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1. 发明申请

WO2004026909A2 EXPRESSION OF DC-SIGN BY MACROPHAGES AND METHODS OF TREATING AND DIAGNOSING RHEUMATOID ARTHRITIS 审中-公开
标题翻译：通过大量表达直流信号的表达和治疗和诊断恶性肿瘤的方法
公开(公告)号：WO2004026909A2
公开(公告)日：2004-04-01
申请号：PCT/IB0305181
申请日：2003-09-19
申请人： STICHTING KATHOLIEKE UNIV , FIGDOR CARL GUSTAV , TORENSMA RUURD , VAN LENT PETRUS LEONARDUS EVER , VAN DEN BERG WIM B
发明人： FIGDOR CARL GUSTAV , TORENSMA RUURD , VAN LENT PETRUS LEONARDUS EVER , VAN DEN BERG WIM B
IPC分类号： A61K31/7004 , A61K38/16 , A61P19/02 , C07K16/28 , G01N33/564 , C07K16/00
CPC分类号： A61K31/70 , A61K31/7004 , A61K38/162 , A61K38/168 , A61K2039/505 , C07K16/2851 , C07K16/2896 , G01N33/564 , G01N2800/102
摘要： The C-type lectin DC-SIGN is absent in normal synovium but is highly expressed by CD68 positive macrophages in the synovium of rheumatoid arthritis patients. Accordingly, rheumatoid arthritis is diagnosed or treated by, respectively, assaying or blocking DC-SIGN. This can be accomplished by the use of agents, e.g., antibodies, which bind specifically to DCSIGN. Agents that bind to ICAM-3 are used to block inhibition of activation of macrophages by DC-SIGN-ICAM-3 interaction and cause inhibition of rheumatoid arthritis symptoms.
摘要翻译： C型凝集素DC-SIGN在正常滑膜中不存在，但在类风湿关节炎患者滑膜中的CD68阳性巨噬细胞高度表达。因此，通过分别诊断或阻断DC-SIGN来诊断或治疗类风湿性关节炎。这可以通过使用特异性结合DCSIGN的试剂，例如抗体来实现。结合ICAM-3的药物用于阻断DC-SIGN-ICAM-3相互作用对巨噬细胞活化的抑制，并引起对类风湿关节炎症状的抑制。

2. 发明申请

WO2004026326A2 ANTIGEN UPTAKE RECEPTOR FOR CANDIDA ALBICANS ON DENDRITIC CELLS 审中-公开
标题翻译：杜氏利什曼对树突状细胞的树突状细胞摄取受体
公开(公告)号：WO2004026326A2
公开(公告)日：2004-04-01
申请号：PCT/IB2003/004661
申请日：2003-09-19
申请人： STICHTING KATHOLIEKE UNIVERSITEIT , FIGDOR, Carl, Gustav , TORENSMA, Ruurd
发明人： FIGDOR, Carl, Gustav , TORENSMA, Ruurd
IPC分类号： A61K38/00
CPC分类号： A61K38/08 , A61K31/702 , A61K38/1774 , A61K2039/505 , C07K16/2851 , C07K2317/34 , C07K2317/76
摘要： Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans , the major cause of hospital-acquired fungal infections, is found at similar sites. Here it is demonstrated that DC-SIGN is able to bind Candida albicans both in DC-SIGN transfected cell lines and in human monocyte derived DC. Moreover, in immature DC, DC-SIGN is able to internalize Candida in specific DC-SIGN enriched vesicles, distinct from those containing the mannose receptor (MR; CD206), which is another Candida receptor on DC. Together, these results demonstrate that C . albicans has two major receptors on human monocyte derived DC, these receptors being DC-SIGN and MR. Targeting of DC-SIGN offers novel opportunities to combat chronic forms of candidiasis.
摘要翻译：表达II型C型凝集素DC-SIGN（CD209）的树突细胞（DC）位于介导HIV-1进入的组织的粘膜下层中。有趣的是，病原体假丝酵母白色念珠菌是医院获得性真菌感染的主要原因，发现于类似的部位。在此证明DC-SIGN能够在DC-SIGN转染的细胞系和人单核细胞衍生的DC中均结合白色念珠菌。此外，在未成熟的DC中，DC-SIGN能够在富含特异性DC-SIGN的囊泡中内化Candida，与含有甘露糖受体（MR; CD206）的那些不同，后者是另一种假丝酵母 / DC受体。这些结果一起证明了C 。白色念珠菌在人单核细胞衍生的DC上具有两种主要受体，这些受体是DC-SIGN和MR。靶向DC-SIGN为慢性念珠菌病的治疗提供了新的机会。

3. 发明申请

WO2004026909A3 METHOD OF TREATING RHEUMATOID ARTHRITIS BY INTERFERING WITH EXPRESSION OF DC-SIGN BY MACROPHAGES AND DIAGNOSIS THEREOF 审中-公开
公开(公告)号：WO2004026909A3
公开(公告)日：2004-04-01
申请号：PCT/IB2003/005181
申请日：2003-09-19
申请人： STICHTING KATHOLIEKE UNIVERSITEIT , FIGDOR, Carl, Gustav , TORENSMA, Ruurd , VAN LENT, Petrus, Leonardus, Everardus, Maria , VAN DEN BERG, Wim, B.
发明人： FIGDOR, Carl, Gustav , TORENSMA, Ruurd , VAN LENT, Petrus, Leonardus, Everardus, Maria , VAN DEN BERG, Wim, B.
IPC分类号： A61K31/70
摘要： The C-type lectin DC-SIGN is absent in normal synovium but is highly expressed by CD68 positive macrophages in the synovium of rheumatoid arthritis patients. Accordingly, rheumatoid arthritis is diagnosed or treated by, respectively, assaying or blocking DC-SIGN. This can be accomplished by the use of agents, e.g., antibodies, which bind specifically to DCSIGN. Agents that bind to ICAM-3 are used to block inhibition of activation of macrophages by DC-SIGN-ICAM-3 interaction and cause inhibition of rheumatoid arthritis symptoms.

4. 发明申请

WO0250119A3 METHOD FOR MODULATING THE BINDING ACTIVITY OF A NOVEL ICAM-3 BINDING RECEPTOR ON SINUSOIDAL ENDOTHELIAL CELLS IN LIVER AND LYMPH NODES 审中-公开
标题翻译：一种新型ICAM-3结合受体在肝脏和淋巴结转移瘤内皮细胞上的调节活性的方法
公开(公告)号：WO0250119A3
公开(公告)日：2002-09-19
申请号：PCT/EP0115392
申请日：2001-12-21
申请人： STICHTING KATHOLIEKE UNIV , FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HER , VAN KOOYK YVETTE , TORENSMA RUURD
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HER , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/02 , A61K39/21 , A61K39/395 , A61K45/00 , A61P31/18 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/28 , C12N5/00 , C12N5/071 , C12R1/91 , G01N33/53 , C12N5/06
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/505 , A61K2039/6087 , C07K14/7056 , C07K16/2851 , C12N5/069 , C12N2740/16134
摘要： The invention relates to the use of a compound that binds to a C-type lectin on the surface of a sinusoid endothelial layer, in the preparation of a composition for modulating, in particular reducing, the immune response in animal, in particular a human or another mammal. The sinusoid endothelial layer may be either constituted by liver sinusoid endothelial cells (LSEC) or by the lymph node sinusoidal zone.
摘要翻译：本发明涉及在制备用于调节，特别是降低动物，特别是人的免疫应答的组合物中使用结合于正弦内皮层表面上的C型凝集素的化合物另一只哺乳动物正弦内皮层可以由肝窦内皮细胞（LSEC）或淋巴结正弦区构成。

5. 发明申请

WO2004026326A3 ANTIGEN UPTAKE RECEPTOR FOR CANDIDA ALBICANS ON DENDRITIC CELLS 审中-公开
标题翻译：抗原吸收剂对于甘露糖酸钠对细胞的吸收
公开(公告)号：WO2004026326A3
公开(公告)日：2004-05-21
申请号：PCT/IB0304661
申请日：2003-09-19
申请人： STICHTING KATHOLIEKE UNIV , FIGDOR CARL GUSTAV , TORENSMA RUURD
发明人： FIGDOR CARL GUSTAV , TORENSMA RUURD
IPC分类号： A61K31/702 , A61K38/17 , A61P31/00 , C07K16/28 , A61K38/08 , A61K39/395
CPC分类号： A61K38/08 , A61K31/702 , A61K38/1774 , A61K2039/505 , C07K16/2851 , C07K2317/34 , C07K2317/76
摘要： Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans, the major cause of hospital-acquired fungal infections, is found at similar sites. Here it is demonstrated that DC-SIGN is able to bind Candida albicans both in DC-SIGN transfected cell lines and in human monocyte derived DC. Moreover, in immature DC, DC-SIGN is able to internalize Candida in specific DC-SIGN enriched vesicles, distinct from those containing the mannose receptor (MR; CD206), which is another Candida receptor on DC. Together, these results demonstrate that C. albicans has two major receptors on human monocyte derived DC, these receptors being DC-SIGN and MR. Targeting of DC-SIGN offers novel opportunities to combat chronic forms of candidiasis.
摘要翻译：表达II型C型凝集素DC-SIGN（CD209）的树突状细胞（DC）位于组织粘膜下层，其中介导HIV-1进入。有趣的是，病原体白色念珠菌是医院获得性真菌感染的主要原因，发现于相似的部位。这证明DC-SIGN能够在DC-SIGN转染的细胞系和人单核细胞衍生的DC中结合白色念珠菌。此外，在未成熟的DC中，DC-SIGN能够将念珠菌内含于特异性DC-SIGN富集的囊泡中，与含有甘露糖受体（MR; CD206）的那些不同，这是DC上的另一种念珠菌受体。这些结果一起证明白色念珠菌在人单核细胞衍生的DC上具有两个主要受体，这些受体是DC-SIGN和MR。针对DC-SIGN提供了新的机会来抵抗慢性念珠菌病。

6. 发明申请

WO1992008805A1 METHOD AND KIT FOR DEMONSTRATING MICROORGANISMS 审中-公开
标题翻译：用于演示微生物的方法和工具包
公开(公告)号：WO1992008805A1
公开(公告)日：1992-05-29
申请号：PCT/NL1991000230
申请日：1991-11-15
申请人： U-GENE RESEARCH B.V. , VERHOEF, Jan , FLUIT, Adriaan, Camille , TORENSMA, Ruurd
发明人： U-GENE RESEARCH B.V.
IPC分类号： C12Q01/68
CPC分类号： G01N33/56911 , C12Q1/6804 , C12Q1/6865 , C12Q1/689
摘要： Detection of microorganisms by first isolating them from the sample by means of antibodies and a solid support for the antibodies and then, optionally after isolation of the DNA from the bound microorganisms, carrying out a PCR. The antibodies to be used are specific for the microorganisms to be detected and most preferably generated against still living microorganisms. Especially magnetic particles are suitable as solid support. In PCR, primers are used that are specific for the microorganisms to be detected, most preferably based on an rRNA sequence or a DNA replication origin sequence.
摘要翻译：通过首先通过抗体和抗体的固体支持物从样品中分离出微生物，然后任选地在从结合的微生物中分离出DNA后进行PCR。待使用的抗体对待检测的微生物是特异性的，最优选地针对静止的微生物产生。特别是磁性颗粒适合作为固体支持物。在PCR中，使用对待检测微生物特异的引物，最优选基于rRNA序列或DNA复制起始序列。

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