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1. 发明申请

WO2005112895A2 INGESTIBLE DEVICE PLATFORM FOR THE COLON 审中-公开
标题翻译：不可思议的设备平台
公开(公告)号：WO2005112895A2
公开(公告)日：2005-12-01
申请号：PCT/IL2005/000517
申请日：2005-05-19
申请人： V-TARGET TECHNOLOGIES LTD. , ZILBERSTEIN, Yoel , NAGLER, Michael , ROUSSO, Benny , HALAHMI, Izhar
发明人： ZILBERSTEIN, Yoel , NAGLER, Michael , ROUSSO, Benny , HALAHMI, Izhar
IPC分类号： A61K9/20
CPC分类号： A61B1/00156 , A61B1/041 , A61B5/0077 , A61B5/073 , A61B5/14539 , A61B5/1459 , A61B5/205 , A61B5/415 , A61B5/4255 , A61B5/6861 , A61B6/425 , A61B6/4258 , A61B6/482 , A61B6/508 , A61B6/5247 , A61B8/12 , A61B8/4416
摘要： An ingestible pill platform for colon imaging is provided, designed to recognize its entry to the colon and expand in the colon, for improved imaging of the colon walls. On approaching the external anal sphincter muscle, the ingestible pill may contract or deform, for elimination. Colon recognition may be based on a structural image, based on the differences in diameters between the small intestine and the colon, and particularly, based on the semilunar fold structure, which is unique to the colon. Additionally or alternatively, colon recognition may be based on a functional image, based on the generally inflammatory state of the vermiform appendix. Additionally or alternatively, pH, flora, enzymes and (or) chemical analyses may be used to recognize the colon. The imaging of the colon walls may be functional, by nuclear-radiation imaging of radionuclide-labeled antibodies, or by optical-fluorescence-spectroscopy imaging of fluorescence-labeled antibodies. Additionally or alternatively, it may be structural, for example, by visual, ultrasound or MRI means. Due to the proximity to the colon walls, the imaging in accordance with the present invention is advantageous to colonoscopy or virtual colonoscopy, as it is designed to distinguish malignant from benign tumors and detect tumors even at their incipient stage, and overcome blood-pool background radioactivity.
摘要翻译：提供用于结肠成像的可摄取药丸平台，旨在识别其进入结肠并在结肠中扩张，以改善结肠壁的成像。在接近外肛门括约肌时，可摄取的药丸可能收缩或变形，以消除。结肠识别可以基于基于小肠和结肠之间的直径差异的结构图像，特别是基于结肠特有的半月形折叠结构。另外或替代地，结肠识别可以基于功能图像，基于蠕形阑尾的通常炎症状态。另外或替代地，可以使用pH，菌群，酶和（或）化学分析来识别结肠。结肠壁的成像可以通过放射性核素标记的抗体的核辐射成像或荧光标记的抗体的光学 - 荧光光谱成像来实现。另外或替代地，其可以是结构性的，例如通过视觉，超声或MRI手段。由于靠近结肠壁，根据本发明的成像对于结肠镜检查或虚拟结肠镜检查是有利的，因为其被设计为将恶性肿瘤与良性肿瘤区分开，甚至在初期阶段检测肿瘤，并克服血池背景放射性。

2. 发明申请

WO2005067383A2 MULTI-DIMENSIONAL IMAGE RECONSTRUCTION 审中-公开
标题翻译：多维图像重建
公开(公告)号：WO2005067383A2
公开(公告)日：2005-07-28
申请号：PCT/IL2005/000048
申请日：2005-01-13
申请人： V-TARGET TECHNOLOGIES LTD. , ROUSSO, Benny , NAGLER, Michael
发明人： ROUSSO, Benny , NAGLER, Michael
IPC分类号： G01T1/161 , G01T1/166
CPC分类号： A61B6/481 , A61B6/4057 , A61B6/4258 , A61B6/486 , A61B6/5217 , A61B6/5241 , A61B90/39 , A61M5/007 , G01T1/161 , G01T1/166
摘要： Apparatus for radiation based imaging of a non-homogenous target area having distinguishable regions therein, comprises: an imaging unit configured to obtain radiation intensity data from a target region in the spatial dimensions and at least one other dimension, and an image four-dimension analysis unit analyzes the intensity data in the spatial dimension and said at least one other dimension in order to map the distinguishable regions. The system typically detects rates of change over time in signals from radiopharmaceuticals and uses the rates of change to identify the tissues. In a preferred embodiment, two or more radiopharmaceuticals are used, the results of one being used as a constraint on the other.
摘要翻译：用于其中具有可区分区域的非均匀目标区域的用于基于辐射的成像的装置包括：成像单元，被配置为从空间维度和至少一个其他维度中的目标区域获得辐射强度数据，以及图像四维分析单元分析空间维度中的强度数据和所述至少一个其他维度，以便映射可区分的区域。该系统通常检测来自放射性药物的信号随时间的变化率，并使用变化率来识别组织。在优选实施方案中，使用两种或更多种放射性药物，一种用于另一种放射性药物的结果。

3. 发明申请

WO2004042546A1 APPARATUS AND METHODS FOR IMAGING AND ATTENUATION CORRECTION 审中-公开
标题翻译：用于成像和衰减校正的装置和方法
公开(公告)号：WO2004042546A1
公开(公告)日：2004-05-21
申请号：PCT/IL2003/000917
申请日：2003-11-04
申请人： V-TARGET TECHNOLOGIES LTD. , KIMCHY, Yoav , AMRAMI, Roni , ZILBERSTEIN, Yoel
发明人： KIMCHY, Yoav , AMRAMI, Roni , ZILBERSTEIN, Yoel
IPC分类号： G06F3/00
CPC分类号： G06T5/50 , A61B1/0005 , A61B1/05 , A61B1/31 , A61B5/06 , A61B6/037 , A61B6/4417 , A61B6/482 , A61B6/5247 , A61B8/00 , A61B8/4472 , A61B8/5238 , A61B34/20 , A61B34/25 , A61B2034/2051 , A61B2034/2072 , A61B2090/364 , A61B2090/365 , A61B2090/378 , A61N7/02 , G01R33/481 , G06T2207/10081 , G06T2207/10088 , G06T2207/10132 , G06T2207/30004
摘要： Imaging apparatus (10), is provided, comprising a first device, for obtaining a first image, by a first modality, selected from the group consisting of SPECT, PET, CT, an extracorporeal gamma scan, an extracorporeal beta scan, x-rays, an intracorporeal gamma scan, an intracorporeal beta scan, an intravascular gamma scan, an intravascular beta scan, and a combination thereof, and a second modality, selected from the group consisting of a three-dimensional ultrasound, an MRI operative by an internal magnetic field, an extracorporeal ultrasound, an extracorporeal MRI operative by an external magnetic field, an intracorporeal ultrasound, an intracorporeal MRI operative by an external magnetic field, an intravascular ultrasound, and a combination thereof, and wherein the apparatus (10) further includes a computerized system (50), configured to construct an attenuation map, for the first image, based on the second, structural image. Additionally, the computerized system (50) is configured to display an attenuation corrected first image as well as a superposition of the attenuation-corrected first image and the second, structural image. Furthermore, the apparatus is operative to guide an in-vivo instrument based on superposition.
摘要翻译：提供成像设备（10），其包括用于通过第一模态获得第一图像的第一装置，所述第一模式选自SPECT，PET，CT，体外γ扫描，体外β扫描，x射线，体内γ扫描，体内β扫描，血管内γ扫描，血管内β扫描及其组合，以及选自三维超声，由内部磁性装置操作的MRI的第二模式领域，体外超声，通过外部磁场操作的体外MRI，体内超声，通过外部磁场操作的体内MRI，血管内超声及其组合，并且其中，所述装置（10）还包括计算机化系统（50），被配置为针对第一图像构建衰减图，基于第二结构图像。另外，计算机化系统（50）被配置为显示经衰减校正的第一图像以及经衰减校正的第一图像和第二结构图像的叠加。此外，该装置可操作以基于叠加引导体内仪器。

4. 发明申请

WO2002058531A3 INGESTIBLE DEVICE 审中-公开
公开(公告)号：WO2002058531A3
公开(公告)日：2002-08-01
申请号：PCT/IL2002/000057
申请日：2002-01-22
申请人： V-TARGET TECHNOLOGIES LTD. , KIMCHY, Yoav , AMRAMI, Roni , BOUSKILA, Yona , ANTEBI, Udi
发明人： KIMCHY, Yoav , AMRAMI, Roni , BOUSKILA, Yona , ANTEBI, Udi
IPC分类号： A61B5/103
摘要： An ingestible device (12), adapted to travel in the gastrointestinal tract (14) and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract (14). Specially, the ingestible device (12) may be arranged to perform a diagnostic image of nuclear radiation (81) of a radiophamaceutical, scintillation of a scintillation liquid (94), responsive to nuclear radiation (81) of a radiophamaceutical, optical fluorescence of a fluorescing-pharmaceutical or of bare gastrointestinal-tract tissue, infrared radiation of the gastrointestinal-tract tissue, temperature-differences along the gastrointestinal-tract, impedance, ultrasound reflection, magnetic resonance, and a combination thereof. The ingestible device (12) may be adapted for general screening of a large population, on the one hand, and for specific diagnoses of suspected pathologies, on the other.

5. 发明申请

WO2005104939A2 INTRACORPOREAL-IMAGING HEAD 审中-公开
标题翻译： INTRACORPOREAL成像头
公开(公告)号：WO2005104939A2
公开(公告)日：2005-11-10
申请号：PCT/IL2005/000394
申请日：2005-04-14
申请人： V-TARGET TECHNOLOGIES LTD. , NAGLER, Michael , ZILBERSTEIN, Yoel
发明人： NAGLER, Michael , ZILBERSTEIN, Yoel
IPC分类号： A61B5/05
CPC分类号： G01T1/161 , A61B1/05 , A61B1/31 , A61B5/0035 , A61B5/06 , A61B5/415 , A61B5/418 , A61B6/4057 , A61B6/425 , A61B6/4258
摘要： An intracorporeal-imaging head, is provided, which combines at least optical and radioactive-emission imaging, possibly also with high-resolution position tracking. The radioactive-emission-imaging probe has a wide-aperture, or coarse collimator, for high count-rate efficiency; nevertheless, the high-resolution position tracking ensures high resolution of the radioactive-emission image. Specifically, wide-aperture collimation - deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactive-emission source, by scanning the radioactive-emission source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive-emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. The intracorporeal-imaging head may further include ultrasound and MRI imagers, as well as a surgical instrument, such as a biopsy needle, a knife, a cryosurgery device, a resection wire, a laser ablation device, an ultrasound ablation device, other devices for localized radiation ablations, devices for implanting brachytherapy seeds, and other minimally invasive devices. According to another embodiment, an intracorporeal-detecting head is provided, which combines at least optical and radioactive-emission detectors, for a "Yes or No" type detection, by the at least two modalities.
摘要翻译：提供体内成像头，其至少组合光学和放射性发射成像，可能还具有高分辨率位置跟踪。放射性发射成像探针具有宽孔径或粗略的准直器，以实现高计数率效率; 然而，高分辨率位置跟踪确保了放射性发射图像的高分辨率。具体地说，通过使用宽孔径准直仪的探头扫描放射性发射源，并且在相同的情况下，提供宽孔径准直 - 去卷积算法，以获得放射性发射源的高效率高分辨率图像时间，以非常精细的时间间隔监测放射性发射探头的位置，以获得细孔准直的等效性。然后在数学上校正宽光圈的模糊效果。体内成像头可以进一步包括超声和MRI成像仪，以及手术器械，例如活检针，刀，冷冻手术装置，切除线，激光消融装置，超声消融装置，用于局部放射线消融，用于植入近距离放射治疗种子的装置和其它微创装置。根据另一个实施例，提供一种体内检测头，其通过至少两种方式将至少光学和放射性发射检测器组合为“是或否”型检测。

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