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1. 发明申请

WO2012167260A2 SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE 审中-公开
标题翻译：用于监控基于时间的照片活动代理商交付或照片活动标记的系统和方法
公开(公告)号：WO2012167260A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/040758
申请日：2012-06-04
申请人： AVEDRO, INC. , FRIEDMAN, Marc D. , KAMAEV, Pavel , MULLER, David , PERTAUB, Radha , SCHARF, Ronald , SHERR, Evan , USHER, David
发明人： FRIEDMAN, Marc D. , KAMAEV, Pavel , MULLER, David , PERTAUB, Radha , SCHARF, Ronald , SHERR, Evan , USHER, David
IPC分类号： A61B3/107 , A61B3/14
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像，以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

2. 发明申请

WO2010115121A1 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2010115121A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029806
申请日：2010-04-02
申请人： AVEDRO, INC. , MULLER, David , RYAN, Thomas , SCHARF, Ronald
发明人： MULLER, David , RYAN, Thomas , SCHARF, Ronald
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1815 , A61F9/007 , A61F9/0079 , A61F9/013 , A61F2009/00872 , A61N1/403
摘要： An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The energy conducting applicator includes an outer conductor and an inner conductor extending to the distal end. The outer conductor and the inner conductor are separated by a gap. The outer conductor includes a plurality of moveable outer segments and the inner conductor includes a plurality of moveable inner segments. The plurality of outer segments and the plurality of inner segments form a total contact surface at the distal end. The total contact surface is positionable at a surface of an eye. The electrical energy is applied to the eye according to the total contact surface.
摘要翻译：一个实施例中的电能施加器从近端延伸到远端。能量传导施加器在近端处包括与一个或多个电能源的连接。能量传导施加器将电能从一个或多个电能源引导到远端。能量传导施加器包括外导体和延伸到远端的内导体。外导体和内导体间隔开。外导体包括多个可移动外部段，并且内部导体包括多个可移动的内部段。多个外部段和多个内部段在远端处形成总接触表面。总接触表面可定位在眼睛的表面。电能根据总接触面施加到眼睛。

3. 发明申请

WO2011116306A3 SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
公开(公告)号：WO2011116306A3
公开(公告)日：2011-09-22
申请号：PCT/US2011/029033
申请日：2011-03-18
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Ronald , KAMAEV, Pavel , PERTAUB, Radha
发明人： MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Ronald , KAMAEV, Pavel , PERTAUB, Radha
IPC分类号： A61F9/00 , A61B3/10 , A61N5/06 , A61M35/00 , A61B3/107
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

4. 发明申请

WO2009094049A1 SYSTEM AND METHOD FOR RESHAPING AN EYE FEATURE 审中-公开
标题翻译：用于修复眼睛特征的系统和方法
公开(公告)号：WO2009094049A1
公开(公告)日：2009-07-30
申请号：PCT/US2008/076062
申请日：2008-09-11
申请人： AVEDRO, INC. , MULLER, David , SCHARF, Ronald , RYAN, Thomas , MARSHALL, Neal , WU, Artie
发明人： MULLER, David , SCHARF, Ronald , RYAN, Thomas , MARSHALL, Neal , WU, Artie
IPC分类号： A61N1/00
CPC分类号： A61B18/14 , A61B18/18 , A61B18/1815 , A61B2018/00017 , A61B2018/00035 , A61B2090/065 , A61F9/0079 , A61F9/009 , A61F9/013 , A61F2009/00853 , A61F2009/00872
摘要： A system for applying therapy to an eye includes an applicator having a conducting element configured to direct energy from an energy source to an application end of the conducting element, where the application end has at least one eye contact portion. A positioning system positions the at least one eye contact portion in stable engagement with the eye surface. The conducting element is disposed within a housing for the applicator and at least one adjustment system is employed to move the conducting element relative to the housing. The at least one adjustment system enables controlled movement of the conducting element and the at least one eye contact portion against the corneal surface. In particular embodiments, sufficient contact between the applicator and the cornea is determined by causing applanation of the cornea. In other embodiments, at least one measurement device is employed to determine when sufficient contact has been established.
摘要翻译：用于向眼睛施加治疗的系统包括具有导电元件的施用器，该导电元件被配置为将能量从能量源引导到导电元件的施加端，其中施加端具有至少一个眼睛接触部分。定位系统将至少一个眼睛接触部分定位成与眼睛表面稳定接合。导电元件设置在用于施用器的壳体内，并且使用至少一个调节系统来相对于壳体移动导电元件。所述至少一个调节系统使得能够控制所述导电元件和所述至少一个眼睛接触部分抵靠角膜表面的移动。在特定实施例中，施加器和角膜之间的充分接触是通过引起角膜的扁平化来确定的。在其他实施例中，采用至少一个测量装置来确定何时建立了足够的接触。

5. 发明申请

WO2010115126A1 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2010115126A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029812
申请日：2010-04-02
申请人： AVEDRO, INC. , MULLER, David , RYAN, Thomas , SCHARF, Ronald
发明人： MULLER, David , RYAN, Thomas , SCHARF, Ronald
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1815 , A61F9/007 , A61F9/0079
摘要： Embodiments according to aspects of the present invention provide a single convenient and versatile tool that allows an operator to apply energy to the cornea according to different patterns to suit different treatment cases, without requiring multiple applicators or interchangeable components. An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The distal end is positionable at a surface of an eye. The energy conducting applicator includes at least three selectable conductors coupled to the one or more electrical energy sources. The selectable conductors define an outer conductor and an inner conductor being separated by a gap.
摘要翻译：根据本发明的方面的实施例提供了一种单一的方便和通用的工具，其允许操作者根据不同的模式将能量施加到角膜以适应不同的治疗情况，而不需要多个施用器或可互换部件。一个实施例中的电能施加器从近端延伸到远端。能量传导施加器在近端处包括与一个或多个电能源的连接。能量传导施加器将电能从一个或多个电能源引导到远端。远端可定位在眼睛的表面。能量传导施加器包括耦合到一个或多个电能源的至少三个可选导体。可选择的导体限定外部导体和内部导体，间隔开。

6. 发明申请

WO2012167260A3 SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE 审中-公开
标题翻译：用于监控基于时间的照片活动代理商交付或照片活动标记的系统和方法
公开(公告)号：WO2012167260A3
公开(公告)日：2013-03-14
申请号：PCT/US2012040758
申请日：2012-06-04
申请人： AVEDRO INC , FRIEDMAN MARC D , KAMAEV PAVEL , MULLER DAVID , PERTAUB RADHA , SCHARF RONALD , SHERR EVAN , USHER DAVID
发明人： FRIEDMAN MARC D , KAMAEV PAVEL , MULLER DAVID , PERTAUB RADHA , SCHARF RONALD , SHERR EVAN , USHER DAVID
IPC分类号： A61B3/107 , A61B3/14
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像，以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

7. 发明申请

WO2011116306A2 SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
标题翻译：用于应用和监测眼睛治疗的系统和方法
公开(公告)号：WO2011116306A2
公开(公告)日：2011-09-22
申请号：PCT/US2011029033
申请日：2011-03-18
申请人： AVEDRO INC , MULLER DAVID , MARSHALL JOHN , FRIEDMAN MARC , BLINN STEPHEN , SCHARF RONALD , KAMAEV PAVEL , PERTAUB RADHA
发明人： MULLER DAVID , MARSHALL JOHN , FRIEDMAN MARC , BLINN STEPHEN , SCHARF RONALD , KAMAEV PAVEL , PERTAUB RADHA
IPC分类号： A61F9/00 , A61B3/10 , A61B3/107 , A61M35/00 , A61N5/06
CPC分类号： A61N5/0625 , A61B3/10 , A61B3/107 , A61F9/00 , A61F9/0079 , A61F9/008 , A61F2009/00844 , A61F2009/00857 , A61F2009/00872 , A61N5/062 , A61N2005/0643 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
摘要翻译：用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。提供反馈系统以获取测量并将反馈信息传递给控制器。反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。还提供反馈系统的方面来监测和诊断眼睛的特征1.还提供了根据由反馈系统提供的信息激活交联以提高交联疗法的准确性和安全性的方法。

8. 发明申请

WO2010056848A1 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2010056848A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064189
申请日：2009-11-12
申请人： AVEDRO, INC. , RYAN, Thomas , PERTAUB, Radha , MEYERS, Steven , DRESHER, Russ , MULLER, David , SCHARF, Ronald
发明人： RYAN, Thomas , PERTAUB, Radha , MEYERS, Steven , DRESHER, Russ , MULLER, David , SCHARF, Ronald
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1815 , A61B2090/065 , A61F9/0079
摘要： Systems and methods improve operation of an applicator that delivers heat- generating energy to an eye as a part of an eye therapy. For example, reflected power may be measured to determine whether sufficient contact has been established between the applicator and the eye for accurate and precise delivery of energy to the eye. In addition, at least one of forward and reflected power may be measured to monitor the application of coolant pulses that control the generation of heat in the eye when the applicator delivers energy to the eye. Further, the forward and reflected power may be measured to determine an efficiency of energy transfer or an impedance mismatch. Based on the efficiency of energy transfer or the impedance mismatch, an adjustable parameter of a tuning element may be modified.
摘要翻译：系统和方法改善了作为眼部治疗的一部分向眼睛提供热量产生能量的施用器的操作。例如，可以测量反射功率以确定施用器和眼睛之间是否已经建立足够的接触，以准确和精确地将能量递送到眼睛。此外，可以测量正向和反射功率中的至少一个以监测当施用器向眼睛递送能量时控制眼睛中的热量产生的冷却剂脉冲的应用。此外，可以测量正向和反射功率以确定能量传递的效率或阻抗失配。基于能量传递的效率或阻抗失配，可以修改调谐元件的可调参数。

9. 发明申请

WO2010039117A1 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2010039117A1
公开(公告)日：2010-04-08
申请号：PCT/US2008/076023
申请日：2008-09-11
申请人： AVEDRO, INC. , MULLER, David , SCHARF, Ronald , RYAN, Thomas , MARSHALL, Neal , PERTAUB, Radha , WU, Artie
发明人： MULLER, David , SCHARF, Ronald , RYAN, Thomas , MARSHALL, Neal , PERTAUB, Radha , WU, Artie
IPC分类号： A61B18/04
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/00011 , A61F9/007 , A61F9/0079
摘要： A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.
摘要翻译：用于向眼睛施加治疗的系统选择性地将冷却剂施加到角膜表面，以在热机器人成形期间最小化对角膜表面的热损伤。实施例可以包括能量源，导电元件，冷却剂供应和冷却剂输送系统。导电元件可操作地连接到能量源并且从近端延伸到远端。导电元件将能量从能量源引导到可在眼睛处定位的远端。冷却剂输送系统与冷却剂供应源连通并且可操作以将冷却剂的微控制脉冲输送到远端。

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