专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008092888A1 1-OXA-3-AZASPIRO[4,5]DECAN--2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS 审中-公开
标题翻译： 1-OXA-3-AZASPIRO [4,5] DECAN - 用于治疗排卵障碍的2-ONE衍生物
公开(公告)号：WO2008092888A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051111
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , BENTLEY, Jonathan , BIAGETTI, Matteo , DI FABIO, Romano , GENSKI, Thorsten , GUERY, Sebastien , KOPF, Silvia, Rosalia , LESLIE, Colin, Philip , MAZZALI, Angelica , MELOTTO, Sergio , PIZZI, Domenica, Antonia , SABBATINI, Fabio, Maria , SERI, Catia
发明人： BENTLEY, Jonathan , BIAGETTI, Matteo , DI FABIO, Romano , GENSKI, Thorsten , GUERY, Sebastien , KOPF, Silvia, Rosalia , LESLIE, Colin, Philip , MAZZALI, Angelica , MELOTTO, Sergio , PIZZI, Domenica, Antonia , SABBATINI, Fabio, Maria , SERI, Catia
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , A61K31/423 , A61P3/00 , A61P25/00
CPC分类号： C07D413/14
摘要： The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R is an aryl or heteroaryl; which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; Z 1 is H, C1-C4 alkyl or F; Z is CH 2 , CH(C1-C4 alkyl), C(C1-C4 alkyl) 2 or a bond; A is a 5 membered heteroaryl, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; B is hydrogen or is a 5-6 membered heteroaryl, or phenyl, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; being A and B linked via any atom; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.
摘要翻译：本发明涉及新的式（I）化合物或其药学上可接受的盐或溶剂化物，其中R是芳基或杂芳基; 其可以被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; Z 1是H，C 1 -C 4烷基或F; Z是CH 2，CH（C 1 -C 4烷基），C（C 1 -C 4烷基）2或键; A是5元杂芳基，其可以被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; B是氢或是5-6元杂芳基，或苯基，其可以被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; 是通过任何原子连接的A和B; 它们的制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为NPY Y5受体拮抗剂以及用于治疗和/或预防进食障碍如暴饮暴食症的药剂。

2. 发明申请

WO2008092887A1 I-OXA-3-AZASPIRO (4.5) DECAN-2-ONE AND 1-OXA-3, 8-DIAZASPIRO (4.5) DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS 审中-公开
标题翻译： I-OXA-3-AZASPIRO（4.5）Decan-2-ONE和1-OXA-3,8-DIAZASPIRO（4.5）Decan-2-ONE衍生物用于治疗排卵病
公开(公告)号：WO2008092887A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051110
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , BENTLEY, Jonathan , BIAGETTI, Matteo , CARDULLO, Francesca , GENSKI, Thorsten , KOPF, Silvia Rosalia , LESLIE, Colin Philip , MELOTTO, Sergio , MENICONI, Mirco , MERLO, Giancarlo , PIZZI, Domenica Antonia , SERI, Catia
发明人： BENTLEY, Jonathan , BIAGETTI, Matteo , CARDULLO, Francesca , GENSKI, Thorsten , KOPF, Silvia Rosalia , LESLIE, Colin Philip , MELOTTO, Sergio , MENICONI, Mirco , MERLO, Giancarlo , PIZZI, Domenica Antonia , SERI, Catia
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , C07D498/10 , A61K31/423 , A61P3/00 , A61P25/00
CPC分类号： C07D498/10 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, formula (I) wherein R is an aryl or heteroaryl; which may be substituted by one or more: halogen, C1 -C4 alkyl, C1-C4 alkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkoxy, cyano; W is -CZ 1 or nitrogen; Z 1 is hydrogen, C1 -C4 alkyl; A is a 5 membered heteroaryl, pyrazine, pyrimidine, or quinoline or quinazoline which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkoxy, cyano; B is hydrogen or a 5-10 membered aryl or heteroaryl which may be substituted by one or more: halogen, C1-C 4 alkyl, C1-C4 alkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkoxy, cyano; being A and B linked via any atom; provided that when W is -CZ 1 , compounds of formula (I) have a trans stereochemistry; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.
摘要翻译：本发明涉及新的式（I）化合物或其药学上可接受的盐或溶剂合物，式（I）其中R是芳基或杂芳基; 其可以被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; W是-CZ 1 N或氮; Z 1是氢，C 1 -C 4烷基; A是可以被一个或多个卤素取代的5元杂芳基，吡嗪，嘧啶或喹啉或喹唑啉：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; B是氢或可被一个或多个取代基取代的5-10元芳基或杂芳基：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; 是通过任何原子连接的A和B; 条件是当W是-CZ 1时，式（I）的化合物具有反式立体化学; 它们的制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为NPY Y5受体拮抗剂以及用于治疗和/或预防进食障碍如狂饮病症的药剂。

3. 发明申请

WO2009095377A1 SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： SPIRO化合物作为NPY Y5受体拮抗剂
公开(公告)号：WO2009095377A1
公开(公告)日：2009-08-06
申请号：PCT/EP2009/050867
申请日：2009-01-27
申请人： GLAXO GROUP LIMITED , BIAGETTI, Matteo , CONTINI, Stefania Anne , GENSKI, Thorsten , GUERY, Sebastien , LESLIE, Colin Philip , MAZZALI, Angelica , PIZZI, Domenica Antonia , SABBATINI, Fabio Maria , SERI, Catia
发明人： BIAGETTI, Matteo , CONTINI, Stefania Anne , GENSKI, Thorsten , GUERY, Sebastien , LESLIE, Colin Philip , MAZZALI, Angelica , PIZZI, Domenica Antonia , SABBATINI, Fabio Maria , SERI, Catia
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , A61K31/423 , A61P3/00
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt thereof, (I) wherein R is an aryl or heteroaryl, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano; Z 1 is H, C 1 -C 4 alkyl or F; Z is CH 2 , CH(C 1 -C 4 alkyl), C(C 1 -C 4 alkyl)2 or a bond; A is a 6-10 membered aryl or heteroaryl, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano; or -C(=O)-X; or O(CH 2 ) 0-1 R 1 ; B is hydrogen or is a 5-6 membered heteroaryl, or a 4-6 membered heterocycle, or phenyl, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, hydroxyl, cyano; A and B being linked via any atom; R 1 is -(C 1 -C 4 )alkyl(C 1 -C 4 )alkoxy; or C 3 -C 8 cycloalkyl; or R 1 is an aryl or heteroaryl, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano; or R 1 is a 4-6 membered heterocycle, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano; X is OR 2 or NR 3 R 4 ; R 2 is C 1 -C 4 alkyl; R 3 is hydrogen or together with R 4 and the nitrogen form a 5-6 saturated membered ring; R 4 is C 3 -C 8 cycloalkyl; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.
摘要翻译：本发明涉及新的式（I）化合物或其药学上可接受的盐，其中R是芳基或杂芳基，其可被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4 烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; Z 1是H，C 1 -C 4烷基或F; Z是CH 2，CH（C 1 -C 4烷基），C（C 1 -C 4烷基）2或键; A是6-10元芳基或杂芳基，其可以被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; 或-C（= O）-X; 或O（CH 2）0-1R1; B是氢或是5-6元杂芳基或4-6元杂环，或苯基，其可被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C4卤代烷氧基，羟基，氰基; A和B通过任何原子相连; R1是 - （C1-C4）烷基（C1-C4）烷氧基; 或C 3 -C 8环烷基; 或者R 1是可被一个或多个卤素取代的芳基或杂芳基：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; 或R 1是4-6元杂环，其可以被一个或多个取代：卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基; X为OR2或NR3R4; R2是C1-C4烷基; R3是氢或与R4一起形成5-6饱和的元环; R4是C3-C8环烷基; 它们的制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为NPY Y5受体拮抗剂以及用于治疗和/或预防进食障碍如狂饮病症的药剂。

4. 发明申请

WO2008152089A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2008152089A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008/057373
申请日：2008-06-12
申请人： GLAXO GROUP LIMITED , GIANOTTI, Massimo , LOVELL, Peter, John , SERI, Catia , TEHAN, Benjamin, Gerald
发明人： GIANOTTI, Massimo , LOVELL, Peter, John , SERI, Catia , TEHAN, Benjamin, Gerald
IPC分类号： C07D295/185 , A61K31/496 , A61P25/18
CPC分类号： C07D295/185
摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof for treating diseases and conditions mediated by positive allosteric modulation of the G- protein coupled metabotropic subtype 5 receptor (mGluR5), such as neurological and psychiatric disorders, for example schizophrenia. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，用于治疗由G-蛋白偶联的代谢型5型受体（mGluR5）的正性变构调节介导的疾病和病症，例如神经和精神疾病，例如精神分裂症。此外，本发明涉及含有衍生物的组合物及其制备方法。

5. 发明申请

WO2008129007A1 BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS 审中-公开
标题翻译：具有异戊二烯残基的苯并咪唑作为NPY-Y5拮抗剂
公开(公告)号：WO2008129007A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054757
申请日：2008-04-18
申请人： GLAXO GROUP LIMITED , BARTON, Nick , BELLENIE, Ben , BENTLEY, Jonathan , BIAGETTI, Matteo , GENSKI, Thorsten , LESLIE, Colin, Philip , MAZZALI, Angelica , PIZZI, Domenica, Antonia , SABBATINI, Fabio, Maria , SERI, Catia
发明人： BARTON, Nick , BELLENIE, Ben , BENTLEY, Jonathan , BIAGETTI, Matteo , GENSKI, Thorsten , LESLIE, Colin, Philip , MAZZALI, Angelica , PIZZI, Domenica, Antonia , SABBATINI, Fabio, Maria , SERI, Catia
IPC分类号： C07D221/20 , C07D471/10 , C07D471/20
CPC分类号： C07D498/10 , C07D221/20 , C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts, solvates, stereoisomers thereof, formula (I), R 1 may be C 1 -C 4 alkyl, aryl or heteroaryl, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano; R 2 may be halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano, nitro; or aryl, heteroaryl or heterocycle, which may be substituted by one or more: halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, cyano; or R 2 may correspond to -0-R 3 ; R 3 is a 6-membered aromatic carbocyclic ring which may contain 1 or 2 nitrogen X is carbon or oxygen; Z is carbon or nitrogen; G is a fused 6-membered aromatic carbocyclic ring which may contain 1 or 2 nitrogen; m may be 0 or an integer ranging from 1 to 4; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY- Y5 receptor antagonists.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，其立体异构体，式（I），R 1可以是C 1 -C 可以被一个或多个取代基取代的烷基，芳基或杂芳基：卤素，C 1 -C 4烷基，C 1 -C 4烷基， C 1 -C 4烷氧基，C 1 -C 4卤代烷基，C 1 -C 3烷基，C 1 -C 4烷基，C 1 -C 4烷基，卤代烷氧基，氰基; R 2可以是卤素，C 1 -C 4烷基，C 1 -C 4烷基，C 1 -C 4烷基， C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，氰基，硝基 ; 或芳基，杂芳基或杂环，其可被一个或多个取代基取代：卤素，C 1 -C 4烷基，C 1 -C C 1-4烷氧基，C 1 -C 4卤代烷基，C 1 -C 4烷基，C 1 -C 4烷基，卤代烷氧基，氰基; 或R 2可以对应于-O-R 3; R 3是6元芳族碳环，其可以含有1或2个氮，X是碳或氧; Z是碳或氮; G是稠合的6元芳族碳环，其可以含有1或2个氮; m可以是0或1至4的整数; 作为其制备方法，在这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为NPY-Y5受体拮抗剂。

6. 发明申请

WO2009043883A1 AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开
标题翻译： AZABICYCLO [3。作为DOPAMINE D3受体的调节剂的HEXYL衍生物
公开(公告)号：WO2009043883A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063166
申请日：2008-10-01
申请人： Glaxo Group Limited , BERTANI, Barbara , CARDULLO, Francesca , DAMBRUOSO, Paolo , MARZORATI, Paola , MICHELI, Fabrizio , PASQUARELLO, Alessandra , SERI, Catia , TEDESCO, Giovanna
发明人： BERTANI, Barbara , CARDULLO, Francesca , DAMBRUOSO, Paolo , MARZORATI, Paola , MICHELI, Fabrizio , PASQUARELLO, Alessandra , SERI, Catia , TEDESCO, Giovanna
IPC分类号： C07D403/14 , C07D413/14 , C07D417/14 , C07D491/052 , A61K31/513 , A61P25/00
CPC分类号： C07D413/14 , C07D403/14 , C07D417/14 , C07D491/052
摘要： The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R 1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl, haloC 1-4 alkoxy and SF 5 , and n is 1 or 2; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
摘要翻译：本发明涉及新的式（I）化合物或其盐：其中R 1是5元杂芳基，任选地与6元杂或碳环稠合; 这样的5或11元系可以任选被1,2,3或4个选自以下的取代基取代：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，C 1-4烷酰基，卤代C 1-4烷基， 4烷氧基和SF5，n为1或2; 它们的制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为多巴胺D3受体的调节剂。治疗药物依赖性，作为抗精神病药，治疗强迫性强迫性疾病或早泄。

7. 发明申请

WO2004099143A1 CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：循环胺衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：WO2004099143A1
公开(公告)日：2004-11-18
申请号：PCT/EP2004/005005
申请日：2004-05-07
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , ARISTA, Luca , CARDULLO, Francesca , D'ADAMO, Lucilla , FERIANI, Aldo , GIOVANNINI, Riccardo , SERI, Catia
发明人： ALVARO, Giuseppe , ARISTA, Luca , CARDULLO, Francesca , D'ADAMO, Lucilla , FERIANI, Aldo , GIOVANNINI, Riccardo , SERI, Catia
IPC分类号： C07D211/34
CPC分类号： C07D405/04 , C07D211/34 , C07D405/12
摘要： A compound of formula (I) wherein R represents a radical selected from i) ii) iii) iv) where the substituents R1, R2, R3, R4, R4, R 7 and the indices m, n and p are as defined in the description; or pharmaceutically acceptable salts and solvates thereof; processes for their preparation to pharmaceutical compositions containing them and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
摘要翻译：式（I）化合物，其中R表示选自i）ii）iii）iv）中的基团，其中取代基R 1，R 2，R 3，R 4，R 4，R 7和索引m，n和p如说明书中所定义 ; 或其药学上可接受的盐和溶剂合物; 其制备方法用于含有它们的药物组合物及其用于治疗由速激肽介导的病症和/或通过选择性抑制5-羟色胺再摄取转运蛋白。

8. 发明申请

WO2004005255A1 N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ AND/ OR SEROTONIN REUPTAKE INHIBITORS 审中-公开
标题翻译：作为TACHYKININ和/或SEROTONIN REUPTAKE抑制剂的N-苄基-3-苯基-3-间苯二甲酰胺化合物
公开(公告)号：WO2004005255A1
公开(公告)日：2004-01-15
申请号：PCT/EP2003/007126
申请日：2003-07-02
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , CARDULLO, Francesca , D'ADAMO, Lucilla , PIGA, Elisabetta , SERI, Catia
发明人： ALVARO, Giuseppe , CARDULLO, Francesca , D'ADAMO, Lucilla , PIGA, Elisabetta , SERI, Catia
IPC分类号： C07D211/14
CPC分类号： C07D207/08 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/535 , C07D207/20 , C07D211/34 , C07D211/38 , C07D211/70 , C07D213/56 , C07D265/30
摘要： The present invention relates to heterocyclic derivatives of formula (1) wherein R 1 represents a 5 or 6 membered heteroaryl group, in which the 5-membered heteroaryl group contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6-membered heteroaryl group contains from 1 to 3 nitrogen atoms, or R 1 represents a 4,5 or 6 membered heterocyclic group, wherein saids 5 or 6 membered heteroaryl or the 4,5 or 6 membered heterocyclic group may optionally be substituted by one to three substituents, which may be the same or different, selected from (CH 2 ) p R 6 , wherein p is zero or an integer from 1 to 4 and wherein R and R 2 - R 6 are each as defined in the description and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
摘要翻译：本发明涉及式（1）的杂环衍生物，其中R 1表示5或6元杂芳基，其中5元杂芳基含有至少一个选自氧，硫或氮的杂原子和6元杂芳基含有1至3个氮原子，或R 1表示4,5或6元杂环基，其中所述5或6元杂芳基或4,5或6元杂环基可以任选被一至三个取代基取代，相同或不同，选自（CH 2）p R 6，其中p为0或1至4的整数，并且其中R和R 2 -R 6各自如说明书中所定义及其药学上可接受的盐和溶剂合物; 其制备方法及其用于治疗由速激肽介导的病症和/或通过选择性抑制5-羟色胺再摄取转运蛋白。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式