKINS, Richard , FEAR, Mark , MILECH, Nadia, Marian, Dorothy
IPC分类号： G01N30/00
CPC分类号： G01N33/5008 , C12N15/1079 , Y02A50/57
摘要： The present invention provides a non-hybrid screening method for the identification and/or isolation of a peptide that is capable of modulating a phenotype in a cell, tissue or organism. For example, the non-hybrid screening method identifies a peptide that is derived from an organism that is unrelated to the cell, tissue or organism. Alternatively, or in addition, the non-hybrid screening method identifies a peptide thaty is capable of rescuing the cell, tissue or organism from cell death or inducing a cell, tissue or organism to grow. The present invention also provides a non-hybrid screening method for identifying a peptide that is useful for treating a disease and/or disorder.
摘要翻译：本发明提供了用于鉴定和/或分离能够调节细胞，组织或生物体中的表型的肽的非混合筛选方法。例如，非混合筛选方法鉴定衍生自与细胞，组织或生物体无关的生物体的肽。或者或另外，非混合筛选方法鉴定能够从细胞死亡中拯救细胞，组织或生物体的诱导细胞，组织或生物体生长的肽。本发明还提供了用于鉴定可用于治疗疾病和/或病症的肽的非混合筛选方法。

4. 发明申请

WO2012159164A1 METHOD OF DETERMINING, IDENTIFYING OR ISOLATING CELL-PENETRATING PEPTIDES 审中-公开
标题翻译：确定，鉴定或分离细胞穿刺肽的方法
公开(公告)号：WO2012159164A1
公开(公告)日：2012-11-29
申请号：PCT/AU2012/000579
申请日：2012-05-23
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard , HOFFMAN, Katrin
发明人： WATT, Paul Michael , HOPKINS, Richard , HOFFMAN, Katrin
IPC分类号： C40B40/08 , C07K7/00
CPC分类号： G01N33/5014 , C07K14/4723 , C07K2319/00 , C07K2319/74 , C12N2503/02 , C40B60/12
摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.
摘要翻译：本发明提供了确定或鉴定或分离具有细胞类型选择性和/或至少能够通过动物受试者的血液脑屏障的细胞穿透肽（CPP）或其类似物或衍生物的方法。本发明还提供CPP及其类似物及其衍生物，例如序列表SEQ ID NO：1-27所列的那些，以及包含一种或多种CPP的组合物，包括其中CPP或其类似物或衍生物的缀合物与货物分子有关。本发明还提供了将货物分子跨细胞膜运送到细胞内的特定位置，以及用于治疗，预防和/或诊断本发明的CPP或类似物或衍生物所连接的货物分子可治疗的疾病的方法。本发明还提供用于鉴定或分离CPP的定制肽文库。

5. 发明申请

WO2004106543A1 AN IMPROVED GENETIC SCREEN FOR INTERACTION INTERFACE MAPPING 审中-公开
标题翻译：用于交互界面映射的改进的遗传屏幕
公开(公告)号：WO2004106543A1
公开(公告)日：2004-12-09
申请号：PCT/AU2004/000723
申请日：2004-05-31
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard , BOGOYEVITCH, Marie
发明人： WATT, Paul Michael , HOPKINS, Richard , BOGOYEVITCH, Marie
IPC分类号： C12Q1/68
CPC分类号： C12N15/1055 , C12Q1/6897 , C12Q2565/201
摘要： The present invention provides improved reverse hybrid assay methods for identifying amino acid residues within a protein that are required for its interaction or physical association with another protein, wherein disruption of an interaction between a protein of interest and its binding partner protein is assayed for a library of mutations of said protein of interest, and maintenance of an interaction between the protein of interest and another binding partner is assayed simultaneously in a single step, thereby reducing the incidence of uninformative mutations in the protein of interest that are detected.
摘要翻译：本发明提供了改进的用于鉴定蛋白质内与氨基酸残基相互作用或与另一种蛋白质相互作用所必需的氨基酸残基的改进的反向杂交测定方法，其中测定目标蛋白质与其结合配偶体蛋白质之间的相互作用的破坏为文库的所述目的蛋白质的突变，以及在一个步骤中同时测定目的蛋白质和另一个结合配偶体之间的相互作用的维持，从而降低检测到的感兴趣的蛋白质中的不知情突变的发生率。

6. 发明申请

WO2004074479A1 METHODS OF CONSTRUCTING BIODIVERSE GENE FRAGMENT LIBRARIES AND BIOLOGICAL MODULATORS ISOLATED THEREFROM 审中-公开
标题翻译：构建生物多样性基因片段和其分离的生物调节剂的方法
公开(公告)号：WO2004074479A1
公开(公告)日：2004-09-02
申请号：PCT/AU2004/000214
申请日：2004-02-20
申请人： PHYLOGICA LIMITED , WATT, Paul , THOMAS, Wayne , HOPKINS, Richard
发明人： WATT, Paul , THOMAS, Wayne , HOPKINS, Richard
IPC分类号： C12N15/11
CPC分类号： C12N15/1086 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/1034 , C40B30/04 , G01N33/569 , G01N33/574 , Y02A50/57 , Y02A50/58
摘要： Methods for producing nucleic acid fragment libraries that express highly diverse peptide domains, wherein the nucleic acid fragments are derived form microorganisms or eukaryotes with compact genomes. Also peptides derived form the libraries wherein the peptides are selected on the basis of their abilities to bind selected target proteins, including c-jun and antibodies raised against dust mite allergens.
摘要翻译：用于产生表达高度多样化肽结构域的核酸片段文库的方法，其中所述核酸片段衍生自微生物或具有紧密基因组的真核生物。还衍生自形成文库的肽，其中基于它们结合选择的靶蛋白（包括c-jun和针对尘螨过敏原产生的抗体）的能力来选择所述肽。

7. 发明申请

WO2012034188A1 PEPTIDE INHIBITORS OF CD40L SIGNALING AND USES THEREFOR 审中-公开
标题翻译： CD40L信号肽肽抑制剂及其用途
公开(公告)号：WO2012034188A1
公开(公告)日：2012-03-22
申请号：PCT/AU2011/001198
申请日：2011-09-16
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard , HOFFMANN, Katrin
发明人： WATT, Paul Michael , HOPKINS, Richard , HOFFMANN, Katrin
IPC分类号： C07K14/195 , C07K7/08 , C07K14/235 , A61K38/10 , C07K14/205 , C07K14/245 , A61K38/16 , C07K14/21 , C07K14/255 , A61P7/04 , C07K14/215 , C07K14/32 , A61P37/00 , C07K14/22
CPC分类号： C07K14/195 , A61K38/00 , C07K14/21 , C07K14/235 , C07K14/255 , C07K14/36 , C12N9/0071 , C12N9/1007 , C12N9/1205 , C12N9/22 , C12N9/2417 , C12N9/2451 , C12N9/80 , C12N9/88 , C12N9/90 , C12N9/93 , C12Y402/01059 , C12Y601/01014 , C12Y603/05002 , Y02A50/481
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L- dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-Cd40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译：本发明提供了包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基肽抑制剂的组合物。更具体地，本发明的肽基抑制剂衍生自不表达CD40-Cd40L共刺激途径的天然来源。本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

8. 发明申请

WO2010003193A1 PEPTIDE INHIBITORS OF CD40L SIGNALING AND USES THEREFOR 审中-公开
标题翻译： CD40L信号肽肽抑制剂及其用途
公开(公告)号：WO2010003193A1
公开(公告)日：2010-01-14
申请号：PCT/AU2009/000896
申请日：2009-07-13
申请人： PHYLOGICA LIMITED , WATT, Paul Michael , HOPKINS, Richard
发明人： WATT, Paul Michael , HOPKINS, Richard
IPC分类号： C07K14/195 , A61K38/10 , A61P7/04 , A61P31/12 , A61P35/00 , A61P37/00 , C07K7/08 , C07K14/205 , C07K14/21 , C07K14/215 , C07K14/22 , C07K14/235 , C07K14/245 , C07K14/255 , C07K14/32 , A61K38/16
CPC分类号： C07K14/195 , A61K38/00 , C07K7/08
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译：本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导蛋白抑制剂。更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

9. 发明申请

WO2014205518A1 METHOD OF MONITORING CELLULAR TRAFFICKING OF PEPTIDES 审中-公开
标题翻译：监测细胞细胞运输的方法
公开(公告)号：WO2014205518A1
公开(公告)日：2014-12-31
申请号：PCT/AU2014/050094
申请日：2014-06-26
申请人： PHYLOGICA LIMITED
发明人： HOPKINS, Richard , HOFFMANN, Katrin , HEINRICH, Tatjana , CUNNINGHAM, Paula , WATT, Paul , MILECH, Nadia
IPC分类号： G01N33/50 , G01N33/52 , C12N15/62
CPC分类号： G01N33/5035 , C12Q1/25 , G01N33/52 , G01N33/68 , G01N2333/9015 , G01N2440/32 , G01N2500/10
摘要： ABSTRACT This disclosure provides a method of isolating peptides having cell-penetrating function, wherein the peptides are detected as biotinylated molecules only following their translocation through the cell membrane. The disclosure also provides methods for validating the cell-penetrating function of the peptides, or that may be employed in their own right to isolate such peptides, wherein the peptides are detectable by virtue of their ability to transport a detectable cargo into the cytoplasm, such as a cargo toxin or a fragment of a green fluorescent protein (GFP) that is required for complementation of a functional GFP. The disclosure also provides non-canonical peptides having cell-penetrating function that differ structurally from known CPPs such as TAT, VP22, transportan and penetratin, and that are capable of translocating cell membranes and escaping the endosome. The disclosed peptides have utility in transporting cargo therapeutics and diagnostics into cells.
摘要翻译：摘要本公开提供了一种分离具有细胞穿透功能的肽的方法，其中肽仅在其通过细胞膜的移位后才被检测为生物素化分子。本公开还提供了用于验证肽的细胞穿透功能的方法，或者可以以其本身的权利来分离这些肽，其中肽可以通过将可检测的货物运输到细胞质中而被检测，例如作为补充功能性GFP所需的货物毒素或绿色荧光蛋白（GFP）的片段。本公开还提供了具有细胞穿透功能的非标准肽，其结构不同于已知的CPP，例如TAT，VP22，转运蛋白和穿透素，并且能够移位细胞膜并逃逸内体。所公开的肽可用于将货物治疗和诊断转运到细胞中。

10. 发明申请

WO2008109223A2 UNIVERSAL INTERFACE FOR MEDICAL IMAGING RECEPTORS 审中-公开
标题翻译：医学成像受体的通用界面
公开(公告)号：WO2008109223A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/053174
申请日：2008-02-06
申请人： INFIMED, INC. , HOPKINS, Richard , KHUTORYANSKY, Oscar
发明人： HOPKINS, Richard , KHUTORYANSKY, Oscar
IPC分类号： G06K9/20 , H04N5/225
CPC分类号： H04N5/23203 , H04N1/00347 , H04N5/23222 , H04N5/23225 , H04N2005/2255 , H04N2201/0051
摘要： The present invention provides a plurality of interchangeable modules each of which is adapted to interface with at least one image receptor having predetermined physical interface parameters, including means for receiving image data from the at least one image receptor, processing means for converting the received image data into a converted, common format, and bus means for adapting to and communicating with a mother board. The interchangeable modules can be embodied in a plurality of daughter boards that are adapted for electrical connection to a mother board. Each daughter board can include the physical interface corresponding with the image receptor for which it has been programmed to receive data, with the physical interface being adapted for extending outwardly from a cabinet enclosing the daughter board and mother board.
摘要翻译：本发明提供多个可互换模块，每个模块都适于与具有预定物理接口参数的至少一个图像接收器接口，所述至少一个图像接收器包括用于从所述至少一个图像接收器接收图像数据的装置，处理装置，用于将接收到的图像数据转换为转换后的通用格式;以及总线装置，用于适应母板并与之通信。可互换模块可以被实施为适于电连接到母板的多个子板。每个子板可以包括与图像接收器相对应的物理接口，其已经被编程为接收数据，物理接口适于从包围子板和母板的机柜向外延伸。

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