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1. 发明申请

WO2017191219A1 NANO-SYSTEMS FOR THERAPY AND/OR DIAGNOSIS AND/OR THERAPY MONITORING AND/OR THERANOSTICS OF DISEASE 审中-公开
标题翻译：纳米系统用于治疗和/或诊断和/或治疗监测和/或疾病的治疗
公开(公告)号：WO2017191219A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/060579
申请日：2017-05-03
申请人： COSMOPHOS LTD , UNIVERSIDAD AUTÓNOMA DE MADRID , KØBENHAVNS UNIVERSITET , UNIVERSITY OF EASTERN FINLAND
发明人： TROHOPOULOS, Panagiotis , CHRISTENSEN, Jørn Bolstad , TORRES-CEBADA, Tomás , MOGHIMI, Seyed Moein , YLÄ-HERTTUALA, Seppo Pasi Antero , FICKER, Mario , WU, Linping , MEDEL GONZÁLEZ, María , MÄKINEN, Petri Ilmari
IPC分类号： A61K41/00 , A61K49/00 , A61P9/10
CPC分类号： A61K41/0071 , A61K49/0036 , A61K49/0054 , A61K49/0093 , A61P9/10 , A61P35/00
摘要： There is disclosed a composition comprising self-assembled nano-particles, the nano-particles comprising dendrimers having a phthalocyanine covalently bound to the periphery thereof. The composition is useful in the therapy and/or diagnosis and/or therapy monitoring and/or theranostics of a lesion of a tissue.
摘要翻译：公开了包含自组装纳米颗粒的组合物，所述纳米颗粒包含具有与其外周共价结合的酞菁的树枝状大分子。该组合物可用于组织病变的治疗和/或诊断和/或治疗监测和/或诊断。

2. 发明申请

WO2017060560A1 ARRANGEMENT FOR CARRYING OUT ELECTRODE MEASUREMENTS 审中-公开
标题翻译：执行电极测量的布置
公开(公告)号：WO2017060560A1
公开(公告)日：2017-04-13
申请号：PCT/FI2015/050676
申请日：2015-10-08
申请人： UNIVERSITY OF EASTERN FINLAND
发明人： KELLOKOSKI, Jari , LAPPALAINEN, Reijo , LEPOLA, Pasi , MERVAALA, Esa , MYLLYMAA, Katja , MYLLYMAA, Sami , SIPILÄ, Kirsi , TÖYRÄS, Juha
IPC分类号： A61B5/0408 , A61B5/0478 , A61B5/0492 , A61B5/0496 , A61B5/00 , A61B5/0428 , A61B5/04
CPC分类号： A61B5/04085 , A61B5/04004 , A61B5/04087 , A61B5/0428 , A61B5/0478 , A61B5/0492 , A61B5/0496 , A61B5/4557 , A61B5/4812 , A61B5/4818 , A61B5/6814 , A61B5/6822 , A61B5/6823 , A61B5/6833 , A61B2560/0412 , A61B2560/045 , A61B2562/0209 , A61B2562/0214 , A61B2562/043 , A61B2562/046 , A61B2562/164 , A61B2562/166
摘要： An object of the invention is an arrangement for carrying out electrode measurements on the surface of the skin of a patient. The arrangement for carrying out at least one hour sleeping time or non-sleeping time electrode measurements comprises a matrix electrode configuration, which comprises a body part (100) of non-conductive material conforming to the contours of the surface of the skin, and which body part (100) comprises an electrode placement configuration (108) for maintaining the mutual placements of the electrodes essentially the same with respect to one another, and which arrangement comprises electrodes being arranged to measure electroencephalography (EEG) signals and electromyography (EMG) signals, at least one electrooculography (EOG) electrode to measure eye movements, at least one electrode (102) attached in the patient's chest area for carrying out electro cardiac measurements (ECG), and electrodes for performing jaw region measurements, means (104) for transmitting the measurement data obtained by said electrodes, said means (104) for transmitting being connected to the body part (100), and a measurement data unit for receiving the measurement data transmitted by said means (104) for further processing of the measurement data.
摘要翻译：本发明的目的是在患者皮肤表面进行电极测量的装置。执行至少一小时睡眠时间或非睡眠时间电极测量的布置包括矩阵电极配置，其包括符合皮肤表面轮廓的非导电材料的主体部分（100），以及哪个主体部分（100）包括电极放置配置（108），用于将电极的相互放置保持彼此基本相同，并且该布置包括布置成测量脑电图（EEG）信号和肌电图（EMG）信号的电极，用于测量眼睛运动的至少一个电刻（EOG）电极，附接在患者胸部区域中用于进行心脏心脏测量（ECG）的至少一个电极（102）和用于进行钳位区域测量的电极，用于发送由所述电极获得的测量数据，所述用于发送的装置（104）连接到主体部分（100）测量数据单元，用于接收由所述装置（104）发送的用于进一步处理测量数据的测量数据。

3. 发明申请

WO2010100337A1 NOVEL PRODRUGS OF METFORMIN 审中-公开
标题翻译：新的METFORMIN公司
公开(公告)号：WO2010100337A1
公开(公告)日：2010-09-10
申请号：PCT/FI2010/050165
申请日：2010-03-03
申请人： UNIVERSITY OF EASTERN FINLAND , HUTTUNEN, Kristiina , LEPPÄNEN, Jukka , RAUTIO, Jarkko , VEPSÄLÄINEN, Jouko
发明人： HUTTUNEN, Kristiina , LEPPÄNEN, Jukka , RAUTIO, Jarkko , VEPSÄLÄINEN, Jouko
IPC分类号： C07C313/30 , A61K31/155 , A61P3/10 , C07C279/26
CPC分类号： C07C279/26 , C07C313/30 , C07C2601/14
摘要： The present invention relates to novel prodrugs of metformin, their pharmaceutically acceptable salts, pharmaceutical compositions containing the prodrugs, and methods of using the prodrugs. In particular, the present invention relates to prodrugs wherein sulfur-containing promoieties are attached to metformin to form novel bioreversible sulfenyl guanidine (N-S) prodrugs of metformin with improved oral absorption, and consequently promoted bioavailability.
摘要翻译：本发明涉及二甲双胍的新型前药，其药学上可接受的盐，含有前体药物的药物组合物，以及使用前体药物的方法。特别地，本发明涉及其中含硫衍生物与二甲双胍连接以形成具有改善的口服吸收的二甲双胍的新型生物可逆性亚硫酰基胍（N-S）前药并因此促进生物利用度的前药。

4. 发明申请

WO2014128254A1 IL-33 AND TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译： IL-33和治疗神经损伤性疾病
公开(公告)号：WO2014128254A1
公开(公告)日：2014-08-28
申请号：PCT/EP2014/053414
申请日：2014-02-21
申请人： UNIVERSITY OF EASTERN FINLAND (KUOPION KAMPUS)
发明人： KOISTINAHO, Jari , MALM, Tarja , POLLARI, Eveliina , KANNINEN, Katja
IPC分类号： A61K38/20 , A61P25/28
CPC分类号： A61K38/20
摘要： The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to therapies of neurodegenerative diseases. More specifically, the present invention relates to interleukin-33 (IL-33), a fragment thereof, a polynucleotide encoding IL-33 or a fragment thereof for use in treatment or prevention of a neurodegenerative disease involving inflammation in a subject and to a method of treating or preventing a neurodegenerative disease involving neuroinflammation in a subject. Still, the present invention relates to IL-33, a fragment thereof, a polynucleotide encoding IL-33 or a fragment thereof for use in improving or restoring neuronal function or endogenous neuronal repair mechanisms, or enhancing endogenous neurogenesis, oligodendrogenesis or neuronal differentiation in a subject. Also, the present invention relates to a method of improving or restoring neuronal function or endogenous neuronal repair mechanisms, or enhancing endogenous neurogenesis, oligodendrogenesis or neuronal differentiation in a subject.
摘要翻译：本发明涉及生命科学和医学领域。具体地，本发明涉及神经变性疾病的治疗。更具体地，本发明涉及用于治疗或预防受试者中涉及炎症的神经变性疾病的白细胞介素-33（IL-33），其片段，编码IL-33或其片段的多核苷酸及其方法治疗或预防受试者中涉及神经炎症的神经变性疾病。本发明还涉及IL-33，其片段，编码IL-33或其片段的多核苷酸，用于改善或恢复神经元功能或内源性神经元修复机制，或增强内源性神经发生，少突胶质细胞增生或神经元分化学科。此外，本发明涉及一种改善或恢复神经元功能或内源性神经元修复机制或增强受试者内源性神经发生，少突胶质细胞增生或神经元分化的方法。

5. 发明申请

WO2018154187A1 IL-13 AND TREATMENT OF DISEASES OR DEFECTS OF THE CENTRAL NERVOUS SYSTEM 审中-公开
公开(公告)号：WO2018154187A1
公开(公告)日：2018-08-30
申请号：PCT/FI2018/050138
申请日：2018-02-26
申请人： UNIVERSITY OF EASTERN FINLAND
发明人： KOISTINAHO, Jari , GOLDSTEINS, Gundars , DHUNGANA, Hiramani
IPC分类号： A61K38/20 , A61K48/00 , A61P25/00 , A61P9/10
CPC分类号： A61P9/10 , A01K2207/30 , A01K2227/105 , A01K2267/03 , A61K38/2086 , A61P25/00
摘要： The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to therapies of central nervous system defects. More specifically, the present invention relates to interleukin-13 (IL-13) for use in treatment or prevention of a central nervous system defect in a subject, wherein the central nervous system defect is selected from the group consisting of a cerebrovascular disease, spinal cord injury and spinal cord neurodegeneration. Still, the present invention relates to a method of treating or preventing a central nervous system defect in a subject and to a method of reducing lesion site or infarct volume or promoting motor function recovery of the central nervous system, wherein said methods comprise administration of IL-13 to a subject in need thereof.

6. 发明申请

WO2018055227A1 SUSPENSIONS OF CARBON NANOPARTICLES FOR USE AS INKS AND THIN FILMS AND METHODS FOR PREPARING THE SAME 审中-公开
标题翻译：用作油墨和薄膜的碳纳米颗粒悬浮液及其制备方法
公开(公告)号：WO2018055227A1
公开(公告)日：2018-03-29
申请号：PCT/FI2016/050648
申请日：2016-09-20
申请人： UNIVERSITY OF EASTERN FINLAND
发明人： JOKINIEMI, Jorma , LÄHDE, Anna , MIETTINEN, Mirella
IPC分类号： C01B32/18 , C01B32/194
CPC分类号： C01B32/18 , C01B32/15 , C01B32/194 , C09D11/037 , C09D11/52
摘要： The method of the invention for producing suspensions of carbon nanoparticles comprises the steps of providing an organosilane compound comprising a silicon-silicon bond as a precursor material, and vaporizing the precursor material, heating the vaporized precursor material for obtaining silicon-carbon nanoparticles, heating the obtained silicon-carbon nanoparticles by induction for obtaining multilayer graphene, MLG, sheets and carbon nanoflowers, CNFs, and mixing the obtained silicon-carbon nanoparticles with an organic solvent a sufficient time for obtaining a homogenous suspension as a result. The suspensions of the inventions are suspensions of carbon nanoparticles in an organic solvent, wherein the carbon nanoparticles comprises multilayer graphene, MLG, sheets and/or carbon nanoflowers, CNFs. Conductive inks, thin films and spray coatings that are prepared from the suspensions are also part of the invention.
摘要翻译：本发明用于生产碳纳米颗粒悬浮液的方法包括以下步骤：提供包含硅 - 硅键的有机硅烷化合物作为前体材料，并蒸发前体材料，加热汽化的前体材料用于通过诱导获得硅 - 碳纳米颗粒，通过诱导获得多层石墨烯，MLG，片材和碳纳米花，CNF，并将得到的硅 - 碳纳米颗粒与有机溶剂混合足够时间以获得均匀悬浮液结果。本发明的悬浮液是碳纳米颗粒在有机溶剂中的悬浮液，其中碳纳米颗粒包含多层石墨烯，MLG，片和/或碳纳米花CNF。由悬浮液制备的导电油墨，薄膜和喷涂涂层也是本发明的一部分。

7. 发明申请

WO2017093596A1 AN ENERGY STORAGE ELECTRODE 审中-公开
标题翻译：一种储能电极
公开(公告)号：WO2017093596A1
公开(公告)日：2017-06-08
申请号：PCT/FI2015/050851
申请日：2015-12-03
申请人： UNIVERSITY OF EASTERN FINLAND
发明人： JOKINIEMI, Jorma , LÄHDE, Anna , MIETTINEN, Mirella
IPC分类号： C01B31/02 , C01B31/04 , H01M4/133 , H01M10/0525 , B82Y30/00 , B82Y40/00
CPC分类号： H01M10/0525 , B82Y30/00 , B82Y40/00 , H01M4/134 , H01M4/1395 , H01M4/386 , H01M4/625
摘要： Provided herein is an energy storage electrode comprising graphene/carbon nanoflower composite (G/CNF) material, wherein said G/CNF material comprises multi-layered graphene sheets and a plurality of carbon nanoflowers (CNFs), said carbon nanoflowers being circular curved multi-layered carbon sheets having a diameter below 100 nm and optionally having a Si core.
摘要翻译：本文提供了包含石墨烯/碳纳米花复合材料（G / CNF）材料的储能电极，其中所述G / CNF材料包含多层石墨烯片和多个碳纳米花（CNF），所述碳纳米花是直径低于100nm且任选具有Si芯的圆形弯曲多层碳片。

8. 发明申请

WO2012168561A1 METHOD OF DIAGNOSING ON INCREASED RISK OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：诊断阿尔茨海默病风险升高的方法
公开(公告)号：WO2012168561A1
公开(公告)日：2012-12-13
申请号：PCT/FI2012/050571
申请日：2012-06-08
申请人： TEKNOLOGIAN TUTKIMUSKESKUS VTT , UNIVERSITY OF EASTERN FINLAND , OREŠIC, Matej , SOININEN, Hilkka , HYÖTYLÄINEN, Tuulia
发明人： OREŠIC, Matej , SOININEN, Hilkka , HYÖTYLÄINEN, Tuulia
IPC分类号： G01N33/68
CPC分类号： G01N30/02 , G01N33/6896 , G01N2800/2821 , G01N2800/50
摘要： This invention relates to a method for diagnosing a subject's increased risk of progressing to Alzheimer disease by measuring the concentration of a metabolite and comparing them to respective mean concentration of healthy subjects. According to the invention the increased risk of progressing to Alzheimer's disease by a subject with mild cognitive impairment can be diagnosed without invasive technology.
摘要翻译：本发明涉及通过测量代谢物的浓度并将其与健康受试者的平均浓度进行比较来诊断受试者增加进入阿尔茨海默病的风险的方法。根据本发明，具有轻度认知障碍的受试者进展为阿尔茨海默病的风险增加可以被诊断而无侵入性技术。

9. 发明申请

WO2018002170A1 POLYMERIC MICELLE –PHTHALOCYANINE NANO-SYSTEMS FOR PHOTODYNAMIC THERAPY AND/OR FLUORESCENCE-BASED IMAGING 审中-公开
标题翻译：用于光动力学治疗和/或荧光成像的聚合物胶束 - 酞菁纳米系统
公开(公告)号：WO2018002170A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/066050
申请日：2017-06-28
申请人： COSMOPHOS LTD , UNIVERSIDAD AUTÓNOMA DE MADRID , UNIVERSITEIT UTRECHT HOLDING B.V. , UNIVERSITY OF EASTERN FINLAND
发明人： TROHOPOULOS, Panagiotis , TORRES-CEBADA, Tomás , VAN NOSTRUM, Cornelus, F. , YLÄ-HERTTUALA, Seppo Pasi Antero , DE LA ESCOSURA NAVAZO, Andres , SETARO, Francesca , WENNICK, Johannes, W., H. , MÄKINEN, Petri Ilmari , VAN DE WINCKEL, Eveline
IPC分类号： A61K41/00 , A61K49/00
摘要： Polymeric micelle - phthalocyanine nano-systems are useful as therapeutic, diagnostic, and theranostic (therapeutic and diagnostic) nano-systems for photodynamic therapy and/or fluorescence-based imaging. In particular, there is provided a composition comprising polymeric micelles as a nanocarrier and one or more molecules of a phthalocyanine as a payload, wherein the phthalocyanine is of the formula (I) in which R 1 -R 8 and R a and R b are as defined. The invention also provides certain groups of phthalocyanines of general formula (I) that are also novel.
摘要翻译：聚合物胶束 - 酞菁纳米系统可用作光动力疗法和/或基于荧光的成像的治疗，诊断和治疗（治疗和诊断）纳米系统。具体而言，提供了包含聚合物胶束作为纳米载体和一个或多个酞菁分子作为有效负载的组合物，其中酞菁具有式（I），其中R 1 -R 2 - sub> 8，并且R a和R b如定义。本发明还提供了也是新颖的通式（I）的某些酞菁基团。

10. 发明申请

WO2017187008A1 EXPOSURE DEVICE USING THERMOPHORESIS AND A METHOD FOR AEROSOL EXPOSURE 审中-公开
标题翻译：暴露装置使用热电泳和气溶胶暴露的方法
公开(公告)号：WO2017187008A1
公开(公告)日：2017-11-02
申请号：PCT/FI2017/050140
申请日：2017-03-03
申请人： UNIVERSITY OF EASTERN FINLAND
发明人： JOKINIEMI, Jorma , KUUSPALO, Kari , HIRVONEN, Maija-Riitta , JALAVA, Pasi , IHALAINEN, Mika
IPC分类号： C12M1/32 , C12M1/02 , C12M1/34 , C12Q1/02 , G01N33/50
CPC分类号： C12M41/46 , C12M23/12 , C12M41/24 , G01N33/5014
摘要： The present invention relates to exposing of viable cells to particles and gases in aerosols/gases using air-liquid interface (ALI) technique. A device using thermophoresis for in vitro aerosol/gas exposure, a method for in vitro aerosol/gas exposure using thermophoresis and a method for testing of aerosol/gasin vitroare dis- closed. The device and the methods according to the invention provide good conditions to the cells to be exposed thereby reducing noise caused by e.g. drying of the cells during the exposure.
摘要翻译：本发明涉及使用气液界面（ALI）技术将活细胞暴露于气溶胶/气体中的颗粒和气体。使用热泳进行体外气雾剂/气体暴露的装置，使用热泳的体外气雾剂/气体暴露的方法和检测气雾剂/气体的方法。根据本发明的装置和方法为待暴露的细胞提供良好的条件，从而减少由例如由于暴露于细胞而引起的噪声。在曝光过程中干燥细胞。

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