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1. 发明申请

WO2018191379A2 CHITINASE ADMINISTRATION TO THE AIRWAY TO TREAT INFLAMMATION AND AGE-RELATED PULMONARY FIBROSIS 审中-公开
公开(公告)号：WO2018191379A2
公开(公告)日：2018-10-18
申请号：PCT/US2018/027111
申请日：2018-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LOCKSLEY, Richard , VAN DYKEN, Steven
IPC分类号： C12N9/42 , A61K9/00 , A61P11/00 , C12Q1/34 , G01N33/68 , A61K38/00
CPC分类号： A61P11/00 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K38/00 , A61K38/47 , C12N9/2442 , C12Q1/34 , G01N33/68 , G01N33/6893 , G01N2333/924 , G01N2800/12
摘要： Herein is demonstrated that expression of the enzyme chitinase in the lungs of animals is protective against adverse chitin-mediated inflammation and that with impaired chitinase expression, various inflammatory pathways are enhanced, contributing to conditions such as fibrotic lung disease. Further, it is shown that the prevention and treatment of pulmonary fibrosis and other improvements to lung health are achieved by administration of chitinase to the lungs. Additionally, methods of assessing chitinase activity in the lungs provide a novel diagnostic measure of lung health.

2. 发明申请

WO2018048088A1 AN INJECTION COMPOSITION COMPRISING HYALURONIDASE FOR REMOVAL OF TOPICAL FAT 审中-公开
标题翻译：包含透明质酸酶用于去除局部脂肪的注射组合物
公开(公告)号：WO2018048088A1
公开(公告)日：2018-03-15
申请号：PCT/KR2017/007821
申请日：2017-07-20
申请人： SON, Youna
发明人： SON, Youna
IPC分类号： A61K38/47 , A61K31/167 , A61K31/4402 , A61K31/205 , A61K31/375 , A61K9/00 , A61K8/64 , A61Q19/06
CPC分类号： A61K38/47 , A61K8/20 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/4926 , A61K8/66 , A61K8/676 , A61K9/0019 , A61K9/08 , A61K31/167 , A61K31/195 , A61K31/375 , A61K31/4402 , A61K45/06 , A61K47/02 , A61K2800/782 , A61K2800/91 , A61Q19/06 , C12Y302/01035 , A61K2300/00
摘要： The present invention relates to an injection composition comprising hyaluronidase for topical fat reduction. More particularly, the present invention relates to an injection composition comprising 300 IU to 600 IU of hyaluronidase and a local anesthetic, an antihistamine, a lipolysis stimulator and a collagen production stimulator. Still more particularly, the present invention relates to an injection composition for topical fat removal comprising 300 IU to 600 IU of hyaluronidase and, based on the weight of the total composition, 0.08 to 0.4 % by weight of a local anesthetic, 0.01 to 0.02 % by weight of an antihistamine, 0.01 to 4.0 % by weight of a lipolysis stimulator, and 0.1 to 2.0 % by weight of a collagen production stimulator, with the remainder being saline solution The present invention promotes the reduction of topical fat tissue, thereby improving obesity and helping weight loss and maintenance of body shape while preventing side effects or skin imbalance by the even removal of fat. Further, at the same time, the present invention can achieve a skin lifting effect where skin resilience is maintained by the stimulation of collagen production.
摘要翻译：本发明涉及包含用于局部降脂的透明质酸酶的注射组合物。更具体地说，本发明涉及包含300IU-600IU透明质酸酶和局部麻醉剂，抗组胺剂，脂解刺激剂和胶原产生刺激剂的注射组合物。更具体地说，本发明涉及用于局部脱脂的注射组合物，其包含300IU至600IU的透明质酸酶，并且基于总组合物的重量，0.08至0.4重量％的局部麻醉剂，0.01至0.02重量％重量的抗组胺药，0.01-4.0％重量的脂解刺激剂和0.1-2.0％重量的胶原产生刺激剂，其余为盐溶液。本发明促进了局部脂肪组织的减少，从而改善了肥胖症并通过均匀去除脂肪来防止副作用或皮肤不平衡，同时帮助减肥和保持身体形状。此外，同时，本发明可以通过刺激胶原蛋白的产生而实现皮肤弹性维持的皮肤提升效果。

3. 发明申请

WO2017123757A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE 审中-公开
标题翻译：用于治疗神经疾病的方法和组合物
公开(公告)号：WO2017123757A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013189
申请日：2017-01-12
申请人： SANGAMO THERAPEUTICS, INC. , REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： DEKELVER, Russell , MCIVOR, R. Scott , OU, Li , WECHSLER, Thomas , WHITLEY, Chester B.
IPC分类号： A61K48/00 , A61P3/00 , C12N5/10 , C12N9/40 , C12N15/09
CPC分类号： A61K38/47 , A61K9/0019 , A61K38/1703 , A61K38/465 , A61K48/0058 , C12N7/00 , C12N9/16 , C12N9/2402 , C12N2750/10041 , C12N2750/14143 , C12Y301/06013 , C12Y302/01076
摘要： Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of MPS I or MPS II disease.
摘要翻译：使用这些核酸酶将编码治疗性IDUA或IDS蛋白质如酶的序列插入细胞中的核酸酶和方法，由此提供用于治疗和/或预防MPS I的蛋白质或细胞治疗剂，或 MPS II疾病。

4. 发明申请

WO2017117407A1 AUGMENTED ACID ALPHA-GLUCOSIDASE FOR THE TREATMENT OF POMPE DISEASE 审中-公开
标题翻译：增强的酸性α-葡糖苷酶用于治疗POMPE疾病
公开(公告)号：WO2017117407A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069243
申请日：2016-12-29
申请人： AMICUS THERAPEUTICS, INC.
发明人： DO, Hung V. , KHANNA, Richie , GOTSCHALL, Russell
IPC分类号： A61K38/47 , A61K31/445
CPC分类号： A61K38/47 , A61K31/445 , C12Y302/0102
摘要： A method for treating Pompe disease including administration of recombinant human acid α-glucosidase having optimal glycosylation with mannose-6-phosphate residues in combination with an amount of miglustat effective to maximize tissue uptake of recombinant human acid α-glucosidase while minimizing inhibition of the enzymatic activity of the recombinant human acid α-glucosidase is provided.
摘要翻译：治疗庞培病的方法包括给予具有甘露糖-6-磷酸残基的最佳糖基化的重组人酸性α-葡萄糖苷酶以及有效使最大化组织摄取重组人酸α 提供了对重组人酸性α-葡糖苷酶的酶活性的抑制最小化。

5. 发明申请

WO2017052455A1 AMYLASE FRAGMENTS FOR BLOOD GLUCOSE CONTROL 审中-公开
标题翻译：用于血液葡萄糖控制的AMYLASE片段
公开(公告)号：WO2017052455A1
公开(公告)日：2017-03-30
申请号：PCT/SE2016/050886
申请日：2016-09-21
申请人： ANARA AB
发明人： PIERZYNOWSKI, Stefan , GONCHAROVA, Kateryna
IPC分类号： A61K38/47 , A61P3/04 , A61P1/00 , A61P1/18 , A61P25/28 , A61P43/00
CPC分类号： A61K38/47
摘要： A composition comprising one or more effective fragments of an amylase, for use as a medicament or a dietary supplement, in particular for the treatment of hyperglycemic conditions, conditions involving hyperinsulinemia and conditions involving impaired insulin sensitivity, such as diabetes. The composition may comprise Aspergillus oryzae-amylase digested with trypsin.
摘要翻译：一种组合物，其包含一种或多种淀粉酶的有效片段，用作药物或膳食补充剂，特别是用于治疗高血糖病症，涉及高胰岛素血症的病症和涉及胰岛素敏感性降低的病症，例如糖尿病。组合物可以包含用胰蛋白酶消化的米曲霉 - 淀粉酶。

6. 发明申请

WO2017044989A1 Clostridium difficile BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF Clostridium difficile BACTERIA INFECTION 审中-公开
标题翻译：难辨梭状芽胞杆菌检测和治疗难辨梭状芽孢杆菌感染的嗜碱性细菌
公开(公告)号：WO2017044989A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/051495
申请日：2016-09-13
申请人： THE ROCKEFELLER UNIVERSITY
发明人： FISCHETTI, Vincent , EULER, Chad , WANG, Qiong
IPC分类号： A61K38/50 , C07K14/33 , C12N1/06 , C12N9/80 , C12Q1/34
CPC分类号： C12N9/80 , A61K38/47 , C12N1/06
摘要： Provided are compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including bacilli, and related conditions. The compositions and methods incorporate and utilize Clostridium difficile derived bacteriophage lysins, particularly PlyCD truncations. Methods for treatment of humans and non-human mammals are provided.
摘要翻译：提供可用于预防和治疗改善和治疗革兰氏阳性细菌（包括杆菌）和相关条件的组合物和制品。组合物和方法结合并利用艰难梭菌衍生的噬菌体溶素，特别是PlyCD截短。提供了治疗人和非人哺乳动物的方法。

7. 发明申请

WO2017023680A1 MYCOBACTERIUM LYSTERASE: A NOVEL TREATMENT FOR ACNE 审中-公开
标题翻译： MYCOBACTERIUM LYSTERASE：一种新的治疗方法
公开(公告)号：WO2017023680A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/044427
申请日：2016-07-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MODLIN, Robert, L. , HATFULL, Graham, F. , BARBEAU, Dominique, J. , OJHA, Anil, K.
IPC分类号： A61K38/43 , A61K9/06 , A61K47/10 , A61P17/10
CPC分类号： A61K47/10 , A61K9/0014 , A61K38/162 , A61K38/47 , C12Y302/0117
摘要： Certain aspects of the invention relate to methods for preventing or treating a skin condition in a subject, comprising administering a composition comprising a lysterase to the subject. Some aspects of the invention relate to pharmaceutical compositions comprising a lysterase. Some aspects of the invention relate to methods for producing a pharmaceutical composition, comprising expressing a lysterase in a recombinant cell and purifying the lysterase.
摘要翻译：本发明的某些方面涉及用于预防或治疗受试者皮肤病症的方法，包括向受试者施用包含裂解酶的组合物。本发明的一些方面涉及包含裂解酶的药物组合物。本发明的一些方面涉及制备药物组合物的方法，包括在重组细胞中表达裂解酶并纯化裂解酶。

8. 发明申请

WO2017012993A1 PROCESS AND COMPOSITION FOR LOW DOSE INSEMINATION 审中-公开
标题翻译：低剂量制剂的方法和组合
公开(公告)号：WO2017012993A1
公开(公告)日：2017-01-26
申请号：PCT/EP2016/066815
申请日：2016-07-14
申请人： IMV TECHNOLOGIES
发明人： SCHMITT, Eric
IPC分类号： A61K35/52 , A61D19/00 , A61K38/16 , A61K38/47
CPC分类号： A61K38/47 , A61D19/02 , A61K9/0034 , A61K35/52 , A61K38/168 , C12Y302/01018 , A61K2300/00
摘要： The present invention relates to a composition for use in low dose artificial insemination and to a process for artificial insemination of a female mammal using a dose of sperm originating from a male mammal of the same species that is significantly lower than necessary in the absence of the composition. The preferred female mammal is a sow (sus scrofa), and preferably the composition is for use in artificial uterine insemination, and the process for artificial insemination preferably is uterine insemination.
摘要翻译：本发明涉及用于低剂量人工授精的组合物和使用源自同种物种的雄性哺乳动物剂量的雌性哺乳动物人工授精的方法，该剂量明显低于在不存在组成。优选的雌性哺乳动物是母猪（sus scrofa），优选该组合物用于人造子宫授精，并且人工授精的方法优选为子宫授精。

9. 发明申请

WO2017001701A1 ANIMAL FEED COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：动物饲料组合物及其用途
公开(公告)号：WO2017001701A1
公开(公告)日：2017-01-05
申请号：PCT/EP2016/065682
申请日：2016-07-04
申请人： NOVOZYMES A/S , DSM IP ASSETS B.V.
发明人： SANDVANG, Dorthe, Hoej , GAD, Esben , KELLY, Nicholas, Michael , KLAUSEN, Mikkel , THOEGERSEN, Juliane, Charlotte, Gregaard , OLSEN, Peter, Bjarke , NIELSEN, Preben , COHN, Marianne, Thorup
IPC分类号： A23K10/10 , A23K20/147
CPC分类号： A23K20/189 , A61K9/0053 , A61K38/465 , A61K38/47 , C12Y301/03026 , C12Y302/01017 , A61K2300/00
摘要： The present invention relates to animal feed compositions comprising polypeptides having lysozyme activity and polypeptides having phytase activity and uses thereof.
摘要翻译：本发明涉及包含具有溶菌酶活性的多肽和具有植酸酶活性的多肽的动物饲料组合物及其应用。

10. 发明申请

WO2016181122A1 FABRY DISEASE GENE THERAPY 审中-公开
标题翻译：纤维蛋白病基因治疗
公开(公告)号：WO2016181122A1
公开(公告)日：2016-11-17
申请号：PCT/GB2016/051328
申请日：2016-05-10
申请人： UCL BUSINESS PLC
发明人： NATHWANI, Amit , RAJ, Deepak
IPC分类号： A61K48/00 , C12N9/40 , C12N15/67 , C12N15/864
CPC分类号： A61K48/0058 , A01K2217/075 , A61K38/47 , A61P3/00 , C12N9/2465 , C12N15/86 , C12N2750/14143 , C12N2750/14171 , C12N2800/22
摘要： There is described a nucleic acid molecule comprising a nucleotide sequence encoding for a functional α-galactosidase A protein wherein the nucleotide sequence has at least 85% identity to the sequence of SEQ ID NO. 1. Also described is a vector, host cell or transgenic animal comprising the nucleic acid molecule; and a pharmaceutical composition comprising the nucleic acid molecule or the vector. Further, the use of the nucleic acid molecule in a method of treating Fabry disease is described.
摘要翻译：描述了包含编码功能性α-半乳糖苷酶A蛋白的核苷酸序列的核酸分子，其中所述核苷酸序列与SEQ ID NO的序列具有至少85％的同一性。还描述了包含核酸分子的载体，宿主细胞或转基因动物; 和包含核酸分子或载体的药物组合物。此外，描述了在治疗法布里病的方法中使用核酸分子。

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