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1. 发明申请

WO0103671A3 METHOD FOR PRODUCING POWDERY PARTICLE-REDUCED FORMULATIONS WITH THE AID OF COMPRESSED GASES 审中-公开
标题翻译：用于生产粉状颗粒减小的制剂使用压缩气体
公开(公告)号：WO0103671A3
公开(公告)日：2001-05-10
申请号：PCT/EP0006709
申请日：2000-07-13
申请人： SUEDDEUTSCHE KALKSTICKSTOFF , HEIDLAS JUERGEN , OBER MARTIN , WIESMUELLER JOHANN
发明人： HEIDLAS JUERGEN , OBER MARTIN , WIESMUELLER JOHANN
IPC分类号： A61K9/14 , A61K9/16 , B01J3/00
CPC分类号： A61K9/14 , A61K9/1617 , Y10S514/959 , Y10S516/922 , Y10S516/928
摘要： The invention relates to the production of powdery particle-reduced formulations with the aid of compressed gases. The inventive method is characterized in that: the solid compound to be formulated, said compound consisting of a poorly soluble and mostly bioactive substance, is homogeneously comminuted together with 10-99 wt. % (with regard to the formulation) of a supporting material, which is essentially soluble in the compressed gas mixture, in an agitated autoclave provided with a mechanical comminution device in the presence of compressed gas or mixtures thereof, at method temperatures ranging from 10 to 200 DEG C, and under method pressures ranging from 5 to 500 bar, and, in a second method step; the compressed gas mixture, consisting mostly of dimethyl ether, pure propane and/or carbon dioxide, is expanded by lowering the pressure and is separated away from the homogenate that can also be provided in the form of a molten material. Finally, the powdery particle-reduced formulation is obtained from the resulting homogenate and exhibits significant improvements with regard to solubility properties and especially with regard to the biological availability of compounds which, initially, are poorly soluble or insoluble.
摘要翻译：对于具有压缩气体的辅助下粉状颗粒减小制剂的制备是要配制固体化合物，难溶的，并且通常的生物活性剂，连同10-99重量％（基于所述制剂）的载体材料的可溶于所述压缩气体混合物基本上，在压缩气体，或它们的混合物与机械式粉碎机的搅拌高压釜中存在的情况下处理温度10至200℃，并在5和500之间的过程压力接地棒均匀，并且在第二处理阶段，压缩气体混合物，通常是二甲醚，纯丙烷和/或之间二氧化碳，通过降低压力和匀浆其也可以作为熔体，分离放宽。最后，从所得到的匀浆中回收，在粉粒降低制剂可以与释放性质的所指的改进，特别是重链和最初的非水溶性化合物的生物利用度来实现。

2. 发明申请

WO0220177A8 METHOD FOR IMPREGNATING A SUPPORT MATRIX WITH SOLID AND/OR LIQUID COMPOUNDS USING COMPRESSED GASES, AND MATERIALS IMPREGNATED IN THIS MANNER 审中-公开
标题翻译： METHOD FOR含浸在使用压缩气体，固体和/或液体连线等浸渍的物质的载体基质
公开(公告)号：WO0220177A8
公开(公告)日：2002-06-06
申请号：PCT/EP0109669
申请日：2001-08-21
申请人： DEGUSSA , HEIDLAS JUERGEN , ZHANG ZHENGFENG , STORK KURT , WIESMUELLER JOHANN , OBER MARTIN , OBERSTEINER JOHANN
发明人： HEIDLAS JUERGEN , ZHANG ZHENGFENG , STORK KURT , WIESMUELLER JOHANN , OBER MARTIN , OBERSTEINER JOHANN
IPC分类号： B05D1/18 , A01C1/00 , A23K40/00 , A23L5/00 , A23L5/30 , B01J3/00 , B01J20/32 , B05D1/00 , B05D1/40 , B05D7/00 , C04B41/45 , C08J7/00 , A23L1/00
CPC分类号： C08J9/122 , A01C1/06 , A01N25/00 , A23K40/00 , A23L5/00 , A23L5/30 , A23V2002/00 , C08J2201/032 , C08J2203/06 , C08J2203/08 , Y02P20/544 , A23V2300/44
摘要： The invention relates to a method for impregnating a support matrix with solid and/or liquid compounds using a compressed gas or a compressed mixture of gases at gas densities ranging from 0.15 to 1.3 kg/l and at least two unsymmetrical pressure changes (pulsations). The method is further characterized in that both a multitude of impregnating substances such as biologically active compounds, technical materials or metal-organic compounds, as well as support matrices of biological origin and organic or inorganic substances can be used that have large inner surfaces and/or inner surfaces that are difficult to access.
摘要翻译：至少两个延伸不对称变压序列（脉动）下，使用在气体密度压缩气体（混合物）从0.15至1.3千克/升含浸固体和/或液体化合物的载体基质中的方法。该方法的特征在于，两个多个浸渍材料，例如生物活性化合物，技术织物或有机金属化合物，以及生物来源的载体基质，以及有机或无机物质，可以使用其难以访问所有的大的和/或有内表面。

3. 发明申请

WO2007017205A3 METHOD FOR OBTAINING FRUIT WAX 审中-公开
标题翻译：提取果实生长过程
公开(公告)号：WO2007017205A3
公开(公告)日：2007-03-29
申请号：PCT/EP2006007756
申请日：2006-08-04
申请人： DEGUSSA , WIESMUELLER JOHANN , PILZ STEPHAN
发明人： WIESMUELLER JOHANN , PILZ STEPHAN
IPC分类号： A61K36/73 , A23L19/00 , A61K8/92 , B01D11/04
CPC分类号： B01D11/0203 , A61K8/922 , A61K8/97 , A61K36/73 , A61Q19/00
摘要： The invention relates to a method for obtaining fruit wax from plant constituents, said method being carried out essentially using compressed C 2 -C 4 hydrocarbons. Unlike previous extraction methods with supercritical CO 2 , the inventive method can be carried out at low pressures and with a reduced extraction means throughput. Residues from the fruit treatment, especially peel from the juicing process, are used as starting materials. Preferred extraction agents are ethane, propane, butane and the mixtures thereof, the extraction itself being carried out in batches at pressures of
摘要翻译：基本上借助压实的C 2 SUB 2 C SUB 4 CUB进行根据本发明的用于从蔬菜成分获得果实蜡的方法。与先前使用的超临界CO 2萃取过程相反，所提出的过程可以在较低的压力下进行并且具有降低的萃取剂通过量。作为起始原料，来自水果加工的残留物，特别是来自果汁提取物的果皮，成为问题。优选的萃取剂是乙烷，丙烷，丁烷及其混合物，其中甚至在<50mPa的压力和= 70℃的温度下，在4至20kg / kg的起始材料的萃取剂通过量下分批进行萃取。提取的果蜡适用于化妆品或药物制剂，特别适用于皮肤的护理和治疗。

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