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1. 发明申请

WO2016065342A1 TEMPORARILY IMPLANTABLE GI SENSOR AND STIMULATOR AND RELATED METHODS 审中-公开
标题翻译：临时可植入GI传感器和刺激器及相关方法
公开(公告)号：WO2016065342A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057248
申请日：2015-10-23
申请人： THE FOUNDRY, LLC
发明人： DEEM, Mark , GIFFORD, Hanson, S.
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/0507
摘要： GI tract treatment and monitoring devices configured for temporary implantation in the GI tract and non-invasive removal via natural body processes are disclosed. Methods of implantation, treatment and monitoring with disclosed devices are also disclosed. Devices include bio-active fixation that allows removal from the body by natural processes after a time that may be engineered in the fixation elements. In some embodiments, devices are configured to be implanted on GI tract tissue and transmurally migrate into the GI tract to be passed from the body. In other embodiments, devices are configured for placement within the GI tract via a delivery tube such as an NJ/NG tube. Embodiments include stimulation devices for treating conditions such as ileus and sensors for monitoring GI leaks and/or biological or chemical markers for various GI tract conditions.
摘要翻译：公开了用于临时植入胃肠道的胃肠道治疗和监测装置以及通过自然身体过程的非侵入性去除。还公开了所公开的装置的植入，处理和监测方法。装置包括生物活性固定，其允许在可以在固定元件中设计的时间之后通过自然过程从身体移除。在一些实施例中，装置被配置为植入GI道组织并且透射迁移到胃肠道以从身体通过。在其他实施例中，装置被配置用于通过诸如NJ / NG管的输送管放置在胃肠道内。实施例包括用于治疗诸如肠梗阻的病症的刺激装置和用于监测GI泄漏的传感器和/或用于各种胃肠道状况的生物或化学标记物。

2. 发明申请

WO2013009761A1 METHODS AND APPARATUS FOR DELIVERING A THERAPEUTIC AGENT TO NASOPHARYNGEAL MUCOSA TARGETS 审中-公开
标题翻译：将治疗药物递送至鼻咽癌MUCOSA目标的方法和装置
公开(公告)号：WO2013009761A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/046089
申请日：2012-07-10
申请人： THE FOUNDRY, LLC , MORISS, John , REICH, Cary , GIFFORD, Hanson
发明人： MORISS, John , REICH, Cary , GIFFORD, Hanson
IPC分类号： A61K9/12 , A61K8/00 , A61Q11/00
CPC分类号： A61K38/4893 , A61K9/0043 , A61K9/122 , A61M31/00 , C12Y304/24069
摘要： A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.
摘要翻译：用于将治疗剂递送到鼻咽粘膜靶的系统包括泡沫生成机构，气体，液体形式的抑制粘液生成的治疗剂和递送装置。泡沫发生机构的致动将液体中的气体夹带气泡，从而形成泡沫。将治疗剂分散在具有适于填充鼻咽空间并将治疗剂递送至粘膜靶的膨胀构型的泡沫中。输送装置用于将泡沫输送到鼻咽空间。泡沫还可以具有用于从鼻咽部空间去除或将治疗剂浓缩到粘膜上的收缩构型。

3. 发明申请

WO2010148125A1 MICROFRACTURE DEVICE AND METHOD 审中-公开
标题翻译： MICROFRACTURE设备和方法
公开(公告)号：WO2010148125A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/038875
申请日：2010-06-16
申请人： THE FOUNDRY, LLC , DEEM, Mark , HENDRICKSEN, Michael , GITTINGS, Darin C.
发明人： DEEM, Mark , HENDRICKSEN, Michael , GITTINGS, Darin C.
IPC分类号： A61B17/3203
CPC分类号： A61B17/3203 , A61B18/22 , A61B2017/003 , A61B2017/00318 , A61B2018/2238
摘要： Devices and methods are provided for performing microfracture surgery on an articular surface in a joint space. A surgical tool comprising an elongated body and a distal probe is provided. The probe is coupled to the elongated body and is adapted to be inserted in the joint space. The probe is positioned over the articular surface. A first and second channel through the subchondral bone into the marrow cavity are created with perforating elements, fluid jets, laser beams, or other channeling methods. The second channel is discrete from the first channel and is separated therefrom by a predetermined distance. The first channel and the second channel may be simultaneously created. In this way, a microfracture procedure is performed faster and with greater precision than existing techniques and with less risk of thermal damage and other complications.
摘要翻译：提供了用于在关节空间中的关节表面上进行微创骨折手术的装置和方法。提供了包括细长主体和远端探针的手术工具。探针耦合到细长主体并且适于插入关节空间中。探针位于关节面上方。通过软骨下骨进入骨髓腔的第一和第二通道用穿孔元件，流体射流，激光束或其它引导方法产生。第二通道与第一通道离散并且与之隔开预定距离。可以同时创建第一通道和第二通道。以这种方式，微裂缝程序比现有技术更快，更精确地执行，并且具有较少的热损伤和其他并发症的风险。

4. 发明申请

WO2021195664A1 EXPANDABLE DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2021195664A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/070306
申请日：2021-03-24
申请人： THE FOUNDRY, LLC
发明人： GIFFORD, Hanson, S., III , GIFFORD, Edward, DeWitt , LEVERING, Vrad, W.
IPC分类号： A61F2/915 , A61F2/24 , A61F2/07 , A61F2/2418 , A61F2/243 , A61F2002/825 , A61F2002/91575 , A61F2002/9505 , A61F2230/0067 , A61F2250/0037
摘要： Devices, systems, and methods for treating a blood flow passage are disclosed herein. For example, expandable devices of the present technology may comprise a stent having a collapsed configuration for delivery through a delivery device to a treatment site in a body conduit and an expanded configuration. The stent may comprise a plurality of struts and longitudinally extending first and second spines configured to move in opposing axial directions as the stent expands. Each of the struts may extend between and connect one of the first spines and one of the second spines. Moving the first spines axially relative to the second spines may cause the struts to push circumferentially adjacent spines to move away from one another, thereby increasing a diameter of the stent.

5. 发明申请

WO2011025959A1 METHOD AND APPARATUS FOR FORCE REDISTRIBUTON IN ARTICULAR JOINTS 审中-公开
标题翻译：方法和装置在大型连接中的强制重新配置
公开(公告)号：WO2011025959A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046996
申请日：2010-08-27
申请人： THE FOUNDRY LLC , SHENOY, Vivek , DEEM, Mark , GIFFORD, Hanson
发明人： SHENOY, Vivek , DEEM, Mark , GIFFORD, Hanson
IPC分类号： A61F2/08
CPC分类号： A61B17/56 , A61B2017/564 , A61B2017/565
摘要： Pathologies of joints arising from improper force distributions are addressed by displacement of targeted connective and muscle tissues surrounding the joint in order to realign force vectors and alter moment arms loading the joint.
摘要翻译：由不正确的力分布产生的关节的病理学是通过围绕关节的目标连接和肌肉组织的位移来解决的，以便重新对准力向量并改变加载关节的力矩臂。

6. 发明申请

WO2021163635A1 VASCULAR TREATMENT SYSTEMS 审中-公开
公开(公告)号：WO2021163635A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/018047
申请日：2021-02-12
申请人： THE FOUNDRY, LLC
发明人： GIFFORD, III, Hanson, S. , GIFFORD, Edward, DeWitt , LEVERING, Vrad, W.
IPC分类号： A61M25/00 , A61M25/10 , A61M2025/0024 , A61M2025/1061 , A61M2025/1084 , A61M2025/1097 , A61M25/0052 , A61M25/1002 , A61M25/1011 , A61M25/1029
摘要： Systems (1100) for treating a blood flow passage are discloses herein. In one example, a treatment device includes an expandable element (1104) configured to be positioned within the passage and a reinforcing element (1102). The expandable element may have an expanded configuration in which the expandable element defines a lumen (1108) therethrough. The reinforcing element may be positioned within the lumen of the expandable element. The reinforcing element may be coupled to the expandable element such that expansion of the expandable element causes the reinforcing element to radially expand, thereby creating a perfusion lumen through the device.

7. 发明申请

WO2020257211A1 HYBRID EXPANDABLE DEVICE 审中-公开
公开(公告)号：WO2020257211A1
公开(公告)日：2020-12-24
申请号：PCT/US2020/037963
申请日：2020-06-16
申请人： THE FOUNDRY, LLC
发明人： GIFFORD, Hanson, S. , KIM, Steven
IPC分类号： A61F2/24
摘要： The present technology is directed to the treatment of cardiac valves. Many embodiments of the present technology comprise an anchor member configured to be positioned at an implantation site proximate a native valve annulus. The anchor member may comprise an expandable structure having a first portion and a second portion. When the first portion is positioned at the implantation site at body temperature and released from a constrained delivery state, the first portion is configured to self-expand into apposition with tissue at or near the annulus to secure the anchor member at the implantation site. The second portion remains in a low-profile state at or around body temperature and is configured to expand into apposition with tissue at or near the annulus when heated above a second temperature greater than the first temperature and body temperature.

8. 发明申请

WO2013009874A1 DELIVERY DEVICES FOR NASOPHARYNGEAL MUCOSA TARGETS 审中-公开
标题翻译：用于NASOPHARYNGEM MUCOSA目标的递送设备
公开(公告)号：WO2013009874A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/046258
申请日：2012-07-11
申请人： THE FOUNDRY, LLC , MORRISS, John , GIFFORD, Hanson
发明人： MORRISS, John , GIFFORD, Hanson
IPC分类号： A61M11/06
CPC分类号： A61M31/007 , A61K38/4893 , A61M5/329 , A61M11/001 , A61M11/007 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/0438 , A61M16/0456 , A61M16/0461 , A61M16/0481 , A61M31/002 , A61M2210/0618 , A61M2210/0681
摘要： A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue has a shaft, a porous pad of compliant material coupled to the shaft near the distal end, and a drug reservoir. The porous pad is configured to expand from a contracted configuration to an expanded configuration. The expanded configuration is adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration has a size suitable for introduction into the nasal cavity. The drug reservoir holds a therapeutic agent and is at least partially covered by the porous pad. The drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes, and has a wall with a plurality of channels fluidly coupled with the porous pad.
摘要翻译：用于将治疗剂递送到鼻咽粘膜组织的系统具有轴，在远端附近耦合到轴的柔性材料的多孔垫和药物储存器。多孔垫被构造成从收缩构型扩展到扩展构型。膨胀构型适于与鼻腔中的粘膜组织相配合并且收缩构型具有适于引入鼻腔的尺寸。药物储存器保持治疗剂并且至少部分被多孔垫覆盖。药物储存器构造成在小于约120分钟的时间段内将固定体积的治疗剂释放到多孔垫中，并且具有与多孔垫片流体耦合的多个通道的壁。

9. 发明申请

WO2012087842A1 SYSTEM FOR MITRAL VALVE REPAIR AND REPLACEMENT 审中-公开
标题翻译：麻醉阀维修和更换系统
公开(公告)号：WO2012087842A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065627
申请日：2011-12-16
申请人： THE FOUNDRY, LLC , GIFFORD, III, Hanson S. , FANN, James I. , MORRISS, John , DEEM, Mark , GRAINGER, Jeffry J.
发明人： GIFFORD, III, Hanson S. , FANN, James I. , MORRISS, John , DEEM, Mark , GRAINGER, Jeffry J.
IPC分类号： A61F2/24
CPC分类号： A61F2/2454 , A61F2/2418 , A61F2/243 , A61F2/2445 , A61F2/2466 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2250/0003 , A61F2250/0004 , A61F2250/0008 , A61F2250/006
摘要： Systems for mitral valve repair are disclosed where one or more mitral valve interventional devices may be advanced intravascularly into the heart of a patient and deployed upon or along the mitral valve to stabilize the valve leaflets. The interventional device may also facilitate the placement or anchoring of a prosthetic mitral valve implant. The interventional device may generally comprise a distal set of arms pivotably and/or rotating coupled to a proximal set of arms which are also pivotably and/or rotating coupled. The distal set of arms may be advanced past the catheter opening to a subannular position (e.g., below the mitral valve) and reconfigured from a low-profile delivery configuration to a deployed securement configuration. The proximal arm members may then be deployed such that the distal and proximal arm members may grip the leaflets between the two sets of arms to stabilize the leaflets.
摘要翻译：公开了用于二尖瓣修复的系统，其中一个或多个二尖瓣介入装置可以血管内推进到患者的心脏中并部署在二尖瓣上或沿着二尖瓣以稳定瓣膜小叶。介入装置还可以促进假体二尖瓣植入物的放置或锚定。介入装置通常可包括可枢转地和/或旋转地联接到也可枢转地和/或旋转耦合的近侧臂组的远侧臂组。远侧组的臂可以通过导管开口前进到子宫位置（例如，在二尖瓣下方），并且从低轮廓递送配置重新配置到展开的固定构造。近端臂构件然后可以被展开，使得远端和近端臂构件可以夹紧两组臂之间的传单以稳定传单。

10. 发明申请

WO2009152470A1 METHODS AND APPARATUS FOR JOINT DISTRACTION 审中-公开
标题翻译：用于联合分配的方法和装置
公开(公告)号：WO2009152470A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/047263
申请日：2009-06-12
申请人： THE FOUNDRY, LLC. , BOUDREAULT, David , SHENOY, Vivek , GIFFORD, Hanson, S. , DEEM, Mark , HENDRICKSEN, Michael , SUTTON, Doug
发明人： BOUDREAULT, David , SHENOY, Vivek , GIFFORD, Hanson, S. , DEEM, Mark , HENDRICKSEN, Michael , SUTTON, Doug
IPC分类号： A61B17/58
CPC分类号： A61B17/025 , A61B1/317 , A61B17/02 , A61B17/0218 , A61B17/3421 , A61B2017/00115 , A61B2017/00557 , A61B2017/0212 , A61B2017/0225 , A61B2017/0275 , A61B2017/3488 , A61F5/0193 , A61M25/0068 , A61M25/008 , A61M25/0102 , A61M25/0147 , A61M25/1002 , A61M25/1027 , A61M2025/0063 , A61M2025/0081 , A61M2025/0163 , A61M2025/1068 , A61M2025/1072 , A61M2025/1081 , A61M2025/1086 , A61M2025/1088
摘要： A method of treating a patient's joint having opposing joint surfaces includes providing an elongate member having a proximal end, a distal end and an expandable member near the distal end. The expandable member is positioned in the joint between the joint surfaces and expanded so as to separate the joint surfaces away from one another into a distracted position. The joint is manipulated while in the distracted position so that the joint is distracted and in flexion. A diagnostic or therapeutic procedure is then performed on the joint while maintaining the joint in the flexed and distracted position.
摘要翻译：治疗具有相对关节表面的患者关节的方法包括提供具有近端，远端和靠近远端的可扩张构件的细长构件。可扩张构件定位在接头表面之间的接合处并且膨胀以将接合表面彼此远离地分离成分心位置。关节在处于分心位置时被操作，使得关节分心并且屈曲。然后在关节上进行诊断或治疗程序，同时将关节保持在弯曲和分心的位置。

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