专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009043883A1 AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开
标题翻译： AZABICYCLO [3。作为DOPAMINE D3受体的调节剂的HEXYL衍生物
公开(公告)号：WO2009043883A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063166
申请日：2008-10-01
申请人： Glaxo Group Limited , BERTANI, Barbara , CARDULLO, Francesca , DAMBRUOSO, Paolo , MARZORATI, Paola , MICHELI, Fabrizio , PASQUARELLO, Alessandra , SERI, Catia , TEDESCO, Giovanna
发明人： BERTANI, Barbara , CARDULLO, Francesca , DAMBRUOSO, Paolo , MARZORATI, Paola , MICHELI, Fabrizio , PASQUARELLO, Alessandra , SERI, Catia , TEDESCO, Giovanna
IPC分类号： C07D403/14 , C07D413/14 , C07D417/14 , C07D491/052 , A61K31/513 , A61P25/00
CPC分类号： C07D413/14 , C07D403/14 , C07D417/14 , C07D491/052
摘要： The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R 1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl, haloC 1-4 alkoxy and SF 5 , and n is 1 or 2; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
摘要翻译：本发明涉及新的式（I）化合物或其盐：其中R 1是5元杂芳基，任选地与6元杂或碳环稠合; 这样的5或11元系可以任选被1,2,3或4个选自以下的取代基取代：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，C 1-4烷酰基，卤代C 1-4烷基， 4烷氧基和SF5，n为1或2; 它们的制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为多巴胺D3受体的调节剂。治疗药物依赖性，作为抗精神病药，治疗强迫性强迫性疾病或早泄。

2. 发明申请

WO2007113232A1 AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开
标题翻译： AZABICYCLO [3。作为DOPAMINE D3受体的调节剂的HEXYL衍生物
公开(公告)号：WO2007113232A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/053074
申请日：2007-03-30
申请人： Glaxo Group Limited , BERTANI, Barbara , BONANOMI, Giorgio , CAPELLI, Anna Maria , CHECCHIA, Anna , DI FABIO, Romano , GENTILE, Gabriella , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TEDESCO, Giovanna , TERRENI, Silvia
发明人： BERTANI, Barbara , BONANOMI, Giorgio , CAPELLI, Anna Maria , CHECCHIA, Anna , DI FABIO, Romano , GENTILE, Gabriella , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TEDESCO, Giovanna , TERRENI, Silvia
IPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/513 , A61P25/00
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel compounds of formula (I)' or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11 -membered heteroaryl bicyclic group; A is a group P1 or a group P2 Wherein p is an integer ranging from 0 to 5; R 1 is halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1- 4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 6 ; and when p is an integer ranging from 2 to 5, each R 1 may be the same or different; R 2 is hydrogen or C 1-4 alkyl; n is 3, 4, 5 or 6; R 6 is a moiety selected from the group consisting of: isoxazolyl, -CH 2 -N-pyrrolyl, 1,1 -dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such R 6 group is optionally substituted by one or two substituents selected from: halogen, cyano, C 1- 4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl; R 4 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1- 4 alkyl, C 3-7 cycloalkyl, haloC 1-4 alkyl, C 1-4- alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR'R"; or R 4 is a phenyl group, a 5-14 membered heterocyclic group; and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl, haloC 1-4 alkoxy and SF 5 ; R 5 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, C 3-7 cycloalkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR'R"; or R 5 is a phenyl group, a 5-14 membered heterocyclic group; and any of such phenyl or heterocyclic groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; R 7 is hydrogen or C 1-2 alkyl; R' is H, C 1-4 alkyl or C 1-4 alkanoyl; R" is defined as R'; R' and R" taken together with the interconnecting nitrogen atom may form a 5-, 6- membered saturated or unsaturated heterocyclic ring; wherein at least one of R 4 and R 5 is hydrogen; and wherein only one R 2 group may be different from hydrogen; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
摘要翻译：本发明涉及新的式（I）化合物或其盐：其中G选自：苯基，5-或6-元单环杂芳基或8-至11元杂芳基双环基团 A是基团P1或基团P2，其中p是0至5的整数; R 1是卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷基，烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5; 或对应于基团R 6; 并且当p是2至5的整数时，每个R 1可以相同或不同; R 2是氢或C 1-4烷基; n为3,4,5或6; R 6是选自以下的部分：异恶唑基，-CH 2 - N-吡咯基，1,1-二氧代-2-异噻唑烷基，噻吩基，噻唑基，吡啶基，2-吡咯烷酮基和这样的R 6 C 6基团任选地被一个或两个选自以下的取代基取代：卤素，氰基，C 1-4 - >一

3. 发明申请

WO2007125061A1 SPIROCOMPOUNDS USEFUL AS MODULATORS FOR DOPAMINE D3 RECEPTORS 审中-公开
标题翻译：作为DOPAMINE D3受体的调节剂的螺旋体有用
公开(公告)号：WO2007125061A1
公开(公告)日：2007-11-08
申请号：PCT/EP2007/054003
申请日：2007-04-24
申请人： GLAXO GROUP LIMITED , BERTANI, Barbara , DI FABIO, Romano , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TARSI, Luca , TERRENI, Silvia
发明人： BERTANI, Barbara , DI FABIO, Romano , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TARSI, Luca , TERRENI, Silvia
IPC分类号： C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/10 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/506 , A61P25/18
CPC分类号： C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/10
摘要： The present invention relates to compounds of formula (I) or salts thereof wherein A, X and R 4 are defined herein, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or to enhance cognition.
摘要翻译：本发明涉及式（I）化合物或其盐，其中A，X和R 4在本文中定义，其制备方法，用于这些方法的中间体，含有它们的药物组合物及其用途在治疗中，作为多巴胺D 3受体的调节剂，例如，治疗药物依赖性，作为抗精神病药，治疗强迫性强迫症，早泄或增强认知。

4. 发明申请

WO2007113260A1 AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开
标题翻译： AZABICYCLO [3。作为DOPAMINE D3受体的调节剂的HEXYL衍生物
公开(公告)号：WO2007113260A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/053117
申请日：2007-03-30
申请人： GLAXO GROUP LIMITED , BERTANI, Barbara , CHECCHIA, Anna , DI FABIO, Romano , GENTILE, Gabriella , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TERRENI, Silvia
发明人： BERTANI, Barbara , CHECCHIA, Anna , DI FABIO, Romano , GENTILE, Gabriella , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TERRENI, Silvia
IPC分类号： C07D401/14 , C07D403/06 , C07D405/14 , A61K31/513 , A61P25/00
CPC分类号： C07D401/14 , C07D403/06 , C07D405/14
摘要： The present invention relates to novel compounds or pharmaceutically acceptable saltsthereof: wherein G is selected from a group consisting of : phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11-membered heteroaryl bicyclic group; A is a group P wherein P is p is an integer ranging from 0 to 5; Rl, R2, R3, R4,R5 and R7 are as defined in the claims, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
摘要翻译：本发明涉及新化合物或其药学上可接受的盐衍生物：其中G选自：苯基，5-或6-元单环杂芳基或8-至11元杂芳基双环基; A为基团P，其中P为p为0至5的整数; R 1，R 2，R 3，R 4，R 5和R 7如权利要求书中所定义，其制备方法，在这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为多巴胺D3受体的调节剂。治疗药物依赖性，作为抗精神病药，治疗强迫性强迫性疾病或早泄。

5. 发明申请

WO2008031772A1 AZABICYCLIC COMPOUNDS AS INHIBITORS OF MONOAMINES REUPTAKE 审中-公开
标题翻译：单一化合物作为单体反应的抑制剂
公开(公告)号：WO2008031772A1
公开(公告)日：2008-03-20
申请号：PCT/EP2007/059381
申请日：2007-09-07
申请人： GLAXO GROUP LIMITED , BERTANI, Barbara , DI FABIO, Romano , MICHELI, Fabrizio , TEDESCO, Giovanna , TERRENI, Silvia
发明人： BERTANI, Barbara , DI FABIO, Romano , MICHELI, Fabrizio , TEDESCO, Giovanna , TERRENI, Silvia
IPC分类号： C07D221/04 , A61K31/435 , A61P25/00
CPC分类号： C07D221/04
摘要： The present invention relates to novel compounds of formula (I)´, pharmaceutically acceptable salts, prodrugs or solvates thereof: wherein R 1 is hydrogen or C 1-4 alkyl; R 2 is a group A, K or W wherein A is (II) K is an α or β naphthyl group, optionally substituted by 1 or 2 groups R 18 , each of them being the same or different; and W is (III) and wherein G is a 5,6-membered monocyclic heteroaryl, or a 8- to 11-membered heteroaryl bicyclic group; such G may be substituted by (R 15 ) p , which can be the same or different; p is an integer from 0 to 5; R 3 is selected in the group consisting of: hydrogen, fluorine, and C 1-4 alkyl; or corresponds to a group X or X 1 ; R 4 is selected in the group consisting of: hydrogen, fluorine, and C 1-4 alkyl; or corresponds to a group X or X 1 ; R 5 is hydrogen or C 1-4 alkyl; R 7 is hydrogen or C 1-4 alkyl; or is a group X, X 1 , X 2 or X 3 ; wherein X is (IV) X 1 is (V) X 2 is (VI) and X 3 is (VII) R 6 is hydrogen or C 1-4 alkyl; or is a group X or X 1 ; R 9 is C 1-4 alkyl; R 10 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 8 ; R 8 is a 5-6 membered heterocycle group, which may be substituted by one or two substituents selected from a group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy and C 1-4 alkanoyl; R 11 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 aIkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 8 ; R 12 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 aIkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 8 ; R 13 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 8 ; R 14 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 aIkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 8 ; R 15 is selected from a group consisting of: halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 8 ; R 16 is hydrogen, C 1-4 alkyl, C 3-6 cycloalkyl or C 3-6 cycloalkylC 1-3 alkyl; R 17 is hydrogen or C 1-4 alkyl; R 18 is selected from a group consisting of: halog
摘要翻译：本发明涉及新的式（I）化合物，其药学上可接受的盐，前药或溶剂合物：其中R 1是氢或C 1-4烷基; R 2是基团A，K或W，其中A是（II）K是任选被1或2个基团R 18取代的a或β萘基，每个他们是相同或不同的; 并且W是（III），并且其中G是5,6-元单环杂芳基或8至11元杂芳基双环基团; 这样的G可以被相同或不同的（R 15） p是0至5的整数; R 3 3选自：氢，氟和C 1-4烷基; 或对应于组X或X 1 1; R 4选自：氢，氟和C 1-4烷基; 或对应于组X或X 1 1; R 5是氢或C 1-4烷基; R 7是氢或C 1-4烷基; 或者为X，X 1，X 2或X 3; 其中X是（Ⅳ）ⅩⅢ是（Ⅴ）ⅩⅥ是（Ⅵ），ⅩⅢ是（Ⅶ） 6是氢或C 1-4烷基; 或者是X或X 1族; R 9是C 1-4烷基; R 10选自：氢，卤素，羟基，氰基，C 1-4 - 烷基，卤代C 1-4 - 烷基 C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5; 或对应于基团R 8; R 8是5-6元杂环基团，其可以被一个或两个选自以下的取代基取代：卤素，氰基，C 1-4烷基卤代C 1-4烷基，C 1-4烷氧基和C 1-4烷酰基; R 11选自：氢，卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5。或对应于基团R 8; R 12选自：氢，卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5。或对应于基团R 8; R 13选自：氢，卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基 C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5; 或对应于基团R 8; R 14选自：氢，卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5。或对应于基团R 8; R 15选自：卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4个碳原子的烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5。或对应于基团R 8; R 16是氢，C 1-4烷基，C 3-6环烷基或C 3-6环烷基C _{1-3 烷基; R 17是氢或C 1-4烷基; R 18选自：卤素}

6. 发明申请

WO2009043884A1 AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开
标题翻译： AZABICYCLO [3。作为DOPAMINE D3受体的调节剂的HEXYL衍生物
公开(公告)号：WO2009043884A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063168
申请日：2008-10-01
申请人： Glaxo Group Limited , BERTANI, Barbara , CREMONESI, Susanna , FONTANA, Stefano , PASQUARELLO, Alessandra
发明人： BERTANI, Barbara , CREMONESI, Susanna , FONTANA, Stefano , PASQUARELLO, Alessandra
IPC分类号： C07D207/36 , C07D209/02 , C07D401/14 , C07D403/06 , C07D417/14 , A61K31/53 , A61P25/18
CPC分类号： C07D403/06 , C07D207/36 , C07D209/02 , C07D401/14 , C07D417/14
摘要： The present invention relates to novel compounds of formula (I) or a salt thereof, wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11-membered heteroaryl bicyclic group; p is an integer ranging from 0 to 5; R 1 is halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ; or corresponds to a group R 6 ; and when p is an integer ranging from 2 to 5, each R 1 may be the same or different; R 2 is hydrogen or C 1-4 alkyl; n is 3, 4, 5 or 6; R 6 is a moiety selected from the group consisting of: isoxazolyl, -CH 2 -N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such R 6 group is optionally substituted by one or two substituents selected from: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl; R 4 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C 1-4 alkyl, C 3-7 cycloalkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and NR'R"; or R 4 is a phenyl group, a 5-14 membered heterocyclic group; and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl, haloC 1-4 alkoxy and SF 5 ; R 7 is hydrogen or C 1-2 alkyl; R' is H, C 1-4 alkyl or C 1-4 alkanoyl; R" is defined as R'; R' and R" taken together with the interconnecting nitrogen atom may form a 5-, 6-membered saturated or unsaturated heterocyclic ring; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
摘要翻译：本发明涉及新的式（I）化合物或其盐，其中G选自：苯基，5-或6-元单环杂芳基或8至11元杂芳基双环组; p为0〜5的整数。 R 1是卤素，羟基，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和SF 5; 或对应于基团R6; 并且当p是2至5的整数时，每个R 1可以相同或不同; R2是氢或C1-4烷基; n为3,4,5或6; R6是选自以下的部分：异恶唑基，-CH 2 -N-吡咯基，1,1-二氧化-2-异噻唑烷基，噻吩基，噻唑基，吡啶基，2-吡咯烷酮基，这些R 6基团任选地被一个或多个选自以下的两个取代基：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，C 1-4烷酰基; R4选自：氢，卤素，羟基，氰基，C 1-4烷基，C 3-7环烷基，卤代C 1-4烷基，C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基和NR'R“;或R 4是苯基，5-14元杂环基;任何这样的苯基或杂环基任选被1,2或3或4个选自以下的取代基取代：卤素，氰基，C 1-4烷基，卤代C 1-4烷基 C 1-4烷氧基，C 1-4烷酰基，卤代C 1-4烷氧基和SF 5; R 7是氢或C 1-2烷基; R'是H，C 1-4烷基或C 1-4烷酰基; R“定义为R' R'和R“与互连氮原子一起可以形成5-，6-元饱和或不饱和杂环;其制备方法，在这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为调节剂多巴胺D3受体，例如治疗药物依赖性，作为抗精神病药，治疗强迫性强迫症或早泄。

7. 发明申请

WO2008037681A1 5-{2-[4-(2-METHYL-5-QUINOLINYL)-L-PIPERIDINYL] ETHYL} QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIREMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. 审中-公开
标题翻译：作为5HT1A受体调节剂的5- {2- [4-（2-甲基-5-喹啉基）-L-哌啶子基]乙基}喹啉酮衍生物，用于治疗性功能障碍，认知障碍，精神病，焦虑，抑郁等。
公开(公告)号：WO2008037681A1
公开(公告)日：2008-04-03
申请号：PCT/EP2007/060082
申请日：2007-09-24
申请人： GLAXO GROUP LIMITED , BERTANI, Barbara , BROMIDGE, Steven, Mark , GIANOTTI, Massimo , PASQUARELLO, Alessandra , ZUCCHELLI, Valeria
发明人： BERTANI, Barbara , BROMIDGE, Steven, Mark , GIANOTTI, Massimo , PASQUARELLO, Alessandra , ZUCCHELLI, Valeria
IPC分类号： C07D401/12 , C07D401/14 , C07D487/08 , A61K31/496
CPC分类号： C07D401/12 , C07D401/14 , C07D487/08
摘要： The invention provides compounds of formula (I) wherein R 1 is C 1-6 alkyl, halo or haloC 1-6 alkyl; R 2 is hydrogen or C 1-6 alkyl; ===== is a single or double bond; each R 3 and R 4 , which may be the same or different, are hydrogen, C 1-6 alkyl or haloC 1-6 alkyl; wherein i) when ===== is a double bond p and q are 1, and ii) when ===== is a single bond, p and q are 2, and one of R 3 and one of R 4 together with their interconnecting atoms, forms a cyclopropane ring which may be substituted by one or two halo or methyl groups, which groups may be the same or different; X is CH or N; when present each R 5 , which may be the same or different, is C 1-6 alkyl or halo; or two R 5 groups may join to form a bridge, which bridge contains one or two atoms; n is 0, 1, 2 or 3; when present each R 6 which may be the same or different, is C 1-6 alkyl or halo; and m is 0, 1, 2 or 3.
摘要翻译：本发明提供了式（I）的化合物，其中R 1是C 1-6烷基，卤素或卤代C 1-6 烷基; R 2是氢或C 1-6烷基; ^{===== 是单键或双键; 每个R 3和R 4可以相同或不同，为氢，C 1-6烷基或卤代C 1 -6 烷基; 其中i）当^{===== 是双键时p和q是1，并且ii）当^{===== 是单键时，p和q 是2，并且R 3和R 4中的一个与它们的相互连接原子一起形成环丙烷环，其可以被一个或两个卤素或甲基取代，哪些组可能是相同的或不同的; X是CH或N; 当存在时，每个R 5可以相同或不同，为C 1-6烷基或卤代; 或者两个R 5基团可以连接形成桥，该桥包含一个或两个原子; n是0,1,2或3; 当存在时，每个R 6可以相同或不同，为C 1-6烷基或卤代; 而m是0,1,2或3。}}}

8. 发明申请

WO2007113258A1 AZABICYCLO [3. 1. O] HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开
标题翻译： AZABICYCLO [3。作为DOPAMINE D3受体的调节剂的HEXANE衍生物
公开(公告)号：WO2007113258A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/053115
申请日：2007-03-30
申请人： GLAXO GROUP LIMITED , BERTANI, Barbara , FABRIZIO, Micheli , PASQUARELLO, Alessandra , TERRENI, Silvia
发明人： BERTANI, Barbara , FABRIZIO, Micheli , PASQUARELLO, Alessandra , TERRENI, Silvia
IPC分类号： C07D401/06 , C07D401/14 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof where the substitvents are as defined in claim 1 processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中方案如权利要求1所定义，其制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为多巴胺D3受体，例如治疗药物依赖性，作为抗精神病药，治疗强迫性强迫性疾病或早泄。

9. 发明申请

WO2006024517A1 FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开
标题翻译：用于治疗心理障碍的融合三聚体衍生物
公开(公告)号：WO2006024517A1
公开(公告)日：2006-03-09
申请号：PCT/EP2005/009379
申请日：2005-08-29
申请人： GLAXO GROUP LIMITED , BENTLEY, Jonathan , BERGAUER, Markus , BERTANI, Barbara , BIAGETTI, Matteo , BORRIELLO, Manuela , BROMIDGE, Steven, Mark , GIANOTTI, Massimo , GRANCI, Enrica , LESLIE, Colin, Philip , PASQUARELLO, Alessandra , ZUCCHELLI, Valeria
发明人： BENTLEY, Jonathan , BERGAUER, Markus , BERTANI, Barbara , BIAGETTI, Matteo , BORRIELLO, Manuela , BROMIDGE, Steven, Mark , GIANOTTI, Massimo , GRANCI, Enrica , LESLIE, Colin, Philip , PASQUARELLO, Alessandra , ZUCCHELLI, Valeria
IPC分类号： C07D498/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) wherein R 1 , R 2 , X, A, Y, B, Z 1 , Q, p, r and s are defined in the specification for treating inter alia psychotic disorders, depressive disorders, anxiety disorders and sexual dysfunctions.
摘要翻译：式（I）化合物，其中R

10. 发明申请

WO2011151361A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2011151361A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/059011
申请日：2011-06-01
申请人： GLAXO GROUP LIMITED , BERTANI, Barbara , CREMONESI, Susanna , GARZYA, Vincenzo , MICHELI, Fabrizio , RUPCIC, Renata , SABBATINI, Fabio Maria
发明人： BERTANI, Barbara , CREMONESI, Susanna , GARZYA, Vincenzo , MICHELI, Fabrizio , RUPCIC, Renata , SABBATINI, Fabio Maria
IPC分类号： C07D513/04 , A61K31/542 , A61P25/00
CPC分类号： C07D513/04
摘要： The invention relates to tricyclic derivatives, and their use in treating diseases and conditions mediated by antagonism of the mGluR 5 receptor, in particular substance related disorders. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
摘要翻译：本发明涉及三环衍生物及其在治疗由mGluR5受体的拮抗作用介导的疾病和病症中的用途，特别是与物质有关的疾病。此外，本发明涉及含有衍生物的组合物及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式