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1. 发明申请

WO2019046131A1 ARTHROSCOPIC DEVICES AND METHODS 审中-公开
公开(公告)号：WO2019046131A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/048018
申请日：2018-08-24
申请人： RELIGN CORPORATION , GERMAIN, Aaron , NORTON, Jeff , KLEIN, Kyle , WALKER, Michael D.
发明人： GERMAIN, Aaron , NORTON, Jeff , KLEIN, Kyle , WALKER, Michael D.
IPC分类号： A61B1/015 , A61B17/32 , A61B17/42 , A61B18/08 , A61B18/12 , A61B18/14
摘要： A resecting probe includes a shaft assembly having an outer sleeve and an inner sleeve. The outer sleeve has an axial bore and an outer window in a distal side thereof, and the inner sleeve has an axial extraction channel and inner window in a distal side thereof. The inner sleeve is rotationally disposed in the axial bore of the outer sleeve to allow the inner sleeve window to be rotated in and out of alignment with the outer sleeve window, and the shaft assembly forms a flow aperture in a distal portion when the inner cutting window and the outer cutting window are out of alignment. An electrode is carried on the inner sleeve, and a motor drive is coupled to rotate the inner sleeve relative to the outer sleeve. A controller is coupled to the motor drive and controls rotation of the inner sleeve and can stop rotation of the inner sleeve in a stop position where the outer and inner windows are out of alignment, providing the flow aperture to allow cooling of fluid in a working space and cooling of the probe handpiece during use.

2. 发明申请

WO2017070486A1 ARTHROSCOPIC DEVICES AND METHODS 审中-公开
标题翻译：关节设备和方法
公开(公告)号：WO2017070486A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058145
申请日：2016-10-21
申请人： GERMAIN, Aaron , KLEIN, Kyle , WALKER, Michael, D.
发明人： GERMAIN, Aaron , KLEIN, Kyle , WALKER, Michael, D.
IPC分类号： A61B17/16
CPC分类号： A61B18/148 , A61B17/1615 , A61B17/1626 , A61B17/1628 , A61B17/1631 , A61B17/1633 , A61B17/1637 , A61B17/32002 , A61B2017/00039 , A61B2017/0023 , A61B2017/00473 , A61B2017/00836 , A61B2017/0088 , A61B2017/22079 , A61B2017/320028 , A61B2018/00577 , A61B2018/00601 , A61B2018/00702 , A61B2018/142 , A61B2217/005 , A61B2217/007 , A61B2218/007
摘要： A medical device includes an elongated sleeve having a longitudinal axis, a proximal end and a distal end. A cutting member extends distally from the distal end of the elongated sleeve, and has sharp cutting edges. The cutting head is formed from a wear-resistant ceramic material, and a motor coupled to the proximal end of elongated sleeve rotate the cutting member. The cutter is engaged against bone and rotated to cut bone tissue without leaving any foreign particles in the site.
摘要翻译：医疗装置包括具有纵向轴线，近端和远端的细长套筒。切割构件从细长套筒的远端向远侧延伸，并具有锋利的切割边缘。切割头由耐磨陶瓷材料形成，并且连接至细长套筒的近端的马达使切割构件旋转。切割器与骨接合并旋转以切割骨组织，而不会在该部位留下任何外来粒子。

3. 发明申请

WO2013003570A1 SURGICAL FLUID MANAGEMENT SYSTEM AND METHODS 审中-公开
标题翻译：手术流体管理系统及方法
公开(公告)号：WO2013003570A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044609
申请日：2012-06-28
申请人： ARQOS SURGICAL, INC. , TRUCKAI, Csaba , GERMAIN, Aaron , KLEIN, Kyle , SHADDUCK, John, H. , WALKER, Michael, D. , ORCZY-TIMKO, Benedek , LESKO, Balazs
发明人： TRUCKAI, Csaba , GERMAIN, Aaron , KLEIN, Kyle , SHADDUCK, John, H. , WALKER, Michael, D. , ORCZY-TIMKO, Benedek , LESKO, Balazs
IPC分类号： A61M1/00 , A61N1/30
CPC分类号： A61B17/42 , A61B17/3205 , A61B18/1485 , A61B2017/4216 , A61B2018/00196 , A61B2018/00559 , A61B2018/00601 , A61M1/0031 , A61M1/0058 , A61M1/006 , A61M1/008 , A61M3/0229
摘要： A fluid management system for use with a fluid reservoir includes an inflow pump and an outflow pump. The inflow pump is connectable to a probe for delivering a distention fluid to a body cavity. The outflow pump removes the distention fluid through the same probe, thus establishing a re-circulating volume of distention fluid within the body cavity. The removed fluid is filtered and returned to a fluid reservoir for eventual recycling to the body cavity. A controller adjusts the flow rates of the inflow pump and the outflow pump to maintain a pre-selected fluid pressure or volume within the body cavity.
摘要翻译：用于流体储存器的流体管理系统包括流入泵和流出泵。流入泵可连接到用于将膨胀流体输送到体腔的探针。流出泵通过相同的探针去除膨胀流体，从而在体腔内建立膨胀流体的再循环体积。去除的流体被过滤并返回到流体储存器，以最终循环到体腔。控制器调节流入泵和流出泵的流量，以维持体腔内的预先选定的流体压力或体积。

4. 发明申请

WO2012178120A1 TISSUE EXTRACTION DEVICES AND METHODS 审中-公开
标题翻译：组织提取装置和方法
公开(公告)号：WO2012178120A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043892
申请日：2012-06-22
申请人： ARQOS SURGICAL, INC. , SHADDUCK, John, H. , GERMAIN, Aaron , KLEIN, Kyle , WALKER, Michael, D. , TRUCKAI, Csaba
发明人： SHADDUCK, John, H. , GERMAIN, Aaron , KLEIN, Kyle , WALKER, Michael, D. , TRUCKAI, Csaba
IPC分类号： A61B17/32
CPC分类号： A61B18/1482 , A61B1/015 , A61B1/05 , A61B17/32002 , A61B17/3205 , A61B18/00 , A61B18/1206 , A61B18/18 , A61B2017/320028 , A61B2018/00196 , A61B2018/00202 , A61B2018/00559 , A61B2018/00589 , A61B2018/00601 , A61B2018/00625 , A61B2018/048 , A61B2018/126 , A61B2018/1437 , A61B2218/002 , A61B2218/007
摘要： Tissue may be cut and extracted from an interior location in a patient's body using a probe or tool which both effects cutting and causes vaporization of a liquid or other fluid to propel the cut tissue through an extraction lumen of the cutting device. The cutting may be achieved using an electrosurgical electrode assembly, including a first electrode on a cutting member and a second electrode within a cutting probe or tool. Thus, over a first cutting portion, radio frequency current may help cut the tissue and over a second or over transition region, the RF current may initiate vaporization of the fluid or other liquid to propel the tissue from the cutting device.
摘要翻译：可以使用探针或工具从患者体内的内部位置切割并提取组织，所述探针或工具都会影响切割并引起液体或其它流体的蒸发，以将切割的组织推动通过切割装置的提取腔。可以使用电外科电极组件来实现切割，所述电外科电极组件包括切割构件上的第一电极和切割探针或工具内的第二电极。因此，在第一切割部分上，射频电流可以帮助切割组织并且在第二或过渡过渡区域上，RF电流可以引发流体或其它液体的蒸发以从切割装置推进组织。

5. 发明申请

WO2013044243A1 SURGICAL FLUID MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：手术流体管理系统和方法
公开(公告)号：WO2013044243A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056936
申请日：2012-09-24
申请人： ARQOS SURGICAL, INC. , KLEIN, Kyle , GERMAIN, Aaron , TRUCKAI, Csaba , WALKER, Michael, D.
发明人： KLEIN, Kyle , GERMAIN, Aaron , TRUCKAI, Csaba , WALKER, Michael, D.
IPC分类号： A61M31/00
CPC分类号： A61M1/0064 , A61B1/012 , A61B1/303 , A61B17/32 , A61B17/32002 , A61B18/1485 , A61B2017/4216 , A61B2018/00559 , A61B2018/00601 , A61B2018/00625 , A61B2018/1213 , A61B2018/162 , A61B2090/064 , A61B2217/005 , A61B2217/007 , A61M1/0056 , A61M1/006 , A61M3/0229 , A61M3/0266 , A61M2202/0021 , A61M2202/0028 , A61M2205/3344 , A61M2205/75 , A61M2205/7545 , A61M2210/1433
摘要： A surgical fluid management system delivers fluid for distending a uterine cavity to allow cutting and extraction of uterine fibroid tissue, polyps and other abnormal uterine tissue. The system comprises a fluid source, fluid deliver lines, one or more pumps, and a filter for recirculating the distension fluid between the source and the uterine cavity. A controller can monitor fluid retention by the patient.
摘要翻译：手术流体管理系统提供用于扩张子宫腔的流体，以允许子宫肌瘤组织，息肉和其他异常子宫组织的切割和提取。该系统包括流体源，流体输送管线，一个或多个泵以及用于在源和子宫腔之间再循环膨胀流体的过滤器。控制器可以监测患者的流体保留。

6. 发明申请

WO2012178119A2 TISSUE EXTRACTION DEVICES AND METHODS 审中-公开
标题翻译：组织提取装置和方法
公开(公告)号：WO2012178119A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043891
申请日：2012-06-22
申请人： ARQOS SURGICAL, INC. , GERMAIN, Aaron , KLEIN, Kyle , ORCZY-TIMKO, Benedek , WALKER, Michael, D. , SHADDUCK, John, H. , TRUCKAI, Csaba , LESKO, Balazs
发明人： GERMAIN, Aaron , KLEIN, Kyle , ORCZY-TIMKO, Benedek , WALKER, Michael, D. , SHADDUCK, John, H. , TRUCKAI, Csaba , LESKO, Balazs
IPC分类号： A61B17/32
CPC分类号： A61B18/1485 , A61B17/32002 , A61B18/1482 , A61B18/18 , A61B2017/320028 , A61B2018/00083 , A61B2018/00196 , A61B2018/00559 , A61B2018/00601 , A61B2018/00982 , A61B2018/142 , A61B2218/002 , A61B2218/007
摘要： The tissue cutting device comprises an elongated assembly including both an outer sleeve and an inner sleeve. The outer sleeve has a tissue-receiving window, and the inner sleeve has a distal end which cuts tissue as the inner sleeve is advanced past the window. The tissue is received into a lumen of the inner sleeve, and the inner sleeve lumen is typically enlarged in a proximal direction to reduce the tendency of resected tissue to lodge therein. The tissue displacement member is optionally provided at a distal end of the outer sleeve to further aid in dislodging tissue which becomes captured in a distal end of the inner sleeve of the lumen.
摘要翻译：组织切割装置包括包括外套筒和内套筒的细长组件。外套筒具有组织接收窗口，并且内套筒具有远端，当内套筒推进通过窗口时，其切断组织。组织被容纳到内套筒的内腔中，并且内套筒腔通常在近端方向上增大，以减少切除的组织在其中的倾向。组织移位构件任选地设置在外套筒的远端处，以进一步有助于移除在管腔的内套筒的远端中被捕获的组织。

7. 发明申请

WO2005015990A8 NEW DIABETES TYPE 2 ANIMAL MODEL 审中-公开
标题翻译：新型糖尿病2型动物模型
公开(公告)号：WO2005015990A8
公开(公告)日：2005-07-21
申请号：PCT/SE2004001209
申请日：2004-08-18
申请人： BETAGENON AB , YEDA RES & DEV , EDLUND HELENA , WALKER MICHAEL D , RUBINS NIR , STENEBERG PAER
发明人： EDLUND HELENA , WALKER MICHAEL D , RUBINS NIR , STENEBERG PAER
IPC分类号： A01K67/027 , C07K14/72 , C12N15/85
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0362 , C07K14/723 , C12N15/8509 , C12N2830/008
摘要： A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipf1/Pdx1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the disease.
摘要翻译：公开了一种糖尿病2型模型实验室动物，其包含在Ipf1 / Pdx1启动子控制下过度表达GPR40的细胞。还公开了使用模型动物来鉴定针对GPR40的激动剂或拮抗剂，其用于开发用于治疗该疾病的药物。

8. 发明申请

WO2005015990A1 NEW DIABETES TYPE 2 ANIMAL MODEL 审中-公开
标题翻译：新型糖尿病2型动物模型
公开(公告)号：WO2005015990A1
公开(公告)日：2005-02-24
申请号：PCT/SE2004/001209
申请日：2004-08-18
申请人： BETAGENON AB , YEDA RESEARCH AND DEVELOPMENT CO LTD , EDLUND, Helena , WALKER, Michael D. , RUBINS, Nir , STENEBERG, Pär
发明人： EDLUND, Helena , WALKER, Michael D. , RUBINS, Nir , STENEBERG, Pär
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0362 , C07K14/723 , C12N15/8509 , C12N2830/008
摘要： A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipf1/Pdx1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the disease.
摘要翻译：公开了一种糖尿病2型模型实验室动物，其包含在Ipf1 / Pdx1启动子控制下过度表达GRP40的细胞。还公开了使用模型动物来鉴定针对GRP40的激动剂或拮抗剂，其用于开发用于治疗该疾病的药物。

9. 发明申请

WO1995011431A1 SYSTEMS AND METHODS FOR APPLYING GRID LINES TO A SHAFT AND SENSING MOVEMENT THEREOF 审中-公开
标题翻译：将网格线应用于轴和感测运动的系统和方法
公开(公告)号：WO1995011431A1
公开(公告)日：1995-04-27
申请号：PCT/US1994011725
申请日：1994-10-18
申请人： WALKER, Dana, A. , WALKER, Michael, D.
IPC分类号： G01H09/00
CPC分类号： G01H1/003 , G01H9/00 , G01L3/12 , G01P1/00 , G01P3/486 , G01P3/56
摘要： Methods for precisely applying finely spaced grid lines (114) to an existing shaft (112) on site include, in a first embodiment, attachment of a master grid line carrier (607) to the shaft (112). In preferred embodiments, the carrier (607) is helically wrapped about the shaft (112) or mated at a diagonal seam across the carrier (607). Photosensitive material is then applied to the shaft (112) at one or more axial locations. The shaft (112) is rotated and passage of the grid lines (114) on the master is sensed by an optical sensor (104). A light source (624) synchronized to the detection of the master grid lines (114) exposes the photosensitive material as the shaft (112) is rotated to create identical sets of finely spaced grid lines at multiple axial locations on the shaft (112). The invention also includes a synchronous laser Doppler velocimeter (SLDV) which accurately senses the passage of the lines on the shaft. An extremely accurate torsional interferometer can be constructed using the SLDVs.
摘要翻译：在第一实施例中，将精细间隔格栅线（114）精确地应用于现有轴（112）的方法包括在主网格线载体（607）附接到轴（112）上。在优选实施例中，载体（607）围绕轴（112）螺旋缠绕，或者跨过载体（607）的对角线缝合。然后将感光材料在一个或多个轴向位置处施加到轴（112）。旋转轴（112）并且通过光学传感器（104）感测主机上的格线（114）的通过。与主栅格线（114）的检测同步的光源（624）在轴（112）旋转时暴露感光材料，以在轴（112）上的多个轴向位置处产生相同的精细间隔格栅线组。本发明还包括准确地感测轴上的线路通过的同步激光多普勒测速仪（SLDV）。可以使用SLDV构建非常精确的扭转干涉仪。

10. 发明申请

WO2017136414A1 ARTHROSCOPIC DEVICES AND METHODS 审中-公开
标题翻译：关节设备和方法
公开(公告)号：WO2017136414A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016002
申请日：2017-02-01
申请人： RELIGN CORPORATION , GERMAIN, Aaron , KLEIN, Kyle , WALKER, Michael, D. , MANGANO, Salvatore, G.
发明人： GERMAIN, Aaron , KLEIN, Kyle , WALKER, Michael, D. , MANGANO, Salvatore, G.
IPC分类号： A61B17/32 , A61B17/00 , A61B18/00 , A61B18/08 , A61B18/12 , A61B18/14
CPC分类号： A61B17/32002 , A61B17/16 , A61B17/1615 , A61B17/1633 , A61B17/3205 , A61B18/14 , A61B18/1482 , A61B90/30 , A61B2017/0088 , A61B2018/00565 , A61B2018/00595 , A61B2018/00601
摘要： A medical device includes an elongated sleeve having a longitudinal axis, a proximal end and a distal end. A cutting member having sharp edges formed from a wear-resistant ceramic material is carried at the distal end of the elongated sleeve. A motor drive is coupled to the proximal end of the elongated sleeve to rotate the sleeve at cutting member at high speed to cut bone and other hard tissue. An electrode is carried in a surface portion of ceramic cutting member for cautery or radiofrequency ablation of tissue when the sleeve and cutting member are is a stationary position.
摘要翻译：医疗装置包括具有纵向轴线，近端和远端的细长套筒。具有由耐磨陶瓷材料形成的尖锐边缘的切割构件被承载在细长套筒的远端处。马达驱动器联接到细长套筒的近端以高速旋转切割构件处的套筒以切割骨头和其他硬组织。当套管和切割构件处于静止位置时，电极被承载在陶瓷切割构件的表面部分中用于烧灼或射频消融组织。

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