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1. 发明申请

WO2011073867A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2011073867A1
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055723
申请日：2010-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius , SCHLEIPEN, Johannes Joseph Hubertina Barbara , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , VAN LIESHOUT, Ron Martinus Laurentius
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius , SCHLEIPEN, Johannes Joseph Hubertina Barbara , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , VAN LIESHOUT, Ron Martinus Laurentius
IPC分类号： G01N21/86
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

2. 发明申请

WO2011036634A1 A BIOSENSOR SYSTEM FOR SINGLE PARTICLE DETECTION 审中-公开
标题翻译：一种用于单粒子检测的生物传感器系统
公开(公告)号：WO2011036634A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054292
申请日：2010-09-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
发明人： SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
IPC分类号： G01R33/12 , G01N21/55
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface,a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic subunits separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一生物传感器磁体组件，其包括由间隙分开的至少两个磁性子单元，第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学检测是通过磁体组件的间隙完成。

3. 发明申请

WO2012101539A1 LOCALIZATION OF DETECTION SPOTS 审中-公开
标题翻译：检测点的本地化
公开(公告)号：WO2012101539A1
公开(公告)日：2012-08-02
申请号：PCT/IB2012/050156
申请日：2012-01-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN LIESHOUT, Ron Martinus Laurentius , VAN ZON, Joannes Baptist Adrianus Dionisius , EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred
发明人： VAN LIESHOUT, Ron Martinus Laurentius , VAN ZON, Joannes Baptist Adrianus Dionisius , EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred
IPC分类号： G01B11/28 , G01N21/55
CPC分类号： G01N21/552 , G01N33/54313 , G01N33/54366 , G01N33/54373
摘要： The invention relates to a method and a sensor device(100) that allow for the determination of geometrical properties like the position and/or area of at least one detection spot(153) on a contact surface(152), wherein said detection spot(153) has a height that is different from the height of the residual surface. The detection spot(153) may for example be a region coated with binding sites for target molecules. The localization of the detection spot(153) is achieved by illuminating the contact surface(152) with evanescent waves and by observing an output light beam(L2, L2') which is affected by an interaction between test particles(1), which cover the detection spot(153) and the contact surface(152), and said evanescent waves. The test particles may for example be magnetic particles(1) that are attracted to the contact surface(152) by magnetic forces, or they may be transported to the contact surface(152) by sedimentation. The location of the detection spot(153) may be determined at the end or at the beginning of an assay and be used during the evaluation of measurements.
摘要翻译：本发明涉及一种方法和传感器装置（100），其允许确定诸如接触表面（152）上的至少一个检测点（153）的位置和/或面积的几何特性，其中所述检测点 153）具有与残余表面的高度不同的高度。检测点（153）可以例如是涂覆有靶分子的结合位点的区域。通过用ev逝波照射接触表面（152）并且通过观察被测试颗粒（1）之间的相互作用影响的输出光束（L2，L2'）来实现检测点（153）的定位，其覆盖检测点（153）和接触表面（152）以及所述ev逝波。测试颗粒可以是例如通过磁力吸引到接触表面（152）的磁性颗粒（1），或者它们可以通过沉降被输送到接触表面（152）。检测点（153）的位置可以在测定结束或开始时确定，并且在评估测量期间使用。

4. 发明申请

WO2011036638A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2011036638A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054304
申请日：2010-09-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , EVERS, Toon Hendrik , SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich , VAN OMMERING, Kim
发明人： EVERS, Toon Hendrik , SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich , VAN OMMERING, Kim
IPC分类号： G01N15/06 , G01N35/00 , G01N15/14 , G01N21/55 , G01N33/543
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。具有附着物质的颗粒结合至结合表面（30）。感测单元（33）适于产生感测信号，该感测信号指示i）结合在装订表面（30）和装订表面（30）上的颗粒之间的距离和ii）平面内位置的结合表面上的颗粒。绑定识别单元（34）适于根据产生的感测信号来区分绑定在绑定表面（30）上的粒子的不同种类的绑定。绑定识别单元（34）优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元，并且基于该确定的感测信号的部分来确定物质。

5. 发明申请

WO2011138705A2 SENSING DEVICE FOR DETECTING A SUBSTANCE IN A FLUID 审中-公开
标题翻译：用于检测流体中的物质的感测装置
公开(公告)号：WO2011138705A2
公开(公告)日：2011-11-10
申请号：PCT/IB2011/051797
申请日：2011-04-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN LIESHOUT, Ron Martinus Laurentius , PENTERMAN, Roel
发明人： VAN LIESHOUT, Ron Martinus Laurentius , PENTERMAN, Roel
IPC分类号： G01N21/27 , G01N21/55 , G01N33/543 , B01L3/00
CPC分类号： G01N21/55 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/04 , B01L2200/0684 , B01L2200/143 , B01L2300/025 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/0677 , G01N21/274 , G01N21/552 , G01N21/553 , G01N21/648 , G01N21/65 , G01N21/76 , G01N29/022 , G01N29/30 , G01N2021/0346 , G01N2021/7723 , G01N2201/0221 , G01N2291/0255 , G01N2291/0256 , Y10T29/49826
摘要： The invention relates to a sensing device (1) for detecting a substance (3) in a fluid (6), wherein the sensing device comprises a sensing region (2) for being used for generating a sensing signal depending on the substance, a reference region (4) for being used for providing a reference signal, and a reference element (5) covering the reference region. The reference element is adapted to shield the reference region from the substance and to allow the fluid to penetrate the reference element. This reduces the influence of the reference signal by the substance and, since the reference element is adapted to allow the fluid to penetrate the reference element, differences regarding properties of the fluid at the sensing region and of the reference element at the reference region can be reduced. This reduction leads to an improved reference signal, which can be used, for example, for correcting the sensing signal.
摘要翻译：本发明涉及用于检测流体（6）中的物质（3）的感测装置（1），其中感测装置包括用于根据物质产生感测信号的感测区域（2），参考用于提供参考信号的区域（4）和覆盖参考区域的参考元件（5）。参考元件适于将参考区域与物质隔离并允许流体穿透参考元件。这减少了物质对参考信号的影响，并且由于参考元件适于允许流体穿透参考元件，所以与感测区域处的流体和参考区域处的参考元件的性质有关的差异可以是降低。该减少导致改进的参考信号，其可以用于例如校正感测信号。

6. 发明申请

WO2013064990A1 DETECTION OF SURFACE-BOUND MAGNETIC PARTICLES 审中-公开
标题翻译：表面磁性颗粒的检测
公开(公告)号：WO2013064990A1
公开(公告)日：2013-05-10
申请号：PCT/IB2012/056044
申请日：2012-10-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V.
发明人： VAN ZON, Joannes Baptist Adrianus Dionisius , VAN LIESHOUT, Ron Martinus Laurentius
IPC分类号： G01N21/55
CPC分类号： G01N33/543 , G01N21/552 , G01N27/745
摘要： The invention relates to a method and a sensor device (100) for the detection of magnetic particles (1) bound to the binding surface (111) of a sample chamber (112), wherein said detection is made during and/or immediately after the action of an attractive magnetic field. Preferably, the attractive magnetic field (B) is preceded by a repulsive magnetic field (B) which removes unbound magnetic particles away from the binding surface (111). Due to the attractive magnetic field (B), bound magnetic particles (1) come closer to the binding surface (111), which increases the signal of surface specific detection techniques like frustrated total internal reflection. A further enhancement of the signal can be achieved by an attractive magnetic field that is parallel to the binding surface (111), thus inducing the generation of chains between unbound and bound magnetic particles.
摘要翻译：本发明涉及一种用于检测结合到样品室（112）的结合表面（111）的磁性颗粒（1）的方法和传感器装置（100），其中所述检测是在和/或之后有吸引力的磁场的作用。优选地，吸引磁场（B）之前是排斥磁场（B），其将未结合的磁性颗粒从结合表面（111）移除。由于有吸引力的磁场（B），结合的磁性颗粒（1）更靠近结合表面（111），这增加了表面特异性检测技术的信号，如沮丧的全内反射。可以通过平行于结合表面（111）的有吸引力的磁场来实现信号的进一步增强，从而诱导在未结合和结合的磁性颗粒之间产生链。

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