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1. 发明申请

WO2004099143A1 CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：循环胺衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：WO2004099143A1
公开(公告)日：2004-11-18
申请号：PCT/EP2004/005005
申请日：2004-05-07
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , ARISTA, Luca , CARDULLO, Francesca , D'ADAMO, Lucilla , FERIANI, Aldo , GIOVANNINI, Riccardo , SERI, Catia
发明人： ALVARO, Giuseppe , ARISTA, Luca , CARDULLO, Francesca , D'ADAMO, Lucilla , FERIANI, Aldo , GIOVANNINI, Riccardo , SERI, Catia
IPC分类号： C07D211/34
CPC分类号： C07D405/04 , C07D211/34 , C07D405/12
摘要： A compound of formula (I) wherein R represents a radical selected from i) ii) iii) iv) where the substituents R1, R2, R3, R4, R4, R 7 and the indices m, n and p are as defined in the description; or pharmaceutically acceptable salts and solvates thereof; processes for their preparation to pharmaceutical compositions containing them and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
摘要翻译：式（I）化合物，其中R表示选自i）ii）iii）iv）中的基团，其中取代基R 1，R 2，R 3，R 4，R 4，R 7和索引m，n和p如说明书中所定义 ; 或其药学上可接受的盐和溶剂合物; 其制备方法用于含有它们的药物组合物及其用于治疗由速激肽介导的病症和/或通过选择性抑制5-羟色胺再摄取转运蛋白。

2. 发明申请

WO2004005256A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2004005256A2
公开(公告)日：2004-01-15
申请号：PCT/EP2003/007127
申请日：2003-07-02
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , CARDULLO, Francesca , DI FABIO, Romano , GIOVANNINI, Riccardo , PIGA, Elisabetta , TRANQUILLINI, Maria, Elvira
发明人： ALVARO, Giuseppe , CARDULLO, Francesca , DI FABIO, Romano , GIOVANNINI, Riccardo , PIGA, Elisabetta , TRANQUILLINI, Maria, Elvira
IPC分类号： C07D211/34
CPC分类号： C07D211/34 , C07D211/64 , C07D223/04 , C07D223/06
摘要： The present invention relates to cyclic amine derivatives of formula(I) (I)whereinR represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy;R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy;R2 represents hydrogen or C1-4 alkyl;R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl;R5 represents trifluoromethyl, S(O)t C 1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano;R6 represents hydrogen or (CH2)rR7;R7 represents hydrogen, C3-7 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2 , OC(O)NR9R8 , NR8C(O)R9 or C(O)NR9R8;R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4;n represents 1 or 2;p is zero or an integer from 1 to 3;q is an integer from 1 to 3;r is an integer from 1 to 4;t is 0 , 1 or 2 ;provided that when m is 0, p is 2, q , r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein .
摘要翻译：本发明涉及式（I）（I）的环胺衍生物，其中R代表卤素，C 1-4烷基，氰基，C 1-4烷氧基，三氟甲基或三氟甲氧基; R 1代表氢，卤素，氰基或C1-4烷基; R2代表氢或C1-4烷基; R3和R4独立地代表氢，氰基，C1-4烷基或R3 与R 4一起代表C 3-7环烷基; R 5代表三氟甲基，S（O）t C 1-4烷基，C 1-4烷基，C 1-4烷氧基，三氟甲氧基，卤素或氰基; R 6代表氢或（CH 2）r R 7; R 7 （C 1-4烷基），N（C 1-4烷基）2，OC（O）NR 9 R 8，NR 8 C（O）R 9或C（O）NR 9 R 8; R9和R8独立地表示氢，C1-4烷基或C3-7环烷基; m表示0或1至4的整数; n表示1或2; p为0或1至3的整数; q为1至3的整数; r为1至4的整数; t为0， 1或2;条件是当m为0时，p为2，q，r和n表示1，R1，R2，R3，R4，R5和R7是氢并且R是氯，R5不是碘; 及其药学上可接受的盐和溶剂合物; 它们的制备方法以及它们在治疗由粘着激肽介导的病症和/或通过选择性抑制血清素再摄取转运蛋白中的用途。

3. 发明申请

WO2007042239A1 PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS 审中-公开
标题翻译：丙酰胺衍生物作为钠通道调节剂
公开(公告)号：WO2007042239A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/009731
申请日：2006-10-06
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , BERGAUER, Markus , GIOVANNINI, Riccardo , PROFETA, Roberto
发明人： ALVARO, Giuseppe , BERGAUER, Markus , GIOVANNINI, Riccardo , PROFETA, Roberto
IPC分类号： C07D207/22 , A61K31/401 , A61P25/24
CPC分类号： C07D207/22
摘要： The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.
摘要翻译：本发明提供式（I）化合物，其溶剂合物，盐或前药，其可用于治疗通过调节依赖于电压门控钠通道介导的疾病和病症。

4. 发明申请

WO2007042250A1 PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS 审中-公开
标题翻译：丙酰胺衍生物作为钠通道调节剂
公开(公告)号：WO2007042250A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/009746
申请日：2006-10-06
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , ANDREOTTI, Daniele , BERGAUER, Markus , GIOVANNINI, Riccardo , MARASCO, Agostino
发明人： ALVARO, Giuseppe , ANDREOTTI, Daniele , BERGAUER, Markus , GIOVANNINI, Riccardo , MARASCO, Agostino
IPC分类号： C07D207/22 , A61K31/401 , A61P25/24 , C07D211/60 , C07D401/04 , C07D487/04 , A61K31/451 , A61K31/407
CPC分类号： C07D487/04 , C07D207/22 , C07D211/60 , C07D401/04
摘要： This invention relates to novel -aminocarboxyamide derivatives of formula (I) for treating diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.
摘要翻译：本发明涉及式（I）的新型氨基羧基酰胺衍生物，其用于治疗通过调节依赖于电压门控钠通道介导的疾病和病症。

5. 发明申请

WO2005049600A1 BETA-LACTAMS FOR TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS疾病的BETA-LACTAMS
公开(公告)号：WO2005049600A1
公开(公告)日：2005-06-02
申请号：PCT/EP2004/012772
申请日：2004-11-10
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , DI FABIO, Romano , GIOVANNINI, Riccardo , PAIO, Alfredo , TRANQUILLINI, Maria, Elvira , MATTIOLI, Lucia
发明人： ALVARO, Giuseppe , DI FABIO, Romano , GIOVANNINI, Riccardo , PAIO, Alfredo , TRANQUILLINI, Maria, Elvira , MATTIOLI, Lucia
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to novel compounds of formula (I) wherein ---- represents a single or a double bond; R represents a radical selected from formulae i), ii), iii) and iv) in which R 1 is halogen, cyano, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethyl or trifluoromethoxy and p is zero or an integer from 1 to 3; R 2 represents hydrogen or C 1-4 alkyl; R 3 represents hydrogen, hydroxy or C 1-4 alkyl; R 4 represents hydrogen or R 4 together with R 3 represents =0 or =CH 2 ; R 5 represents phenyl, naphthyl, a 9 to 10 membered fused bicyclic heterocyclic group or a 5 or 6 membered heteroaryl group, wherein said groups are optionally substituted by 1 to 3 groups independently selected from trifluoromethyl, C 1-4 alkyl, hydroxy, cyano, C 1-4 alkoxy, trifluoromethoxy, halogen or S(O)qC 1-4 alkyl; R 6 and R 7 independently represent hydrogen, cyano, C 1-4 alkyl; R 8 is (CH 2 )rR 10 ; R 9 represents hydrogen, halogen, C 3-7 cycloalkyl, hydroxy, nitro, cyano or C 1-4 alkyl optionally substituted by one or two groups selected from halogen, cyano, hydroxy or C 1-4 alkoxy; R 10 represents hydrogen or C 3-7 cycloalkyl; n represents 1 or 2; q is 0, 1 or 2; r is 0 or an integer from 1 to 4; or a pharmaceutically acceptable salt or a solvate thereof, process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of the serotonin reuptake transporter protein.
摘要翻译：本发明涉及式（I）的新化合物，其中----表示单键或双键; R表示选自式i），ii），iii）和iv）中的基团，其中R 1为卤素，氰基，C 1-4烷基，C 1-4烷氧基，三氟甲基或三氟甲氧基，p为0或1至3的整数 ; R2代表氢或C1-4烷基; R3表示氢，羟基或C1-4烷基; R4表示氢或R4，R3表示= 0或= CH2; R5表示苯基，萘基，9至10元稠合双环杂环基或5或6元杂芳基，其中所述基团任选被1至3个独立地选自三氟甲基，C 1-4烷基，羟基，氰基，C 1-4烷氧基，三氟甲氧基，卤素或S（O）qC 1-4烷基; R6和R7独立地表示氢，氰基，C1-4烷基; R8为（CH2）rR10; R9代表氢，卤素，C3-7环烷基，羟基，硝基，氰基或任选被一个或两个选自卤素，氰基，羟基或C 1-4烷氧基的基团取代的C 1-4烷基; R 10表示氢或C 3-7环烷基; n表示1或2; q是0,1或2; r为0或1至4的整数; 或其药学上可接受的盐或溶剂合物，其制备方法及其用于治疗由粘蛋白介导的病症和/或通过选择性抑制5-羟色胺再摄取转运蛋白。

6. 发明申请

WO2007028654A1 PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开
标题翻译：吡啶衍生物及其在治疗心理疾病中的应用
公开(公告)号：WO2007028654A1
公开(公告)日：2007-03-15
申请号：PCT/EP2006/008845
申请日：2006-09-07
申请人： SMITHKLINE BEECHAM CORPORATION , ALVARO, Giuseppe , ANDREOTTI, Daniele , BELVEDERE, Sandro , DI FABIO, Romano , FALCHI, Alessandro , GIOVANNINI, Riccardo
发明人： ALVARO, Giuseppe , ANDREOTTI, Daniele , BELVEDERE, Sandro , DI FABIO, Romano , FALCHI, Alessandro , GIOVANNINI, Riccardo
IPC分类号： C07D513/04 , C07D487/04 , C07D498/04 , A61K31/4985 , A61K31/5383 , A61K31/542 , A61K31/4439 , A61K31/551 , A61P25/00
CPC分类号： C07D487/04 , C07D513/04
摘要： There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: X represents a nitrogen atom; Y represents -C(H 2 )-, (-C(H 2 )-) 2 , -S(O 2 )- or -C(=O)-; Z represents -C(H 2 )-, -S(O 2 )-, -N(R z )-, or an oxygen or sulphur atom; A represents hydrogen or -CH 2 OH; R z represents hydrogen, C 1-6 alkyl, C 1-6 alkoxy, -COR7 or -SO2R7; R 1 represents halogen, C 1-6 alkyl, C 1-6 alkoxy, =O, haloC 1-6 alkyl, haloC 1-6 alkoxy, hydroxyl or -CH 2 OH; m represents an integer from 0 to 3; R 2 represents halogen, =O, C 1-6 alkyl (optionally substituted by one or more hydroxyl groups), -COOR 7 , -CONR 7 R 8 , C 1-6 alkoxy, haloC 1-6 alkyl, haloC 1-6 alkoxy or C 1-6 alkyloC 1-6 alkyl; n represents an integer from 0 to 3; p and q independently represent an integer from 0 to 2; R 3 represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, C 1-6 alkyl (optionally substituted by one or more hydroxyl groups), C 3-8 cycloalkyl, C 1-6 alkoxy, hydroxyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, cyano, -S-C 1-6 alkyl, -SO-C 1-6 alkyl, -SO 2 -C 1-6 alkyl, -COR 7 , -CONR 7 R 8 , -NR 7 R 8 , -NR 7 COC 1-6 alkyl, -NR 7 SO 2 -C 1-6 alkyl, C 1-6 alkyl-NR 7 R 8 , -OCONR 7 R 8 , -NR 7 CO 2 R 8 or -SO 2 NR 7 R 8 groups; R 4 and R 5 independently represent C 1-6 alkyl, or R 4 and R 5 together with the carbon atom to which they are attached may together form a C 3-8 cycloalkyl group; R6 represents halogen, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, haloC 1-6 alkyl or haloC 1-6 alkoxy; s represents an integer from 0 to 4; R 7 and R 8 independently represent hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl; or solvates thereof.
摘要翻译：根据本发明提供式（I）的新化合物或其药学上可接受的盐：（I）其中：X表示氮原子; Y表示-C（H）2 - ， - （-C（H）2） - ）2，-S（O）2 - 或-C（= O） - ; Z表示-C（H）2 - ， - S（O）2 - ， - N（R z） - 或氧或硫原子; A表示氢或-CH 2 OH; R z表示氢，C 1-6烷基，C 1-6烷氧基，-COR 7或-SO 2 R 7; R 1表示卤素，C 1-6烷基，C 1-6烷氧基，= O，卤代C 1-6 - 烷基，卤代C 1-6烷氧基，羟基或-CH 2 OH; m表示0〜3的整数， R 2表示卤素，= O，C 1-6烷基（任选被一个或多个羟基取代），-COOR 7， - CONR 7，R 8，C 1-6烷氧基，卤代C 1-6烷基，卤代C 1 -6个烷氧基或C 1-6烷基C 1-6烷基; n表示0〜3的整数， p和q独立地表示0至2的整数; R 3表示芳基，杂芳基，杂环基， - 芳基 - 芳基， - 芳基 - 杂芳基， - 芳基 - 杂环基， - 杂芳基 - 芳基 - 杂芳基 - 杂芳基 - 杂芳基 - 杂环基， - 杂环基 - 芳基 - 杂环基 - 杂芳基或 - 杂环基 - 杂环基，其全部可以任选被一个或多个（例如1,2或3）卤素，C 1-6 - 烷基（任选被一个或多个羟基取代），C 3-8环烷基，C 1-6烷氧基，羟基，卤代C 1-6烷基，卤代C 1-6烷氧基，氰基，-SC 1-6烷基，-SO-C 1-6烷基，-SO _{8或-SO 2 NR 7 R 8 8个基团; R 4和R 5独立地表示C 1-6烷基，或R 4和R 5 与它们所连接的碳原子一起可以一起形成C 3〜C 8环烷基; R 6表示卤素，C 1-6烷基，C 3-8环烷基，C 1-6烷氧基，卤代C 1-6 烷基或卤代C 1-6烷氧基; s表示0〜4的整数， R 7和R 8独立地表示氢，C 1-6烷基或C 3-8环烷基; 或溶剂化物。}

7. 发明申请

WO2010115836A4 SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS 审中-公开
公开(公告)号：WO2010115836A4
公开(公告)日：2010-10-14
申请号：PCT/EP2010/054396
申请日：2010-04-01
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , GRUNDL, Marc , DOLLINGER, Horst , GIOVANNINI, Riccardo , HOENKE, Christoph , HOFFMANN, Matthias , KRIEGL, Jan , MARTYRES, Domnic , RAST, Georg , SEITHER, Peter
发明人： GRUNDL, Marc , DOLLINGER, Horst , GIOVANNINI, Riccardo , HOENKE, Christoph , HOFFMANN, Matthias , KRIEGL, Jan , MARTYRES, Domnic , RAST, Georg , SEITHER, Peter
IPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/4523 , A61K31/454 , A61P31/00 , A61P35/00 , A61P37/00
摘要： Object of the present invention are novel substituted compounds of the formula 1, wherein A, R 1 , R 2 , R 3 and R 4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

8. 发明申请

WO2010070032A1 CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD 审中-公开
标题翻译： CYPIC PYRIMIDIN-4-CARBOXAMIDES作为CCR2受体拮抗剂用于治疗炎症，哮喘和COPD
公开(公告)号：WO2010070032A1
公开(公告)日：2010-06-24
申请号：PCT/EP2009/067378
申请日：2009-12-17
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , EBEL, Heiner , FRATTINI, Sara , GIOVANNINI, Riccardo , HOENKE, Christoph , TRIESELMANN, Thomas , TIELMANN, Patrick , SCHEUERER, Stefan , HOBBIE, Silke (Marie Katrin)
发明人： EBEL, Heiner , FRATTINI, Sara , GIOVANNINI, Riccardo , HOENKE, Christoph , TRIESELMANN, Thomas , TIELMANN, Patrick , SCHEUERER, Stefan , HOBBIE, Silke (Marie Katrin)
IPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14 , A61K31/506 , A61P29/00 , C07D407/14 , C07D471/10
CPC分类号： C07D498/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/052 , Y02A50/385 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, =CH-, -CH 2 -, -O-, -S-, and -NH-; wherein n is 1, 2 or 3; wherein Z is C or N, the other variables are as defined in the claims, as well as in form of their acid addition salts with pharmacologically acceptable acids.
摘要翻译：本发明涉及CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。式（I）其中A选自单键，= CH - ， - CH 2 - ， - O - ， - S - 和-NH-; 其中n为1,2或3; 其中Z是C或N，其它变量如权利要求中所定义，以及其与药理学上可接受的酸的酸加成盐的形式。

9. 发明申请

WO2012110599A1 TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：三环吡啶衍生物，含有这些化合物的药物，其使用及其制备方法
公开(公告)号：WO2012110599A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052687
申请日：2012-02-16
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , WAGNER, Holger , BERTA, Daniela , FUCHS, Klaus , GIOVANNINI, Riccardo , HAMPRECHT, Wolfgang , KONETZKI, Ingo , STREICHER, Ruediger , TRIESELMANN, Thomas
发明人： WAGNER, Holger , BERTA, Daniela , FUCHS, Klaus , GIOVANNINI, Riccardo , HAMPRECHT, Wolfgang , KONETZKI, Ingo , STREICHER, Ruediger , TRIESELMANN, Thomas
IPC分类号： C07D491/04 , A61P3/06 , A61P9/00 , A61K31/4741
CPC分类号： C07D491/048 , C07D491/107 , C07D491/18
摘要： The present invention relates to compounds defined by formula (I), wherein the variables R 1 -R 8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
摘要翻译：本发明涉及由式（I）定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理学活性。特别地，化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病。

10. 发明申请

WO2011018495A1 NEW COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的新化合物
公开(公告)号：WO2011018495A1
公开(公告)日：2011-02-17
申请号：PCT/EP2010/061735
申请日：2010-08-12
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , HEINE, Niklas , DORNER-CIOSSEK, Cornelia , EICKMEIER, Christian , FIEGEN, Dennis , FOX, Thomas , FUCHS, Klaus , GIOVANNINI, Riccardo , ROSENBROCK, Holger , SCHAENZLE, Gerhard , BAERFACKER, Lars
发明人： HEINE, Niklas , DORNER-CIOSSEK, Cornelia , EICKMEIER, Christian , FIEGEN, Dennis , FOX, Thomas , FUCHS, Klaus , GIOVANNINI, Riccardo , ROSENBROCK, Holger , SCHAENZLE, Gerhard , BAERFACKER, Lars
IPC分类号： C07D487/04 , A61K31/522 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention relates to novel pyrazolopyrimidinones according to formula (I). The new compounds shall be used for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease. Further aspects of the present invention refer to a process for the manufacture of the compounds and their use for producing medicaments.
摘要翻译：本发明涉及式（I）的新型吡唑并嘧啶酮。新化合物应用于制造药物，特别是用于治疗有关感知，集中，学习或记忆缺陷的病症的药物。新化合物也用于制备用于治疗阿尔茨海默氏病的药物。本发明的其它方面是指化合物的制造方法及其制造用药物的用途。

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