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    • 2. 发明申请
    • STAPHYLOCOCCUS AUREUS SPECIFIC DIAGNOSTICS
    • 。US。。。。。。。。。。。
    • WO2005106032A3
    • 2006-01-05
    • PCT/NL2005000326
    • 2005-04-29
    • NSCHAPPELIJK ONDERZOEK TNO NLUMC UTRECHT HOLDING BVSCHUREN FRANK HENRI JOHANVERHOEF JANMONTIJN ROY CHRISTIAAN
    • SCHUREN FRANK HENRI JOHANVERHOEF JANMONTIJN ROY CHRISTIAAN
    • C12Q1/68G06F19/20G06F19/24
    • C12Q1/6837C12Q1/689G06F19/20G06F19/24C12Q2565/513
    • A method for typing sample nucleic acid derived or obtained from a Staphylococcus aureus strain, comprising providing an array comprising a plurality of nucleic acid molecules, wherein said plurality of nucleic acid molecules is derived from a first set of at least two different strains of Staphylococcus aureus, providing at least two different reference hybridization patterns by hybridizing said array with at least two different reference nucleic acids obtained or derived from a second set of at least two different strains of Staphylococcus aureus, wherein said strains of Staphylococcus aureus in said second set are separable into at least two groups on the basis of a value for at least one phenotypic parameter, creating at least two different clusters of reference hybridization patterns by clustering the reference hybridization patterns by unsupervised multivariate analysis, hybridizing the same array as used for preparing the reference hybridization patterns with sample nucleic acid to obtain a sample hybridization pattern, and assigning the sample hybridization pattern to one of said at least two different clusters of reference hybridization patterns.
    • 用于分型衍生或从金黄色葡萄球菌菌株获得的样品核酸的方法,包括提供包含多个核酸分子的阵列,其中所述多个核酸分子衍生自第一组至少两种不同的金黄色葡萄球菌菌株 通过将所述阵列与获得或衍生自第二组至少两种不同的金黄色葡萄球菌菌株的至少两种不同参考核酸杂交,提供至少两种不同的参考杂交模式,其中所述第二组中的所述金黄色葡萄球菌菌株是可分离的 基于至少一个表型参数的值至少两个组,通过无参与多变量分析聚类参考杂交模式产生至少两个不同的参考杂交模式簇,将用于制备参考杂交的相同阵列杂交 样品核酸样品 以获得样品杂交模式,并将样品杂交模式分配给所述至少两个不同参考杂交模式簇之一。