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1. 发明申请

WO2012073182A1 A SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 审中-公开
标题翻译：一种用于磁力驱动颗粒的传感器装置
公开(公告)号：WO2012073182A1
公开(公告)日：2012-06-07
申请号：PCT/IB2011/055341
申请日：2011-11-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
发明人： DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
IPC分类号： G01N33/53 , G01N21/27 , G01N21/55
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an "auxiliary parameter" is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).
摘要翻译：本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，而与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

2. 发明申请

WO2012117332A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2012117332A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050892
申请日：2012-02-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Joannes, Baptist, Adrianus, Dionisius , EVERS, Toon, Hendrik , VAN LIESHOUT, Ron, Martinus, Laurentius , HARDEMAN, Wilhelmina, Maria , KLUNDER, Derk, Jan, Wilfred
发明人： VAN ZON, Joannes, Baptist, Adrianus, Dionisius , EVERS, Toon, Hendrik , VAN LIESHOUT, Ron, Martinus, Laurentius , HARDEMAN, Wilhelmina, Maria , KLUNDER, Derk, Jan, Wilfred
IPC分类号： G01N27/14 , G01N33/543 , G01N21/65 , G01N21/55
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N21/7703 , G01N27/745
摘要： The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置（19）。位置事件确定单元（34）确定指示可以附着物质的粒子位于感测区域中的位置事件和来自通过感测感测区域产生的感测信号的位置事件的特性。位置事件选择单元（70）选择具有预定属性范围的属性的位置事件的一部分，物质确定单元（40）基于所选择的位置事件部分来确定流体（3）内的物质。这允许将流体内的物质的测定调整到期望的特性范围，这可以涉及期望类型的结合颗粒，从而减少不期望的影响对物质的测定的影响，从而提高确定精度。

3. 发明申请

WO2011036597A1 BINDING ASSAY WITH MULTIPLE MAGNETICALLY LABELLED TRACER BINDING AGENTS. 审中-公开
标题翻译：具有多个磁性标签的追踪器绑定代理的绑定测试。
公开(公告)号：WO2011036597A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054094
申请日：2010-09-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen, Hans , EVERS, Toon, Hendrik
发明人： NIEUWENHUIS, Jeroen, Hans , EVERS, Toon, Hendrik
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N27/745
摘要： The present invention relates to a cartridge (1) for the detection of an analyte (2) in a binding assay with magnetic labels (3), the cartridge comprising at least one capture binding agent (4) against a binding site on the analyte and comprising at least two magnetically labelled tracer binding agents (51 and 52) against further different binding sites on the analyte, characterised in that the cartridge comprises at least two regions (61 and 62) wherein a first region (61) comprises the at least one capture binding agent (4) and a first magnetically labelled tracer binding agent (51) and wherein a second region (62) comprises at least one capture binding agent (4) and a second magnetically labelled tracer binding agent (52). Herein the first region (61) does not comprise a magnetically labelled tracer binding agent other than the first magnetically labelled tracer bind agent (51) and wherein the second region (62) does not comprise a magnetically labelled tracer binding agent other than the second magnetically labelled tracer binding agent (52).
摘要翻译：本发明涉及一种用于在具有磁性标签（3）的结合测定中检测分析物（2）的盒（1），所述盒包含针对分析物上的结合位点的至少一种捕获结合剂（4）包括至少两个磁性标记的示踪剂结合剂（51和52），其抵抗所述分析物上的另外不同的结合位点，其特征在于，所述盒包括至少两个区域（61和62），其中第一区域（61）包括所述至少一个捕获结合剂（4）和第一磁性标记的示踪剂结合剂（51），并且其中第二区域（62）包含至少一种捕获结合剂（4）和第二磁性标记示踪剂结合剂（52）。本文中，第一区域（61）不包含除了第一磁性标记的示踪剂结合剂（51）之外的磁性标记的示踪剂结合剂，并且其中第二区域（62）不包括除了第二磁性标记的磁性标记的示踪剂结合剂标记示踪剂结合剂（52）。

4. 发明申请

WO2012004723A1 EXAMINATION SYSTEM WITH SAMPLE INCUBATION 审中-公开
标题翻译：检验系统与样本孵化
公开(公告)号：WO2012004723A1
公开(公告)日：2012-01-12
申请号：PCT/IB2011/052945
申请日：2011-07-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HARDEMAN, Wilhelmina, Maria , EVERS, Toon, Hendrik , JANSEN, Theodorus, Petrus, Henricus, Gerardus
发明人： HARDEMAN, Wilhelmina, Maria , EVERS, Toon, Hendrik , JANSEN, Theodorus, Petrus, Henricus, Gerardus
IPC分类号： G01N33/53
CPC分类号： G01N21/75 , B01L3/502715 , B01L2200/027 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , G01N33/54366
摘要： The invention relates to a cartridge(10) and its use in an examination apparatus(100). A sample(1) can be introduced into an inlet(11) of the cartridge(10) and conducted through a channel(12) to a reaction chamber(13). In the reaction chamber(13), an examination of the sample takes place, for example by frustrated total internal reflection. An agent(21) is applied to the sample close to the inlet(11), wherein said agent(21) is preferably stored in a reservoir(16) at the inlet(11). In this way the filling time of the reaction chamber(13) is simultaneously used for the incubation of the sample with the agent(21). Moreover, the filling-course of the cartridge and/or the reaction chamber may preferably be determined and taken into account during the execution of the examination and/or the evaluation of the results.
摘要翻译：本发明涉及一种盒（10）及其在检查装置（100）中的应用。样品（1）可以被引入到药筒（10）的入口（11）中并且通过通道（12）传导到反应室（13）。在反应室（13）中，例如通过沮丧的全内反射来检查样品。将试剂（21）施加到靠近入口（11）的样品上，其中所述试剂（21）优选储存在入口（11）处的储存器（16）中。以这种方式，反应室（13）的填充时间同时用于样品与试剂（21）的孵育。此外，可以在执行检查和/或评估结果期间优选地确定和考虑盒和/或反应室的填充过程。

5. 发明申请

WO2013072842A1 LONG RIGID SPACERS TO ENHANCE BINDING KINETICS IN IMMUNOASSAYS 审中-公开
标题翻译：长距离加强免疫组织结合动力学
公开(公告)号：WO2013072842A1
公开(公告)日：2013-05-23
申请号：PCT/IB2012/056378
申请日：2012-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V.
发明人： EVERS, Toon, Hendrik , KOETS, Maatje
IPC分类号： G01N21/00 , G01N33/52 , G01N33/553 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54393 , G01N21/552 , G01N33/54326 , G01N33/54353 , G01N33/54366 , G01N33/553 , G01N33/6887 , G01N33/74 , G01N2333/58
摘要： The present invention relates to a device for detecting a target molecule within a sample comprising a sample container for the measurement of the target molecule within a sample, a first particle,wherein said first particle is functionalized with a first binding molecule capable of specifically binding to said target molecule, and a surface structure comprising a second binding molecule, wherein said surface structure covers a flat sensor or is present on a second particle, wherein said first particle is capable of binding said second binding molecule of the surface structure directly or indirectly; wherein said first and/or second binding molecule is indirectly attached to the particle surface of said first and/or second particle and/or the flat sensor surface via a long and rigid linker molecule; wherein the length and the consistency of said linker molecule is selected such as to result in an average extension length of said linker of more than 60 nm; and wherein the number of particle clusters or of bound particles is directly or inversely related to the amount of target molecules present in the sample.In a further aspect the present invention relates to a method of detecting the presence or amount of a target molecule within a sample. The present invention also describes the use of a particle according to the invention for detecting a target molecule within a sample.
摘要翻译：本发明涉及一种用于检测样品内目标分子的装置，包括用于测量样品内目标分子的样品容器，第一颗粒，其中所述第一颗粒用能够特异性结合所述靶分子和包含第二结合分子的表面结构，其中所述表面结构覆盖平坦传感器或存在于第二颗粒上，其中所述第一颗粒能够直接或间接地结合表面结构的所述第二结合分子; 其中所述第一和/或第二结合分子通过长而刚性的连接分子间接连接到所述第一和/或第二颗粒和/或平面传感器表面的颗粒表面; 其中选择所述连接体分子的长度和稠度，使所述接头的平均延伸长度大于60nm; 并且其中颗粒簇或结合的颗粒的数量与样品中存在的靶分子的量直接或相反。另一方面，本发明涉及一种检测靶分子的存在或量的方法，样品。本发明还描述了根据本发明的颗粒用于检测样品中的靶分子的用途。

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