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    • 3. 发明申请
    • MICROCHIP AND WEDGE ION FUNNELS AND PLANAR ION BEAM ANALYZERS USING SAME
    • 使用相同的微型和离子束离子束和平面离子束分析仪
    • WO2012141771A1
    • 2012-10-18
    • PCT/US2012/021338
    • 2012-01-13
    • BATTELLE MEMORIAL INSTITUTESHVARTSBURG, Alexandre A.ANDERSON, Gordon A.SMITH, Richard D.
    • SHVARTSBURG, Alexandre A.ANDERSON, Gordon A.SMITH, Richard D.
    • H01J49/00H01J49/06
    • H01J49/0018H01J49/066
    • Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.
    • 电动离子漏斗使用振荡电场的Dehmelt电位限制,引导或聚焦气体中的离子。 描述了处于或接近大气压力的新漏斗设计。 在这种压力下的有效离子聚焦是通过极大幅度和频率的场来实现的,微观间隙允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值。 新的微间隙漏斗可用于将大气压电离源与包括差分IMS或FAIMS的质谱(MS)和离子迁移率分离(IMS)阶段以及各种配置的IMS和MS阶段进行接口。 特别地,包括两个平坦的表面定位成角度的楔形漏斗和从其衍生的楔形漏斗捕获器可以在一个维度上压缩离子束,产生窄的带状波束和横向延伸的立方体分组。 这种光束轮廓降低了离子密度,从而降低了空间电荷效应,减轻了MS和IMS分析仪的分辨率,测量精度和动态范围的不利影响,而与共面光或粒子束的更大重叠可有利于光谱方法 。
    • 4. 发明申请
    • MOTOR NERVE ROOT STIMULATION
    • 电动神经根刺激
    • WO2012064968A1
    • 2012-05-18
    • PCT/US2011/060205
    • 2011-11-10
    • IINN, INC.SHAH, Jawad, A.IQBAL, AmerSMITH, Richard, H.
    • SHAH, Jawad, A.IQBAL, AmerSMITH, Richard, H.
    • A61N1/00
    • A61N1/0551A61H3/04A61N1/0553A61N1/0556A61N1/0558A61N1/36067A61N1/36103
    • A motor device for bypassing or bridging an area of neurological damage, including at least one electrode having an electric mechanism for generating electric current, and a programming mechanism for programming the electrode. A biofeedback system and an artificial spinal cord. A method of stimulating muscle in a person having neurological damage, by applying electric current to nerves, bypassing or bridging an area of neurological damage, and moving the muscle in a natural manner. Methods of moving muscles of a paraplegic, reducing or eliminating pain from an individual, and treating foot drop. A therapeutic method for exercising for an individual with neurological damage. A method of generating movement of muscle and sensing that movement in a person having neurological damage. A method of generating movement of muscle using information from the brain and sensing that movement in a person having neurological damage. A method of diagnosing neurological damage.
    • 用于绕过或桥接神经损伤区域的电动机装置,包括至少一个具有用于产生电流的电机构的电极,以及用于编程电极的编程机构。 生物反馈系统和人造脊髓。 通过对神经施加电流,绕过或桥接神经损伤区域,以自然的方式移动肌肉,刺激具有神经损伤的人的肌肉的方法。 移动截瘫肌肉的方法,减少或消除个体疼痛,治疗脚痛。 用于对具有神经损伤的个体进行锻炼的治疗方法。 一种产生肌肉运动并感知有神经损伤的人的运动的方法。 使用来自大脑的信息产生肌肉运动的方法,并感测到具有神经损伤的人的运动。 诊断神经损伤的方法。