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1. 发明申请

WO2011128808A1 DETECTION SYSTEM FOR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：用于检测磁性颗粒的检测系统
公开(公告)号：WO2011128808A1
公开(公告)日：2011-10-20
申请号：PCT/IB2011/051454
申请日：2011-04-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen Hans , LEENAARS, Adriaan
发明人： NIEUWENHUIS, Jeroen Hans , LEENAARS, Adriaan
IPC分类号： G01R33/12
CPC分类号： G01R33/1269
摘要： The invention relates to a detection system (54) for detecting magnetic particles (25) on a detection surface (90) of the detection system (54). A magnetic unit (19) generates a magnetic field for arranging the magnetic particles on the detection surface (90), and a sensing unit (20, 21, 22, 23) generates a sensing signal depending on the arrangement of magnetic particles (25) on the detection surface (90). Characteristics of the magnetic field on the detection surface (90) are provided by a magnetic field characteristics providing unit (42), and a sensing signal correction unit (43) corrects the generated sensing signal depending on the provided characteristics of the magnetic field. This allows correcting the sensing signal for variations of the characteristics of the magnetic field on the detection surface.
摘要翻译：本发明涉及一种用于检测检测系统（54）的检测表面（90）上的磁性颗粒（25）的检测系统（54）。磁性单元（19）产生用于将磁性颗粒布置在检测表面（90）上的磁场，并且感测单元（20,21,22,23）根据磁性颗粒（25）的布置产生感测信号，在检测表面（90）上。检测表面（90）上的磁场的特性由磁场特性提供单元（42）提供，并且感测信号校正单元（43）根据所提供的磁场特性校正产生的感测信号。这允许校正感测信号用于检测表面上的磁场特性的变化。

2. 发明申请

WO2008142492A1 METHOD FOR DETECTING LABEL PARTICLES 审中-公开
标题翻译：检测标签颗粒的方法
公开(公告)号：WO2008142492A1
公开(公告)日：2008-11-27
申请号：PCT/IB2007/052938
申请日：2007-07-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen Hans
发明人： NIEUWENHUIS, Jeroen Hans
IPC分类号： G01N33/543 , G01N33/58 , G01N15/06
CPC分类号： G01N33/54373 , B01L3/502761 , B01L2200/0668 , B01L2400/0415 , B01L2400/043 , G01N15/0656 , G01N21/11 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54326 , G01N33/58 , G01N33/585 , G01N35/0098 , G01R33/1269
摘要： The invention relates to a method and a microelectronic sensor device for the detection of target components comprising label particles, for example magnetic nano-particles (1). The method comprises the determination of at least one "reference value" (S bg , S sat ) before and/or after target components have been admitted to a binding surface (12), and the measurement of a "signal value" (S sig ) after unbound target components have been removed from the binding surface (12). The reference values may particularly comprise a background reference value (S bg ) measured while no target components are at the binding surface (12), and a saturation reference value (S sat ) measured while a maximal amount of target components is attracted to the binding surface (12). The reference values (S bg , S sat ) can be used to correct the signal value (S sig ), to determine a reliability measure, and/or to detect error states. A movement of the target components is preferably achieved by electrical or magnetic fields (B) acting on their labels (1), while the measurement of target components at the binding surface (12) is done with an independent, for example optical measurement principle.
摘要翻译：本发明涉及用于检测包含标记颗粒（例如磁性纳米颗粒（1））的靶组分的方法和微电子传感器装置。该方法包括在目标组分已经进入结合表面之前和/或之后确定至少一个“参考值”（S B B S S S S S S SAT）（12 ），并且在未结合的目标成分已经从结合表面（12）移除之后，测量“信号值”（S SUB sig ）。参考值可以特别地包括在没有目标分量处于结合表面（12）时测量的背景参考值（S BAT），并且饱和基准值（S SUB> ），而最大量的目标组分被吸引到结合表面（12）。可以使用参考值（S S B B S S S S S T S T S T S T S T S T S T S T S T S S T S S T S T S T S T S T S S S T S T S T S T S T S T S S T S T S T S T S T S T S T S T S T S T S T S T S T S T S T S T S T H S T S T H S T 和/或检测错误状态。目标部件的移动优选通过作用在其标签（1）上的电场或磁场（B）来实现，而在绑定表面（12）处的目标部件的测量是用独立的例如光学测量原理完成的。

3. 发明申请

WO2008084343A1 A SENSOR DEVICE FOR AND A METHOD OF SENSING PARTICLES 审中-公开
标题翻译：用于传感颗粒的传感器装置和方法
公开(公告)号：WO2008084343A1
公开(公告)日：2008-07-17
申请号：PCT/IB2007/052967
申请日：2007-07-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , VERHOECKX, Godefridus Johannes , PRINS, Menno Willem Jose , VAN LANKVELT, Petrus Johannes Wilhelmus , VAN OMMERING, Kim
发明人： NIEUWENHUIS, Jeroen Hans , VERHOECKX, Godefridus Johannes , PRINS, Menno Willem Jose , VAN LANKVELT, Petrus Johannes Wilhelmus , VAN OMMERING, Kim
IPC分类号： G01R33/12 , G01N15/06
CPC分类号： G01R33/12 , B82Y25/00 , G01N15/0656 , G01N2011/008 , G01N2015/0053 , G01R33/093 , G01R33/1284
摘要： A sensor device (50) for sensing particles (15) of a sample, the sensor device (50) comprising a sensing unit (11, 20) adapted for sensing a detection signal indicative of the presence of the particles (15), a viscosity measurement unit (11, 17, 20) adapted for measuring the viscosity of the sample, and a correction unit (20, 30) adapted for correcting the detection signal based on the measured viscosity.
摘要翻译：一种用于感测样品的颗粒（15）的传感器装置（50），所述传感器装置（50）包括适于感测指示所述颗粒（15）的存在的检测信号的感测单元（11,20），粘度适于测量样品粘度的测量单元（11,17,20）以及适于基于所测量的粘度校正检测信号的校正单元（20,30）。

4. 发明申请

WO2008035252A2 A SENSOR DEVICE FOR AND A METHOD OF SENSING PARTICLES 审中-公开
标题翻译：用于传感颗粒的传感器装置和方法
公开(公告)号：WO2008035252A2
公开(公告)日：2008-03-27
申请号：PCT/IB2007/053679
申请日：2007-09-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , PRINS, Menno Willem Jose
发明人： NIEUWENHUIS, Jeroen Hans , PRINS, Menno Willem Jose
IPC分类号： G01N15/06 , G01N33/543 , G01N35/00
CPC分类号： G01N15/12 , G01N15/0656 , G01N15/1056 , G01N2015/1087
摘要： A sensor device (100) for sensing first particles (504, 505) of a sample comprising the first particles (504, 505) and second particles (503), the sensor device (100) comprising a detection unit (11, 12) adapted to detect a signal which depends on a quantity of the first particles (504, 505) and which depends on a quantity of the second particles (503) based on a measurement performed with the sample comprising the first particles (504, 505) and the second particles (503), an estimation unit (30) for estimating information indicative of the quantity of the second particles (503) based on an impedance measurement, and a determining unit (20) adapted for determining the quantity of the first particles (504, 505) based on the detected signal under consideration of the estimated information.
摘要翻译：一种用于感测包括第一颗粒（504,505）和第二颗粒（503）的样品的第一颗粒（504,505）的传感器装置（100），所述传感器装置（100）包括适配的检测单元（11,12）基于由包含第一颗粒（504,505）的样品和第一颗粒（504,505）进行的测量，检测取决于第一颗粒（504,505）的量并且取决于第二颗粒（503）的量的信号，第二粒子（503），用于基于阻抗测量来估计指示第二粒子（503）的量的信息的估计单元（30），以及用于确定第一粒子（504）的量的确定单元，505），其基于考虑了估计信息的检测信号。

5. 发明申请

WO2007132366A3 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：WO2007132366A3
公开(公告)日：2008-03-27
申请号：PCT/IB2007051505
申请日：2007-04-24
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
发明人： NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3），参与结合曲线，例如， Langmuir等温线可以适应于采样的测量信号，以确定样品中所需的颗粒浓度。此外，在持续采样过程中，可以动态拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数与目标颗粒移动到敏感区域之外或之内的单个事件。

6. 发明申请

WO2008001263A2 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSOR ELEMENTS 审中-公开
标题翻译：具有场发生器和传感器元件的磁性传感器装置
公开(公告)号：WO2008001263A2
公开(公告)日：2008-01-03
申请号：PCT/IB2007/052327
申请日：2007-06-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , ZON, Hans , KAHLMAN, Johannes Arnoldus Henricus Maria
发明人： NIEUWENHUIS, Jeroen Hans , ZON, Hans , KAHLMAN, Johannes Arnoldus Henricus Maria
CPC分类号： G01R33/12 , B82Y25/00 , G01R33/093 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising (a) excitation wires (11, 13) for generating a magnetic excitation field (B) that magnetizes particles (2) in an investigation region (5), and (b) a magnetic sensor element, for example a GMR sensor (12), for detecting reaction fields (B') generated by the magnetized particles (2). The excitation wires (11, 13) and the GMR element (12) are driven by current pulses such that the average power dissipation is kept constant while the signal-to-noise ratio is optimized. The sampling frequency of said pulses is preferably larger than the thermal time constant (τ) of the magnetic sensor device (10).
摘要翻译：本发明涉及一种磁性传感器装置（10），其包括：（a）用于产生励磁场（B）的激励导线（11,13），所述激励导线将研究区域中的粒子（2）（b）磁性传感器元件，例如GMR传感器（12），用于检测由磁化粒子（2）产生的反应场（B'）。激励导线（11,13）和GMR元件（12）由电流脉冲驱动，使得平均功耗保持恒定，同时优化信噪比。所述脉冲的采样频率优选大于磁传感器装置（10）的热时间常数（τ）。

7. 发明申请

WO2013024381A1 CONTROL OF FLUID FLOW IN A MICROFLUIDIC SYSTEM 审中-公开
标题翻译：流体流动控制在微流体系统中的应用
公开(公告)号：WO2013024381A1
公开(公告)日：2013-02-21
申请号：PCT/IB2012/053788
申请日：2012-07-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER BEEK, Maurice Hubertus Elisabeth , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , MAAS, Joost Hubert
发明人： VAN DER BEEK, Maurice Hubertus Elisabeth , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , MAAS, Joost Hubert
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L2200/0621 , B01L2200/0684 , B01L2300/044 , B01L2300/0816 , B01L2400/0688
摘要： The invention relates to the means for controlling the processing of a sample fluid (S) in a microfluidic system (110). The sample fluid (S) is introduced into an inlet port such that air is captured in the microfluidic system (110). Further advancement of the sample fluid(S) is only possible after a venting port (115) has controllably been opened, wherein said flow comes to a rest at a fluidic stop (130) before reaching the venting port (115). In a particular embodiment, the microfluidic system (110) is disposed in a cartridge (100), and the venting port (115) is covered by a foil (102). After insertion of the cartridge (100) into a sensor apparatus (150), said foil can be pierced, thus starting the filling of the microfluidic system (110) and processing of the sample fluid.
摘要翻译：本发明涉及用于控制微流体系统（110）中的样品流体（S）的处理的装置。将样品流体（S）引入入口端口，使得空气被捕获在微流体系统（110）中。样品流体（S）的进一步推进仅在通气口115可控地打开之后才可能，其中所述流在到达通气口115之前在流体停止（130）处休息。在特定实施例中，微流体系统（110）设置在盒（100）中，并且通气口（115）被箔（102）覆盖。在将盒（100）插入传感器装置（150）之后，可以刺穿所述箔，从而开始填充微流体系统（110）并处理样品流体。

8. 发明申请

WO2012147021A1 EVALUATING ASSAYS WHICH OPTICAL INHOMOGENEITIES 审中-公开
标题翻译：评估光学不均匀性的测定
公开(公告)号：WO2012147021A1
公开(公告)日：2012-11-01
申请号：PCT/IB2012/052028
申请日：2012-04-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred , NIEUWENHUIS, Jeroen Hans , VAN ZON, Joannes Baptist Adrianus Dionisius
发明人： EVERS, Toon Hendrik , KLUNDER, Derk Jan Wilfred , NIEUWENHUIS, Jeroen Hans , VAN ZON, Joannes Baptist Adrianus Dionisius
IPC分类号： G01N21/27 , G01N21/55 , G01N21/88 , G06T7/00
CPC分类号： G01N21/00 , G01N21/552 , G01N21/8851 , G01N21/94 , G01N2021/157 , G06T7/0012 , G06T2207/30072 , G06T2207/30168
摘要： The invention relates to a method and a sensor device(100) for evaluating an assay with a sample. During the assay, optical measurements are made at a sensing surface(112), and at least one "homogeneity-image" of the sensing surface(112) is generated. From this image, an "homogeneity-indicator" is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest(ROI) may be rejected.
摘要翻译：本发明涉及用于评价样品的测定方法和传感器装置（100）。在测定期间，在感测表面（112）处进行光学测量，并且产生感测表面（112）的至少一个“均匀性图像”。从该图像中，对于至少一个感兴趣的区域确定“均匀性指示符”，然后根据所述指示符来评估光学测量。均匀度指示符可以例如是二进制值，其指示是否检测到不均匀性。如果检测到不均匀性，则所有光学测量可能被拒绝，只有感兴趣区域的测量可能被拒绝，或者所涉及的感兴趣区域（ROI）的选定子区域的测量可能被拒绝。

9. 发明申请

WO2008072183A1 SENSOR DEVICE COMPRISING MEANS FOR DETERMINING THE SAMPLE COVERED AREA OF THE SENSITIVE SURFACE 审中-公开
标题翻译：传感器装置包含用于确定敏感表面样品覆盖区域的方法
公开(公告)号：WO2008072183A1
公开(公告)日：2008-06-19
申请号：PCT/IB2007/055024
申请日：2007-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , DE THEIJE, Femke Karina , VEEN, Jeroen
发明人： NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , DE THEIJE, Femke Karina , VEEN, Jeroen
IPC分类号： G01N27/02 , G01N27/04 , G01N27/22
CPC分类号： G01N13/00 , G01N27/745 , G01N33/54326 , G01R33/1269
摘要： The invention relates to a microelectronic device (100) with means for the determination of the wetting grade of a sensitive surface (22) that lies adjacent to a sample chamber (1) with a sample fluid. In a particular embodiment, the device may be a magnetic sensor device comprising magnetic excitation wires (11, 13) for the generation of magnetic fields (B) in the sample chamber and a GMR sensor (12) for sensing reaction fields (B') generated by magnetized particles (2). A detector module (30) can optionally be adapted to measure the resistance of conductors (11, 12, 13) which depends, via the dissipation of heat generated by electrical currents, on the wetting grade of the sensitive surface (22). In another embodiment, the capacitance of conductors is measured, which is affected at the sensitive surface by the presence of gas bubbles (4).
摘要翻译：本发明涉及一种微电子器件（100），其具有用于利用样品流体确定位于样品室（1）附近的敏感表面（22）的润湿等级的装置。在特定实施例中，该装置可以是包括用于在样品室中产生磁场（B）的磁激励线（11,13）和用于感测反应场（B'）的GMR传感器（12）的磁传感器装置，由磁化颗粒（2）产生。检测器模块（30）可以可选地适于测量导体（11,12,13）的电阻，这取决于电流产生的热量消耗在敏感表面（22）的润湿等级上。在另一个实施例中，测量导体的电容，其通过气泡的存在而受到敏感表面的影响（4）。

10. 发明申请

WO2012073182A1 A SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 审中-公开
标题翻译：一种用于磁力驱动颗粒的传感器装置
公开(公告)号：WO2012073182A1
公开(公告)日：2012-06-07
申请号：PCT/IB2011/055341
申请日：2011-11-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
发明人： DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
IPC分类号： G01N33/53 , G01N21/27 , G01N21/55
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an "auxiliary parameter" is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).
摘要翻译：本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，而与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

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