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1. 发明申请

WO9910527A3 METHOD FOR ISOLATING ANIONIC ORGANIC SUBSTANCES FROM AQUEOUS SYSTEMS USING CATIONIC POLYMER NANOPARTICLES 审中-公开
标题翻译：方法阳离子高分子纳米颗粒水性体系中阴离子有机物分离
公开(公告)号：WO9910527A3
公开(公告)日：1999-05-20
申请号：PCT/EP9805340
申请日：1998-08-21
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , BAYER ERNST , FRITZ HANS , MAIER MARTIN , SCHEWITZ JENS , GERSTER MICHAEL
发明人： BAYER ERNST , FRITZ HANS , MAIER MARTIN , SCHEWITZ JENS , GERSTER MICHAEL
IPC分类号： B01J41/04 , C07B63/00 , C07C51/47 , C07C55/14 , C07C63/26 , C07C201/16 , C07C205/21 , C07H21/02 , C07H21/04 , C07K2/00 , C12N15/10 , C12Q1/68 , C07H1/06 , C07C37/82
CPC分类号： B01J41/04 , C12N15/1006 , C12Q1/6806 , Y10S977/906
摘要： The invention relates to a method for isolating anionic organic substances from aqueous systems using polymer nanoparticles with cationic pH-sensitive surface groups. Extraction can be carried out directly from diluted solutions, biological media (blood plasma, serum, urine, etc.) and complex buffer systems (e.g. PCR preparations containing detergents) without prior derivatization of the samples or addition of binding buffers. After separation from the surrounding medium the conjugates of the corresponding substances and polymer nanoparticles obtained in this manner can be purified through additional washing steps and effectively desalinated. Owing to the pH-sensitivity of the basic surface groups, the bound substances can be released in a targeted manner after separation by modification of the pH of the medium. By using volatile bases contamination of the released samples with ionic residues can be avoided. By adding small quantities of SDS and acetonitrile during the separation stage, the sensitivity of the method can be raised further, especially when the substances to be isolated are present in low concentrations (
摘要翻译：该方法描述了使用具有阳离子pH敏感表面基团的聚合物纳米粒子从含水体系中分离阴离子有机物质。提取可以直接从稀溶液中进行，生物介质（血浆，血清，尿液等）和复杂的缓冲系统（例如含去污剂的PCR批次）没有样品的先前衍生或添加结合缓冲液是必需的。由此获得的相应物质与聚合物纳米颗粒的缀合物可以在其通过额外的洗涤步骤与周围介质分离并被有效脱盐后被纯化。碱性表面基团的pH敏感性使得可以通过介质的pH变化选择性地释放结合物质。通过使用挥发性碱，可以避免离子残留物污染释放的样品。通过在分离步骤中添加少量SDS和乙腈，特别是在低浓度待分离物质（<1 mol / L）中，该方法的灵敏度可以进一步提高。该方法是低分子量阴离子化合物以及肽，核酸和核酸衍生物的通用萃取方法，回收率可达100％。

2. 发明申请

WO8800620A3 QUICKLY SOLUBLE ADDUCT FOR MOLTEN BATH 审中-公开
标题翻译：快速溶解润滑剂
公开(公告)号：WO8800620A3
公开(公告)日：1988-03-10
申请号：PCT/EP8700387
申请日：1987-07-16
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , MEYER GRUENOW HARTMUT
发明人： MEYER-GRUENOW HARTMUT
IPC分类号： C22C1/02
CPC分类号： C22C1/026
摘要： A quickly soluble adduct for molten baths contains between 2 and 50 weight % of a component A composed of alcaline aluminium fluoride or of a salt containing alcaline aluminium fluoride and a component B composed of one or several alloy metals, the components A and B being intimately mixed. This adduct has an unexpectedly high speed of dissolution also with high contents of alloy metals and at the same time yields completely the alloy metal.

3. 发明申请

WO0103671A3 METHOD FOR PRODUCING POWDERY PARTICLE-REDUCED FORMULATIONS WITH THE AID OF COMPRESSED GASES 审中-公开
标题翻译：用于生产粉状颗粒减小的制剂使用压缩气体
公开(公告)号：WO0103671A3
公开(公告)日：2001-05-10
申请号：PCT/EP0006709
申请日：2000-07-13
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , HEIDLAS JUERGEN , OBER MARTIN , WIESMUELLER JOHANN
发明人： HEIDLAS JUERGEN , OBER MARTIN , WIESMUELLER JOHANN
IPC分类号： A61K9/14 , A61K9/16 , B01J3/00
CPC分类号： A61K9/14 , A61K9/1617 , Y10S514/959 , Y10S516/922 , Y10S516/928
摘要： The invention relates to the production of powdery particle-reduced formulations with the aid of compressed gases. The inventive method is characterized in that: the solid compound to be formulated, said compound consisting of a poorly soluble and mostly bioactive substance, is homogeneously comminuted together with 10-99 wt. % (with regard to the formulation) of a supporting material, which is essentially soluble in the compressed gas mixture, in an agitated autoclave provided with a mechanical comminution device in the presence of compressed gas or mixtures thereof, at method temperatures ranging from 10 to 200 DEG C, and under method pressures ranging from 5 to 500 bar, and, in a second method step; the compressed gas mixture, consisting mostly of dimethyl ether, pure propane and/or carbon dioxide, is expanded by lowering the pressure and is separated away from the homogenate that can also be provided in the form of a molten material. Finally, the powdery particle-reduced formulation is obtained from the resulting homogenate and exhibits significant improvements with regard to solubility properties and especially with regard to the biological availability of compounds which, initially, are poorly soluble or insoluble.
摘要翻译：对于具有压缩气体的辅助下粉状颗粒减小制剂的制备是要配制固体化合物，难溶的，并且通常的生物活性剂，连同10-99重量％（基于所述制剂）的载体材料的可溶于所述压缩气体混合物基本上，在压缩气体，或它们的混合物与机械式粉碎机的搅拌高压釜中存在的情况下处理温度10至200℃，并在5和500之间的过程压力接地棒均匀，并且在第二处理阶段，压缩气体混合物，通常是二甲醚，纯丙烷和/或之间二氧化碳，通过降低压力和匀浆其也可以作为熔体，分离放宽。最后，从所得到的匀浆中回收，在粉粒降低制剂可以与释放性质的所指的改进，特别是重链和最初的非水溶性化合物的生物利用度来实现。

4. 发明申请

WO9817317A2 PROCESS FOR PRODUCING BIOLOGICALLY ACTIVE POLYMER NANOPARTICLE-NUCLEIC ACID CONJUGATES 审中-公开
标题翻译：用于生产生物活性的聚合物纳米粒子 - 核酸结合物
公开(公告)号：WO9817317A2
公开(公告)日：1998-04-30
申请号：PCT/EP9705790
申请日：1997-10-21
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , BAYER ERNST , FRITZ HANS , MAIER MARTIN
发明人： BAYER ERNST , FRITZ HANS , MAIER MARTIN
IPC分类号： C12N15/09 , A61K9/51 , A61K47/30 , A61K47/48 , A61K48/00 , C12N15/113 , C12N15/88 , A61K9/00
CPC分类号： C12N15/1138 , A61K9/5138 , A61K9/5146 , A61K9/5192 , A61K47/58 , A61K47/6933 , A61K48/00 , B82Y5/00 , C12N15/88 , C12N2310/315
摘要： A process is disclosed for producing biologically active polymer nanoparticle-nucleic acid conjugates by polymerising vinyl monomers with a low water solubility in an aqueous solution, then reacting the resulting polymer suspensions with the nucleic acids. The process is characterised in that the vinyl monomers are emulsion polymerised in the presence of cationic radical starters but in the absence of any emulsifier. The thus obtained polymer nanoparticle-nucleic acid conjugates are sufficiently stable in biological media and are characterised by a high transport efficiency through cellular membranes.
摘要翻译：它是由具有在水溶液中和所得聚合物悬浮液，该方法的特征在于，乙烯基单体在聚合的后续反应低水溶性乙烯基单体的聚合用核酸描述一种用于生物活性聚合物纳米颗粒 - 核酸结合物的制备阳离子自由基引发剂的存在和是在无乳化剂乳液聚合的形式进行。以这种方式制备的聚合物纳米颗粒 - 核酸缀合物具有在生物介质中足够的稳定性，并通过细胞膜在运输特征在于高效率。

5. 发明申请

WO0052014A3 METHOD FOR PRODUCING N-PHOSPHONOMETHYL IMINODIACETIC ACID 审中-公开
标题翻译：工艺生产N-膦酰亚氨基二乙酸
公开(公告)号：WO0052014A3
公开(公告)日：2002-02-14
申请号：PCT/EP0001896
申请日：2000-03-03
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , GROEGER HARALD , FLEISCHER FRANK , HAMMER BENEDIKT , HITZLER MARTIN
发明人： GROEGER HARALD , FLEISCHER FRANK , HAMMER BENEDIKT , HITZLER MARTIN
IPC分类号： C07F9/38
CPC分类号： C07F9/3808
摘要： The invention relates to a method for producing N-phosphonomethyl iminodiacetic acid by reacting iminodiacetic acids with phosphorous acid and formaldehyde in an aqueous solution, in the presence of a strong mineral acid. The invention is characterised in that the reaction is carried out at a temperature of 110 to 150 DEG C in an atmosphere containing inert gas. The main advantages of this method are the high yields and purity with regard to the N-phosphonomethyl iminodiacetic acid and the almost stoichiometric need for educts, in addition to the lower quantity of waste that is associated with the same.
摘要翻译：提供了一种用于通过亚氨基二乙酸与亚磷酸和甲醛在强无机酸的存在下在水溶液中描述，其特征在于，在110〜150℃的温度下在保护气体气氛下进行反应反应制备N-膦亚氨基二乙酸的方法执行。这种方法的主要优点是高的产率和纯度相对于所述N-膦酸以及反应物的接近化学计量需求和较低量的与其相关联的浪费的。

6. 发明申请

WO0134560A3 METHOD FOR PRODUCING IMINODICARBOXYLIC ACIDS 审中-公开
标题翻译：用于生产亚氨基二羧酸
公开(公告)号：WO0134560A3
公开(公告)日：2001-12-13
申请号：PCT/EP0011092
申请日：2000-11-09
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , GROEGER HARALD , HAMMER BENEDIKT
发明人： GROEGER HARALD , HAMMER BENEDIKT
IPC分类号： C07C227/12 , C07C229/16
CPC分类号： C07C227/12 , C07C229/16
摘要： The invention relates to a method for producing iminodicarboxylic acids by amidocarbonylating compounds of formula (I), wherein R = H, NH2, C1-28-alkyl, C6-12 aryl with carbon monoxide in the acidic medium and in the presence of a catalytic palladium complex and of an aldehyde as well as of the terminating hydrolytic cleavage of the N-acyl group. The inventive method is characterized in that the amidocarbonylation is carried out in a hydrous medium. Formamide, acetamide or urea are used as a particularly suitable starting material. Inorganic Pd(II) salts, such as palladium acetate or palladium chloride, or heterogeneous Pd catalysts are mainly used in mixtures containing a mineral acid and in quantities ranging from 0.01 to 0.25 mol %, whereby the catalytic system should contain, in particular, hydrobromic acid or hydrochloric acid. The invention also provides that the reaction is carried out in the presence of a maximum of 35 mol % of a halogenide salt.
摘要翻译：本发明是通过式（I），其中R = H，NH 2，C1-28烷基，C6-12芳基，与一氧化碳在在钯催化络合物的存在下，在酸性介质中，和化合物的酰胺基羰基的制备的亚氨基二羧酸的方法醛和N-酰基基团，其特征在于，所述酰胺基羰基是在水性介质中进行的最终水解裂解。一种特别合适的起始材料甲酰胺，可以使用乙酰胺或脲。无机的Pd（II）盐，如乙酸或氯化钯，或钯多相催化剂主要用在用无机酸混合物，在0.01〜0.25摩尔％，其中所述催化体系的量，特别是溴应包含或盐酸。还提供的是在最大的存在下进行反应。 35摩尔％的卤化物盐。

7. 发明申请

WO0002827A3 USE OF WATER-SOLUBLE MIXED POLYMERS AS A FLOWING MEDIUM AND/OR AS A HARDENING RETARDER FOR REFRACTORY MATERIALS WHICH CONTAIN ALUMINATE CEMENT 审中-公开
标题翻译：使用水溶性混合聚合物的溶剂和/或缓凝剂ALUMINATZEMENTHALTIGE耐火材料团结构
公开(公告)号：WO0002827A3
公开(公告)日：2000-05-18
申请号：PCT/EP9904813
申请日：1999-07-08
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , WACHE STEFFEN , PLANK JOHANN , WUTZ KONRAD , BICHLER MANFRED
发明人： WACHE STEFFEN , PLANK JOHANN , WUTZ KONRAD , BICHLER MANFRED
IPC分类号： C04B24/16 , C04B24/26 , C04B28/06 , C04B35/634 , C04B35/66 , C08F220/06 , C08F222/04 , C08F228/00
CPC分类号： C04B35/63404 , C04B24/163 , C04B24/2641 , C04B24/2664 , C04B28/06 , C04B35/66 , C08F220/06 , C08F222/04 , C08F228/00
摘要： The invention relates to the use of a three-constituent, water-soluble polymer comprised of 5-90 wt.% of a constituent a), preferably of maleic acid, fumaric acid or itaconic acid, 5-90 wt.% of a constituent b) essentially comprised of the group 2-acrylamido-2-methylpropane sulfonic acid, vinyl sulfonic acid, vinyl phosphonic acid, and 5-90 wt.% of the constituent c) comprised of acrylic acid, methacrylic acid, acrylamide and methacrylamide. The inventive polymer is used as a flowing medium for refractory materials which contain aluminate cement. The mixed polymer which comprises a preferred molecular weight of Mw
摘要翻译：描述了使用包括5-90重量组分A的％的三组分的水溶性聚合物），优选的类型马来酸，富马酸或衣康酸，5-90重量的成分B的％）的基本上由集团2- 丙烯酰胺基-2-甲基丙磺酸，乙烯基磺酸，乙烯基膦酸，以及5-90重量的组分c％）选自由丙烯酸，甲基丙烯酸，丙烯酰胺和甲基丙烯酰胺作为洗脱剂为aluminatzementhaltige耐火组合物。具有优选的分子量Mw <50000，该共聚物可以与其它质量改善添加剂如硅石，石灰或碳酸钠和超出耐火组合物另外的常规添加剂结合。

8. 发明申请

WO0138554A3 METHOD FOR PRODUCING OPTICALLY ACTIVE CYANHYDRINS 审中-公开
标题翻译：生产光学活性氰氢的方法
公开(公告)号：WO0138554A3
公开(公告)日：2001-12-27
申请号：PCT/EP0011743
申请日：2000-11-24
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , GROEGER HARALD , VORLOP KLAUS DIETER , CAPAN EMINE
发明人： GROEGER HARALD , VORLOP KLAUS-DIETER , CAPAN EMINE
IPC分类号： C12N11/08 , C12N11/10 , C12P13/00 , C12N9/88 , C12N11/00
CPC分类号： C12P13/004 , C12N11/08 , C12N11/10 , C12Y401/0201
摘要： The invention relates to a method for producing optically active cyanhydrins by reacting oxo compounds, such as for example aldehyde and/or ketone with hydrogen cyanide and/or with a cyanide donor in the presence of an inclusion compound which contains an oxynitrilase with an increased molecular weight. According to said method, an oxynitrilase is used, whose molecular weight is first increased by cross-linkage and which is subsequently converted into a gel inclusion compound and/or a gel complex compound, said conversions occurring substantially in two independent steps. The method which is carried out in particular at temperatures of between - 10 and + 30 DEG C and at pH values of between 3.0 and 6.0, preferably in an aqueous or hydrous system, but also in organic solvents, uses a component which contains enzymes. In said component, the molecular-weight of the enzyme has been increased, in particular by co-cross-linkage or by flocculation and said enzyme is used either in a free form or is enclosed by natural or artificial cells. A deciding factor in this method is the fact that the enzyme is enclosed by or complexed in a gel, which results in negligibly small attrition and leaching losses at a practically constant high level of enzyme activity, rendering the method extremely effective and economic.
摘要翻译：公开了一种用于被氧化合物的反应的光学活性氰醇，如，醛和/或酮与氢氰化物和/或与一个包含molekuargewichtsvergrösserte氰醇，其中一个使用了氰醇的包合化合物的存在下，氰化物供体的制备方法，其已经通过交联在两个独立步骤中基本上分子扩大，并随后转化为凝胶夹杂物和/或凝胶复合物化合物。的方法，特别是，在之间的温度 - 10执行和+ 30℃，并以3.0至6.0的pH值，优选在含水或含水的系统中，而且在有机溶剂中，使用的酶含有组分，其中所述酶本身是特别通过共交联或通过絮凝molekulargewichtsvergrössert并用于包括以游离形式或以天然或人工细胞。关键在这个过程是酶被封装在凝胶或络合，使磨损小和浸出损失可以忽略不计在几乎不变的高酶活性，这使得该方法非常有效和经济的事实。

9. 发明申请

WO0154676A2 FORMULATIONS FOR STATES OF DEHYDRATION 审中-公开
标题翻译：配方脱水条件
公开(公告)号：WO0154676A2
公开(公告)日：2001-08-02
申请号：PCT/EP0100863
申请日：2001-01-26
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , GLOXHUBER CHRISTIAN , MERTSCHENK BERND
发明人： GLOXHUBER CHRISTIAN , MERTSCHENK BERND
IPC分类号： A61K31/198 , A61P7/00 , A61K31/00
CPC分类号： A61K31/198
摘要： Formulations for dehydration states are disclosed, which comprise creatine and/or creatine derivatives, such as creatine monohydrate, creatine ascorbate, and creatine pyruvate and/or mixtures thereof, in such quantities that the creatine components do not exceed a daily dose of 4g of creatine. Said formulations which are, most notably, available in the form of infusion solutions and drinks, but also as tablets, capsules and powders, are used, preferably in patients with dehydration states caused, in particular, by age and/or immobility and/or by a disturbed fluid uptake. Said formulations can also be applied in the framework of an adjutant therapy in dehydration states. Said formulations achieve not just a better and increased water uptake in the various body tissues, but also achieve a significantly longer storage of water in the tissue.
摘要翻译：描述的是用于脱水的条件制剂肌酸和/或肌酸衍生物如肌酸，肌酸抗坏血酸盐，肌酸丙酮酸和它们的任何混合物，其比例包含在特定使得肌酸组件不是肌酸4克的每日剂量超过。这些制剂，其主要存在于输注液和饮料的形式，也可作为片剂，胶囊和粉末在那些在特定年龄和/或immobilitätsbedingt和/或通过受损的液体摄入量导致患者脱水状态优选使用 ; 然而，所要求保护的制剂也可以作为在脱水条件下的辅助疗法的一部分。用这些制剂，更好的和增强的水吸收到各种人体组织不仅实现新制剂的礼物也意味着组织水显著更长存储。

10. 发明申请

WO0103325A3 USE OF CREATINE AND/OR CREATINE DERIVATIVES FOR TREATING FEELINGS OF ILL-HEALTH IN WOMEN 审中-公开
标题翻译：肌苷和/或肌苷衍生物用于治疗女性缺陷性疾病
公开(公告)号：WO0103325A3
公开(公告)日：2001-08-02
申请号：PCT/EP0006084
申请日：2000-06-29
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , PISCHEL IVO , HOLLAND HELEN LOUISE , SCHWARTZ BRIGITTA , HUBER ANDREA , JAEGER RALF
发明人： PISCHEL IVO , HOLLAND HELEN LOUISE , SCHWARTZ BRIGITTA , HUBER ANDREA , JAEGER RALF
IPC分类号： A61K31/155 , A61K31/195 , A61K31/223 , A61K31/341 , A61P5/24 , A61P15/00
CPC分类号： A61K31/155 , A61K31/195 , A61K31/223 , A61K31/341
摘要： The invention relates to the use of creatine and/or creatine derivatives for treating feelings of ill-health such as PMS or dysmenorrhoea in women. According to the invention, especially the creatine monohydrate, the pyruvates, ascorbates and alpha ketoglutarates of creatine which represent creatine derivatives are used in preferred daily doses of 0.1 to 20 g/d for prophylaxis or in the form of a therapeutical agent. The invention also relates to the use of creatine or its derivatives as admixture in a pyruvate, ascorbate or alpha ketoglutarate. The inventive creatine or its corresponding derivatives are not limited to a certain mode of administration and are therefore especially suitable for many symptoms of the feeling of ill-health of women.
摘要翻译：描述了使用肌酸和/或肌酸衍生物用于在妇女的心境障碍，如PMS或治疗痛经，特别是其中的一水肌酸，丙酮酸，-ascorbate和 - α酮戊二酸作为优选的每日剂量的0肌酸衍生物， 1至20g / d预防或以治疗剂的形式。提供的肌酸或它的衍生物也是，使它们与一种混合物使用α-酮戊二酸，丙酮酸盐，抗坏血酸盐，或，其中，所述肌酸或它的相应的衍生物不局限于施用除了适合女性情绪障碍的许多症状的具体形式。

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