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1. 发明申请

WO2005042308A2 PASSENGER RESTRAINT SYSTEM 审中-公开
标题翻译：乘客限制系统
公开(公告)号：WO2005042308A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036509
申请日：2004-11-01
申请人： DISNEY ENTERPRISES, INC. , SMITH, Doug , BURGESS, James , FRITSCHE, Joel , HELLSTEN, Chris , KELLEY, Tim , MATHAISEL, Michael , SCARABINO, Mario , WIEDMAN, Dave
发明人： SMITH, Doug , BURGESS, James , FRITSCHE, Joel , HELLSTEN, Chris , KELLEY, Tim , MATHAISEL, Michael , SCARABINO, Mario , WIEDMAN, Dave
IPC分类号： B60R
CPC分类号： B60R22/48 , A63G7/00 , B60R22/34 , B60R2022/4816 , B60R2022/4883 , Y10T24/45623
摘要： A passenger restraint system for a vehicle having a plurality of seats, each seat having a seatbelt, a retractor from which the seatbelt is extendable, and a receiver used to latch the seatbelt. Each retractor includes a first pneumatic locking element and a second pneumatic locking element for limiting movement of the seatbelt and each receiver includes a receiver pneumatic locking element for locking the seatbelt within the receiver. A controller controls the operation of a plurality of first valves for supplying air to the first pneumatic locking element of a corresponding one of the plurality of retractors, a second valve for supplying air to each of the second pneumatic locking element of the plurality of retractors, and a plurality of third valves for supplying air to the receiver pneumatic locking element of a corresponding one of the plurality of receivers. Control decisions may be made based upon feedback received from sensors within the receiver that sense a state of the seatbelt with respect to the receiver.
摘要翻译：一种用于车辆的乘客约束系统，具有多个座椅，每个座椅具有安全带，可从该安全带延伸的牵开器，以及用于闩锁安全带的接收器。每个牵开器包括用于限制安全带运动的第一气动锁定元件和第二气动锁定元件，并且每个接收器包括用于将座椅安全带锁定在接收器内的接收器气动锁定元件。控制器控制用于向多个牵开器中的相应一个牵开器的第一气动锁定元件供应空气的多个第一阀的操作，用于向多个牵开器中的每个第二气动锁定元件供应空气的第二阀，以及用于向所述多个接收器中的相应一个接收器的接收器气动锁定元件供应空气的多个第三阀。控制决定可以基于从接收机内的传感器接收到的反馈信号，该传感器感测安全带相对于接收器的状态。

2. 发明申请

WO2006128272A1 THIN FOAM COATING COMPRISING DISCRETE, CLOSED-CELL CAPSULES 审中-公开
标题翻译：薄泡沫涂料包括分离，封闭细胞囊
公开(公告)号：WO2006128272A1
公开(公告)日：2006-12-07
申请号：PCT/CA2005/001472
申请日：2005-09-27
申请人： MIV THERAPEUTICS INC. , LIEN, Mao-Jung Maurice , SMITH, Doug , LIU, Dean-Mo
发明人： LIEN, Mao-Jung Maurice , SMITH, Doug , LIU, Dean-Mo
IPC分类号： A61K9/58 , A61K9/52 , A61K9/48 , A61K47/30 , A61L27/54 , A61L27/34
CPC分类号： A61L31/16 , A61L31/146 , A61L31/148 , A61L2300/606
摘要： This application relates to a thin foam coating comprising discrete, closed cell capsules. The coating may be applied to an implantable medical device, such as a stent. The closed-cell capsules each have an outer polymeric shell and an inner liquid core containing the drug. The polymeric shells degrade in vivo to achieve controlled elution of the drug.
摘要翻译：本申请涉及一种包含离散的闭孔胶囊的薄泡沫涂层。涂层可以应用于可植入医疗装置，例如支架。闭孔胶囊各具有外聚合物壳和含有药物的内液芯。聚合物壳在体内降解以实现药物的受控洗脱。

3. 发明申请

WO2005042308A3 PASSENGER RESTRAINT SYSTEM 审中-公开
标题翻译：乘客限制系统
公开(公告)号：WO2005042308A3
公开(公告)日：2006-04-13
申请号：PCT/US2004036509
申请日：2004-11-01
申请人： DISNEY ENTPR INC , SMITH DOUG , BURGESS JAMES , FRITSCHE JOEL , HELLSTEN CHRIS , KELLEY TIM , MATHAISEL MICHAEL , SCARABINO MARIO , WIEDMAN DAVE
发明人： SMITH DOUG , BURGESS JAMES , FRITSCHE JOEL , HELLSTEN CHRIS , KELLEY TIM , MATHAISEL MICHAEL , SCARABINO MARIO , WIEDMAN DAVE
IPC分类号： A63G7/00 , B60R20060101 , B60R21/00 , B60R22/48 , B63G31/16
CPC分类号： B60R22/48 , A63G7/00 , B60R22/34 , B60R2022/4816 , B60R2022/4883 , Y10T24/45623
摘要： A passenger restraint system for a vehicle having a plurality of seats, each seat having a seatbelt (10), a retractor (14) from which the seatbelt is extendable, and a receiver (16) used to latch the seatbelt. Each retractor includes a first pneumatic locking element (32) and a second pneumatic locking element (32) for limiting movement of the seatbelt and each receiver includes a receiver pneumatic locking element (38) for locking the seatbelt within the receiver. A controller (24) controls the operation of a plurality of first valves for supplying air to the first pneumatic locking element of a corresponding one of the retractors, a second valve for supplying air to each of the second pneumatic locking element of the retractors, and a plurality of third valves for supplying air to the receiver pneumatic locking element of a corresponding one of the receivers.
摘要翻译：一种用于具有多个座位的车辆的乘客约束系统，每个座椅具有安全带（10），所述牵开器（14）可从所述安全带延伸;以及接收器（16），用于闩锁所述安全带。每个牵开器包括用于限制安全带移动的第一气动锁定元件（32）和第二气动锁定元件（32），并且每个接收器包括用于将安全带锁定在接收器内的接收器气动锁定元件（38）。控制器（24）控制用于向对应的一个牵开器的第一气动锁定元件供应空气的多个第一阀的操作，用于向牵开器的每个第二气动锁定元件供应空气的第二阀，以及多个第三阀，用于向对应的一个接收器的接收器气动锁定元件供应空气。

4. 发明申请

WO2022011153A1 SMART COMPUTE RESISTIVE MEMORY 审中-公开
公开(公告)号：WO2022011153A1
公开(公告)日：2022-01-13
申请号：PCT/US2021/040909
申请日：2021-07-08
申请人： NUMEM INC. , HALL, Eric , SMITH, Doug , HENDRICKSON, Nicholas T. , GUEDJ, Jack
发明人： HALL, Eric , SMITH, Doug , HENDRICKSON, Nicholas T. , GUEDJ, Jack
IPC分类号： G08F12/00
摘要： Systems, methods and devices are disclosed for a smart compute memory circuitry that has the flexibility to perform a wide range of functions inside the memory via logic circuitry and an integrated processor. In one embodiment, the smart compute memory circuitry comprises an integrated processor and logic circuitry to enable adaptive System on a Chip (SOC) and electronics subsystem power or performance improvements, and adaptive memory management and control for the smart compute memory circuitry. A resistive memory array is coupled to the integrated processor. An adaptive memory management and control circuitry (AMMC) to provide extended test, performance, and power optimizing capabilities for a resistive memory is disclosed herein. In one embodiment, a resistive memory comprises a resistive memory array and an Adaptive Memory Management and Control circuitry (AMMC). The AMMC is configured with extended test, reliability, performance and power optimizing capabilities for the resistive memory.

5. 发明申请

WO2012174426A1 SINGLE-SIDED STICKY GASKET 审中-公开
标题翻译：单面贴纸垫
公开(公告)号：WO2012174426A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042742
申请日：2012-06-15
申请人： AVIATION DEVICES & ELECTRONIC COMPONENTS, L.L.C. , BUSBY, Jeff , BOOMER, Kent , BOYD, Matt , DRY, Michael , SMITH, Doug , SCHMIDT, David
发明人： BUSBY, Jeff , BOOMER, Kent , BOYD, Matt , DRY, Michael , SMITH, Doug , SCHMIDT, David
IPC分类号： H05K9/00
CPC分类号： H05K9/0015
摘要： Applicants provide a gasket having a sticky or tacky (to the touch) flexible or elastomeric, resilient body. The body has an upper surface which contacts an upper skin, a fabric, typically woven, non-sticky (to the touch and to the removable workpiece) and at least partly permeable (to the body when under compression), and a lower or second surface that is uncoated and uncovered. The upper skin adheres to the upper surface of the body but is generally non-tacky with respect to a removable workpiece and/or static base structure, which structure and workpiece will receive a gasket, typically under compression, therebetween. The body of the gasket may include a flexible skeleton or other flexible member substantially enclosed within the body.
摘要翻译：申请人提供具有粘性或粘性（触感）的柔性或弹性弹性体的垫圈。身体具有与上皮肤接触的上表面，通常织造的，不粘的（触摸的和可移除的工件）和至少部分可渗透的（在压缩时对身体）的上部表面，以及较低或第二未涂覆和未覆盖的表面。上皮肤粘附到主体的上表面，但是相对于可移除的工件和/或静态基部结构通常是非粘性的，该结构和工件将在其间容纳通常处于压缩状态的垫圈。衬垫的主体可以包括基本上封闭在主体内的柔性骨架或其它柔性构件。

6. 发明申请

WO2007014445A1 MICRODEVICES COMPRISING NANOCAPSULES FOR CONTROLLED DELIVERY OF DRUGS AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：包含用于控制药物输送的纳米颗粒的微型装置及其制造方法
公开(公告)号：WO2007014445A1
公开(公告)日：2007-02-08
申请号：PCT/CA2005/001201
申请日：2005-08-02
申请人： MIV THERAPEUTICS INC. , LIEN, Mao-Jung Maurice , SMITH, Doug , RAJTAR, Arc , LIU, Dean-Mo
发明人： LIEN, Mao-Jung Maurice , SMITH, Doug , RAJTAR, Arc , LIU, Dean-Mo
IPC分类号： A61K9/58 , A61K9/51
CPC分类号： A61K9/5123 , A61K9/1647 , A61K9/5138 , A61K9/5146 , A61K9/5153 , A61K9/5192
摘要： This application relates to a microdevice for delivering drugs to a target location. The microdevice comprises a plurality of nanocapsules assembled together, each having an outer hydrophobic shell and an inner liquid core contained within the shell. At least one drug is dissolved within the inner liquid core. The liquid core comprises a mixture of solvents including at least one solvent for maintaining the hydrophilicity of the inner core (and hence the phase difference between the polymeric shell and the liquid core) and at least one second solvent for enhancing the solubility and bioavailability of the drug. For example, the second solvent may be selected to enable a hydrophobic drug to dissolve within the hydrophilic inner core environment. The inner core may also include a small amount of water-soluble polymer. The application also relates to a method of making the microdevices by formulating a homogenous emulsified solution containing the drug and forming the nanocapsules from the emulsified solution, such as by an atomization process.
摘要翻译：本申请涉及用于将药物递送至目标位置的微型装置。微型装置包括组装在一起的多个纳米胶囊，每个具有外部疏水壳体和包含在壳体内的内部液体芯体。至少一种药物溶解在内液芯内。液芯包括溶剂混合物，包括至少一种溶剂，用于保持内芯的亲水性（因此聚合物壳与液芯之间的相位差）和至少一种第二溶剂用于增强溶解度和生物利用度药物。例如，可以选择第二溶剂以使疏水性药物溶解在亲水性内核环境中。内核也可以包含少量的水溶性聚合物。本申请还涉及通过配制含有药物的均匀乳化溶液并通过雾化方法从乳化溶液形成纳米胶囊来制备微型装置的方法。

7. 发明申请

WO2006063430A1 MULTI-LAYER DRUG DELIVERY DEVICE AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：多层药物递送装置及其制造方法
公开(公告)号：WO2006063430A1
公开(公告)日：2006-06-22
申请号：PCT/CA2005/001066
申请日：2005-07-08
申请人： MIV THERAPEUTICS INC. , LIEN, Mao-Jung Maurice , SMITH, Doug , LIU, Dean-Mo
发明人： LIEN, Mao-Jung Maurice , SMITH, Doug , LIU, Dean-Mo
IPC分类号： A61L27/54 , A61F2/06 , A61L27/40 , A61K31/337 , A61L27/28 , A61L27/34
CPC分类号： A61K31/337 , A61F2250/0067 , A61F2310/00389 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61L2300/61 , A61L2420/08 , C08L67/04
摘要： This application relates to a multi-layer drug delivery device and a method of manufacture. The device comprises a substrate; at least one first layer on the substrate containing the drug and a first solvent; and at least one second layer applied to the first layer to regulate release of the drug from the first layer, wherein the second layer comprises a polymer. The first solvent substantially prevents direct contact between the drug and the polymer. When applied to the first layer, the polymer is preferably dissolved in a second solvent which is immiscible with the first solvent to substantially prevent inter-diffusion between the first and second layers. In one application the substrate is a medical device, such as an implantable stent, having a biocompatible outer surface. The second layer is preferably biodegradable, bioabsorbable and/or bioresolvable in vivo to permit gradual exposure of the first layer and elution of the drug therefrom.
摘要翻译：本申请涉及多层药物递送装置和制造方法。该装置包括基板; 在含有药物的基材上的至少一个第一层和第一溶剂; 以及施加到第一层的至少一个第二层以调节药物从第一层的释放，其中第二层包含聚合物。第一溶剂基本上防止药物和聚合物之间的直接接触。当施加到第一层时，优选将聚合物溶解在与第一溶剂不混溶的第二溶剂中，以基本上防止第一和第二层之间的相互扩散。在一个应用中，衬底是具有生物相容性外表面的医疗装置，例如可植入支架。第二层优选是可生物降解的，生物可吸收的和/或在体内可生物分解的，以允许逐渐暴露第一层并从其中洗脱药物。

8. 发明申请

WO2006024125A1 METHOD OF MODIFYING A METAL SUBSTRATE TO IMPROVE SURFACE COVERAGE OF A COATING 审中-公开
标题翻译：改善金属基材以改善涂料表面覆盖度的方法
公开(公告)号：WO2006024125A1
公开(公告)日：2006-03-09
申请号：PCT/CA2004/001585
申请日：2004-08-30
申请人： MIV THERAPEUTICS INC. , LIEN, Mao-Jung Maurice , SMITH, Doug , RAJTAR, Arc
发明人： LIEN, Mao-Jung Maurice , SMITH, Doug , RAJTAR, Arc
IPC分类号： C23C16/02
CPC分类号： C23C18/04 , A61L31/022 , A61L31/086 , A61L31/14 , A61L2400/18 , C23C18/1208 , C23C18/1225 , C23C18/1241 , C23C18/1254 , C23C18/1275 , C23C18/1291 , C23C18/1295 , C23C24/00 , Y10T428/31678
摘要： This application relates to a method of modifying the surface of a metal substrate to improve the surface coverage of a coating applied to the substrate. The method comprises heating at least the surface of the substrate to a temperature within the range of approximately 175 - 400° C; and applying at least one layer of the coating to the substrate. In one particular embodiment the substrate is heated to a temperature within the range of 200 - 350° C. The low temperature heating enhances the hydrophilicity of the metal substrate while avoiding the disadvantages of high temperature thermal oxidation.
摘要翻译：本申请涉及一种改变金属基底的表面以改善施加到基底的涂层的表面覆盖度的方法。该方法包括至少将基底表面加热至约175-400℃范围内的温度; 以及将至少一层所述涂层施加到所述基底上。在一个具体实施方案中，将基底加热到200-350℃的温度。低温加热增强了金属基底的亲水性，同时避免了高温热氧化的缺点。

9. 发明申请

WO2022011153A8 SMART COMPUTE RESISTIVE MEMORY 审中-公开
公开(公告)号：WO2022011153A8
公开(公告)日：2022-01-13
申请号：PCT/US2021/040909
申请日：2021-07-08
申请人： NUMEM INC. , HALL, Eric , SMITH, Doug , HENDRICKSON, Nicholas T. , GUEDJ, Jack
发明人： HALL, Eric , SMITH, Doug , HENDRICKSON, Nicholas T. , GUEDJ, Jack
IPC分类号： G06F12/00 , G11C11/1697 , G11C11/2297 , G11C11/54 , G11C13/0004 , G11C13/0014 , G11C13/0038 , G11C2029/1206 , G11C2029/3602 , G11C2207/2227 , G11C2213/35 , G11C29/02 , G11C29/021 , G11C29/028 , G11C29/10 , G11C29/12 , G11C29/16 , G11C5/025 , G11C7/1006 , G11C7/22
摘要： Systems, methods and devices are disclosed for a smart compute memory circuitry that has the flexibility to perform a wide range of functions inside the memory via logic circuitry and an integrated processor. In one embodiment, the smart compute memory circuitry comprises an integrated processor and logic circuitry to enable adaptive System on a Chip (SOC) and electronics subsystem power or performance improvements, and adaptive memory management and control for the smart compute memory circuitry. A resistive memory array is coupled to the integrated processor. An adaptive memory management and control circuitry (AMMC) to provide extended test, performance, and power optimizing capabilities for a resistive memory is disclosed herein. In one embodiment, a resistive memory comprises a resistive memory array and an Adaptive Memory Management and Control circuitry (AMMC). The AMMC is configured with extended test, reliability, performance and power optimizing capabilities for the resistive memory.

10. 发明申请

WO2007124572A1 ELECTROLYTE SOLUTION AND METHOD FOR ELECTROLYTIC CO-DEPOSITION OF THIN FILM CALCIUM PHOSPHATE AND DRUG COMPOSITES 审中-公开
标题翻译：电解质溶液和薄膜磷酸钙和药物复合材料的电沉积方法
公开(公告)号：WO2007124572A1
公开(公告)日：2007-11-08
申请号：PCT/CA2007/000707
申请日：2007-04-26
申请人： MIV THERAPEUTICS INC. , LIU, Dean-Mo , LIEN, Mao-Jung, Maurice , SMITH, Doug , TSUI, Manus , RAJTAR, Arc
发明人： LIU, Dean-Mo , LIEN, Mao-Jung, Maurice , SMITH, Doug , TSUI, Manus , RAJTAR, Arc
IPC分类号： A61L31/16 , A61K47/02 , A61L31/08 , C25D15/00 , C25D15/02
CPC分类号： A61L27/32 , A61L27/54 , A61L2300/408 , A61L2300/41 , A61L2300/416 , A61L2300/62 , C25D13/02 , C25D15/00
摘要： Disclosed herein are electrolyte solutions and methods for electrolytic co-deposition of calcium phosphate and drug composites. The electrolyte solution may be formed by mixing solutions comprising calcium and phosphate precursors together to form an electrolyte solution. The electrolyte solution can have a water content less than 30 weight percent. The electrolyte solution may comprise a water-soluble non-aqueous solvent. A therapeutic agent, such as water-insoluble drug, is also present in the solution. The electrolyte solution thus formed may be used to co-deposit a calcium phosphate coating and the therapeutic agent on a substrate. One method includes the steps of immersing the substrate in the electrolyte solution and applying an electrical potential to the substrate to thereby cause (i) the calcium and phosphate precursors to electrochemically react with hydroxyl groups on the surface of the substrate and deposit the calcium phosphate coating thereon; and (ii) the therapeutic agent to electrophoretically migrate to the substrate and become co-deposited thereon together with the calcium phosphate coating. The method thus provides a convenient and easily controllable means for depositing thin film calcium phosphate and drug composites on substrates such as implantable medical devices.
摘要翻译：本文公开了电解质溶液和用于电解共沉积磷酸钙和药物复合材料的方法。可以通过将包含钙和磷酸盐前体的溶液混合在一起形成电解质溶液来形成电解质溶液。电解质溶液的含水量可以低于30重量％。电解质溶液可以包含水溶性非水溶剂。治疗剂，如水不溶性药物，也存在于该溶液中。由此形成的电解质溶液可用于将磷酸钙涂层和治疗剂共沉积在基底上。一种方法包括以下步骤：将基底浸入电解质溶液中并向基底施加电势，从而使（i）钙和磷酸盐前体与基底表面上的羟基电化学反应并沉积磷酸钙涂层在其上; 和（ii）治疗剂电泳迁移至基质并与磷酸钙涂层共同沉积在其上。因此，该方法提供了一种方便且易于控制的方法，用于在诸如可植入医疗装置的基底上沉积薄膜磷酸钙和药物复合物。

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