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1. 发明申请

WO2017218907A1 SYSTEMS, DEVICES, AND METHODS FOR DETERMINING AN OVERALL STRENGTH ENVELOPE 审中-公开
标题翻译：用于确定整体强度包络的系统，装置和方法
公开(公告)号：WO2017218907A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037898
申请日：2017-06-16
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , SLEPIAN, Marvin J.
发明人： SLEPIAN, Marvin J.
IPC分类号： A61B5/00 , A61B5/11 , A61B5/113 , G01L1/00 , G01P7/00 , G08B23/00
CPC分类号： A61B5/1121 , A61B5/0022 , A61B5/0205 , A61B5/021 , A61B5/02405 , A61B5/1071 , A61B5/1079 , A61B5/1114 , A61B5/1128 , A61B5/14546 , A61B5/224 , A61B5/4266 , A61B5/486 , A61B5/6801 , A61B5/6867 , A61B5/7425 , A61B2562/0219 , A61B2562/0261 , G01L1/00
摘要： Systems, methods, and software products determine an overall motion, flexibility and/or strength envelope for an individual. Force, movement and position data of the individual is captured and processed to generate an overall motion, flexibility and/or strength envelope for the individual that defines overall motion, flexibility and/or strength of the individual. The system includes a flexibility server with memory and a processor that are adapted to receive force, movement and position data of the individual. A motion, flexibility and/or strength analyzer of the system, implemented as machine readable instructions stored in the memory and executed by the digital processor, is capable of processing the force, movement and position data to generate an overall motion, flexibility and/or strength envelope for the individual that defines the overall motion, flexibility and/or strength of the individual.
摘要翻译：系统，方法和软件产品确定个体的整体运动，灵活性和/或强度包络。捕获和处理个体的力，运动和位置数据以产生个体的整体运动，灵活性和/或强度包络，其定义个体的整体运动，灵活性和/或力量。该系统包括具有存储器和处理器的灵活性服务器，其适于接收个体的力，运动和位置数据。系统的运动，灵活性和/或强度分析器被实现为存储在存储器中并由数字处理器执行的机器可读指令，能够处理力，运动和位置数据以产生整体运动，灵活性和/或个人的强度包围，定义个体的整体运动，灵活性和/或力量。

2. 发明申请

WO2008077059A3 PORTABLE ORGAN AND TISSUE PRESERVATION APPARATUS, KIT AND METHODS 审中-公开
标题翻译：便携式组织和组织保存装置，工具包和方法
公开(公告)号：WO2008077059A3
公开(公告)日：2009-04-23
申请号：PCT/US2007087975
申请日：2007-12-18
申请人： ORGAN TRANSP SYSTEMS INC , FRANKLIN THOMAS D , HYATT STACIE L , WARNER HOWELL E , WENRICH MARSHALL , SLEPIAN MARVIN J , LAMBERT SHELL
发明人： FRANKLIN THOMAS D , HYATT STACIE L , WARNER HOWELL E , WENRICH MARSHALL , SLEPIAN MARVIN J , LAMBERT SHELL
IPC分类号： A01N1/02 , F25B21/02 , F25D3/08
CPC分类号： A01N1/02 , A01N1/0252
摘要： An organ and tissue preservation and transport apparatus comprising a chamber, a temperature control mechanism and a system monitor. A medium bathes an organ within the chamber. The temperature control mechanism adjusts the temperature of the medium. The system monitor receiving and records the temperature of the chamber.
摘要翻译：一种器官和组织保存和输送设备，包括腔室，温度控制机构和系统监测器。中等沐浴室内的器官。温度控制机构调节介质的温度。系统监视器接收和记录室的温度。

3. 发明申请

WO2007047368A1 CHANNELED ENDOMURAL THERAPY 审中-公开
标题翻译：通道内分泌治疗
公开(公告)号：WO2007047368A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/039891
申请日：2006-10-13
申请人： ENDOLUMINAL THERAPEUTICS, INC. , SLEPIAN, Marvin, J.
发明人： SLEPIAN, Marvin, J.
IPC分类号： A61B17/22 , A61B17/00 , A61B18/24 , A61B17/88
CPC分类号： A61B17/3207 , A61B17/00491 , A61B17/12022 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B17/22 , A61B18/24 , A61B2017/00247 , A61B2017/1205 , A61B2017/22077 , A61B2018/00392 , A61K35/545
摘要： Diseases, aging, trauma, environmental exposure, infection and other events or agents can alter tissue function. In one embodiment, treatment is provided by therapeutically altering tissue function. This may be by continuing normal tissue function, suppressing tissue function, or enhancing tissue function. In a preferred embodiment, this treatment is effectuated by penetrating an organ, organ component or tissue structure and placing a supplemental material in a newly created space. This space is generally referred to herein as a "privileged space", i.e. a space not otherwise present in native tissue. Supplemental materials can be deposited and secured within the zone. Supplemental materials include materials forming barriers, supports, and/or materials that deliver agents having a pharmacologic, biochemical, or physiologic effect in vivo. Suitable supplemental materials include polymeric and non-polymeric materials, pharmacologic agents, cells, tissue fragments, microorganisms, viral agents, or other reagents modifying tissue function. The supplemental material is typically in the form of a reservoir/depot, or continuous or discontinuous layer. In one embodiment, supplemental materials, and methods of use thereof, are provided for the continuous or discontinuous therapy of defined regions of an organ, organ component or tissue structure. The supplemental materials may be delivered directly to any one or more of the three zones, endoluminal (or ectomural, for solid organs), endomural, or ectoluminal, of organs, organ components, or tissue structures. The supplemental materials can include natural or synthetic polymeric materials that are biodegradable or non-biodegradable. The supplemental materials can also contain bioactive agents to effectuate a change in an organ or organ component in need thereof. For example, agents that result in a reduced/hyponormal response or an amplified/hypernormal response may be included in the supplemental materials.
摘要翻译：疾病，衰老，创伤，环境暴露，感染和其他事件或代理可以改变组织功能。在一个实施方案中，通过治疗改变组织功能来提供治疗。这可以通过继续正常的组织功能，抑制组织功能，或增强组织功能。在一个优选的实施方案中，这种治疗是通过穿透器官，器官组织或组织结构并将补充材料放置在新创建的空间中来实现的。这个空间在本文中通常被称为“特许空间”，即不存在于天然组织中的空间。补充材料可以在区域内沉积和固定。补充材料包括形成障碍，支持物和/或材料的材料，其在体内递送具有药理学，生物化学或生理学作用的试剂。合适的补充材料包括聚合物和非聚合物材料，药理学试剂，细胞，组织片段，微生物，病毒剂或修饰组织功能的其他试剂。补充材料通常以储库/储库或连续或不连续层的形式存在。在一个实施方案中，补充材料及其使用方法被提供用于器官，器官组分或组织结构的限定区域的连续或不连续治疗。补充材料可以直接递送至三个区域中的任何一个或多个区域，腔内（或外部，用于实体器官），器官，器官组织或组织结构的腔内或腔外。补充材料可以包括可生物降解或不可生物降解的天然或合成聚合物材料。补充材料还可以含有生物活性剂以实现有需要的器官或器官组分的变化。例如，导致降低的/低反应性反应或扩增/超常反应的药剂可以包括在补充材料中。

4. 发明申请

WO2008077059A2 PORTABLE ORGAN AND TISSUE PRESERVATION APPARATUS, KIT AND METHODS 审中-公开
标题翻译：便携式组织和组织保存装置，工具包和方法
公开(公告)号：WO2008077059A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/087975
申请日：2007-12-18
申请人： ORGAN TRANSPORT SYSTEMS, INC. , FRANKLIN, Thomas, D. , HYATT, Stacie, L. , WARNER, Howell, E. , WENRICH, Marshall , SLEPIAN, Marvin, J. , LAMBERT, Shell
发明人： FRANKLIN, Thomas, D. , HYATT, Stacie, L. , WARNER, Howell, E. , WENRICH, Marshall , SLEPIAN, Marvin, J. , LAMBERT, Shell
IPC分类号： A01N1/02 , F25B21/02 , F25D3/08
CPC分类号： A01N1/02 , A01N1/0252
摘要： An organ and tissue preservation and transport apparatus comprising a chamber, a temperature control mechanism and a system monitor. A medium bathes an organ within the chamber. The temperature control mechanism adjusts the temperature of the medium. The system monitor receiving and records the temperature of the chamber.
摘要翻译：一种器官和组织保存和输送设备，包括腔室，温度控制机构和系统监测器。中等沐浴室内的器官。温度控制机构调节介质的温度。系统监视器接收和记录室的温度。

5. 发明申请

WO0158368A9 TRANSURETHRAL VOLUME REDUCTION OF THE PROSTATE (TUVOR) 审中-公开
标题翻译：前列腺减压（TUVOR）
公开(公告)号：WO0158368A9
公开(公告)日：2002-10-24
申请号：PCT/US0103940
申请日：2001-02-07
申请人： HARMONIA MEDICAL TECHNOLOGIES , SLEPIAN MARVIN J
发明人： SLEPIAN MARVIN J , YACHIA DANIEL , HOSSAINY SYED , LEVY BARUCH , SOHN ZEEV
IPC分类号： A61B17/00 , A61B17/22 , A61B17/34 , A61B19/00 , A61B17/14
CPC分类号： A61B17/320758 , A61B17/00491 , A61B17/320725 , A61B90/361 , A61B2017/00274 , A61B2017/00557 , A61B2017/22072 , A61B2017/3445 , A61B2018/00547
摘要： A process has been developed to reduce or relieve prostatic obstruction. The steps involved in the TUVOR Process include: 1. Transurethral Incision; 2. De-bulking and Intra-Prostatic Volume Reduction; 3. Intra-prostatic void exclusion and space filling with adhesive and/or therapeutic polymeric materials, alone or in combination with bioactive agents and/or mechanical means for closure; 4. Endourethral compression and prostatic mass remolding; 5. Endourethral Polymer Liner Layer. This liner formed from structurally supportive, yet eventually biodegradable, polymers further bolsters and supports the urethra and peri-urethral tissue during healing, eliminating the need for post-procedure catheter drainage. This step may be optional in specific clinical circumstances. The process is designed to allow outpatient treatment under local anesthesia for BPH.
摘要翻译：已经开发了一种减轻或缓解前列腺阻塞的过程。 TUVOR过程涉及的步骤包括：1.经尿道切口; 减少体重和体内前列腺减少; 3.用粘合剂和/或治疗性聚合物材料单独或与生物活性剂和/或用于封闭的机械装置组合的前列腺空洞排除和空间填充; 4.尿道压迫和前列腺体重重塑; 5.尿道内聚合物衬里层。由结构支持但最终可生物降解的聚合物形成的衬垫在愈合过程中进一步支撑和支撑尿道和尿道周围组织，从而无需进行后路导管引流。在特定临床情况下，此步骤可能是可选的。该过程设计为允许门诊在局部麻醉下进行BPH治疗。

6. 发明申请

WO1991012846A1 METHOD AND APPARATUS FOR TREATMENT OF TUBULAR ORGANS 审中-公开
标题翻译：用于治疗管状器官的方法和装置
公开(公告)号：WO1991012846A1
公开(公告)日：1991-09-05
申请号：PCT/US1991001242
申请日：1991-02-25
申请人： SLEPIAN, Marvin, J.
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M2025/1052 , A61M2025/1095
摘要： A catheter device for the treatment of tubular organs and other body lumens, the device comprising a tubular member having plurality of lumens, first and second expansile members (150, 151) disposed on the tubular member, an angioplasy balloon (153) located between the expansile members (150, 151) and a reservoir (159) containing a therapeutic agent.
摘要翻译：一种用于治疗管状器官和其他体腔的导管装置，所述装置包括具有多个内腔的管状构件，设置在所述管状构件上的第一和第二扩张构件（150,151），位于所述管状构件之间的血管淤积球囊（153）膨胀构件（150,151）和含有治疗剂的储存器（159）。

7. 发明申请

WO1990001969A1 BIODEGRADABLE POLYMERIC ENDOLUMINAL SEALING 审中-公开
标题翻译：可生物降解的聚合物内固定密封
公开(公告)号：WO1990001969A1
公开(公告)日：1990-03-08
申请号：PCT/US1989003593
申请日：1989-08-23
申请人： SLEPIAN, Marvin, J. , SCHINDLER, Anton
IPC分类号： A61M29/00
CPC分类号： A61F2/958 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/945 , A61F2/95 , A61F2002/30062 , A61F2002/30583 , A61F2002/30677 , A61F2210/0004 , A61F2210/0085 , A61F2250/0067 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L31/10 , A61L2300/412 , A61L2300/604 , A61L2300/64 , A61M25/0043 , A61M25/1002 , A61M25/1011 , A61M35/00 , A61M37/00 , F16B37/122 , F16B39/06 , Y10S623/92 , Y10S623/921 , Y10T29/49906 , C08L67/04
摘要： A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen (134) and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansible member (133).
摘要翻译：一种用于通过进入组织内腔的内部并将聚合物施加到组织内腔的内表面来铺展或密封组织腔的内表面的新颖方法。这是使用将聚合物递送到组织腔（134）并使其符合内腔内表面的导管来实现的。可以将聚合物作为单体或预聚物溶液或作为可膨胀构件（133）上的至少部分预制层递送至内腔。

8. 发明申请

WO2007047368A9 CHANNELED ENDOMURAL THERAPY 审中-公开
标题翻译：通道内膜治疗
公开(公告)号：WO2007047368A9
公开(公告)日：2007-06-21
申请号：PCT/US2006039891
申请日：2006-10-13
申请人： ENDOLUMINAL THERAPEUTICS INC , SLEPIAN MARVIN J
发明人： SLEPIAN MARVIN J
IPC分类号： A61B17/22 , A61B17/00 , A61B17/88 , A61B18/24 , A61F2/958
CPC分类号： A61B17/3207 , A61B17/00491 , A61B17/12022 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B17/22 , A61B18/24 , A61B2017/00247 , A61B2017/1205 , A61B2017/22077 , A61B2018/00392 , A61K35/545
摘要： Diseases, aging, trauma, environmental exposure, infection and other events or agents can alter tissue function. In one embodiment, treatment is provided by therapeutically altering tissue function. This may be by continuing normal tissue function, suppressing tissue function, or enhancing tissue function. In a preferred embodiment, this treatment is effectuated by penetrating an organ, organ component or tissue structure and placing a supplemental material in a newly created space. This space is generally referred to herein as a "privileged space", i.e. a space not otherwise present in native tissue. Supplemental materials can be deposited and secured within the zone. Supplemental materials include materials forming barriers, supports, and/or materials that deliver agents having a pharmacologic, biochemical, or physiologic effect in vivo. Suitable supplemental materials include polymeric and non-polymeric materials, pharmacologic agents, cells, tissue fragments, microorganisms, viral agents, or other reagents modifying tissue function. The supplemental material is typically in the form of a reservoir/depot, or continuous or discontinuous layer. In one embodiment, supplemental materials, and methods of use thereof, are provided for the continuous or discontinuous therapy of defined regions of an organ, organ component or tissue structure. The supplemental materials may be delivered directly to any one or more of the three zones, endoluminal (or ectomural, for solid organs), endomural, or ectoluminal, of organs, organ components, or tissue structures. The supplemental materials can include natural or synthetic polymeric materials that are biodegradable or non-biodegradable. The supplemental materials can also contain bioactive agents to effectuate a change in an organ or organ component in need thereof. For example, agents that result in a reduced/hyponormal response or an amplified/hypernormal response may be included in the supplemental materials.
摘要翻译：疾病，老化，创伤，环境暴露，感染等事件或药剂可改变组织功能。在一个实施方案中，通过治疗性改变组织功能来提供治疗。这可能是通过持续正常的组织功能，抑制组织功能或增强组织功能。在优选的实施方案中，通过穿透器官，器官组分或组织结构并将补充材料放置在新创建的空间中来实现该治疗。该空间在本文中通常被称为“特权空间”，即在天然组织中不存在的空间。补充材料可以在区域内沉积并固定。补充材料包括形成屏障，载体和/或递送在体内具有药理学，生物化学或生理学作用的物质的材料。合适的补充材料包括聚合物和非聚合材料，药理学试剂，细胞，组织碎片，微生物，病毒试剂或修饰组织功能的其他试剂。补充材料通常是储存器/储存器或连续或不连续层的形式。在一个实施方案中，提供补充材料及其使用方法用于器官，器官组分或组织结构的限定区域的连续或不连续治疗。补充材料可以直接递送到器官，器官成分或组织结构的内腔（或体外，对于固体器官），内膜或体腔内的三个区域中的任何一个或多个。补充材料可以包括可生物降解或不可生物降解的天然或合成聚合材料。补充材料还可以含有生物活性剂以实现有需要的器官或器官成分的变化。例如，可以在补充材料中包括导致减少/低反应或者放大/超正常反应的药剂。

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