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1. 发明申请

WO2010134943A1 MECHANICALLY COMPETENT SCAFFOLD FOR LIGAMENT AND TENDON REGENERATION 审中-公开
标题翻译：机械和电力再生的机会性能
公开(公告)号：WO2010134943A1
公开(公告)日：2010-11-25
申请号：PCT/US2009/069809
申请日：2009-12-30
申请人： SOFT TISSUE REGENERATION, INC. , LAURENCIN, Cato, T. , ARONSON, Mark, T. , NAIR, Lakshmi, Sreedharan
发明人： LAURENCIN, Cato, T. , ARONSON, Mark, T. , NAIR, Lakshmi, Sreedharan
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0077 , A61F2250/0023 , A61F2250/003 , A61L27/14 , A61L27/58 , A61L2430/10
摘要： A multi-region device for repair, regeneration or reconstruction in articular tissue injury such as torn ligaments and tendons is provided. The device comprises at least one degradable material and biocompatible non-degradable polymeric fiber-based material, in a three-dimensional braided scaffold. The two end sections (14a, b) are designed for attachment of the device at the site of implantation and are designed to allow bone cell ingrowth, and one or more middle regions (12) are designed to allow ligament or tendon cell ingrowth.
摘要翻译：提供了一种用于关节组织损伤如撕裂的韧带和腱的修复，再生或重建的多区域装置。该装置包括在三维编织支架中的至少一种可降解材料和生物相容性不可降解聚合纤维基材料。两个端部区域（14a，b）被设计成用于在植入部位处附接装置，并且被设计成允许骨细胞向内生长，并且一个或多个中间区域（12）被设计成允许韧带或肌腱细胞向内生长。

2. 发明申请

WO2004080346A9 IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES 审中-公开
标题翻译：基于丝光纤的医疗器械
公开(公告)号：WO2004080346A9
公开(公告)日：2005-02-17
申请号：PCT/US2004007647
申请日：2004-03-11
申请人： TISSUE REGENERATION INC , ALTMAN GREGORY H , UNIV TUFTS , HORAN DAVID J , CHEN JINGSONG , HORAN REBECCA L
发明人： ALTMAN GREGORY H , HORAN DAVID J , CHEN JINGSONG , HORAN REBECCA L
IPC分类号： A61F20060101 , D04B1/14 , D04B21/16 , D04H1/42 , D06L1/12
CPC分类号： D04B21/16 , A61L27/227 , A61L27/58 , D01F4/02 , D02G3/448 , D04H1/4266 , D10B2211/04 , D10B2509/08
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译：丝被纯化以消除免疫原性组分（特别是丝胶蛋白），并用于形成用于植入的组织支持假体装置。织物可以携带官能团，药物和其他生物试剂。应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。

3. 发明申请

WO2014193926A1 BRAIDING MACHINE FOR PRODUCING THREE-DIMENSIONAL BRAIDED MATRICES 审中-公开
标题翻译：用于生产三维BRAIDED MATRICES的布线机
公开(公告)号：WO2014193926A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/039740
申请日：2014-05-28
申请人： SOFT TISSUE REGENERATION, INC.
发明人： DUKE, Patrick W. , REILLY, Joseph W.
IPC分类号： D04C3/00 , A61F2/00
CPC分类号： D04C1/06 , A61F2/0063 , D04C3/04 , D04C3/20 , D04C3/38 , D10B2509/00
摘要： A braiding machine for that produces three-dimensional braided matrices with a suitable pore structure for even and random distribution and in-growth of cells for tissue growth and repair is described herein. Methods for making three-dimensional matrices with controlled thicknesses and porosity and the resulting matrices are also described. The machine contains curved arches that hold the plurality of carriers. At least two of the arches are moveable in a side-to-side direction. Additionally, a controlled pushing mechanism pushes the carriers up and down the slots in the arches. These motions allow one to form three-dimensional braided matrices that provide sufficient porosity and mechanical support for tissue growth and repair in a variety of sites in the body.
摘要翻译：本文描述了一种编织机，用于产生具有合适的孔结构的三维编织基质，用于组织生长和修复的细胞的均匀和随机分布和生长。还描述了制备具有受控厚度和孔隙率的三维矩阵以及所得矩阵的方法。该机器包含保持多个载体的弯曲拱形。至少两个拱门可以在侧向方向上移动。此外，受控的推动机构将拱顶上的槽上下移动。这些运动允许形成三维编织基质，其为身体各种部位的组织生长和修复提供足够的孔隙度和机械支持。

4. 发明申请

WO2014164769A1 ABSORBABLE SYNTHETIC BRAIDED MATRIX FOR BREAST RECONSTRUCTION AND HERNIA REPAIR 审中-公开
标题翻译：用于乳腺重建和HERNIA修复的可吸收合成基质
公开(公告)号：WO2014164769A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/023424
申请日：2014-03-11
申请人： SOFT TISSUE REGENERATION, INC.
发明人： REILLY, Joseph, W. , LAURENCIN, Cato, T.
IPC分类号： A61F2/00 , A61F2/12 , D04B21/00 , D04B1/00
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , D04C1/06 , D10B2509/08
摘要： A braided, rather than woven, three-dimensional matrix has been developed to provide mechanical support in breast reconstruction or a mastopexy procedure. The braided three-dimensional matrix may be used to assist in hernia repair procedures. The matrix is a supple, strong, and flexible material, that can increase 50% to 100% in size when stretched along the vertical plane, but only extends by about 10% to 20% in length when stretched along the horizontal plane. Although the matrix is degradable, it provides sufficient mechanical and structural support for six to twelve months following implantation to allow for repair or growth of the breast tissue or the abdominal wall. The matrix is formed of three-dimensional braided multifilament polymeric fibers plied to create yarn bundles, and wherein the matrix comprises an inter-connected, open pore structure that enables even and random distribution and in-growth of cells.
摘要翻译：已经开发了编织而不是织造的三维矩阵，以在乳房重建或乳房解剖过程中提供机械支撑。编织三维矩阵可用于辅助疝修补程序。该基质是柔软，坚固且柔软的材料，当沿着垂直平面拉伸时，可以增加50％至100％的尺寸，但是当沿着水平面拉伸时，其仅延伸约10％至20％的长度。尽管基质是可降解的，但它在植入后六至十二个月可提供足够的机械和结构支持，以允许乳房组织或腹壁的修复或生长。基质由三维编织的复丝聚合物纤维形成，以生成纱线束，并且其中基质包括互连的开孔结构，其能够均匀和随机分布和生长细胞。

5. 发明申请

WO2011119831A8 MECHANICALLY COMPETENT SCAFFOLD FOR ROTATOR CUFF AND TENDON AUGMENTATION 审中-公开
标题翻译：机械能力的脚手架用于旋转套管和TENDON增强
公开(公告)号：WO2011119831A8
公开(公告)日：2011-11-10
申请号：PCT/US2011029791
申请日：2011-03-24
申请人： SOFT TISSUE REGENERATION INC , LAURENCIN CATO T , ARONSON MARK T , NAIR LAKSHMI SREEDHARAN , REILLY JOSEPH W
发明人： LAURENCIN CATO T , ARONSON MARK T , NAIR LAKSHMI SREEDHARAN , REILLY JOSEPH W
IPC分类号： A61B17/11 , A61F2/08
CPC分类号： A61B17/1146 , A61F2/08 , D04C1/02 , D10B2509/00
摘要： A device has been developed to augment the rotator cuff tendon tissue as it proceeds in healing. The device has two purposes: to provide initial stability to the rotator cuff repair site to allow early mobilization of the upper extremity of the patient, and to allow for reinforcement of rotator cuff tendon repairs to increase the likelihood of successful rotator cuff tendon repairs. The device consists of an inter-connected, open pore structure that enables even and random distribution and in-growth of tendon cells. The braided structure allows for distribution of mechanical forces over a larger area of tissue at the fixation point(s).
摘要翻译：已经开发出一种装置来增加肩袖肌腱组织，因为它在愈合中进行。该装置具有两个目的：为肩袖修复部位提供初始稳定性，以允许患者的上肢尽早动员，并且允许加强肩袖肌腱修复以增加成功肩袖肌腱修复的可能性。该装置由相互连接的开放孔隙结构组成，使肌腱细胞能够均匀随机分布和向内生长。编织结构允许在固定点处的机械力分布在更大的组织区域上。

6. 发明申请

WO2004080346A2 IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES 审中-公开
标题翻译：基于丝光纤的医疗器械
公开(公告)号：WO2004080346A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/007647
申请日：2004-03-11
申请人： TISSUE REGENERATION, INC. , ALTMAN, Gregory, H. , CHEN, Jingsong , HORAN, Rebecca, L.
发明人： ALTMAN, Gregory, H. , CHEN, Jingsong , HORAN, Rebecca, L.
IPC分类号： A61F
CPC分类号： D04B21/16 , A61L27/227 , A61L27/58 , D01F4/02 , D02G3/448 , D04H1/4266 , D10B2211/04 , D10B2509/08
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined ( e.g ., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译：丝被纯化以消除免疫原性组分（特别是丝胶蛋白），并用于形成用于植入的组织支持假体装置。织物可以携带官能团，药物和其他生物试剂。应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。

7. 发明申请

WO2004080346A3 IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES 审中-公开
标题翻译：免疫原性纤维基医疗器械
公开(公告)号：WO2004080346A3
公开(公告)日：2004-12-09
申请号：PCT/US2004007647
申请日：2004-03-11
申请人： TISSUE REGENERATION INC , ALTMAN GREGORY H , CHEN JINGSONG , HORAN REBECCA L
发明人： ALTMAN GREGORY H , CHEN JINGSONG , HORAN REBECCA L
IPC分类号： A61F20060101 , D04B1/14 , D04B21/16 , D04H1/42 , D06L1/12
CPC分类号： D04B21/16 , A61L27/227 , A61L27/58 , D01F4/02 , D02G3/448 , D04H1/4266 , D10B2211/04 , D10B2509/08
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译：丝被纯化以消除免疫原性组分（特别是丝胶蛋白）并用于形成用于植入的组织支持假体装置。织物可以携带官能团，药物和其他生物试剂。应用包括疝修补术，组织壁重建和器官支持，如膀胱吊带。丝纤维平行排列，并且任选地交织（例如扭曲）以形成构建体; 可以在织物形成过程中的任何时候提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建物。

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