专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005106032A3 STAPHYLOCOCCUS AUREUS SPECIFIC DIAGNOSTICS 审中-公开
标题翻译：。US。。。。。。。。。。。
公开(公告)号：WO2005106032A3
公开(公告)日：2006-01-05
申请号：PCT/NL2005000326
申请日：2005-04-29
申请人： NSCHAPPELIJK ONDERZOEK TNO NL , UMC UTRECHT HOLDING BV , SCHUREN FRANK HENRI JOHAN , VERHOEF JAN , MONTIJN ROY CHRISTIAAN
发明人： SCHUREN FRANK HENRI JOHAN , VERHOEF JAN , MONTIJN ROY CHRISTIAAN
IPC分类号： C12Q1/68 , G06F19/20 , G06F19/24
CPC分类号： C12Q1/6837 , C12Q1/689 , G06F19/20 , G06F19/24 , C12Q2565/513
摘要： A method for typing sample nucleic acid derived or obtained from a Staphylococcus aureus strain, comprising providing an array comprising a plurality of nucleic acid molecules, wherein said plurality of nucleic acid molecules is derived from a first set of at least two different strains of Staphylococcus aureus, providing at least two different reference hybridization patterns by hybridizing said array with at least two different reference nucleic acids obtained or derived from a second set of at least two different strains of Staphylococcus aureus, wherein said strains of Staphylococcus aureus in said second set are separable into at least two groups on the basis of a value for at least one phenotypic parameter, creating at least two different clusters of reference hybridization patterns by clustering the reference hybridization patterns by unsupervised multivariate analysis, hybridizing the same array as used for preparing the reference hybridization patterns with sample nucleic acid to obtain a sample hybridization pattern, and assigning the sample hybridization pattern to one of said at least two different clusters of reference hybridization patterns.
摘要翻译：用于分型衍生或从金黄色葡萄球菌菌株获得的样品核酸的方法，包括提供包含多个核酸分子的阵列，其中所述多个核酸分子衍生自第一组至少两种不同的金黄色葡萄球菌菌株通过将所述阵列与获得或衍生自第二组至少两种不同的金黄色葡萄球菌菌株的至少两种不同参考核酸杂交，提供至少两种不同的参考杂交模式，其中所述第二组中的所述金黄色葡萄球菌菌株是可分离的基于至少一个表型参数的值至少两个组，通过无参与多变量分析聚类参考杂交模式产生至少两个不同的参考杂交模式簇，将用于制备参考杂交的相同阵列杂交样品核酸样品以获得样品杂交模式，并将样品杂交模式分配给所述至少两个不同参考杂交模式簇之一。

2. 发明申请

WO1992008805A1 METHOD AND KIT FOR DEMONSTRATING MICROORGANISMS 审中-公开
标题翻译：用于演示微生物的方法和工具包
公开(公告)号：WO1992008805A1
公开(公告)日：1992-05-29
申请号：PCT/NL1991000230
申请日：1991-11-15
申请人： U-GENE RESEARCH B.V. , VERHOEF, Jan , FLUIT, Adriaan, Camille , TORENSMA, Ruurd
发明人： U-GENE RESEARCH B.V.
IPC分类号： C12Q01/68
CPC分类号： G01N33/56911 , C12Q1/6804 , C12Q1/6865 , C12Q1/689
摘要： Detection of microorganisms by first isolating them from the sample by means of antibodies and a solid support for the antibodies and then, optionally after isolation of the DNA from the bound microorganisms, carrying out a PCR. The antibodies to be used are specific for the microorganisms to be detected and most preferably generated against still living microorganisms. Especially magnetic particles are suitable as solid support. In PCR, primers are used that are specific for the microorganisms to be detected, most preferably based on an rRNA sequence or a DNA replication origin sequence.
摘要翻译：通过首先通过抗体和抗体的固体支持物从样品中分离出微生物，然后任选地在从结合的微生物中分离出DNA后进行PCR。待使用的抗体对待检测的微生物是特异性的，最优选地针对静止的微生物产生。特别是磁性颗粒适合作为固体支持物。在PCR中，使用对待检测微生物特异的引物，最优选基于rRNA序列或DNA复制起始序列。

3. 发明申请

WO2005023852A2 ANTIMICROBIAL COMPOUNDS 审中-公开
标题翻译：抗微生物化合物
公开(公告)号：WO2005023852A2
公开(公告)日：2005-03-17
申请号：PCT/EP2004/010317
申请日：2004-09-13
申请人： UNIVERSITY MEDICAL CENTER UTRECHT, EIJKMAN-WINKLER CENTRE FOR MICROBIOLOGY, INFECTIOUS DISEASES AND INFLAMATION , VERHOEF, Jan , MILATOVIC, Danica , EKKELENKAMP, Miquel, Bart
发明人： VERHOEF, Jan , MILATOVIC, Danica , EKKELENKAMP, Miquel, Bart
IPC分类号： C07K14/31
CPC分类号： C07K14/31 , A61K38/00
摘要： The present invention relates to new antimicrobial compounds, in particular proteins, having the amino acid sequence XAlaUValLeuLysOUIleLysValAlaLysLysTyrAlaLysGlyValA*LeuA*AlaGlyAlaAsnIleOGlyGlyLys wherein X is hydroxy propionyl (Hop), U is ? ??-didehydroalanine (Dha), O is ? ??-didehydrobutyrine (Dhb), A* is aminobutyrine (Abu), wherein lanthionine ring structures are formed between Ala12 and Ala16, between Abu20 and Ala23 and between Abu22 and Ala25, and in which at least one amino acid has been replaced by another amino acid.
摘要翻译：本发明涉及具有氨基酸序列XAlaUValLeuLysOUIleLysValAlaLysLysTyrAlaLysGlyValA * LeuA * AlaGlyAlaAsnIleOGlyGlyLys的新的抗微生物化合物，特别是蛋白质，其中X是羟基丙酰基（Hop），U是<α'-二脱水丙氨酸（Dha）（Dhb），A *是氨基丁酸（Abu），其中在Ala12和Ala16之间，在Abu20和Ala23之间以及在Abu22和Ala25之间形成甲硫氨酸环结构，并且其中至少一个氨基酸被另一个氨基酸替代氨基酸。

4. 发明申请

WO1991008305A1 DNA FRAGMENTS AND DNA PROBES AND PRIMERS BASED THEREON 审中-公开
标题翻译： DNA片段和DNA探针及其基因
公开(公告)号：WO1991008305A1
公开(公告)日：1991-06-13
申请号：PCT/NL1990000178
申请日：1990-11-27
申请人： U-GENE RESEARCH B.V. , FLUIT, Adriaan, Camille , VERHOEF, Jan
发明人： U-GENE RESEARCH B.V.
IPC分类号： C12Q01/68
CPC分类号： C07K14/31 , A61K38/00 , C12Q1/689
摘要： This invention relates to a DNA fragment derived from a methicillin-resistant Staphylococcus strain as well as to a DNA probe, based on such a DNA fragment, for the detection of Staphylococcus bacteria that are resistant to methicillin and related penicillins insensitive to beta -lactamase and to a DNA-primer, based on such a DNA fragment, for DNA amplication by means of a polymerase chain reaction. The DNA fragment according to the invention consists essentially of or is complementary to the sequence shown in the sequence list under SEQ ID NO:1 or a related sequence, such as one of the sequences shown in the sequence list under SEQ ID NO's:2-8, or part of such a sequence having a length of at least 14 nucleotides. The invention also comprises diagnostic kits and processes on the basis of such DNA fragments.
摘要翻译：本发明涉及一种衍生自耐甲氧西林葡萄球菌菌株的DNA片段以及基于这样的DNA片段的DNA探针，用于检测对甲氧西林耐药的葡萄球菌和对β-内酰胺酶不敏感的相关青霉素，基于这样的DNA片段的DNA引物，通过聚合酶链式反应进行DNA扩增。根据本发明的DNA片段基本上由SEQ ID NO：1中的序列表所示的序列或相关序列组成，或者与SEQ ID NO：1中序列表中所示的序列之一相互补充， 8或长度为至少14个核苷酸的这种序列的一部分。本发明还包括基于这样的DNA片段的诊断试剂盒和方法。

5. 发明申请

WO2005023852A3 EPILANCIN 15X LANTIBIOTIC 审中-公开
公开(公告)号：WO2005023852A3
公开(公告)日：2005-06-02
申请号：PCT/EP2004010317
申请日：2004-09-13
申请人： UMC UTRECHT HOLDING BV , VERHOEF JAN , MILATOVIC DANICA , EKKELENKAMP MIQUEL BART
发明人： VERHOEF JAN , MILATOVIC DANICA , EKKELENKAMP MIQUEL BART
IPC分类号： A61K38/00 , C07K14/31
CPC分类号： C07K14/31 , A61K38/00
摘要： The present invention relates to new antimicrobial compounds, in particular proteins, having the amino acid sequence XAlaUValLeuLysOUIleLysValAlaLysLysTyrAlaLysGlyValA*LeuA*AlaGlyAlaAsnIleOGlyGlyLys wherein X is hydroxy propionyl (Hop), U is alpha,beta-didehydroalanine (Dha), O is alpha,beta-didehydrobutyrine (Dhb), A* is aminobutyrine (Abu), wherein lanthionine ring structures are formed between Ala12 and Ala16, between Abu20 and Ala23 and between Abu22 and Ala25, and in which at least one amino acid has been replaced by another amino acid.
摘要翻译：本发明涉及具有氨基酸序列XAlaUValLeuLysOUIleLysValAlaLysLysTyrAlaLysGlyValA * LeuA * AlaGlyAlaAsnIleOGlyGlyLys的新的抗微生物化合物，特别是蛋白质，其中X是羟基丙酰基（Hop），U是α，β-二氢丙氨酸（Dha），O是α，β-二脱氢丁苯（Dhb）中，A *是氨基丁酸（Abu），其中在Ala12和Ala16之间，在Abu20和Ala23之间以及Abu22和Ala25之间形成了羊毛
苷酸环结构，并且其中至少一个氨基酸被另一个氨基酸替代。

6. 发明申请

WO2005106032A2 STAPHYLOCOCCUS AUREUS SPECIFIC DIAGNOSTICS 审中-公开
标题翻译：。US。。。。。。。。。。。
公开(公告)号：WO2005106032A2
公开(公告)日：2005-11-10
申请号：PCT/NL2005/000326
申请日：2005-04-29
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO , UMC UTRECHT HOLDING B.V. , SCHUREN, Frank, Henri, Johan , VERHOEF, Jan , MONTIJN, Roy, Christiaan
发明人： SCHUREN, Frank, Henri, Johan , VERHOEF, Jan , MONTIJN, Roy, Christiaan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/689 , G06F19/20 , G06F19/24 , C12Q2565/513
摘要： A method for typing sample nucleic acid derived or obtained from a Staphylococcus aureus strain, comprising providing an array comprising a plurality of nucleic acid molecules, wherein said plurality of nucleic acid molecules is derived from a first set of at least two different strains of Staphylococcus aureus, providing at least two different reference hybridization patterns by hybridizing said array with at least two different reference nucleic acids obtained or derived from a second set of at least two different strains of Staphylococcus aureus, wherein said strains of Staphylococcus aureus in said second set are separable into at least two groups on the basis of a value for at least one phenotypic parameter, creating at least two different clusters of reference hybridization patterns by clustering the reference hybridization patterns by unsupervised multivariate analysis, hybridizing the same array as used for preparing the reference hybridization patterns with sample nucleic acid to obtain a sample hybridization pattern, and assigning the sample hybridization pattern to one of said at least two different clusters of reference hybridization patterns.
摘要翻译：用于分型衍生或从金黄色葡萄球菌菌株获得的样品核酸的方法，包括提供包含多个核酸分子的阵列，其中所述多个核酸分子衍生自第一组至少两种不同的金黄色葡萄球菌菌株通过将所述阵列与获得或衍生自第二组至少两种不同的金黄色葡萄球菌菌株的至少两种不同参考核酸杂交，提供至少两种不同的参考杂交模式，其中所述第二组中的所述金黄色葡萄球菌菌株是可分离的基于至少一个表型参数的值至少两个组，通过无参与多变量分析聚类参考杂交模式产生至少两个不同的参考杂交模式簇，将用于制备参考杂交的相同阵列杂交样品核酸样品以获得样品杂交模式，并将样品杂交模式分配给所述至少两个不同参考杂交模式簇之一。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式