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1. 发明申请

WO2017085212A2 SURFACE-MODIFIED NANOSPHERES ENCAPSULATING ANTIGEN-BINDING MOLECULES 审中-公开
公开(公告)号：WO2017085212A2
公开(公告)日：2017-05-26
申请号：PCT/EP2016/078057
申请日：2016-11-17
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： CURIC, Anamarija , UNTUCHT, Christopher
IPC分类号： A61K47/62 , A61K47/69
CPC分类号： A61K47/6933 , A61K47/62
摘要： The present invention relates to nanospheres which comprise a polymeric matrix and antigen-binding molecules esterase-releasably incorporated therein and are coated with targeting molecules which increase the cellular uptake of the nanospheres. The polymeric matrix is formed by poly(alkyl cyanoacrylates) and/or alkoxy derivatives thereof. The invention further relates to methods for preparing and compositions comprising such nanospheres.

2. 发明申请

WO2016077215A2 MODULAR NANODEVICES FOR SMART ADAPTABLE VACCINES 审中-公开
标题翻译：用于智能适应性疫苗的模块化纳米设备
公开(公告)号：WO2016077215A2
公开(公告)日：2016-05-19
申请号：PCT/US2015059711
申请日：2015-11-09
申请人： UNIV YALE
发明人： MELLMAN IRA S , FAHMY TAREK M , SALTZMAN WILLIAM MARK , CAPLAN MICHAEL J
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K47/6933 , A61K47/6937 , A61K47/6939 , B82Y5/00 , C12N2710/16134 , C12N2760/16134 , C12N2760/16234
摘要： Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.
摘要翻译：已经开发了模块化纳米颗粒疫苗组合物及其制备和使用方法。模块化纳米颗粒疫苗组合物包含包封在聚合物颗粒中的抗原和模块化地将功能元件偶联至颗粒的适配器元件。这些疫苗组合物的模块化设计涉及抗原，佐剂，免疫增强剂，分子识别和运输介导元件以及细胞内摄取介质的灵活加入和减去，允许精确控制优化有效疫苗中重要的变量输送系统。

3. 发明申请

WO2014197616A1 REPEATED ADMINISTRATION OF NON-IMMUNOSUPRESSIVE ANTIGEN SPECIFIC IMMUNOTHERAPEUTICS 审中-公开
标题翻译：非免疫抑制抗原特异性免疫球蛋白重复给药
公开(公告)号：WO2014197616A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/040938
申请日：2014-06-04
申请人： SELECTA BIOSCIENCES, INC.
发明人： MALDONADO, Roberto, A. , KISHIMOTO, Takashi, Kei
IPC分类号： A61K31/436 , A61K39/395 , A61K48/00 , A61P19/02 , A61P37/00
CPC分类号： A61K38/13 , A61K9/127 , A61K9/5153 , A61K39/001 , A61K39/39 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/6903 , A61K47/6923 , A61K47/6933 , A61K47/6935 , A61K47/6937 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6093 , C07K14/4713 , C07K14/575 , C07K16/18 , C07K2317/21 , C07K2319/00
摘要： This invention relates to repeated administration of antigen- specific immunotherapeutics using protocols, or elements thereof, that do not induce immunosuppression. In some embodiments, the protocol has been previously shown not induce immunosuppression in a subject.
摘要翻译：本发明涉及使用不诱导免疫抑制的方案或其元件重复施用抗原特异性免疫治疗剂。在一些实施方案中，先前已经显示该方案在受试者中不诱导免疫抑制。

4. 发明申请

WO2013160773A3 POLYMERIC NANOPARTICLES AND PROCESS OF PREPARATION THEREOF 审中-公开
标题翻译：聚合纳米粒子及其制备方法
公开(公告)号：WO2013160773A3
公开(公告)日：2014-03-06
申请号：PCT/IB2013001247
申请日：2013-04-22
申请人： NANOGEN PHARMACEUTICALS
发明人： SINGH HARPAL
IPC分类号： C08G63/08 , A61K47/34 , C08G65/08 , C08G65/48
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/454 , A61K31/473 , A61K31/505 , A61K31/704 , A61K47/34 , A61K47/6933 , A61K47/6935 , A61K47/6937 , B82Y30/00 , C08G63/664 , Y10T428/2982
摘要： Disclosed are biodegradable polymeric nanoparticles and a process of producing thereof in the field of nanotechnology. The biodegradable polymeric nanoparticles are made up of block copolymers. The nanoparticles are produced without any emulsifiers which have a size ranging from 30 to 120 nm. Methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded nanoparticles. Provided are also compositions comprising the nanoparticles and the use thereof in therapeutics, diagnostics and therapeusis.
摘要翻译：公开了可生物降解的聚合物纳米颗粒及其在纳米技术领域的生产方法。可生物降解的聚合物纳米颗粒由嵌段共聚物组成。生产的纳米颗粒不具有任何尺寸范围为30至120nm的乳化剂。公开了控制药物负载能力的方法以及生产实体负载的纳米颗粒的方法。还提供了包含纳米颗粒的组合物及其在治疗，诊断和治疗中的用途。

5. 发明申请

WO2012122313A3 TARGETED NANOCARRIER SYSTEMS FOR DELIVERY OF ACTIVES ACROSS BIOLOGICAL MEMBRANES 审中-公开
标题翻译：用于通过生物膜递送活性的靶向纳米系统
公开(公告)号：WO2012122313A3
公开(公告)日：2013-03-14
申请号：PCT/US2012028138
申请日：2012-03-07
申请人： ACCESS PHARMA INC , NOWOTNIK DAVID P , ZARZYCKI RYSZARD , SOOD PAUL , UMMANENI N RAO
发明人： NOWOTNIK DAVID P , ZARZYCKI RYSZARD , SOOD PAUL , UMMANENI N RAO
IPC分类号： A61K47/48 , A61P5/48 , A61P35/02
CPC分类号： A61K9/5161 , A23L33/10 , A23L33/15 , A23P10/30 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/19 , A61K9/5123 , A61K9/513 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K31/713 , A61K38/08 , A61K38/16 , A61K38/28 , A61K47/551 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6929 , A61K47/6931 , A61K47/6933 , A61K47/6935 , A61K47/6939 , B82Y5/00
摘要： Disclosed herein are nanoparticle, micelle and/or liposome compositions, each comprising a therapeutic agent encapsulated in one or more polymer(s), wherein a vitamin B12 or a derivative thereof is attached to the one or more polymer(s) via a linker group, as well as methods for making and using same.
摘要翻译：本文公开了纳米颗粒，胶束和/或脂质体组合物，其各自包含包封在一种或多种聚合物中的治疗剂，其中维生素B12或其衍生物通过连接基团连接到所述一种或多种聚合物，以及制作和使用方法。

6. 发明申请

WO2012068476A3 POLY(VINYL BENZOATE) NANOPARTICLES FOR MOLECULAR DELIVERY 审中-公开
标题翻译：用于分子递送的POLY（乙烯基苯甲酸酯）纳米粒子
公开(公告)号：WO2012068476A3
公开(公告)日：2012-08-30
申请号：PCT/US2011061429
申请日：2011-11-18
申请人： UNIV SOUTH FLORIDA , TUROS EDWARD , LABRUERE RAPHAEL , CORMIER RYAN SCOTT , SICARD RENAUD
发明人： TUROS EDWARD , LABRUERE RAPHAEL , CORMIER RYAN SCOTT , SICARD RENAUD
IPC分类号： A61K47/34 , A61K9/14 , A61K9/16 , A61K47/30 , A61K49/06 , A61K49/12 , C08F18/04
CPC分类号： A61K9/146 , A61K9/0019 , A61K9/10 , A61K9/5138 , A61K47/10 , A61K47/489 , A61K47/6933 , A61K49/0039 , A61K49/0043 , A61K49/0093
摘要： The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using Pluronic F68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases. Kinetics experiments in phosphate buffer indicate that 78% of the coumarin-6 was encapsulated within the polymer matrix of the nanoparticle, and the residual 22% of coumarin-6 was surface-bound and quickly released. The nanoparticles are non-toxic in vitro towards human epithelial cells (IC50 >1000 µg/mL) and primary bovine primary aortic endothelial cells (IC50 >500 µg/mL), and exert non-observable bactericidal activity against a selection of representative test microbes (MIC >250 µg/mL). Poly(vinyl benzoate) nanoparticles are suitable carriers for molecular delivery of lipophilic small molecules such as drugs pharmaceutical and imaging agents.
摘要翻译：本发明包含聚（苯甲酸乙烯酯）纳米颗粒悬浮液作为分子载体。这些纳米颗粒可以通过使用Pluronic F68作为表面活性剂在水中纳米沉淀聚（苯甲酸乙烯酯）以形成直径为约200-250nm的球形纳米结构，其在磷酸盐缓冲液和血清中稳定并且在存在时仅缓慢降解的酯酶。磷酸盐缓冲液中的动力学实验表明，香豆素-6的78％被包封在纳米粒子的聚合物基质内，并且剩余22％的香豆素-6被表面结合并且快速释放。纳米颗粒在体外对人上皮细胞（IC50>1000μg/ mL）和原代牛主动脉内皮细胞（IC50>500μg/ mL）无毒性，并对选择的代表性测试微生物发挥不可观察的杀菌活性（MIC>250μg/ mL）。聚（苯甲酸乙烯酯）纳米粒子是用于分子递送亲脂性小分子的合适载体，例如药物药物和成像剂。

7. 发明申请

WO2011098407A1 MICROSPHERES 审中-公开
标题翻译：微球
公开(公告)号：WO2011098407A1
公开(公告)日：2011-08-18
申请号：PCT/EP2011/051653
申请日：2011-02-04
申请人： CEMM FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH , BINDER, Christoph, J. , WEISMANN, David , TSIANTOULAS, Dimitris
发明人： BINDER, Christoph, J. , WEISMANN, David , TSIANTOULAS, Dimitris
IPC分类号： A61K47/08 , G01N33/50
CPC分类号： G01N33/585 , A61B8/481 , A61K47/58 , A61K47/61 , A61K47/643 , A61K47/645 , A61K47/6921 , A61K47/6933 , A61K47/6939 , G01N2500/04 , G01N2800/00 , G01N2800/52
摘要： The present invention refers to a synthetic microsphere based on malondialdehyde (MDA) coupled to a backbone, with a size ranging between 500 nm and 500 µm, its use for analytic, diagnostic or pharmaceutic purposes, and specifically its use in a method of selecting antagonists of oxidative stress disease from a repertoire of agents possibly binding to oxidation epitopes.
摘要翻译：本发明涉及一种基于丙二醛（MDA）的合成微球，其结合骨架，尺寸范围在500nm和500μm之间，其用于分析，诊断或制药目的，特别是其在选择拮抗剂的方法中的用途的氧化应激疾病来自可能与氧化表位结合的药剂。

8. 发明申请

WO2011053940A2 TEMPLATED NANOCONJUGATES 审中-公开
标题翻译：模拟的纳米结晶
公开(公告)号：WO2011053940A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/055018
申请日：2010-11-01
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , GILJOHANN, David, A. , DANIEL, Weston, L. , CUTLER, Joshua, I. , ZHANG, Ke , ZHENG, Dan
发明人： MIRKIN, Chad, A. , GILJOHANN, David, A. , DANIEL, Weston, L. , CUTLER, Joshua, I. , ZHANG, Ke , ZHENG, Dan
IPC分类号： A61K48/00
CPC分类号： A61K47/6923 , A61K47/6933 , A61K49/0002 , A61K49/0093 , A61K51/1251 , B82Y5/00 , B82Y15/00 , C12N15/88 , C12Q1/6876 , G01N33/588
摘要： The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
摘要翻译：本公开涉及包含模板纳米缀合物的组合物及其使用方法。

9. 发明申请

WO2009038776A1 THERAPEUTIC NANOCONJUGATES 审中-公开
标题翻译：治疗NANOCONJUGATES
公开(公告)号：WO2009038776A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/010921
申请日：2008-09-18
申请人： MANNEH, Victor
发明人： MANNEH, Victor
IPC分类号： A61K51/00
CPC分类号： A61K41/0071 , A61K47/58 , A61K47/6855 , A61K47/6889 , A61K47/6933 , B82Y5/00
摘要： The construction and use of nanoconjugate molecules that incorporate a linker cleavable by an exogenous agent along with a therapeutic or diagnostic moiety are described. These novel nanoconjugates utilize a drug release mechanism which may incorporate photodynamic therapy drugs or similar compounds and a paired cleavable linker to target, image and/or deliver therapeutic concentrations of free drug to target cells such as cancer cells. Thus, this nanomedicine provides a highly specific and potent drug delivery system with highly improved therapeutic index over the free drug.
摘要翻译：描述了掺入可由外源性试剂与治疗或诊断部分切割的接头的纳米缀合物分子的构建和使用。这些新型纳米缀合物利用药物释放机制，其可以掺入光动力治疗药物或类似化合物和配对的可切割连接体以靶向，成像和/或递送治疗浓度的游离药物至靶细胞例如癌细胞。因此，该纳米医药提供了高度特异性和有效的药物递送系统，其具有高于游离药物的治疗指数。

10. 发明申请

WO2008085556A3 SURFACTANT-FREE NANOPARTICLES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的无表面活性剂的纳米颗粒
公开(公告)号：WO2008085556A3
公开(公告)日：2008-10-16
申请号：PCT/US2007078289
申请日：2007-09-12
申请人： UNIV SOUTH FLORIDA , TUROS EDWARD , GREENHALGH KERRIANN ROBYN , GARAY JULIO CESAR
发明人： TUROS EDWARD , GREENHALGH KERRIANN ROBYN , GARAY JULIO CESAR
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50 , G03C1/498
CPC分类号： A61K47/58 , A61K47/6905 , A61K47/6933 , B82Y5/00
摘要： The present invention concerns nanoparticles, compositions comprising the nanoparticles, methods for their production, and methods of using the nanoparticles for the delivery of biologically active agents (e.g., antibiotics or other drugs) to human or non-human subjects. In one embodiment, the nanoparticle is a "surfactant-free" nanoparticle in which the surfactant moiety is covalently attached to the backbone of the polymer.
摘要翻译：本发明涉及纳米颗粒，包含纳米颗粒的组合物，其制备方法以及使用纳米颗粒将生物活性剂（例如抗生素或其他药物）递送至人类或非人类受试者的方法。在一个实施方案中，纳米粒子是“表面活性剂”纳米粒子，其中表面活性剂部分共价连接到聚合物的骨架上。

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