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1. 发明申请

WO2011036650A3 SENSOR DEVICE WITH IMAGING OPTICS 审中-公开
标题翻译：具有成像光学的传感器设备
公开(公告)号：WO2011036650A3
公开(公告)日：2011-08-11
申请号：PCT/IB2010054328
申请日：2010-09-27
申请人： KONINKL PHILIPS ELECTRONICS NV , KAHLMAN JOSEPHUS ARNOLDUS HENRICUS MARIA , VAN ZON JOANNES BAPTIST ADRIANUS DIONISIUS
发明人： KAHLMAN JOSEPHUS ARNOLDUS HENRICUS MARIA , VAN ZON JOANNES BAPTIST ADRIANUS DIONISIUS
IPC分类号： G01N21/55 , G01N21/64 , G02B21/36
CPC分类号： G01N21/552 , G01N21/648 , G02B21/367
摘要： The invention relates to a method and a sensor device (100) for detecting particles (MP) that are bound to the binding surface (12) of a carrier (11). The sensor device (100) comprises a microscope (50) for imaging bound particles (MP)onto an image sensor (53). In order to increase the spatial resolution of the microscope(50), a displacement unit (60,70,80) is provided that can displace the carrier (11) relative to the image sensor (53). The distance of a bound particle (MP) from the binding surface (12) and/or its lateraldisplacement in reaction to forces can thus be determine with high accuracy. This allows to discriminate specific bindings of large magnetic particles (MP) that are bound to the binding surface (12) via smaller target particles from nonspecific direct bindings.
摘要翻译：本发明涉及一种用于检测与载体（11）的结合表面（12）结合的颗粒（MP）的方法和传感器装置（100）。传感器装置（100）包括用于将结合颗粒（MP）成像到图像传感器（53）上的显微镜（50）。为了增加显微镜（50）的空间分辨率，提供了可相对于图像传感器（53）移动载体（11）的位移单元（60,70,80）。因此，可以以高精度确定结合粒子（MP）与结合面（12）的距离和/或其与力的反应中的侧向位移。这允许通过来自非特异性直接结合的较小靶颗粒来区分与结合表面（12）结合的大磁性颗粒（MP）的特异性结合。

2. 发明申请

WO2012147021A1 EVALUATING ASSAYS WHICH OPTICAL INHOMOGENEITIES 审中-公开
标题翻译：评估光学不均匀性的测定
公开(公告)号：WO2012147021A1
公开(公告)日：2012-11-01
申请号：PCT/IB2012/052028
申请日：2012-04-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred , NIEUWENHUIS, Jeroen Hans , VAN ZON, Joannes Baptist Adrianus Dionisius
发明人： EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred , NIEUWENHUIS, Jeroen Hans , VAN ZON, Joannes Baptist Adrianus Dionisius
IPC分类号： G01N21/27 , G01N21/55 , G01N21/88 , G06T7/00
CPC分类号： G01N21/00 , G01N21/552 , G01N21/8851 , G01N21/94 , G01N2021/157 , G06T7/0012 , G06T2207/30072 , G06T2207/30168
摘要： The invention relates to a method and a sensor device(100) for evaluating an assay with a sample. During the assay, optical measurements are made at a sensing surface(112), and at least one "homogeneity-image" of the sensing surface(112) is generated. From this image, an "homogeneity-indicator" is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest(ROI) may be rejected.
摘要翻译：本发明涉及用于评价样品的测定方法和传感器装置（100）。在测定期间，在感测表面（112）处进行光学测量，并且产生感测表面（112）的至少一个“均匀性图像”。从该图像中，对于至少一个感兴趣的区域确定“均匀性指示符”，然后根据所述指示符来评估光学测量。均匀度指示符可以例如是二进制值，其指示是否检测到不均匀性。如果检测到不均匀性，则所有光学测量可能被拒绝，只有感兴趣区域的测量可能被拒绝，或者所涉及的感兴趣区域（ROI）的选定子区域的测量可能被拒绝。

3. 发明申请

WO2012117332A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2012117332A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050892
申请日：2012-02-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Joannes, Baptist, Adrianus, Dionisius , EVERS, Toon, Hendrik , VAN LIESHOUT, Ron, Martinus, Laurentius , HARDEMAN, Wilhelmina, Maria , KLUNDER, Derk, Jan, Wilfred
发明人： VAN ZON, Joannes, Baptist, Adrianus, Dionisius , EVERS, Toon, Hendrik , VAN LIESHOUT, Ron, Martinus, Laurentius , HARDEMAN, Wilhelmina, Maria , KLUNDER, Derk, Jan, Wilfred
IPC分类号： G01N27/14 , G01N33/543 , G01N21/65 , G01N21/55
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N21/7703 , G01N27/745
摘要： The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置（19）。位置事件确定单元（34）确定指示可以附着物质的粒子位于感测区域中的位置事件和来自通过感测感测区域产生的感测信号的位置事件的特性。位置事件选择单元（70）选择具有预定属性范围的属性的位置事件的一部分，物质确定单元（40）基于所选择的位置事件部分来确定流体（3）内的物质。这允许将流体内的物质的测定调整到期望的特性范围，这可以涉及期望类型的结合颗粒，从而减少不期望的影响对物质的测定的影响，从而提高确定精度。

4. 发明申请

WO2011073867A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2011073867A1
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055723
申请日：2010-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius , SCHLEIPEN, Johannes Joseph Hubertina Barbara , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , VAN LIESHOUT, Ron Martinus Laurentius
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius , SCHLEIPEN, Johannes Joseph Hubertina Barbara , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , VAN LIESHOUT, Ron Martinus Laurentius
IPC分类号： G01N21/86
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

5. 发明申请

WO2011036650A2 SENSOR DEVICE WITH IMAGING OPTICS 审中-公开
标题翻译：具有成像光学元件的传感器装置
公开(公告)号：WO2011036650A2
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054328
申请日：2010-09-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius
CPC分类号： G01N21/552 , G01N21/648 , G02B21/367
摘要： The invention relates to a method and a sensor device (100) for detecting particles (MP) that are bound to the binding surface (12) of a carrier (11). The sensor device (100) comprises a microscope (50) for imaging bound particles (MP)onto an image sensor (53). In order to increase the spatial resolution of the microscope(50), a displacement unit (60,70,80) is provided that can displace the carrier (11) relative to the image sensor (53). The distance of a bound particle (MP) from the binding surface (12) and/or its lateraldisplacement in reaction to forces can thus be determine with high accuracy. This allows to discriminate specific bindings of large magnetic particles (MP) that are bound to the binding surface (12) via smaller target particles from nonspecific direct bindings.
摘要翻译：本发明涉及一种用于检测与载体（11）的结合表面（12）结合的粒子（MP）的方法和传感器装置（100）。传感器装置（100）包括用于将束缚粒子（MP）成像到图像传感器（53）上的显微镜（50）。为了增加显微镜（50）的空间分辨率，提供了可以使载体（11）相对于图像传感器（53）移位的移位单元（60,70,80）。因此，可以高准确度地确定结合表面（MP）与结合表面（12）和/或其对应力的后期位移的距离。这允许通过较小的目标颗粒与非特异性直接结合区分结合到结合表面（12）的大磁性颗粒（MP）的特异性结合。

6. 发明申请

WO2012073182A1 A SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 审中-公开
标题翻译：一种用于磁力驱动颗粒的传感器装置
公开(公告)号：WO2012073182A1
公开(公告)日：2012-06-07
申请号：PCT/IB2011/055341
申请日：2011-11-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
发明人： DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
IPC分类号： G01N33/53 , G01N21/27 , G01N21/55
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an "auxiliary parameter" is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).
摘要翻译：本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，而与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

7. 发明申请

WO2011161499A1 DETECTION OF MAGNETIC PARTICLES AND THEIR CLUSTERING 审中-公开
标题翻译：检测磁性颗粒及其聚集
公开(公告)号：WO2011161499A1
公开(公告)日：2011-12-29
申请号：PCT/IB2010/055495
申请日：2010-11-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Joannes Baptist Adrianus Dionisius , OVSYANKO, Mikhail Mikhaylovich , EVERS, Toon Hendrik , SIJBERS, Mara Johanna Jacoba
发明人： VAN ZON, Joannes Baptist Adrianus Dionisius , OVSYANKO, Mikhail Mikhaylovich , EVERS, Toon Hendrik , SIJBERS, Mara Johanna Jacoba
IPC分类号： H01F1/00 , H01F1/44
CPC分类号： G01N27/72 , B01L3/502761 , B82Y25/00 , G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1276 , H01F1/0036
摘要： The invention relates to a method and associated apparatuses (100) for the detection of magnetic particles (MP) in a sample chamber (111). The method comprises the determination of a "particle-parameter" that is related to the amount of magnetic particles (MP) in a first detection region (P, C), the determination of a "cluster-parameter" that is related to the degree of clustering of magnetic particles (MP) in a second detection region (P, C), and the evaluation of the particle-parameter based on the cluster-parameter. Various apparatuses are disclosed that can be applied in said method. In one apparatus (100), a magnetic field (B) is generated in the sample chamber (111) in such a way that it has different inclinations in a first and second field region (P, C) and/or that it is oblique to the binding surface (112) in at least one field region. Magnetic particles (MP) are then detected in said first and second field region and/or in said at least one field region before and after a permanent switch-off of the inclined magnetic field. The resulting detection signals are related to each other to determine a cluster-parameter. In other embodiments, a cluster- parameter may be determined from light transmission measurements during the application of a magnetic field that is switched on and off.
摘要翻译：本发明涉及一种用于检测样品室（111）中的磁性颗粒（MP）的方法和相关装置（100）。该方法包括确定与第一检测区域（P，C）中的磁性粒子（MP）的量相关的“粒子参数”，确定与该程度相关的“聚类参数” 在第二检测区域（P，C）中的磁性粒子（MP）的聚类，以及基于聚类参数的粒子参数的评估。公开了可以应用于所述方法的各种装置。在一个装置（100）中，在样品室（111）中产生磁场（B），使得其在第一和第二场区域（P，C）中具有不同的倾斜度和/或倾斜到达至少一个场区域中的结合表面（112）。然后在永久关闭倾斜磁场之前和之后，在所述第一和第二场区和/或所述至少一个场区中检测磁性颗粒（MP）。所得到的检测信号彼此相关，以确定簇参数。在其他实施例中，可以在施加接通和关断的磁场期间的光透射测量来确定簇参数。

8. 发明申请

WO2011036634A1 A BIOSENSOR SYSTEM FOR SINGLE PARTICLE DETECTION 审中-公开
标题翻译：一种用于单粒子检测的生物传感器系统
公开(公告)号：WO2011036634A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054292
申请日：2010-09-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
发明人： SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
IPC分类号： G01R33/12 , G01N21/55
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface,a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic subunits separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一生物传感器磁体组件，其包括由间隙分开的至少两个磁性子单元，第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学检测是通过磁体组件的间隙完成。

9. 发明申请

WO2012101539A1 LOCALIZATION OF DETECTION SPOTS 审中-公开
标题翻译：检测点的本地化
公开(公告)号：WO2012101539A1
公开(公告)日：2012-08-02
申请号：PCT/IB2012/050156
申请日：2012-01-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN LIESHOUT, Ron Martinus Laurentius , VAN ZON, Joannes Baptist Adrianus Dionisius , EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred
发明人： VAN LIESHOUT, Ron Martinus Laurentius , VAN ZON, Joannes Baptist Adrianus Dionisius , EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred
IPC分类号： G01B11/28 , G01N21/55
CPC分类号： G01N21/552 , G01N33/54313 , G01N33/54366 , G01N33/54373
摘要： The invention relates to a method and a sensor device(100) that allow for the determination of geometrical properties like the position and/or area of at least one detection spot(153) on a contact surface(152), wherein said detection spot(153) has a height that is different from the height of the residual surface. The detection spot(153) may for example be a region coated with binding sites for target molecules. The localization of the detection spot(153) is achieved by illuminating the contact surface(152) with evanescent waves and by observing an output light beam(L2, L2') which is affected by an interaction between test particles(1), which cover the detection spot(153) and the contact surface(152), and said evanescent waves. The test particles may for example be magnetic particles(1) that are attracted to the contact surface(152) by magnetic forces, or they may be transported to the contact surface(152) by sedimentation. The location of the detection spot(153) may be determined at the end or at the beginning of an assay and be used during the evaluation of measurements.
摘要翻译：本发明涉及一种方法和传感器装置（100），其允许确定诸如接触表面（152）上的至少一个检测点（153）的位置和/或面积的几何特性，其中所述检测点 153）具有与残余表面的高度不同的高度。检测点（153）可以例如是涂覆有靶分子的结合位点的区域。通过用ev逝波照射接触表面（152）并且通过观察被测试颗粒（1）之间的相互作用影响的输出光束（L2，L2'）来实现检测点（153）的定位，其覆盖检测点（153）和接触表面（152）以及所述ev逝波。测试颗粒可以是例如通过磁力吸引到接触表面（152）的磁性颗粒（1），或者它们可以通过沉降被输送到接触表面（152）。检测点（153）的位置可以在测定结束或开始时确定，并且在评估测量期间使用。

10. 发明申请

WO2011073866A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2011073866A1
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055722
申请日：2010-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Joannes Baptist Adrianus Dionisius , EVERS, Toon Hendrik , KOETS, Maatje
发明人： VAN ZON, Joannes Baptist Adrianus Dionisius , EVERS, Toon Hendrik , KOETS, Maatje
IPC分类号： G01N21/86
CPC分类号： G01N21/552 , G01N33/54373
摘要： The invention relates to a substance determining apparatus and method for determining a substance within a fluid. Particles attach to the substance and bind to a binding surface (30), wherein a particle release curve being indicative of a release of bound particles from the binding surface (30) is determined, and a part of the particle release curve caused by particles bound to the binding surface via a predefined kind of binding is determined based on the temporal behaviour of the particle release curve. The substance within the fluid is determined based on the part of the particle release curve. The substance can therefore be determined based on particles which are bound to the binding surface via a certain kind of binding, i.e. other kinds of binding substantially do not affect the determination of the substance, thereby improving the accuracy of determining the substance.
摘要翻译：本发明涉及一种用于确定流体内的物质的物质确定装置和方法。颗粒附着于物质并结合至结合表面（30），其中确定指示结合颗粒从结合表面（30）释放的颗粒释放曲线，并且由颗粒结合引起的部分颗粒释放曲线基于粒子释放曲线的时间行为来确定经由预定类型的结合的结合表面。基于颗粒释放曲线的部分确定流体内的物质。因此，物质可以基于通过某种结合结合到结合表面的颗粒来确定，即其它种类的结合基本上不影响物质的测定，从而提高了确定物质的准确性。

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