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1. 发明申请

WO2005058245A2 SYNTHETIC PROCESS 审中-公开
标题翻译：合成过程
公开(公告)号：WO2005058245A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041920
申请日：2004-12-10
申请人： BRISTOL-MYERS SQUIBB COMPANY , SWAMINATHAN, Shankar , GAVAI, Ashvinikumar V. , FAN, Junying , PATEL, Bharat P. , NORRIS, Derek J. , CORBETT, Richard Michael , ZHENG, Bin
发明人： SWAMINATHAN, Shankar , GAVAI, Ashvinikumar V. , FAN, Junying , PATEL, Bharat P. , NORRIS, Derek J. , CORBETT, Richard Michael , ZHENG, Bin
IPC分类号： A61K
CPC分类号： C07D487/04
摘要： The present invention provides a process for preparing compounds of formula (I) ["insert chemical structure here"](I)or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
摘要翻译：本发明提供了制备式（I）化合物的方法[本文为“插入化学结构”]（I）或其药学上可接受的盐。通过本发明方法制备的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其他疾病的抗增殖剂。

2. 发明申请

WO2013043330A1 PLASMA ACTIVATED CONFORMAL DIELECTRIC FILM DEPOSITION 审中-公开
标题翻译：等离子体激活的均匀介质膜沉积
公开(公告)号：WO2013043330A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/052769
申请日：2012-08-29
申请人： NOVELLUS SYSTEMS, INC. , SWAMINATHAN, Shankar , HENRI, Jon , HAUSMANN, Dennis M. , SUBRAMONIUM, Pramod , SRIRAM, Mandyam , RANGARAJAN, Vishwanathan , KATTIGE, Kirthi K. , VAN SCHRAVENDIJK, Bart J. , McKERROW, Andrew J.
发明人： SWAMINATHAN, Shankar , HENRI, Jon , HAUSMANN, Dennis M. , SUBRAMONIUM, Pramod , SRIRAM, Mandyam , RANGARAJAN, Vishwanathan , KATTIGE, Kirthi K. , VAN SCHRAVENDIJK, Bart J. , McKERROW, Andrew J.
IPC分类号： H01L21/205 , H01L21/31
CPC分类号： H01L21/76825 , C23C16/045 , C23C16/4401 , C23C16/4554 , C23C16/56 , H01L21/02129 , H01L21/02164 , H01L21/02211 , H01L21/02274 , H01L21/0228 , H01L21/02315 , H01L21/0234 , H01L21/02348 , H01L21/3105 , H01L21/31111 , H01L21/76224 , H01L21/76826 , H01L21/76831 , H01L21/76837 , H01L21/76898 , H01L29/66795
摘要： Methods of depositing a film on a substrate surface include surface mediated reactions in which a film is grown over one or more cycles of reactant adsorption and reaction. In one aspect, the method is characterized by intermittent delivery of dopant species to the film between the cycles of adsorption and reaction.
摘要翻译：在基底表面上沉积膜的方法包括表面介导的反应，其中膜在一个或多个反应物吸附和反应循环上生长。在一个方面，该方法的特征在于在吸附和反应的循环之间将掺杂剂物质间歇地递送至膜。

3. 发明申请

WO2011130326A3 PLASMA ACTIVATED CONFORMAL FILM DEPOSITION 审中-公开
公开(公告)号：WO2011130326A3
公开(公告)日：2011-10-20
申请号：PCT/US2011/032186
申请日：2011-04-12
申请人： NOVELLUS SYSTEMS, INC. , LAVOIE, Adrien , SWAMINATHAN, Shankar , KANG, Hu , CHANDRASEKHARAN, Ramesh , DORSH, Tom , HAUSMANN, Dennis, M. , HENRI, Jon , JEWELL, Thomas , LI, Ming , SCHLIEF, Bryan , XAVIER, Antonio , MOUNTSIER, Thomas, W. , VAN SCHRAVENDIJK, Bart, J. , SRINIVASAN, Easwar , SRIRAM, Mandyam
发明人： LAVOIE, Adrien , SWAMINATHAN, Shankar , KANG, Hu , CHANDRASEKHARAN, Ramesh , DORSH, Tom , HAUSMANN, Dennis, M. , HENRI, Jon , JEWELL, Thomas , LI, Ming , SCHLIEF, Bryan , XAVIER, Antonio , MOUNTSIER, Thomas, W. , VAN SCHRAVENDIJK, Bart, J. , SRINIVASAN, Easwar , SRIRAM, Mandyam
IPC分类号： C23C16/44 , C23C16/455 , C23C16/50 , H01L21/205 , H01L21/3065
摘要： Methods of depositing a film on a substrate surface include surface mediated reactions in which a film is grown over one or more cycles of reactant adsorption and reaction. In one aspect, the method is characterized by the following operations: (a) exposing the substrate surface to a first reactant in vapor phase under conditions allowing the first reactant to adsorb onto the substrate surface; (b) exposing the substrate surface to a second reactant in vapor phase while the first reactant is adsorbed on the substrate surface; and (c) exposing the substrate surface to plasma to drive a reaction between the first and second reactants adsorbed on the substrate surface to form the film.

4. 发明申请

WO2011130326A2 PLASMA ACTIVATED CONFORMAL FILM DEPOSITION 审中-公开
标题翻译：等离子体活化共形膜沉积
公开(公告)号：WO2011130326A2
公开(公告)日：2011-10-20
申请号：PCT/US2011032186
申请日：2011-04-12
申请人： NOVELLUS SYSTEMS INC , LAVOIE ADRIEN , SWAMINATHAN SHANKAR , KANG HU , CHANDRASEKHARAN RAMESH , DORSH TOM , HAUSMANN DENNIS M , HENRI JON , JEWELL THOMAS , LI MING , SCHLIEF BRYAN , XAVIER ANTONIO , MOUNTSIER THOMAS W , VAN SCHRAVENDIJK BART J , SRINIVASAN EASWAR , SRIRAM MANDYAM
发明人： LAVOIE ADRIEN , SWAMINATHAN SHANKAR , KANG HU , CHANDRASEKHARAN RAMESH , DORSH TOM , HAUSMANN DENNIS M , HENRI JON , JEWELL THOMAS , LI MING , SCHLIEF BRYAN , XAVIER ANTONIO , MOUNTSIER THOMAS W , VAN SCHRAVENDIJK BART J , SRINIVASAN EASWAR , SRIRAM MANDYAM
IPC分类号： C23C16/44 , C23C16/455 , C23C16/50 , H01L21/205 , H01L21/3065
CPC分类号： H01L21/0228 , C23C16/045 , C23C16/345 , C23C16/402 , C23C16/45523 , C23C16/4554 , C23C16/56 , H01L21/02164 , H01L21/0217 , H01L21/02274 , H01L21/02348 , H01L21/28562 , H01L21/67017 , H01L21/6719 , H01L21/67201 , H01L21/76224 , H01L21/76825 , H01L21/76826 , H01L21/76829 , H01L21/76837 , H01L21/76898
摘要： Methods of depositing a film on a substrate surface include surface mediated reactions in which a film is grown over one or more cycles of reactant adsorption and reaction. In one aspect, the method is characterized by the following operations: (a) exposing the substrate surface to a first reactant in vapor phase under conditions allowing the first reactant to adsorb onto the substrate surface; (b) exposing the substrate surface to a second reactant in vapor phase while the first reactant is adsorbed on the substrate surface; and (c) exposing the substrate surface to plasma to drive a reaction between the first and second reactants adsorbed on the substrate surface to form the film.
摘要翻译：在基底表面上沉积膜的方法包括表面介导的反应，其中膜在一个或多个反应物吸附和反应循环上生长。在一个方面，该方法的特征在于以下操作：（a）在允许第一反应物吸附到基底表面上的条件下，将基底表面暴露于气相的第一反应物; （b）将第一反应物吸附在基底表面上的同时将基底表面暴露于气相的第二反应物; 和（c）将衬底表面暴露于等离子体以驱动吸附在衬底表面上的第一和第二反应物之间的反应以形成膜。

5. 发明申请

WO1994003177A2 SIDE CHAIN DERIVATIZED 15-OXYGENATED STEROLS, METHODS OF USING THEM AND A PROCESS FOR PREPARING THEM 审中-公开
标题翻译：侧链衍生的15-氧化的甾体，使用它们的方法和制备它们的方法
公开(公告)号：WO1994003177A2
公开(公告)日：1994-02-17
申请号：PCT/US1993007230
申请日：1993-08-03
申请人： WILLIAM MARSH RICE UNIVERSITY , SCHROEPFER, George, J., Jr. , HERZ, Josef, E. , SWAMINATHAN, Shankar , WILSON, William, K.
发明人： WILLIAM MARSH RICE UNIVERSITY
IPC分类号： A61K31/575
CPC分类号： C07J9/005 , A61K31/575 , C07J9/00 , C07J31/006 , C07J41/0055
摘要： Pharmaceutical compositions are provided for lowering the activity of HMG-CoA reductase and/or lowering serum cholesterol, comprising a side chain derivatized 15-oxygenated sterol having formula (I): the basic ring structure being saturated or unsaturated, wherein R1 is -OH, =O, -OR7, (a), (b), a sulfate group, a sugar moiety, or a Mg, Na, or K salt of a sulfate group; R2 is -H, -OH, =O, mono- or di-halogen, or a C1 to C6 alkyl group, which may be unsaturated or substituted with halogen; R3 is -H, -OH, halogen, or a C1 to C6 alkyl group, which may be unsaturated or substituted with halogen; R4 is nonexistent when there is a double bond between the 8 and 14 carbons or (alpha)H, (beta)H, or an (alpha)C1 to C6 alkyl group; R5 is -OH, =O, =NOH, or (a); R6 is -CH2CH(CH3)2, in which one or more of the hydrogen atoms is replaced by OH or halogen, -CH=C(CH3)2, in which one or more of the hydrogen atoms may be replaced by OH or halogen, or -CH2N(CH3)2, in which one or more of the hydrogen atoms may be replaced by OH or halogen, provided that no carbon atom with an OH is also substituted with halogen or an additional OH; R7 is a C1 to C6 alkyl group; R8 is a C1 to C20 aliphatic group, which may be substituted or unsubstituted, or a phenyl group; and n is an integer of from 2 to 6; with the proviso that said sterol is not 3(beta), 26-dihydroxy-5(alpha)-cholest-8(14)-en-15-one.
摘要翻译：提供了用于降低HMG-CoA还原酶和/或降低血清胆固醇的活性的药物组合物，其包含具有式（I）的侧链衍生的15-氧化固醇：所述碱性环结构是饱和或不饱和的，其中R 1是-OH， = O，-OR7，（a），（b），硫酸根基团，糖部分或硫酸根基团的Mg，Na或K盐; R2是-H，-OH，= O，单 - 或二 - 卤素，或可以是不饱和的或被卤素取代的C1-C6烷基; R3是-H，-OH，卤素或C1-C6烷基，其可以是不饱和的或被卤素取代的; 在8和14碳之间存在双键或（α）H，（β）H或（α）C 1至C 6烷基时，R 4不存在; R5是-OH，= O，= NOH或（a）; R6是-CH2CH（CH3）2，其中一个或多个氢原子被OH或卤素取代，-CH = C（CH 3）2，其中一个或多个氢原子可以被OH或卤素取代或-CH 2 N（CH 3）2，其中一个或多个氢原子可以被OH或卤素代替，条件是没有碳原子与OH也被卤素或另外的OH取代; R7是C1-C6烷基; R8是可以是取代或未取代的C1〜C20脂肪族基团或苯基; n为2〜6的整数。条件是所述甾醇不是3（β），26-二羟基-5（α） - 胆甾-8（14）-en-15-酮。

6. 发明申请

WO2002060904A2 A PROCESS FOR THE PREPARATION OF EPOTHILONE ANALOGS 审中-公开
标题翻译：一种制备EPOTHILONE类似物的方法
公开(公告)号：WO2002060904A2
公开(公告)日：2002-08-08
申请号：PCT/US2002/001853
申请日：2002-01-22
申请人： BRISTOL-MYERS SQUIBB COMPANY , LI, Wen-Sen , THORNTON, John E. , GUO, Zhenrong , SWAMINATHAN, Shankar
发明人： LI, Wen-Sen , THORNTON, John E. , GUO, Zhenrong , SWAMINATHAN, Shankar
IPC分类号： C07D491/00
CPC分类号： C07D417/06 , C07D491/08
摘要： The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
摘要翻译：本发明涉及通过初始形成新型开环埃坡霉素并在其上进行大环内酯化反应来制备埃坡霉素类似物的方法。本发明方法适于在单独的反应容器中进行，而不分离中间体化合物，并且与现有的制备所需埃坡霉素类似物的方法相比，产率提高至少约三倍。

7. 发明申请

WO02060904A3 A PROCESS FOR THE PREPARATION OF EPOTHILONE ANALOGS 审中-公开
标题翻译：一种制备EPOTHILONE类似物的方法
公开(公告)号：WO02060904A3
公开(公告)日：2003-02-27
申请号：PCT/US0201853
申请日：2002-01-22
申请人： SQUIBB BRISTOL MYERS CO , LI WEN-SEN , THORNTON JOHN E , GUO ZHENRONG , SWAMINATHAN SHANKAR
发明人： LI WEN-SEN , THORNTON JOHN E , GUO ZHENRONG , SWAMINATHAN SHANKAR
IPC分类号： C07D417/06 , C07D491/044 , C07D491/08
CPC分类号： C07D417/06 , C07D491/08
摘要： The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
摘要翻译：本发明涉及通过初始形成新型开环埃坡霉素并在其上进行大环内酯化反应来制备埃坡霉素类似物的方法。本发明方法适于在单独的反应容器中进行，而不分离中间体化合物，并且与现有的制备所需埃坡霉素类似物的方法相比，产率提高至少约三倍。

8. 发明申请

WO2005058245A3 SYNTHETIC PROCESS 审中-公开
标题翻译：合成方法
公开(公告)号：WO2005058245A3
公开(公告)日：2005-08-04
申请号：PCT/US2004041920
申请日：2004-12-10
申请人： SQUIBB BRISTOL MYERS CO , SWAMINATHAN SHANKAR , GAVAI ASHVINIKUMAR V , FAN JUNYING , PATEL BHARAT P , NORRIS DEREK J , CORBETT RICHARD MICHAEL , ZHENG BIN
发明人： SWAMINATHAN SHANKAR , GAVAI ASHVINIKUMAR V , FAN JUNYING , PATEL BHARAT P , NORRIS DEREK J , CORBETT RICHARD MICHAEL , ZHENG BIN
IPC分类号： A61K20060101 , A61K31/53 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a process for preparing compounds of formula (I) ["insert chemical structure here"](I)or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
摘要翻译：本发明提供了制备式（I）化合物[“在此插入化学结构”（I））或其药学上可接受的盐的方法。通过本发明的方法制备的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。

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