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1. 发明申请

WO2005073906A8 MULTI-MODE TRANSPONDER 审中-公开
标题翻译：多模转盘
公开(公告)号：WO2005073906A8
公开(公告)日：2006-11-23
申请号：PCT/US2005002228
申请日：2005-01-19
申请人： BATTELLE MEMORIAL INSTITUTE , GILBERT RONALD W , CARRENDER CURTIS LEE , ANDERSON GORDON A , STEELE KERRY D
发明人： GILBERT RONALD W , CARRENDER CURTIS LEE , ANDERSON GORDON A , STEELE KERRY D
IPC分类号： G06K7/00 , G06K19/07
CPC分类号： G06K19/0724 , G06K7/0008 , G06K19/0707 , G06K19/0712 , G06K19/0723
摘要： A transponder device having multiple modes of operation, such as an active mode and a passive mode, wherein the modes of operation are selected in response to the strength of a received radio frequency signal. A communication system is also provided having a transceiver configured to transmit a radio frequency signal and to receive a responsive signal, and a transponder configured to operate in a plurality of modes and to activate modes of operation in response to the radio frequency signal. Ideally, each mode of operation is activated and deactivated independent of the other modes, although two or more modes may be concurrently operational.
摘要翻译：一种具有多种操作模式的转发器装置，例如主动模式和被动模式，其中响应于所接收的射频信号的强度来选择操作模式。还提供一种通信系统，其具有被配置为发送射频信号并且接收响应信号的收发机，以及被配置为以多种模式操作并响应于射频信号激活操作模式的应答器。理想地，尽管两个或多个模式可以同时操作，但是每个操作模式被激活和去激活，与其他模式无关。

2. 发明申请

WO2004057342A3 METHOD FOR ENHANCED ACCURACY IN PREDICTING THE ELUTION TIMES OF PEPTIDES USING LIQUID SEPARATIONS OR CHROMATOGRAPHY 审中-公开
标题翻译：使用液体分离或色谱法预测肽的时间的增强精度的方法
公开(公告)号：WO2004057342A3
公开(公告)日：2004-10-07
申请号：PCT/US0340949
申请日：2003-12-18
申请人： BATTELLE MEMORIAL INSTITUTE , KANGAS LARS J , AUBERRY KENNETH J , ANDERSON GORDON A , SMITH RICHARD D
发明人： KANGAS LARS J , AUBERRY KENNETH J , ANDERSON GORDON A , SMITH RICHARD D
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G01N30/8693 , G01N33/6806 , G01N2030/8831 , G06F19/24
摘要： A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a plurality of vectors, each vector having a plurality of dimensions, and each dimension representing the elution time of amino acids present in each of these known peptides from the data set. The elution time of any protein is then be predicted by first creating a vector by assigning dimensional values for the elution time of amino acids of at least one hypothetical peptide and then calculating a predicted elution time for the vector by performing a multivariate regression of the dimensional values of the hypothetical peptide using the dimensional values of the known peptides. Preferably, the multivariate regression is accomplished by the use of an artificial neural network and the elution times are first normalized using a transfer function.
摘要翻译：一种通过首先提供已知肽的已知洗脱时间的数据集，然后产生多个载体，每个载体具有多个维度，并且每个维度代表洗脱的方法，用于预测肽在色谱和电泳分离中的洗脱时间的方法来自数据集的这些已知肽各自存在的氨基酸的时间。然后通过首先通过分配至少一个假想肽的氨基酸的洗脱时间的维度值来产生载体，然后通过执行尺寸的多元回归来计算载体的预测洗脱时间来预测任何蛋白质的洗脱时间使用已知肽的尺寸值的假想肽的值。优选地，通过使用人造神经网络实现多元回归，并且首先使用传递函数归一化洗脱时间。

3. 发明申请

WO2007038127A1 METHOD AND APPARATUS FOR HIGH-ORDER DIFFERENTIAL ION MOBILITY SEPARATIONS 审中-公开
标题翻译：用于高阶差分离子移动分离的方法和装置
公开(公告)号：WO2007038127A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/036633
申请日：2006-09-20
申请人： BATTELLE MEMORIAL INSTITUTE , SHVARTSBURG, Alexandre, A. , SMITH, Richard, D. , ANDERSON, Gordon, A.
发明人： SHVARTSBURG, Alexandre, A. , SMITH, Richard, D. , ANDERSON, Gordon, A.
IPC分类号： G01N27/64
CPC分类号： G01N27/624
摘要： The present invention relates generally to separation of ions based on their transport properties. More particularly, the invention relates to separation of ionic mixtures and characterization of ions in gases using higher-order differential ion mobility spectrometry (HODIMS) enabled by asymmetric waveforms of fundamentally new types. The invention discloses a method and apparatus for separation of ionic mixtures and characterization, identification, or quantification of ions in a gas based substantially on the terms of third or higher order in a series expansion of ion mobility as a function of electric field intensity. This is achieved using a periodic, time-dependent electric field with novel waveform profiles that cancel or substantially reduce the contributions to time-averaged ion motion of the leading n (where n ≥ 2) terms of that expansion, thereby achieving ion separations based substantially on the ( n + 1 )th term. Separations using HODIMS with different n are expected to be highly orthogonal, enabling multidimensional separations employing HODIMS analyzers of different orders. The expected high orthogonality between HODIMS and mass spectrometry or ion mobility spectrometry would make HODIMS/MS and HODIMS/IMS combinations powerful analytical tools of broad utility.
摘要翻译：本发明一般涉及基于它们的运输特性分离离子。更具体地，本发明涉及离子混合物的分离和使用通过基本上新型的不对称波形实现的高阶差分离子迁移谱（HODIMS）的气体中的离子表征。本发明公开了一种用于分离离子混合物的方法和装置，并且基于离子迁移率的串联扩展作为电场强度的函数，基本上以三阶或更高阶的项为基础来表征，鉴定或定量气体中的离子。这是使用具有新颖波形分布的周期性，时间依赖性电场来实现的，其消除或基本上减少对该扩展的前导n（其中n = 2）项的时间平均离子运动的贡献，从而实现基本上基于离子分离在第（n + 1）项。使用具有不同n的HODIMS的分离预计将具有高度正交性，可以使用具有不同阶数的HODIMS分析仪进行多维分离。 HODIMS和质谱法或离子迁移光谱法之间预期的高正交性将使HODIMS / MS和HODIMS / IMS组合成为强大的广泛应用的分析工具。

4. 发明申请

WO2005073906A1 MULTI-MODE DEVICE 审中-公开
标题翻译：多模式设备
公开(公告)号：WO2005073906A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/002228
申请日：2005-01-19
申请人： BATTELLE MEMORIAL INSTITUTE , GILBERT, Ronald, W. , CARRENDER, Curtis, Lee , ANDERSON, Gordon, A. , STEELE, Kerry, D.
发明人： GILBERT, Ronald, W. , CARRENDER, Curtis, Lee , ANDERSON, Gordon, A. , STEELE, Kerry, D.
IPC分类号： G06K19/07
CPC分类号： G06K19/0724 , G06K7/0008 , G06K19/0707 , G06K19/0712 , G06K19/0723
摘要： A transponder device having multiple modes of operation, such as an active mode and a passive mode, wherein the modes of operation are selected in response to the strength of a received radio frequency signal. A communication system is also provided having a transceiver configured to transmit a radio frequency signal and to receive a responsive signal, and a transponder configured to operate in a plurality of modes and to activate modes of operation in response to the radio frequency signal. Ideally, each mode of operation is activated and deactivated independent of the other modes, although two or more modes may be concurrently operational.
摘要翻译：一种具有多种操作模式的转发器装置，例如主动模式和被动模式，其中响应于所接收的射频信号的强度来选择操作模式。还提供一种通信系统，其具有被配置为发送射频信号并接收响应信号的收发机，以及被配置为以多种模式操作并响应于射频信号激活操作模式的应答器。理想地，尽管两个或更多个模式可以同时操作，但是每个操作模式被激活和去激活，独立于其他模式。

5. 发明申请

WO2006101495A1 ADVANCED CAPABILITY RFID SYSTEM 审中-公开
标题翻译：高级能力RFID系统
公开(公告)号：WO2006101495A1
公开(公告)日：2006-09-28
申请号：PCT/US2005/009762
申请日：2005-03-23
申请人： BATTELLE MEMORIAL INSTITUTE , GILBERT, Ronald, W. , STEELE, Kerry, D. , ANDERSON, Gordon, A.
发明人： GILBERT, Ronald, W. , STEELE, Kerry, D. , ANDERSON, Gordon, A.
IPC分类号： G06K19/07
CPC分类号： G06K19/0716 , G06K19/0723
摘要： A radio-frequency transponder device having an antenna circuit configured to receive radio-frequency signals and to return modulated radio-frequency signals via continuous wave backscatter, a modulation circuit coupled to the antenna circuit for generating the modulated radio-frequency signals, and a microprocessor coupled to the antenna circuit and the modulation circuit and configured to receive and extract operating power from the received radio-frequency signals and to monitor inputs on at least one input pin and to generate responsive signals to the modulation circuit for modulating the radio-frequency signals. The microprocessor can be configured to generate output signals on output pins to associated devices for controlling the operation thereof. Electrical energy can be extracted and stored in an optional electrical power storage device.
摘要翻译：一种射频应答器装置，其具有被配置为接收射频信号并且经由连续波反向散射返回经调制的射频信号的天线电路，耦合到所述天线电路的用于产生调制的射频信号的调制电路，以及微处理器耦合到所述天线电路和所述调制电路，并且被配置为从所接收的射频信号接收和提取工作功率，并监视至少一个输入引脚上的输入，并产生响应信号到所述调制电路，用于调制所述射频信号。微处理器可被配置为在输出引脚上产生相关器件的输出信号以控制其操作。电能可以提取并存储在可选的电力存储装置中。

6. 发明申请

WO2012141771A1 MICROCHIP AND WEDGE ION FUNNELS AND PLANAR ION BEAM ANALYZERS USING SAME 审中-公开
标题翻译：使用相同的微型和离子束离子束和平面离子束分析仪
公开(公告)号：WO2012141771A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/021338
申请日：2012-01-13
申请人： BATTELLE MEMORIAL INSTITUTE , SHVARTSBURG, Alexandre A. , ANDERSON, Gordon A. , SMITH, Richard D.
发明人： SHVARTSBURG, Alexandre A. , ANDERSON, Gordon A. , SMITH, Richard D.
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/0018 , H01J49/066
摘要： Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.
摘要翻译：电动离子漏斗使用振荡电场的Dehmelt电位限制，引导或聚焦气体中的离子。描述了处于或接近大气压力的新漏斗设计。在这种压力下的有效离子聚焦是通过极大幅度和频率的场来实现的，微观间隙允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值。新的微间隙漏斗可用于将大气压电离源与包括差分IMS或FAIMS的质谱（MS）和离子迁移率分离（IMS）阶段以及各种配置的IMS和MS阶段进行接口。特别地，包括两个平坦的表面定位成角度的楔形漏斗和从其衍生的楔形漏斗捕获器可以在一个维度上压缩离子束，产生窄的带状波束和横向延伸的立方体分组。这种光束轮廓降低了离子密度，从而降低了空间电荷效应，减轻了MS和IMS分析仪的分辨率，测量精度和动态范围的不利影响，而与共面光或粒子束的更大重叠可有利于光谱方法。

7. 发明申请

WO2006083262A2 METHOD FOR ENHANCED ACCURACY IN PREDICTING PEPTIDES ELUTION TIME USING LIQUID SEPARATIONS OR CHROMATOGRAPHY 审中-公开
标题翻译：使用液相分离或色谱法预测肽时间的增强精度的方法
公开(公告)号：WO2006083262A2
公开(公告)日：2006-08-10
申请号：PCT/US2005/015604
申请日：2005-05-05
申请人： BATTELLE MEMORIAL INSTITUTE , PETRITIS, Konstantinos , KANGAS, Lars, J. , ANDERSON, Gordon, A. , SMITH, Richard, D.
发明人： PETRITIS, Konstantinos , KANGAS, Lars, J. , ANDERSON, Gordon, A. , SMITH, Richard, D.
IPC分类号： G06F19/00
CPC分类号： C07K1/16 , G01N30/8693 , G01N33/6803 , G01N33/6806 , G01N2030/8831 , G06F19/24
摘要： A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a plurality of vectors, each vector having a plurality of dimensions, and each dimension representing positional information about at least a portion of the amino acids present in the known peptides. A hypothetical vector is then created by assigning dimensional values for at least one hypothetical peptide, and a predicted elution time for the hypothetical vector is created by performing at least one multivariate regression fitting the hypothetical peptide to the plurality of vectors. Preferably, the multivariate regression is accomplished by the use of an artificial neural network and the elution times are first normalized using linear regression.
摘要翻译：一种用于通过首先提供已知肽的已知洗脱时间的数据集，然后创建多个向量，每个向量具有多个维度，并且每个维度表示位置信息的方法，用于预测肽在色谱和电泳分离中的洗脱时间约至少一部分已知肽中存在的氨基酸。然后通过为至少一个假想肽分配尺寸值来产生假想载体，并且通过对多个载体进行拟合假想肽的至少一个多变量回归而产生假设载体的预测洗脱时间。优选地，通过使用人造神经网络实现多元回归，并且首先使用线性回归归一化洗脱时间。

8. 发明申请

WO2006083262A3 METHOD FOR ENHANCED ACCURACY IN PREDICTING PEPTIDES ELUTION TIME USING LIQUID SEPARATIONS OR CHROMATOGRAPHY 审中-公开
标题翻译：使用液相分离或色谱法预测肽时间的增强精度的方法
公开(公告)号：WO2006083262A3
公开(公告)日：2007-01-11
申请号：PCT/US2005015604
申请日：2005-05-05
申请人： BATTELLE MEMORIAL INSTITUTE , PETRITIS KONSTANTINOS , KANGAS LARS J , ANDERSON GORDON A , SMITH RICHARD D
发明人： PETRITIS KONSTANTINOS , KANGAS LARS J , ANDERSON GORDON A , SMITH RICHARD D
IPC分类号： B01D15/08 , C07K1/16 , G01N33/68 , G06F19/00
CPC分类号： C07K1/16 , G01N30/8693 , G01N33/6803 , G01N33/6806 , G01N2030/8831 , G06F19/24
摘要： A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a plurality of vectors, each vector having a plurality of dimensions, and each dimension representing positional information about at least a portion of the amino acids present in the known peptides. A hypothetical vector is then created by assigning dimensional values for at least one hypothetical peptide, and a predicted elution time for the hypothetical vector is created by performing at least one multivariate regression fitting the hypothetical peptide to the plurality of vectors. Preferably, the multivariate regression is accomplished by the use of an artificial neural network and the elution times are first normalized using linear regression.
摘要翻译：一种用于通过首先提供已知肽的已知洗脱时间的数据集，然后创建多个向量，每个向量具有多个维度，并且每个维度表示位置信息的方法，用于预测肽在色谱和电泳分离中的洗脱时间约至少一部分已知肽中存在的氨基酸。然后通过为至少一个假想肽分配尺寸值来产生假想载体，并且通过对多个载体进行拟合假想肽的至少一个多变量回归而产生假设载体的预测洗脱时间。优选地，通过使用人造神经网络实现多元回归，并且首先使用线性回归归一化洗脱时间。

9. 发明申请

WO2004057342A2 METHOD FOR ENHANCED ACCURACY IN PREDICTING PEPTIDES USING LIQUID SEPARATIONS OR CHROMATOGRAPHY 审中-公开
标题翻译：使用液体分离或色谱法预测肽的增强精度的方法
公开(公告)号：WO2004057342A2
公开(公告)日：2004-07-08
申请号：PCT/US2003/040949
申请日：2003-12-18
申请人： BATTELLE MEMORIAL INSTITUTE , KANGAS, Lars, J. , AUBERRY, Kenneth, J. , ANDERSON, Gordon, A. , SMITH, Richard, D.
发明人： KANGAS, Lars, J. , AUBERRY, Kenneth, J. , ANDERSON, Gordon, A. , SMITH, Richard, D.
IPC分类号： G01N33/68
CPC分类号： G01N30/8693 , G01N33/6806 , G01N2030/8831 , G06F19/24
摘要： A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a plurality of vectors, each vector having a plurality of dimensions, and each dimension representing the elution time of amino acids present in each of these known peptides from the data set. The elution time of any protein is then be predicted by first creating a vector by assigning dimensional values for the elution time of amino acids of at least one hypothetical peptide and then calculating a predicted elution time for the vector by performing a multivariate regression of the dimensional values of the hypothetical peptide using the dimensional values of the known peptides. Preferably, the multivariate regression is accomplished by the use of an artificial neural network and the elution times are first normalized using a transfer function.
摘要翻译：通过首先提供已知肽的已知洗脱时间的数据集，然后产生多个载体，每个载体具有多个维度，并且每个维度代表洗脱液，预测肽在色谱和电泳分离中的洗脱时间的方法从数据集中存在于每个这些已知肽中的氨基酸的时间。然后通过首先通过分配至少一个假想肽的氨基酸的洗脱时间的尺寸值来形成载体，然后通过进行尺寸的多元回归来计算载体的预测洗脱时间来预测任何蛋白质的洗脱时间使用已知肽的尺寸值的假想肽的值。优选地，通过使用人造神经网络实现多元回归，并且首先使用传递函数归一化洗脱次数。

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